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UniProtKB - Q9HAQ2 (KIF9_HUMAN)

Entry version 174 (23 Feb 2022)
Sequence version 4 (05 Oct 2010)
Previous versions | rss
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Protein

Kinesin-like protein KIF9

Gene

KIF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for normal male fertility and for progressive motility of spermatozoa.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi12 – 14ATP3
Nucleotide bindingi93 – 100ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9HAQ2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9HAQ2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16666, KIF9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607910, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9HAQ2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000088727

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		64147

Open Targets

More...OpenTargetsi		ENSG00000088727

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30110

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9HAQ2, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2321637

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIF9

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153656

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254421 – 790Kinesin-like protein KIF9Add BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei530PhosphothreonineCombined sources1
Modified residuei546PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9HAQ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9HAQ2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9HAQ2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9HAQ2

PeptideAtlas

More...PeptideAtlasi		Q9HAQ2

PRoteomics IDEntifications database

More...PRIDEi		Q9HAQ2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81418 [Q9HAQ2-1]
81419 [Q9HAQ2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9HAQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9HAQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088727, Expressed in testis and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9HAQ2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9HAQ2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088727, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HYDIN.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9HAQ2
With#Exp.IntAct
ACBD4 [K7EM05]3EBI-8472129,EBI-16431307
ALAS1 [P13196]3EBI-8472129,EBI-3905054
AMOTL2 [Q9Y2J4]3EBI-8472129,EBI-746752
ATP5IF1 [Q9UII2]3EBI-8472129,EBI-718459
BLZF1 [Q9H2G9]3EBI-8472129,EBI-2548012
CCDC125 [Q86Z20]3EBI-8472129,EBI-11977221
CYTIP [O60759]3EBI-8472129,EBI-997814
DISC1 - isoform 2 [Q9NRI5-2]3EBI-8472129,EBI-11988027
EMD [P50402]3EBI-8472129,EBI-489887
FXR1 - isoform 2 [P51114-2]3EBI-8472129,EBI-11022345
GOLGA6A [Q9NYA3]5EBI-8472129,EBI-11163335
HMBOX1 [Q6NT76]3EBI-8472129,EBI-2549423
HOOK2 - isoform 2 [Q96ED9-2]3EBI-8472129,EBI-10961706
HSF2BP [O75031]3EBI-8472129,EBI-7116203
IHO1 [Q8IYA8]3EBI-8472129,EBI-8638439
IKZF3 [Q9UKT9]3EBI-8472129,EBI-747204
INKA1 [Q96EL1]3EBI-8472129,EBI-10285157
IQCB1 - isoform 2 [Q15051-2]3EBI-8472129,EBI-11944935
KANK2 [Q63ZY3]3EBI-8472129,EBI-2556193
KCTD9 [Q7L273]3EBI-8472129,EBI-4397613
KRT75 [O95678]3EBI-8472129,EBI-2949715
KRTAP10-6 [P60371]3EBI-8472129,EBI-12012928
LZTS1 [Q9Y250]3EBI-8472129,EBI-1216080
MAD1L1 [Q9Y6D9]3EBI-8472129,EBI-742610
MID1 [O15344]3EBI-8472129,EBI-2340316
MID2 - isoform 2 [Q9UJV3-2]3EBI-8472129,EBI-10172526
MIPOL1 [Q8TD10]3EBI-8472129,EBI-2548751
NAB2 [Q15742]3EBI-8472129,EBI-8641936
OIP5 [O43482]3EBI-8472129,EBI-536879
OOEP [A6NGQ2]3EBI-8472129,EBI-18583589
PIBF1 [Q4G0R1]3EBI-8472129,EBI-14066006
PNMA5 [Q96PV4]3EBI-8472129,EBI-10171633
PPP1R13B [Q96KQ4]3EBI-8472129,EBI-1105153
PRICKLE1 [Q96MT3]3EBI-8472129,EBI-2348662
PRMT6 [Q96LA8]2EBI-8472129,EBI-912440
RBM48 [Q5RL73]3EBI-8472129,EBI-473821
SHISA6 [Q6ZSJ9]3EBI-8472129,EBI-12037847
SLAIN1 [Q8ND83]3EBI-8472129,EBI-10269374
STEEP1 [Q9H5V9]3EBI-8472129,EBI-1053419
TFIP11 [Q9UBB9]3EBI-8472129,EBI-1105213
TRIM54 [Q9BYV2]3EBI-8472129,EBI-2130429
VIM [P08670]3EBI-8472129,EBI-353844
VPS52 [Q8N1B4]3EBI-8472129,EBI-2799833
ZBTB8A [Q96BR9]3EBI-8472129,EBI-742740
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-8472129,EBI-14104088
ZCCHC7 [Q8N3Z6]3EBI-8472129,EBI-7265024
ZNF417 [Q8TAU3]3EBI-8472129,EBI-740727
ZNF436 [Q9C0F3]3EBI-8472129,EBI-8489702
ZNF566 [Q969W8]3EBI-8472129,EBI-2555762
ZNF572 [Q7Z3I7]3EBI-8472129,EBI-10172590
ZRANB1 [Q9UGI0]3EBI-8472129,EBI-527853

