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Protein

Chromatin modification-related protein MEAF6

Gene

MEAF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.3 Publications

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein MEAF6
Short name:
MYST/Esa1-associated factor 6
Alternative name(s):
Esa1-associated factor 6 homolog
Short name:
Protein EAF6 homolog
Short name:
hEAF6
Sarcoma antigen NY-SAR-91
Gene namesi
Name:MEAF6Imported
Synonyms:C1orf149, CENP-28, EAF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163875.15
HGNCiHGNC:25674 MEAF6
MIMi611001 gene
neXtProtiNX_Q9HAF1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1.1 Publication

Organism-specific databases

DisGeNETi64769
OpenTargetsiENSG00000163875
PharmGKBiPA165751536

Polymorphism and mutation databases

DMDMi74752760

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002726092 – 191Chromatin modification-related protein MEAF6Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei69N6-acetyllysine; alternateCombined sources1
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei74N6-acetyllysineCombined sources1
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9HAF1
MaxQBiQ9HAF1
PeptideAtlasiQ9HAF1
PRIDEiQ9HAF1
ProteomicsDBi81400
81401 [Q9HAF1-2]
81402 [Q9HAF1-3]

PTM databases

iPTMnetiQ9HAF1
PhosphoSitePlusiQ9HAF1

Expressioni

Gene expression databases

BgeeiENSG00000163875 Expressed in 225 organ(s), highest expression level in pituitary gland
CleanExiHS_C1orf149
ExpressionAtlasiQ9HAF1 baseline and differential
GenevisibleiQ9HAF1 HS

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and MEAF6. Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.5 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi122280, 57 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CPX-722 HBO1-5.2 histone acetyltransferase complex
CPX-723 HBO1-5.3 histone acetyltransferase complex
CPX-727 MOZ1 histone acetyltransferase complex
CPX-733 MOZ2 histone acetyltransferase complex
CPX-736 MOZ3 histone acetyltransferase complex
CPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CPX-978 NuA4 histone acetyltransferase complex
CORUMiQ9HAF1
IntActiQ9HAF1, 17 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9HAF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 47Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the EAF6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000015257
HOGENOMiHOG000290166
HOVERGENiHBG054664
InParanoidiQ9HAF1
KOiK11344
OMAiXEPGSGT
OrthoDBiEOG091G126R
PhylomeDBiQ9HAF1
TreeFamiTF324130

Family and domain databases

InterProiView protein in InterPro
IPR015418 Eaf6
PANTHERiPTHR13476 PTHR13476, 1 hit
PfamiView protein in Pfam
PF09340 NuA4, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HAF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMHNKAAPP QIPDTRRELA ELVKRKQELA ETLANLERQI YAFEGSYLED
60 70 80 90 100
TQMYGNIIRG WDRYLTNQKN SNSKNDRRNR KFKEAERLFS KSSVTSAAAV
110 120 130 140 150
SALAGVQDQL IEKREPGSGT ESDTSPDFHN QENEPSQEDP EDLDGSVQGV
160 170 180 190
KPQKAASSTS SGSHHSSHKK RKNKNRHRID LKLNKKPRAD Y
Length:191
Mass (Da):21,635
Last modified:March 1, 2001 - v1
Checksum:iC0FBC7566BAAF1F7
GO
Isoform 2 (identifier: Q9HAF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-191: RIDLKLNKKPRADY → SPSGMFDYDFEYVY

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):21,625
Checksum:i4A46263CF13F3C99
GO
Isoform 3 (identifier: Q9HAF1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: R → SPSGMFDYDFE

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,755
Checksum:iE30FC55A4AB5EBA0
GO
Isoform 4 (identifier: Q9HAF1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-191: IDLKLNKKPRADY → MNVSPKTGWHQLHL

Note: Gene prediction based on EST data.
Show »
Length:192
Mass (Da):21,709
Checksum:i3DC03438B928A5A3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AK63B1AK63_HUMAN
Chromatin modification-related prot...
MEAF6 C1orf149, hCG_25685
169Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AM → RG in AAO65179 (PubMed:12601173).Curated2
Sequence conflicti4H → P in AAZ13760 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022450178 – 191RIDLK…PRADY → SPSGMFDYDFEYVY in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_022451178R → SPSGMFDYDFE in isoform 3. 1 Publication1
Alternative sequenceiVSP_047018179 – 191IDLKL…PRADY → MNVSPKTGWHQLHL in isoform 4. CuratedAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538212 mRNA Translation: CAD98071.1
BX640719 mRNA Translation: CAE45838.1
AK021792 mRNA Translation: BAB13898.1
DQ099384 mRNA Translation: AAZ13760.1
AL034379 Genomic DNA No translation available.
BC056406 mRNA Translation: AAH56406.1
BC016328 mRNA Translation: AAH16328.1
AY211926 mRNA Translation: AAO65179.1
CCDSiCCDS418.1 [Q9HAF1-3]
CCDS59195.1 [Q9HAF1-4]
CCDS59196.1 [Q9HAF1-1]
RefSeqiNP_001257804.1, NM_001270875.1 [Q9HAF1-1]
NP_001257805.1, NM_001270876.1 [Q9HAF1-4]
NP_073593.2, NM_022756.5 [Q9HAF1-3]
UniGeneiHs.17118

