UniProtKB - Q9HAP2 (MLXIP_HUMAN)

BLAST

>sp|Q9HAP2|MLXIP_HUMAN MLX-interacting protein OS=Homo sapiens OX=9606 GN=MLXIP PE=1 SV=2
MAADVFMCSPRRPRSRGRQVLLKPQVSEDDDDSDTDEPSPPPASGAATPARAHASAAPPP
PRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQTYSFGKTSSCHL
SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKN
PVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDED
LSSLVQDDDMLYWHKHGDGWKTPVPMEEDPLLDTDMLMSEFSDTLFSTLSSHQPVAWPNP
REIAHLGNADMIQPGLIPLQPNLDFMDTFEPFQDLFSSSRSIFGSMLPASASAPVPDPNN
PPAQESILPTTALPTVSLPDSLIAPPTAPSLAHMDEQGCEHTSRTEDPFIQPTDFGPSEP
PLSVPQPFLPVFTMPLLSPSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKA
PSVITHTASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLALSPVTRPPQPRLTFVH
PKPVSLTGGRPKQPHKIVPAPKPEPVSLVLKNARIAPAAFSGQPQAVIMTSGPLKREGML
ASTVSQSNVVIAPAAIARAPGVPEFHSSILVTDLGHGTSSPPAPVSRLFPSTAQDPLGKG
EQVPLHGGSPQVTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVAALKNR
QMKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAITLQKTVEYITKLQQERGQMQEEA
RRLREEIEELNATIISCQQLLPATGVPVTRRQFDHMKDMFDEYVKTRTLQNWKFWIFSII
IKPLFESFKGMVSTSSLEELHRTALSWLDQHCSLPILRPMVLSTLRQLSTSTSILTDPAQ
LPEQASKAVTRIGKRLGES

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History
Entry version 130 (07 Nov 2018)
Sequence version 2 (21 Aug 2007)
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Protein

MLX-interacting protein

Gene

MLXIP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation.By similarity2 Publications

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 11073985
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11073985

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 11073985
regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
Source: GO_Central
Inferred from mutant phenotypeⁱ
- 16782875
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MLX-interacting protein Alternative name(s): Class E basic helix-loop-helix protein 36 Short name: bHLHe36 Transcriptional activator MondoA
Gene namesⁱ	Name:MLXIPImported Synonyms:BHLHE36, KIAA0867, MIRImported, MONDOA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175727.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17055 MLXIP
MIMⁱ	608090 gene
neXtProtⁱ	NX_Q9HAP2

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	22877
Open Targets More...OpenTargetsⁱ	ENSG00000175727
PharmGKBⁱ	PA128394590

Polymorphism and mutation databases

BioMutaⁱ	MLXIP
DMDMⁱ	156632588

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000298763	2 – 919	MLX-interacting proteinAdd BLAST		918

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	9	PhosphoserineCombined sources	1
Modified residueⁱ	27	PhosphoserineCombined sources	1
Modified residueⁱ	33	PhosphoserineCombined sources	1
Modified residueⁱ	39	PhosphoserineBy similarity	1
Modified residueⁱ	669	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9HAP2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9HAP2
PaxDbⁱ	Q9HAP2
PeptideAtlas More...PeptideAtlasⁱ	Q9HAP2
PRIDEⁱ	Q9HAP2
ProteomicsDBⁱ	81411 81412 [Q9HAP2-2] 81413 [Q9HAP2-3] 81414 [Q9HAP2-4] 81415 [Q9HAP2-5]

PTM databases

iPTMnetⁱ	Q9HAP2
PhosphoSitePlusⁱ	Q9HAP2

Expressionⁱ

Tissue specificityⁱ

Widely expressed in adult tissues. Most abundant in skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175727 Expressed in 222 organ(s), highest expression level in caecum
CleanExⁱ	HS_MLXIP
ExpressionAtlasⁱ	Q9HAP2 baseline and differential
Genevisibleⁱ	Q9HAP2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023084

HPAⁱ

HPA023084

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MLX.By similarity1 Publication

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116544, 5 interactors
IntActⁱ	Q9HAP2, 6 interactors
STRINGⁱ	9606.ENSP00000312834

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9HAP2
SMRⁱ	Q9HAP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	719 – 769	bHLHPROSITE-ProRule annotationAdd BLAST		51

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	73 – 327	Required for cytoplasmic localization1 PublicationAdd BLAST	255
Regionⁱ	322 – 445	Transactivation domain1 PublicationAdd BLAST	124
Regionⁱ	769 – 790	Leucine-zipperAdd BLAST	22
Regionⁱ	832 – 881	Mediates heterotypic interactions between MLXIP and MLX and is required for cytoplasmic localization1 PublicationAdd BLAST	50