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122086, 68 interactors

Protein interaction database and analysis system

More...IntActi		Q9HAQ2, 55 interactors

Molecular INTeraction database

More...MINTi		Q9HAQ2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333942

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9HAQ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1790
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9HAQ2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9HAQ2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 340Kinesin motorPROSITE-ProRule annotationAdd BLAST335

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni477 – 578DisorderedSequence analysisAdd BLAST102

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili342 – 380Sequence analysisAdd BLAST39
Coiled coili658 – 690Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi520 – 535Polar residuesSequence analysisAdd BLAST16
Compositional biasi540 – 571Basic and acidic residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4280, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158533

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001485_16_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9HAQ2

Identification of Orthologs from Complete Genome Data

More...OMAi		AFFQAQK

Database of Orthologous Groups

More...OrthoDBi		424630at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9HAQ2

TreeFam database of animal gene trees

More...TreeFami		TF105229

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...PANTHERi		PTHR24115, PTHR24115, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00225, Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00129, KISc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HAQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTRKKVHAF VRVKPTDDFA HEMIRYGDDK RSIDIHLKKD IRRGVVNNQQ 
        60         70         80         90        100
TDWSFKLDGV LHDASQDLVY ETVAKDVVSQ ALDGYNGTIM CYGQTGAGKT 
       110        120        130        140        150
YTMMGATENY KHRGILPRAL QQVFRMIEER PTHAITVRVS YLEIYNESLF 
       160        170        180        190        200
DLLSTLPYVG PSVTPMTIVE NPQGVFIKGL SVHLTSQEED AFSLLFEGET 
       210        220        230        240        250
NRIIASHTMN KNSSRSHCIF TIYLEAHSRT LSEEKYITSK INLVDLAGSE 
       260        270        280        290        300
RLGKSGSEGQ VLKEATYINK SLSFLEQAII ALGDQKRDHI PFRQCKLTHA 
       310        320        330        340        350
LKDSLGGNCN MVLVTNIYGE AAQLEETLSS LRFASRMKLV TTEPAINEKY 
       360        370        380        390        400
DAERMVKNLE KELALLKQEL AIHDSLTNRT FVTYDPMDEI QIAEINSQVR 
       410        420        430        440        450
RYLEGTLDEI DIISLRQIKE VFNQFRVVLS QQEQEVESTL RRKYTLIDRN 
       460        470        480        490        500
DFAAISAIQK AGLVDVDGHL VGEPEGQNFG LGVAPFSTKP GKKAKSKKTF 
       510        520        530        540        550
KEPLSSLARK EGASSPVNGK DLDYVSTSKT QLVPSSKDGD VKDMLSRDRE 
       560        570        580        590        600
TSSIEPLPSD SPKEELRPIR PDTPPSKPVA FEEFKNEQGS EINRIFKENK 
       610        620        630        640        650
SILNERRKRA SETTQHINAI KREIDVTKEA LNFQKSLREK QGKYENKGLM 
       660        670        680        690        700
IIDEEEFLLI LKLKDLKKQY RSEYQDLRDL RAEIQYCQHL VDQCRHRLLM 
       710        720        730        740        750
EFDIWYNESF VIPEDMQMAL KPGGSIRPGM VPVNRIVSLG EDDQDKFSQL 
       760        770        780        790
QQRVLPEGPD SISFYNAKVK IEQKHNYLKT MMGLQQAHRK
Length:790
Mass (Da):89,986
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD5CCEDFA64FA971
GO
Isoform 2 (identifier: Q9HAQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-569: Missing.

