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Entry version 168 (07 Oct 2020)
Sequence version 4 (05 Oct 2010)
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Protein

Kinesin-like protein KIF9

Gene

KIF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi12 – 14ATP3
Nucleotide bindingi93 – 100ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9HAQ2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000088727.12

Human Gene Nomenclature Database

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HGNCi
HGNC:16666, KIF9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607910, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAQ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64147

Open Targets

More...
OpenTargetsi
ENSG00000088727

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30110

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HAQ2, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2321637

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KIF9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153656

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254421 – 790Kinesin-like protein KIF9Add BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei530PhosphothreonineCombined sources1
Modified residuei546PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HAQ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9HAQ2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HAQ2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9HAQ2

PeptideAtlas

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PeptideAtlasi
Q9HAQ2

PRoteomics IDEntifications database

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PRIDEi
Q9HAQ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81418 [Q9HAQ2-1]
81419 [Q9HAQ2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000088727, Expressed in testis and 207 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HAQ2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HAQ2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000088727, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9HAQ2
With#Exp.IntAct
ACBD4 [K7EM05]3EBI-8472129,EBI-16431307
ALAS1 [P13196]3EBI-8472129,EBI-3905054
AMOTL2 [Q9Y2J4]3EBI-8472129,EBI-746752
ATP5IF1 [Q9UII2]3EBI-8472129,EBI-718459
BLZF1 [Q9H2G9]3EBI-8472129,EBI-2548012
CCDC125 [Q86Z20]3EBI-8472129,EBI-11977221
CXorf56 [Q9H5V9]3EBI-8472129,EBI-1053419
CYTIP [O60759]3EBI-8472129,EBI-997814
DISC1 - isoform 2 [Q9NRI5-2]3EBI-8472129,EBI-11988027
EMD [P50402]3EBI-8472129,EBI-489887
FXR1 - isoform 2 [P51114-2]3EBI-8472129,EBI-11022345
GOLGA6A [Q9NYA3]5EBI-8472129,EBI-11163335
HMBOX1 [Q6NT76]3EBI-8472129,EBI-2549423
HOOK2 - isoform 2 [Q96ED9-2]3EBI-8472129,EBI-10961706
HSF2BP [O75031]3EBI-8472129,EBI-7116203
IHO1 [Q8IYA8]3EBI-8472129,EBI-8638439
IKZF3 [Q9UKT9]3EBI-8472129,EBI-747204
INKA1 [Q96EL1]3EBI-8472129,EBI-10285157
IQCB1 - isoform 2 [Q15051-2]3EBI-8472129,EBI-11944935
KANK2 [Q63ZY3]3EBI-8472129,EBI-2556193
KCTD9 [Q7L273]3EBI-8472129,EBI-4397613
KRT75 [O95678]3EBI-8472129,EBI-2949715
KRTAP10-6 [P60371]3EBI-8472129,EBI-12012928
LZTS1 [Q9Y250]3EBI-8472129,EBI-1216080
MAD1L1 [Q9Y6D9]3EBI-8472129,EBI-742610
MID1 [O15344]3EBI-8472129,EBI-2340316
MID2 - isoform 2 [Q9UJV3-2]3EBI-8472129,EBI-10172526
MIPOL1 [Q8TD10]3EBI-8472129,EBI-2548751
NAB2 [Q15742]3EBI-8472129,EBI-8641936
OIP5 [O43482]3EBI-8472129,EBI-536879
OOEP [A6NGQ2]3EBI-8472129,EBI-18583589
PIBF1 [Q4G0R1]3EBI-8472129,EBI-14066006
PNMA5 [Q96PV4]3EBI-8472129,EBI-10171633
PPP1R13B [Q96KQ4]3EBI-8472129,EBI-1105153
PRICKLE1 [Q96MT3]3EBI-8472129,EBI-2348662
PRMT6 [Q96LA8]2EBI-8472129,EBI-912440
RBM48 [Q5RL73]3EBI-8472129,EBI-473821
SHISA6 [Q6ZSJ9]3EBI-8472129,EBI-12037847
SLAIN1 [Q8ND83]3EBI-8472129,EBI-10269374
TFIP11 [Q9UBB9]3EBI-8472129,EBI-1105213
TRIM54 [Q9BYV2]3EBI-8472129,EBI-2130429
VIM [P08670]3EBI-8472129,EBI-353844
VPS52 [Q8N1B4]3EBI-8472129,EBI-2799833
ZBTB8A [Q96BR9]3EBI-8472129,EBI-742740
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-8472129,EBI-14104088
ZCCHC7 [Q8N3Z6]3EBI-8472129,EBI-7265024
ZNF417 [Q8TAU3]3EBI-8472129,EBI-740727
ZNF436 [Q9C0F3]3EBI-8472129,EBI-8489702
ZNF566 [Q969W8]3EBI-8472129,EBI-2555762
ZNF572 [Q7Z3I7]3EBI-8472129,EBI-10172590
ZRANB1 [Q9UGI0]3EBI-8472129,EBI-527853