Phylogenomic databases

eggNOGⁱ	KOG3582 Eukaryota ENOG410XTA5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063219
HOVERGENⁱ	HBG062003
InParanoidⁱ	Q9HAP2
KEGG Orthology (KO) More...KOⁱ	K09113
OMAⁱ	AQPTLHQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02A1
PhylomeDBⁱ	Q9HAP2
TreeFamⁱ	TF324749

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032648 MLXIP
PANTHERⁱ	PTHR15741:SF23 PTHR15741:SF23, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 11 Publication (identifier: Q9HAP2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA 
        60         70         80         90        100
RAHASAAPPP PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD 
       110        120        130        140        150
TVNKQTCQTY SFGKTSSCHL SIDASLTKLF ECMTLAYSGK LVSPKWKNFK 
       160        170        180        190        200
GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN PVCHFVTPLD GSVDVDEHRR 
       210        220        230        240        250
PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED LSSLVQDDDM 
       260        270        280        290        300
LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP 
       310        320        330        340        350
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS 
       360        370        380        390        400
ASAPVPDPNN PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE 
       410        420        430        440        450
HTSRTEDPFI QPTDFGPSEP PLSVPQPFLP VFTMPLLSPS PAPPPISPVL 
       460        470        480        490        500
PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA PSVITHTASA TLTHDAPATT 
       510        520        530        540        550
FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH PKPVSLTGGR 
       560        570        580        590        600
PKQPHKIVPA PKPEPVSLVL KNARIAPAAF SGQPQAVIMT SGPLKREGML 
       610        620        630        640        650
ASTVSQSNVV IAPAAIARAP GVPEFHSSIL VTDLGHGTSS PPAPVSRLFP 
       660        670        680        690        700
STAQDPLGKG EQVPLHGGSP QVTVTGPSRD CPNSGQASPC ASEQSPSPQS 
       710        720        730        740        750
PQNNCSGKSD PKNVAALKNR QMKHISAEQK RRFNIKMCFD MLNSLISNNS 
       760        770        780        790        800
KLTSHAITLQ KTVEYITKLQ QERGQMQEEA RRLREEIEEL NATIISCQQL 
       810        820        830        840        850
LPATGVPVTR RQFDHMKDMF DEYVKTRTLQ NWKFWIFSII IKPLFESFKG 
       860        870        880        890        900
MVSTSSLEEL HRTALSWLDQ HCSLPILRPM VLSTLRQLST STSILTDPAQ 
       910 
LPEQASKAVT RIGKRLGES

Length:919

Mass (Da):101,185

Last modified:August 21, 2007 - v2

Checksum:ⁱ47375FCC4333E0C2

Isoform 21 Publication (identifier: Q9HAP2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-393: Missing.

« Hide

        10         20         30         40         50
MDEQGCEHTS RTEDPFIQPT DFGPSEPPLS VPQPFLPVFT MPLLSPSPAP 
        60         70         80         90        100
PPISPVLPLV PPPATALNPP APPTFHQPQK FAGVNKAPSV ITHTASATLT 
       110        120        130        140        150
HDAPATTFSQ SQGLVITTHH PAPSAAPCGL ALSPVTRPPQ PRLTFVHPKP 
       160        170        180        190        200
VSLTGGRPKQ PHKIVPAPKP EPVSLVLKNA RIAPAAFSGQ PQAVIMTSGP 
       210        220        230        240        250
LKREGMLAST VSQSNVVIAP AAIARAPGVP EFHSSILVTD LGHGTSSPPA 
       260        270        280        290        300
PVSRLFPSTA QDPLGKGEQV PLHGGSPQVT VTGPSRDCPN SGQASPCASE 
       310        320        330        340        350
QSPSPQSPQN NCSGKSDPKN VAALKNRQMK HISAEQKRRF NIKMCFDMLN 
       360        370        380        390        400
SLISNNSKLT SHAITLQKTV EYITKLQQER GQMQEEARRL REEIEELNAT 
       410        420        430        440        450
IISCQQLLPA TGVPVTRRQF DHMKDMFDEY VKTRTLQNWK FWIFSIIIKP 
       460        470        480        490        500
LFESFKGMVS TSSLEELHRT ALSWLDQHCS LPILRPMVLS TLRQLSTSTS 
       510        520 
ILTDPAQLPE QASKAVTRIG KRLGES

Show »

Length:526

Mass (Da):56,822

Checksum:ⁱ0C3ADBD852823E60

Isoform 31 Publication (identifier: Q9HAP2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
578-628: AAFSGQPQAV...APGVPEFHSS → GEPGGETQCG...HIHLNETKVS
629-919: Missing.