Show »
Length:725
Mass (Da):82,972
Checksum:iA1D28B310994F210
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DZK5B4DZK5_HUMAN
Kinesin-like protein
KIF9
333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6PJI1Q6PJI1_HUMAN
KIF9 protein
KIF9
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWZ7C9JWZ7_HUMAN
Kinesin-like protein KIF9
KIF9
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUW8E7EUW8_HUMAN
Kinesin-like protein KIF9
KIF9
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14713 differs from that shown. Dubious isoform. Probable cloning artifact lacking polyadenylation evidence.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02213978V → I. Corresponds to variant dbSNP:rs2270569Ensembl.1
Natural variantiVAR_02044396G → A. Corresponds to variant dbSNP:rs3733092Ensembl.1
Natural variantiVAR_024513638R → W2 PublicationsCorresponds to variant dbSNP:rs2276853Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002868505 – 569Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF311212 mRNA Translation: AAG33849.1
AC104447 Genomic DNA No translation available.
BC030657 mRNA Translation: AAH30657.1
AK023894 mRNA Translation: BAB14713.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2751.1 [Q9HAQ2-2]
CCDS2752.1 [Q9HAQ2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001128350.1, NM_001134878.1 [Q9HAQ2-1]
NP_071737.1, NM_022342.4 [Q9HAQ2-2]
NP_878905.2, NM_182902.3 [Q9HAQ2-1]
XP_011532306.1, XM_011534004.2 [Q9HAQ2-1]
XP_016862518.1, XM_017007029.1 [Q9HAQ2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265529; ENSP00000265529; ENSG00000088727
ENST00000444589; ENSP00000414987; ENSG00000088727 [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727
ENST00000684063; ENSP00000507186; ENSG00000088727

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64147

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64147

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000684063.1; ENSP00000507186.1; NM_182902.4; NP_878905.2

UCSC genome browser

More...UCSCi		uc003cqx.3, human [Q9HAQ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311212 mRNA Translation: AAG33849.1
AC104447 Genomic DNA No translation available.
BC030657 mRNA Translation: AAH30657.1
AK023894 mRNA Translation: BAB14713.1 Sequence problems.
CCDSiCCDS2751.1 [Q9HAQ2-2]
CCDS2752.1 [Q9HAQ2-1]
RefSeqiNP_001128350.1, NM_001134878.1 [Q9HAQ2-1]
NP_071737.1, NM_022342.4 [Q9HAQ2-2]
NP_878905.2, NM_182902.3 [Q9HAQ2-1]
XP_011532306.1, XM_011534004.2 [Q9HAQ2-1]
XP_016862518.1, XM_017007029.1 [Q9HAQ2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NWNX-ray2.00A1-340[»]
SMRiQ9HAQ2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122086, 68 interactors
IntActiQ9HAQ2, 55 interactors
MINTiQ9HAQ2
STRINGi9606.ENSP00000333942

Chemistry databases

ChEMBLiCHEMBL2321637

PTM databases

iPTMnetiQ9HAQ2
PhosphoSitePlusiQ9HAQ2

Genetic variation databases

BioMutaiKIF9
DMDMi308153656

Proteomic databases

jPOSTiQ9HAQ2
MassIVEiQ9HAQ2
MaxQBiQ9HAQ2
PaxDbiQ9HAQ2
PeptideAtlasiQ9HAQ2
PRIDEiQ9HAQ2
ProteomicsDBi81418 [Q9HAQ2-1]
81419 [Q9HAQ2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12887, 121 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		64147

Genome annotation databases

EnsembliENST00000265529; ENSP00000265529; ENSG00000088727
ENST00000444589; ENSP00000414987; ENSG00000088727 [Q9HAQ2-2]
ENST00000452770; ENSP00000391100; ENSG00000088727
ENST00000684063; ENSP00000507186; ENSG00000088727
GeneIDi64147
KEGGihsa:64147
MANE-SelectiENST00000684063.1; ENSP00000507186.1; NM_182902.4; NP_878905.2
UCSCiuc003cqx.3, human [Q9HAQ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64147
DisGeNETi64147

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIF9
HGNCiHGNC:16666, KIF9
HPAiENSG00000088727, Tissue enhanced (testis)
MIMi607910, gene
neXtProtiNX_Q9HAQ2
OpenTargetsiENSG00000088727
PharmGKBiPA30110
VEuPathDBiHostDB:ENSG00000088727

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4280, Eukaryota
GeneTreeiENSGT00940000158533
HOGENOMiCLU_001485_16_2_1
InParanoidiQ9HAQ2
OMAiAFFQAQK
OrthoDBi424630at2759
PhylomeDBiQ9HAQ2
TreeFamiTF105229

Enzyme and pathway databases

PathwayCommonsiQ9HAQ2
ReactomeiR-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins
SignaLinkiQ9HAQ2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64147, 10 hits in 1048 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIF9, human
EvolutionaryTraceiQ9HAQ2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64147
PharosiQ9HAQ2, Tbio

Protein Ontology

More...PROi		PR:Q9HAQ2
RNActiQ9HAQ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088727, Expressed in testis and 208 other tissues
ExpressionAtlasiQ9HAQ2, baseline and differential
GenevisibleiQ9HAQ2, HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640, Kinesin-like_fam
IPR019821, Kinesin_motor_CS
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
PANTHERiPTHR24115, PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225, Kinesin, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00129, KISc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411, KINESIN_MOTOR_1, 1 hit
PS50067, KINESIN_MOTOR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAQ2
Secondary accession number(s): Q86Z28, Q9H8A4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 5, 2010
Last modified: February 23, 2022
This is version 174 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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