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
122086, 64 interactors

Protein interaction database and analysis system

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IntActi
Q9HAQ2, 53 interactors

Molecular INTeraction database

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MINTi
Q9HAQ2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000333942

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HAQ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9HAQ2

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9HAQ2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 340Kinesin motorPROSITE-ProRule annotationAdd BLAST335

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili342 – 380Sequence analysisAdd BLAST39
Coiled coili658 – 690Sequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4280, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158533

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001485_16_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HAQ2

KEGG Orthology (KO)

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KOi
K10397

Identification of Orthologs from Complete Genome Data

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OMAi
TMIGDTR

Database of Orthologous Groups

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OrthoDBi
424630at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAQ2

TreeFam database of animal gene trees

More...
TreeFami
TF105229

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24115, PTHR24115, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225, Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00129, KISc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HAQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTRKKVHAF VRVKPTDDFA HEMIRYGDDK RSIDIHLKKD IRRGVVNNQQ
60 70 80 90 100
TDWSFKLDGV LHDASQDLVY ETVAKDVVSQ ALDGYNGTIM CYGQTGAGKT
110 120 130 140 150
YTMMGATENY KHRGILPRAL QQVFRMIEER PTHAITVRVS YLEIYNESLF
160 170 180 190 200
DLLSTLPYVG PSVTPMTIVE NPQGVFIKGL SVHLTSQEED AFSLLFEGET
210 220 230 240 250
NRIIASHTMN KNSSRSHCIF TIYLEAHSRT LSEEKYITSK INLVDLAGSE
260 270 280 290 300
RLGKSGSEGQ VLKEATYINK SLSFLEQAII ALGDQKRDHI PFRQCKLTHA
310 320 330 340 350
LKDSLGGNCN MVLVTNIYGE AAQLEETLSS LRFASRMKLV TTEPAINEKY
360 370 380 390 400
DAERMVKNLE KELALLKQEL AIHDSLTNRT FVTYDPMDEI QIAEINSQVR
410 420 430 440 450
RYLEGTLDEI DIISLRQIKE VFNQFRVVLS QQEQEVESTL RRKYTLIDRN
460 470 480 490 500
DFAAISAIQK AGLVDVDGHL VGEPEGQNFG LGVAPFSTKP GKKAKSKKTF
510 520 530 540 550
KEPLSSLARK EGASSPVNGK DLDYVSTSKT QLVPSSKDGD VKDMLSRDRE
560 570 580 590 600
TSSIEPLPSD SPKEELRPIR PDTPPSKPVA FEEFKNEQGS EINRIFKENK
610 620 630 640 650
SILNERRKRA SETTQHINAI KREIDVTKEA LNFQKSLREK QGKYENKGLM
660 670 680 690 700
IIDEEEFLLI LKLKDLKKQY RSEYQDLRDL RAEIQYCQHL VDQCRHRLLM
710 720 730 740 750
EFDIWYNESF VIPEDMQMAL KPGGSIRPGM VPVNRIVSLG EDDQDKFSQL
760 770 780 790
QQRVLPEGPD SISFYNAKVK IEQKHNYLKT MMGLQQAHRK
Length:790
Mass (Da):89,986
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD5CCEDFA64FA971
GO
Isoform 2 (identifier: Q9HAQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-569: Missing.