« Hide

        10         20         30         40         50
MAADVFMCSP RRPRSRGRQV LLKPQVSEDD DDSDTDEPSP PPASGAATPA 
        60         70         80         90        100
RAHASAAPPP PRAGPGREEP PRRQQIIHSG HFMVSSPHRE HPPKKGYDFD 
       110        120        130        140        150
TVNKQTCQTY SFGKTSSCHL SIDASLTKLF ECMTLAYSGK LVSPKWKNFK 
       160        170        180        190        200
GLKLQWRDKI RLNNAIWRAW YMQYLEKRKN PVCHFVTPLD GSVDVDEHRR 
       210        220        230        240        250
PEAITTEGKY WKSRIEIVIR EYHKWRTYFK KRLQQHKDED LSSLVQDDDM 
       260        270        280        290        300
LYWHKHGDGW KTPVPMEEDP LLDTDMLMSE FSDTLFSTLS SHQPVAWPNP 
       310        320        330        340        350
REIAHLGNAD MIQPGLIPLQ PNLDFMDTFE PFQDLFSSSR SIFGSMLPAS 
       360        370        380        390        400
ASAPVPDPNN PPAQESILPT TALPTVSLPD SLIAPPTAPS LAHMDEQGCE 
       410        420        430        440        450
HTSRTEDPFI QPTDFGPSEP PLSVPQPFLP VFTMPLLSPS PAPPPISPVL 
       460        470        480        490        500
PLVPPPATAL NPPAPPTFHQ PQKFAGVNKA PSVITHTASA TLTHDAPATT 
       510        520        530        540        550
FSQSQGLVIT THHPAPSAAP CGLALSPVTR PPQPRLTFVH PKPVSLTGGR 
       560        570        580        590        600
PKQPHKIVPA PKPEPVSLVL KNARIAPGEP GGETQCGAPP DPEGCFPIPK 
       610        620 
AFKLVTTTTT LVCTCMRTHI HLNETKVS

Note: No experimental confirmation available.Curated

Show »

Length:628

Mass (Da):69,091

Checksum:ⁱ30A3DE477411D863

Isoform 41 Publication (identifier: Q9HAP2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-393: Missing.
     770-772: QQE → LLS
     773-919: Missing.

« Hide

        10         20         30         40         50
MDEQGCEHTS RTEDPFIQPT DFGPSEPPLS VPQPFLPVFT MPLLSPSPAP 
        60         70         80         90        100
PPISPVLPLV PPPATALNPP APPTFHQPQK FAGVNKAPSV ITHTASATLT 
       110        120        130        140        150
HDAPATTFSQ SQGLVITTHH PAPSAAPCGL ALSPVTRPPQ PRLTFVHPKP 
       160        170        180        190        200
VSLTGGRPKQ PHKIVPAPKP EPVSLVLKNA RIAPAAFSGQ PQAVIMTSGP 
       210        220        230        240        250
LKREGMLAST VSQSNVVIAP AAIARAPGVP EFHSSILVTD LGHGTSSPPA 
       260        270        280        290        300
PVSRLFPSTA QDPLGKGEQV PLHGGSPQVT VTGPSRDCPN SGQASPCASE 
       310        320        330        340        350
QSPSPQSPQN NCSGKSDPKN VAALKNRQMK HISAEQKRRF NIKMCFDMLN 
       360        370 
SLISNNSKLT SHAITLQKTV EYITKLLLS

Show »

Length:379

Mass (Da):39,808

Checksum:ⁱ6EC02D23459161A5

Isoform 51 Publication (identifier: Q9HAP2-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-393: Missing.
     426-443: Missing.
     578-628: AAFSGQPQAV...APGVPEFHSS → GEPGGETQCG...HIHLNETKVS
     629-919: Missing.

