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Entry version 147 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Chromatin modification-related protein MEAF6

Gene

MEAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin modification-related protein MEAF6
Short name:
MYST/Esa1-associated factor 6
Alternative name(s):
Esa1-associated factor 6 homolog
Short name:
Protein EAF6 homolog
Short name:
hEAF6
Sarcoma antigen NY-SAR-91
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MEAF6Imported
Synonyms:C1orf149, CENP-28, EAF6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000163875.15

Human Gene Nomenclature Database

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HGNCi
HGNC:25674 MEAF6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611001 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
64769

Open Targets

More...
OpenTargetsi
ENSG00000163875

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165751536

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HAF1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MEAF6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752760

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002726092 – 191Chromatin modification-related protein MEAF6Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei69N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei74N6-acetyllysineCombined sources1
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HAF1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9HAF1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9HAF1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9HAF1

PeptideAtlas

More...
PeptideAtlasi
Q9HAF1

PRoteomics IDEntifications database

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PRIDEi
Q9HAF1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
3023
81400 [Q9HAF1-1]
81401 [Q9HAF1-2]
81402 [Q9HAF1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAF1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAF1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000163875 Expressed in 225 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9HAF1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HAF1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and MEAF6.

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3.

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122280, 58 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CPX-722 HBO1-5.2 histone acetyltransferase complex
CPX-723 HBO1-5.3 histone acetyltransferase complex
CPX-727 MOZ1 histone acetyltransferase complex
CPX-733 MOZ2 histone acetyltransferase complex
CPX-736 MOZ3 histone acetyltransferase complex
CPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CPX-978 NuA4 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9HAF1

Protein interaction database and analysis system

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IntActi
Q9HAF1, 53 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362166

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HAF1 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili11 – 47Sequence analysisAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EAF6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00390000015257

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000290166

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9HAF1

KEGG Orthology (KO)

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KOi
K11344

Identification of Orthologs from Complete Genome Data

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OMAi
XEPGSGT

Database of Orthologous Groups

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OrthoDBi
1629629at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAF1

TreeFam database of animal gene trees

More...
TreeFami
TF324130

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015418 Eaf6

The PANTHER Classification System

More...
PANTHERi
PTHR13476 PTHR13476, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09340 NuA4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HAF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMHNKAAPP QIPDTRRELA ELVKRKQELA ETLANLERQI YAFEGSYLED
60 70 80 90 100
TQMYGNIIRG WDRYLTNQKN SNSKNDRRNR KFKEAERLFS KSSVTSAAAV
110 120 130 140 150
SALAGVQDQL IEKREPGSGT ESDTSPDFHN QENEPSQEDP EDLDGSVQGV
160 170 180 190
KPQKAASSTS SGSHHSSHKK RKNKNRHRID LKLNKKPRAD Y
Length:191
Mass (Da):21,635
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0FBC7566BAAF1F7
GO
Isoform 2 (identifier: Q9HAF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-191: RIDLKLNKKPRADY → SPSGMFDYDFEYVY

Show »
Length:191
Mass (Da):21,625
Checksum:i4A46263CF13F3C99
GO
Isoform 3 (identifier: Q9HAF1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: R → SPSGMFDYDFE

Show »
Length:201
Mass (Da):22,755
Checksum:iE30FC55A4AB5EBA0
GO
Isoform 4 (identifier: Q9HAF1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-191: IDLKLNKKPRADY → MNVSPKTGWHQLHL

Show »
Length:192
Mass (Da):21,709
Checksum:i3DC03438B928A5A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AK63B1AK63_HUMAN
Chromatin modification-related prot...
MEAF6 C1orf149, hCG_25685
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2 – 3AM → RG in AAO65179 (PubMed:12601173).Curated2
Sequence conflicti4H → P in AAZ13760 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022450178 – 191RIDLK…PRADY → SPSGMFDYDFEYVY in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_022451178R → SPSGMFDYDFE in isoform 3. 1 Publication1
Alternative sequenceiVSP_047018179 – 191IDLKL…PRADY → MNVSPKTGWHQLHL in isoform 4. CuratedAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX538212 mRNA Translation: CAD98071.1
BX640719 mRNA Translation: CAE45838.1
AK021792 mRNA Translation: BAB13898.1
DQ099384 mRNA Translation: AAZ13760.1
AL034379 Genomic DNA No translation available.
BC056406 mRNA Translation: AAH56406.1
BC016328 mRNA Translation: AAH16328.1
AY211926 mRNA Translation: AAO65179.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS418.1 [Q9HAF1-3]
CCDS59195.1 [Q9HAF1-4]
CCDS59196.1 [Q9HAF1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001257804.1, NM_001270875.1 [Q9HAF1-1]
NP_001257805.1, NM_001270876.1 [Q9HAF1-4]
NP_073593.2, NM_022756.5 [Q9HAF1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000296214; ENSP00000296214; ENSG00000163875 [Q9HAF1-1]
ENST00000373073; ENSP00000362164; ENSG00000163875 [Q9HAF1-4]
ENST00000373075; ENSP00000362166; ENSG00000163875 [Q9HAF1-3]
ENST00000448519; ENSP00000394966; ENSG00000163875 [Q9HAF1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64769