Genome annotation databases

EnsembliENST00000296214; ENSP00000296214; ENSG00000163875 [Q9HAF1-1]
ENST00000373073; ENSP00000362164; ENSG00000163875 [Q9HAF1-4]
ENST00000373075; ENSP00000362166; ENSG00000163875 [Q9HAF1-3]
ENST00000448519; ENSP00000394966; ENSG00000163875 [Q9HAF1-2]
GeneIDi64769
KEGGihsa:64769
UCSCiuc001cbe.4 human [Q9HAF1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538212 mRNA Translation: CAD98071.1
BX640719 mRNA Translation: CAE45838.1
AK021792 mRNA Translation: BAB13898.1
DQ099384 mRNA Translation: AAZ13760.1
AL034379 Genomic DNA No translation available.
BC056406 mRNA Translation: AAH56406.1
BC016328 mRNA Translation: AAH16328.1
AY211926 mRNA Translation: AAO65179.1
CCDSiCCDS418.1 [Q9HAF1-3]
CCDS59195.1 [Q9HAF1-4]
CCDS59196.1 [Q9HAF1-1]
RefSeqiNP_001257804.1, NM_001270875.1 [Q9HAF1-1]
NP_001257805.1, NM_001270876.1 [Q9HAF1-4]
NP_073593.2, NM_022756.5 [Q9HAF1-3]
UniGeneiHs.17118

3D structure databases

ProteinModelPortaliQ9HAF1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122280, 57 interactors
ComplexPortaliCPX-718 HBO1-4.1 histone acetyltransferase complex
CPX-719 HBO1-4.2 histone acetyltransferase complex
CPX-720 HBO1-4.3 histone acetyltransferase complex
CPX-721 HBO1-5.1 histone acetyltransferase complex
CPX-722 HBO1-5.2 histone acetyltransferase complex
CPX-723 HBO1-5.3 histone acetyltransferase complex
CPX-727 MOZ1 histone acetyltransferase complex
CPX-733 MOZ2 histone acetyltransferase complex
CPX-736 MOZ3 histone acetyltransferase complex
CPX-738 MORF1 histone acetyltransferase complex
CPX-739 MORF2 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CPX-978 NuA4 histone acetyltransferase complex
CORUMiQ9HAF1
IntActiQ9HAF1, 17 interactors

PTM databases

iPTMnetiQ9HAF1
PhosphoSitePlusiQ9HAF1

Polymorphism and mutation databases

DMDMi74752760

Proteomic databases

EPDiQ9HAF1
MaxQBiQ9HAF1
PeptideAtlasiQ9HAF1
PRIDEiQ9HAF1
ProteomicsDBi81400
81401 [Q9HAF1-2]
81402 [Q9HAF1-3]

Protocols and materials databases

DNASUi64769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296214; ENSP00000296214; ENSG00000163875 [Q9HAF1-1]
ENST00000373073; ENSP00000362164; ENSG00000163875 [Q9HAF1-4]
ENST00000373075; ENSP00000362166; ENSG00000163875 [Q9HAF1-3]
ENST00000448519; ENSP00000394966; ENSG00000163875 [Q9HAF1-2]
GeneIDi64769
KEGGihsa:64769
UCSCiuc001cbe.4 human [Q9HAF1-1]

Organism-specific databases

CTDi64769
DisGeNETi64769
EuPathDBiHostDB:ENSG00000163875.15
GeneCardsiMEAF6
HGNCiHGNC:25674 MEAF6
MIMi611001 gene
neXtProtiNX_Q9HAF1
OpenTargetsiENSG00000163875
PharmGKBiPA165751536
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000015257
HOGENOMiHOG000290166
HOVERGENiHBG054664
InParanoidiQ9HAF1
KOiK11344
OMAiXEPGSGT
OrthoDBiEOG091G126R
PhylomeDBiQ9HAF1
TreeFamiTF324130

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRSiMEAF6 human
GeneWikiiC1orf149
GenomeRNAii64769
PROiPR:Q9HAF1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163875 Expressed in 225 organ(s), highest expression level in pituitary gland
CleanExiHS_C1orf149
ExpressionAtlasiQ9HAF1 baseline and differential
GenevisibleiQ9HAF1 HS

Family and domain databases

InterProiView protein in InterPro
IPR015418 Eaf6
PANTHERiPTHR13476 PTHR13476, 1 hit
PfamiView protein in Pfam
PF09340 NuA4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEAF6_HUMAN
AccessioniPrimary (citable) accession number: Q9HAF1
Secondary accession number(s): B1AK64
, Q4F967, Q7Z311, Q86WE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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