« Hide

        10         20         30         40         50
MDEQGCEHTS RTEDPFIQPT DFGPSEPPLS VPPPISPVLP LVPPPATALN 
        60         70         80         90        100
PPAPPTFHQP QKFAGVNKAP SVITHTASAT LTHDAPATTF SQSQGLVITT 
       110        120        130        140        150
HHPAPSAAPC GLALSPVTRP PQPRLTFVHP KPVSLTGGRP KQPHKIVPAP 
       160        170        180        190        200
KPEPVSLVLK NARIAPGEPG GETQCGAPPD PEGCFPIPKA FKLVTTTTTL 
       210 
VCTCMRTHIH LNETKVS

Note: No experimental confirmation available.Curated

Show »

Length:217

Mass (Da):22,806

Checksum:ⁱCD8533894CB00AB3

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H0V4	F5H0V4_HUMAN	MLX-interacting protein MLX-interacting protein	MLXIP	308	Annotation score:
A0A0G2JR68	A0A0G2JR68_HUMAN	MLX-interacting protein MLX-interacting protein	MLXIP	308	Annotation score:
H0YGR9	H0YGR9_HUMAN	MLX-interacting protein MLX-interacting protein	MLXIP	171	Annotation score:
A0A0G2JQX8	A0A0G2JQX8_HUMAN	MLX-interacting protein MLX-interacting protein	MLXIP	171	Annotation score:
F5H321	F5H321_HUMAN	MLX-interacting protein MLX-interacting protein	MLXIP	73	Annotation score:
A0A0G2JRQ8	A0A0G2JRQ8_HUMAN	MLX-interacting protein MLX-interacting protein	MLXIP	73	Annotation score:

Sequence cautionⁱ

The sequence BAA74890 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059344	396	E → G2 PublicationsCorresponds to variant dbSNP:rs7978353Ensembl.		1
Natural variantⁱVAR_059345	539	V → L. Corresponds to variant dbSNP:rs34702867Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_052499	1 – 393	Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsAdd BLAST	393
Alternative sequenceⁱVSP_052500	426 – 443	Missing in isoform 5. 1 PublicationAdd BLAST	18
Alternative sequenceⁱVSP_052501	578 – 628	AAFSG…EFHSS → GEPGGETQCGAPPDPEGCFP IPKAFKLVTTTTTLVCTCMR THIHLNETKVS in isoform 3 and isoform 5. 1 PublicationAdd BLAST	51
Alternative sequenceⁱVSP_052502	629 – 919	Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST	291
Alternative sequenceⁱVSP_052503	770 – 772	QQE → LLS in isoform 4. 1 Publication	3
Alternative sequenceⁱVSP_052504	773 – 919	Missing in isoform 4. 1 PublicationAdd BLAST	147

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF312918 mRNA Translation: AAG34121.1 AF245480 mRNA Translation: AAL55689.1 AF245481 mRNA Translation: AAL55690.1 AB020674 mRNA Translation: BAA74890.2 Different initiation. BC017656 mRNA Translation: AAH17656.1 BC028309 mRNA Translation: AAH28309.1 BC039704 mRNA Translation: AAH39704.1 BC151841 mRNA Translation: AAI51842.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS73540.1 [Q9HAP2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_055753.3, NM_014938.5 [Q9HAP2-1]
UniGeneⁱ	Hs.437153 Hs.721711 Hs.731847

Genome annotation databases

Ensemblⁱ	ENST00000319080; ENSP00000312834; ENSG00000175727 [Q9HAP2-1] ENST00000377037; ENSP00000366236; ENSG00000175727 [Q9HAP2-5] ENST00000538698; ENSP00000440769; ENSG00000175727 [Q9HAP2-2] ENST00000625732; ENSP00000486569; ENSG00000281178 [Q9HAP2-2] ENST00000628109; ENSP00000486016; ENSG00000281178 [Q9HAP2-5] ENST00000629738; ENSP00000487003; ENSG00000281178 [Q9HAP2-1]
GeneIDⁱ	22877
KEGGⁱ	hsa:22877
UCSC genome browser More...UCSCⁱ	uc001ubq.4 human [Q9HAP2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9HAP2	Isoform 2 of MLX-interacting protein		HUMAN		526	UniRef90_Q9HAP2
MLX interacting protein		CALJA		979
Uncharacterized protein		MACMU		931
MLX-interacting protein		TARSY		925
Uncharacterized protein		PROCO		925
+50
Q9HAP2-5	MLXIP isoform 9 (Fragment)		PONAB		218	UniRef90_Q9HAP2-5
MLX interacting protein		PANTR		217
Uncharacterized protein		PANPA		217
Uncharacterized protein		NOMLE		214
MLX interacting protein		GORGO		200
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9HAP2	MLX-interacting protein		MOUSE		917	UniRef50_Q9HAP2
Isoform 2 of MLX-interacting protein		HUMAN		526
MLX interacting protein		CALJA		979
Uncharacterized protein		MACMU		931
MLX-interacting protein		TARSY		925
+237
Q9HAP2-3	MLXIP (Fragment)		CEREH		706	UniRef50_Q9HAP2-3
MLX-interacting protein		HETGA		802
MLX-interacting protein		CAMFR		810
UPI0003EAE73D		HUMAN		708
UPI00064A33F4		SORAR		778
Q9HAP2-5	MLXIP isoform 9 (Fragment)		PONAB		218	UniRef50_Q9HAP2-5
Uncharacterized protein		PANPA		217
MLX interacting protein		PANTR		217
Uncharacterized protein		NOMLE		214
MLX interacting protein		GORGO		200
+11