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64769

UCSC genome browser

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UCSCi
uc001cbe.4 human [Q9HAF1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538212 mRNA Translation: CAD98071.1
BX640719 mRNA Translation: CAE45838.1
AK021792 mRNA Translation: BAB13898.1
DQ099384 mRNA Translation: AAZ13760.1
AL034379 Genomic DNA No translation available.
BC056406 mRNA Translation: AAH56406.1
BC016328 mRNA Translation: AAH16328.1
AY211926 mRNA Translation: AAO65179.1
CCDSiCCDS418.1 [Q9HAF1-3]
CCDS59195.1 [Q9HAF1-4]
CCDS59196.1 [Q9HAF1-1]
RefSeqiNP_001257804.1, NM_001270875.1 [Q9HAF1-1]
NP_001257805.1, NM_001270876.1 [Q9HAF1-4]
NP_073593.2, NM_022756.5 [Q9HAF1-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGridi122280, 58 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CPX-722 HBO1-5.2 histone acetyltransferase complex
CPX-723 HBO1-5.3 histone acetyltransferase complex
CPX-727 MOZ1 histone acetyltransferase complex
CPX-733 MOZ2 histone acetyltransferase complex
CPX-736 MOZ3 histone acetyltransferase complex
CPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CPX-978 NuA4 histone acetyltransferase complex
CORUMiQ9HAF1
IntActiQ9HAF1, 53 interactors
STRINGi9606.ENSP00000362166

PTM databases

iPTMnetiQ9HAF1
PhosphoSitePlusiQ9HAF1

Polymorphism and mutation databases

BioMutaiMEAF6
DMDMi74752760

Proteomic databases

EPDiQ9HAF1
jPOSTiQ9HAF1
MassIVEiQ9HAF1
MaxQBiQ9HAF1
PeptideAtlasiQ9HAF1
PRIDEiQ9HAF1
ProteomicsDBi3023
81400 [Q9HAF1-1]
81401 [Q9HAF1-2]
81402 [Q9HAF1-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
64769

Genome annotation databases

EnsembliENST00000296214; ENSP00000296214; ENSG00000163875 [Q9HAF1-1]
ENST00000373073; ENSP00000362164; ENSG00000163875 [Q9HAF1-4]
ENST00000373075; ENSP00000362166; ENSG00000163875 [Q9HAF1-3]
ENST00000448519; ENSP00000394966; ENSG00000163875 [Q9HAF1-2]
GeneIDi64769
KEGGihsa:64769
UCSCiuc001cbe.4 human [Q9HAF1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64769
DisGeNETi64769
EuPathDBiHostDB:ENSG00000163875.15

GeneCards: human genes, protein and diseases

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GeneCardsi
MEAF6
HGNCiHGNC:25674 MEAF6
MIMi611001 gene
neXtProtiNX_Q9HAF1
OpenTargetsiENSG00000163875
PharmGKBiPA165751536

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00390000015257
HOGENOMiHOG000290166
InParanoidiQ9HAF1
KOiK11344
OMAiXEPGSGT
OrthoDBi1629629at2759
PhylomeDBiQ9HAF1
TreeFamiTF324130

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MEAF6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C1orf149

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64769
PharosiQ9HAF1 Tbio

Protein Ontology

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PROi
PR:Q9HAF1
RNActiQ9HAF1 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163875 Expressed in 225 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ9HAF1 baseline and differential
GenevisibleiQ9HAF1 HS

Family and domain databases

InterProiView protein in InterPro
IPR015418 Eaf6
PANTHERiPTHR13476 PTHR13476, 1 hit
PfamiView protein in Pfam
PF09340 NuA4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEAF6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAF1
Secondary accession number(s): B1AK64
, Q4F967, Q7Z311, Q86WE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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