Show »
Length:725
Mass (Da):82,972
Checksum:iA1D28B310994F210
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DZK5B4DZK5_HUMAN
Kinesin-like protein
KIF9
333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWZ7C9JWZ7_HUMAN
Kinesin-like protein KIF9
KIF9
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUW8E7EUW8_HUMAN
Kinesin-like protein KIF9
KIF9
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6PJI1Q6PJI1_HUMAN
KIF9 protein
KIF9
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14713 differs from that shown. Dubious isoform. Probable cloning artifact lacking polyadenylation evidence.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02213978V → I. Corresponds to variant dbSNP:rs2270569Ensembl.1
Natural variantiVAR_02044396G → A. Corresponds to variant dbSNP:rs3733092Ensembl.1
Natural variantiVAR_024513638R → W2 PublicationsCorresponds to variant dbSNP:rs2276853Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002868505 – 569Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF311212 mRNA Translation: AAG33849.1
AC104447 Genomic DNA No translation available.
BC030657 mRNA Translation: AAH30657.1
AK023894 mRNA Translation: BAB14713.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2751.1 [Q9HAQ2-2]
CCDS2752.1 [Q9HAQ2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001128350.1, NM_001134878.1 [Q9HAQ2-1]
NP_071737.1, NM_022342.4 [Q9HAQ2-2]
NP_878905.2, NM_182902.3 [Q9HAQ2-1]
XP_011532306.1, XM_011534004.2 [Q9HAQ2-1]
XP_016862518.1, XM_017007029.1 [Q9HAQ2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265529; ENSP00000265529; ENSG00000088727 [Q9HAQ2-1]
ENST00000335044; ENSP00000333942; ENSG00000088727 [Q9HAQ2-1]
ENST00000444589; ENSP00000414987; ENSG00000088727 [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727 [Q9HAQ2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64147

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64147

UCSC genome browser

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UCSCi
uc003cqx.3, human [Q9HAQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311212 mRNA Translation: AAG33849.1
AC104447 Genomic DNA No translation available.
BC030657 mRNA Translation: AAH30657.1
AK023894 mRNA Translation: BAB14713.1 Sequence problems.
CCDSiCCDS2751.1 [Q9HAQ2-2]
CCDS2752.1 [Q9HAQ2-1]
RefSeqiNP_001128350.1, NM_001134878.1 [Q9HAQ2-1]
NP_071737.1, NM_022342.4 [Q9HAQ2-2]
NP_878905.2, NM_182902.3 [Q9HAQ2-1]
XP_011532306.1, XM_011534004.2 [Q9HAQ2-1]
XP_016862518.1, XM_017007029.1 [Q9HAQ2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NWNX-ray2.00A1-340[»]
SMRiQ9HAQ2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122086, 64 interactors
IntActiQ9HAQ2, 53 interactors
MINTiQ9HAQ2
STRINGi9606.ENSP00000333942

Chemistry databases

ChEMBLiCHEMBL2321637

PTM databases

iPTMnetiQ9HAQ2
PhosphoSitePlusiQ9HAQ2

Polymorphism and mutation databases

BioMutaiKIF9
DMDMi308153656

Proteomic databases

jPOSTiQ9HAQ2
MassIVEiQ9HAQ2
MaxQBiQ9HAQ2
PaxDbiQ9HAQ2
PeptideAtlasiQ9HAQ2
PRIDEiQ9HAQ2
ProteomicsDBi81418 [Q9HAQ2-1]
81419 [Q9HAQ2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12887, 119 antibodies

The DNASU plasmid repository

More...
DNASUi
64147

Genome annotation databases

EnsembliENST00000265529; ENSP00000265529; ENSG00000088727 [Q9HAQ2-1]
ENST00000335044; ENSP00000333942; ENSG00000088727 [Q9HAQ2-1]
ENST00000444589; ENSP00000414987; ENSG00000088727 [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727 [Q9HAQ2-1]
GeneIDi64147
KEGGihsa:64147
UCSCiuc003cqx.3, human [Q9HAQ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64147
DisGeNETi64147
EuPathDBiHostDB:ENSG00000088727.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIF9
HGNCiHGNC:16666, KIF9
HPAiENSG00000088727, Tissue enhanced (testis)
MIMi607910, gene
neXtProtiNX_Q9HAQ2
OpenTargetsiENSG00000088727
PharmGKBiPA30110

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4280, Eukaryota
GeneTreeiENSGT00940000158533
HOGENOMiCLU_001485_16_2_1
InParanoidiQ9HAQ2
KOiK10397
OMAiTMIGDTR
OrthoDBi424630at2759
PhylomeDBiQ9HAQ2
TreeFamiTF105229

Enzyme and pathway databases

PathwayCommonsiQ9HAQ2
ReactomeiR-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
64147, 7 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIF9, human
EvolutionaryTraceiQ9HAQ2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64147
PharosiQ9HAQ2, Tbio

Protein Ontology

More...
PROi
PR:Q9HAQ2
RNActiQ9HAQ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088727, Expressed in testis and 207 other tissues
ExpressionAtlasiQ9HAQ2, baseline and differential
GenevisibleiQ9HAQ2, HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
PANTHERiPTHR24115, PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225, Kinesin, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00129, KISc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAQ2
Secondary accession number(s): Q86Z28, Q9H8A4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 5, 2010
Last modified: October 7, 2020
This is version 168 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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