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF312918 mRNA Translation: AAG34121.1 AF245480 mRNA Translation: AAL55689.1 AF245481 mRNA Translation: AAL55690.1 AB020674 mRNA Translation: BAA74890.2 Different initiation. BC017656 mRNA Translation: AAH17656.1 BC028309 mRNA Translation: AAH28309.1 BC039704 mRNA Translation: AAH39704.1 BC151841 mRNA Translation: AAI51842.1
CCDSⁱ	CCDS73540.1 [Q9HAP2-1]
RefSeqⁱ	NP_055753.3, NM_014938.5 [Q9HAP2-1]
UniGeneⁱ	Hs.437153 Hs.721711 Hs.731847

3D structure databases

ProteinModelPortalⁱ	Q9HAP2
SMRⁱ	Q9HAP2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116544, 5 interactors
IntActⁱ	Q9HAP2, 6 interactors
STRINGⁱ	9606.ENSP00000312834

PTM databases

iPTMnetⁱ	Q9HAP2
PhosphoSitePlusⁱ	Q9HAP2

Polymorphism and mutation databases

BioMutaⁱ	MLXIP
DMDMⁱ	156632588

Proteomic databases

EPDⁱ	Q9HAP2
MaxQBⁱ	Q9HAP2
PaxDbⁱ	Q9HAP2
PeptideAtlasⁱ	Q9HAP2
PRIDEⁱ	Q9HAP2
ProteomicsDBⁱ	81411 81412 [Q9HAP2-2] 81413 [Q9HAP2-3] 81414 [Q9HAP2-4] 81415 [Q9HAP2-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	22877
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000319080; ENSP00000312834; ENSG00000175727 [Q9HAP2-1] ENST00000377037; ENSP00000366236; ENSG00000175727 [Q9HAP2-5] ENST00000538698; ENSP00000440769; ENSG00000175727 [Q9HAP2-2] ENST00000625732; ENSP00000486569; ENSG00000281178 [Q9HAP2-2] ENST00000628109; ENSP00000486016; ENSG00000281178 [Q9HAP2-5] ENST00000629738; ENSP00000487003; ENSG00000281178 [Q9HAP2-1]
GeneIDⁱ	22877
KEGGⁱ	hsa:22877
UCSCⁱ	uc001ubq.4 human [Q9HAP2-1]

Organism-specific databases

CTDⁱ	22877
DisGeNETⁱ	22877
EuPathDBⁱ	HostDB:ENSG00000175727.13
GeneCardsⁱ	MLXIP
H-InvDBⁱ	HIX0019678
HGNCⁱ	HGNC:17055 MLXIP
HPAⁱ	HPA023084
MIMⁱ	608090 gene
neXtProtⁱ	NX_Q9HAP2
OpenTargetsⁱ	ENSG00000175727
PharmGKBⁱ	PA128394590
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3582 Eukaryota ENOG410XTA5 LUCA
GeneTreeⁱ	ENSGT00530000063219
HOVERGENⁱ	HBG062003
InParanoidⁱ	Q9HAP2
KOⁱ	K09113
OMAⁱ	AQPTLHQ
OrthoDBⁱ	EOG091G02A1
PhylomeDBⁱ	Q9HAP2
TreeFamⁱ	TF324749

Miscellaneous databases

ChiTaRSⁱ	MLXIP human
GenomeRNAiⁱ	22877
Protein Ontology More...PROⁱ	PR:Q9HAP2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175727 Expressed in 222 organ(s), highest expression level in caecum
CleanExⁱ	HS_MLXIP
ExpressionAtlasⁱ	Q9HAP2 baseline and differential
Genevisibleⁱ	Q9HAP2 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032648 MLXIP
PANTHERⁱ	PTHR15741:SF23 PTHR15741:SF23, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MLXIP_HUMAN
Accessionⁱ	Q9HAP2Primary (citable) accession number: Q9HAP2 Secondary accession number(s): A7MBN0 Q8WYA5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
	Last sequence update:	August 21, 2007
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q9HAP2 (MLXIP_HUMAN)

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MLX-interacting protein

MLXIP

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