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Protein

Protein lin-7 homolog B

Gene

LIN7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).By similarity1 Publication

GO - Molecular functioni

  • L27 domain binding Source: GO_Central
  • PDZ domain binding Source: Ensembl
  • protein domain specific binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-7 homolog B
Short name:
Lin-7B
Short name:
hLin7B
Alternative name(s):
Mammalian lin-seven protein 2
Short name:
MALS-2
Vertebrate lin-7 homolog 2
Short name:
Veli-2
Short name:
hVeli2
Gene namesi
Name:LIN7B
Synonyms:MALS2, VELI2
ORF Names:UNQ3116/PRO10200
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104863.11
HGNCiHGNC:17788 LIN7B
MIMi612331 gene
neXtProtiNX_Q9HAP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi64130
OpenTargetsiENSG00000104863
PharmGKBiPA134914453

Polymorphism and mutation databases

BioMutaiLIN7B
DMDMi59798472

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896261 – 207Protein lin-7 homolog BAdd BLAST207

Proteomic databases

EPDiQ9HAP6
MaxQBiQ9HAP6
PaxDbiQ9HAP6
PeptideAtlasiQ9HAP6
PRIDEiQ9HAP6
ProteomicsDBi81416
81417 [Q9HAP6-2]

PTM databases

iPTMnetiQ9HAP6
PhosphoSitePlusiQ9HAP6

Expressioni

Gene expression databases

BgeeiENSG00000104863 Expressed in 193 organ(s), highest expression level in hypothalamus
CleanExiHS_LIN7B
ExpressionAtlasiQ9HAP6 baseline and differential
GenevisibleiQ9HAP6 HS

Interactioni

Subunit structurei

Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1. Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1 (By similarity). Interacts with ASIC3. Interacts with TOPK. Interacts with RTKN.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MPP3Q133684EBI-821335,EBI-716157

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122079, 22 interactors
IntActiQ9HAP6, 12 interactors
MINTiQ9HAP6
STRINGi9606.ENSP00000221459

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9HAP6
SMRiQ9HAP6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HAP6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 65L27PROSITE-ProRule annotationAdd BLAST56
Domaini93 – 175PDZPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1 – 13Kinase interacting siteBy similarityAdd BLAST13

Domaini

The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.By similarity
The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.By similarity
The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.By similarity

Sequence similaritiesi

Belongs to the lin-7 family.Curated

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiQ9HAP6
KOiK19931
OMAiRQQHTSY
OrthoDBiEOG091G0PR4
PhylomeDBiQ9HAP6
TreeFamiTF316850

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HAP6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAALVEPLGL ERDVSRAVEL LERLQRSGEL PPQKLQALQR VLQSRFCSAI
60 70 80 90 100
REVYEQLYDT LDITGSAEIR AHATAKATVA AFTASEGHAH PRVVELPKTD
110 120 130 140 150
EGLGFNIMGG KEQNSPIYIS RVIPGGVADR HGGLKRGDQL LSVNGVSVEG
160 170 180 190 200
EQHEKAVELL KAAQGSVKLV VRYTPRVLEE MEARFEKMRS ARRRQQHQSY

SSLESRG
Length:207
Mass (Da):22,896
Last modified:March 1, 2001 - v1
Checksum:i63189D82706B9B00
GO
Isoform 2 (identifier: Q9HAP6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-146: Missing.

Show »
Length:137
Mass (Da):15,620
Checksum:iE24A181A837542DD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2U1M0R2U1_HUMAN
Protein lin-7 homolog B
LIN7B
132Annotation score:
S4R3R4S4R3R4_HUMAN
Protein lin-7 homolog B
LIN7B
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65G → R in AI826082 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04215677 – 146Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311862 mRNA Translation: AAG34117.1
AY358744 mRNA Translation: AAQ89104.1
AI826082 mRNA No translation available.
BC027618 mRNA Translation: AAH27618.1
CCDSiCCDS12757.1 [Q9HAP6-1]
CCDS77328.1 [Q9HAP6-2]
RefSeqiNP_001295348.1, NM_001308419.1 [Q9HAP6-2]
NP_071448.1, NM_022165.2 [Q9HAP6-1]
UniGeneiHs.221737

Genome annotation databases

EnsembliENST00000221459; ENSP00000221459; ENSG00000104863 [Q9HAP6-1]
ENST00000391864; ENSP00000375737; ENSG00000104863 [Q9HAP6-2]
GeneIDi64130
KEGGihsa:64130
UCSCiuc002pmp.3 human [Q9HAP6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311862 mRNA Translation: AAG34117.1
AY358744 mRNA Translation: AAQ89104.1
AI826082 mRNA No translation available.
BC027618 mRNA Translation: AAH27618.1
CCDSiCCDS12757.1 [Q9HAP6-1]
CCDS77328.1 [Q9HAP6-2]
RefSeqiNP_001295348.1, NM_001308419.1 [Q9HAP6-2]
NP_071448.1, NM_022165.2 [Q9HAP6-1]
UniGeneiHs.221737

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKRNMR-A93-172[»]
ProteinModelPortaliQ9HAP6
SMRiQ9HAP6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122079, 22 interactors
IntActiQ9HAP6, 12 interactors
MINTiQ9HAP6
STRINGi9606.ENSP00000221459

PTM databases

iPTMnetiQ9HAP6
PhosphoSitePlusiQ9HAP6

Polymorphism and mutation databases

BioMutaiLIN7B
DMDMi59798472

Proteomic databases

EPDiQ9HAP6
MaxQBiQ9HAP6
PaxDbiQ9HAP6
PeptideAtlasiQ9HAP6
PRIDEiQ9HAP6
ProteomicsDBi81416
81417 [Q9HAP6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221459; ENSP00000221459; ENSG00000104863 [Q9HAP6-1]
ENST00000391864; ENSP00000375737; ENSG00000104863 [Q9HAP6-2]
GeneIDi64130
KEGGihsa:64130
UCSCiuc002pmp.3 human [Q9HAP6-1]

Organism-specific databases

CTDi64130
DisGeNETi64130
EuPathDBiHostDB:ENSG00000104863.11
GeneCardsiLIN7B
HGNCiHGNC:17788 LIN7B
MIMi612331 gene
neXtProtiNX_Q9HAP6
OpenTargetsiENSG00000104863
PharmGKBiPA134914453
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiQ9HAP6
KOiK19931
OMAiRQQHTSY
OrthoDBiEOG091G0PR4
PhylomeDBiQ9HAP6
TreeFamiTF316850

Enzyme and pathway databases

ReactomeiR-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

EvolutionaryTraceiQ9HAP6
GeneWikiiLIN7B
GenomeRNAii64130
PROiPR:Q9HAP6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104863 Expressed in 193 organ(s), highest expression level in hypothalamus
CleanExiHS_LIN7B
ExpressionAtlasiQ9HAP6 baseline and differential
GenevisibleiQ9HAP6 HS

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIN7B_HUMAN
AccessioniPrimary (citable) accession number: Q9HAP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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