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Entry version 142 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Ubiquitin domain-containing protein 1

Gene

UBTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBTD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25683 UBTD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616388 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAC8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80019

Open Targets

More...
OpenTargetsi
ENSG00000165886

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134976337

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HAC8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UBTD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752759

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002426741 – 227Ubiquitin domain-containing protein 1Add BLAST227

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9HAC8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HAC8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HAC8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HAC8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HAC8

PeptideAtlas

More...
PeptideAtlasi
Q9HAC8

PRoteomics IDEntifications database

More...
PRIDEi
Q9HAC8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81395

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAC8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9HAC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by cytotoxic agents, it is also increased during premature senescence. the induction seems to be mediated by TP53.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165886 Expressed in 171 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HAC8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034825

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBTD1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123073, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HAC8, 20 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359698

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 224Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0013 Eukaryota
ENOG410XRPV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158630

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231205

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HAC8

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGDKMHI

Database of Orthologous Groups

More...
OrthoDBi
1221075at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAC8

TreeFam database of animal gene trees

More...
TreeFami
TF323925

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.225.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032752 DC-UbP/UBTD2_N
IPR038169 DC-UbP/UBTD2_N_sf
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR039869 UBTD1/2

The PANTHER Classification System

More...
PANTHERi
PTHR13609 PTHR13609, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16455 UBD, 1 hit
PF00240 ubiquitin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00348 UBIQUITIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00213 UBQ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9HAC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK
60 70 80 90 100
RDEFWDTAPA FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG
110 120 130 140 150
TLCECYDELG NRYQLPIYCL SPPVNLLLEH TEEESLEPPE PPPSVRREFP
160 170 180 190 200
LKVRLSTGKD VRLSASLPDT VGQLKRQLHA QEGIEPSWQR WFFSGKLLTD
210 220
RTRLQETKIQ KDFVIQVIIN QPPPPQD
Length:227
Mass (Da):25,938
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D34DB6027797255
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133E → G in BAD96317 (Ref. 2) Curated1
Sequence conflicti173Q → L in BAD96317 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK021869 mRNA Translation: BAB13921.1
AK222597 mRNA Translation: BAD96317.1
AL359388 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49918.1
CH471066 Genomic DNA Translation: EAW49919.1
BC007331 mRNA Translation: AAH07331.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7465.1

NCBI Reference Sequences

More...
RefSeqi
NP_079230.1, NM_024954.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370664; ENSP00000359698; ENSG00000165886

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80019

UCSC genome browser

More...
UCSCi
uc001knv.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021869 mRNA Translation: BAB13921.1
AK222597 mRNA Translation: BAD96317.1
AL359388 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49918.1
CH471066 Genomic DNA Translation: EAW49919.1
BC007331 mRNA Translation: AAH07331.1
CCDSiCCDS7465.1
RefSeqiNP_079230.1, NM_024954.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123073, 25 interactors
IntActiQ9HAC8, 20 interactors
STRINGi9606.ENSP00000359698

PTM databases

iPTMnetiQ9HAC8
PhosphoSitePlusiQ9HAC8
SwissPalmiQ9HAC8

Polymorphism and mutation databases

BioMutaiUBTD1
DMDMi74752759

Proteomic databases

EPDiQ9HAC8
jPOSTiQ9HAC8
MassIVEiQ9HAC8
MaxQBiQ9HAC8
PaxDbiQ9HAC8
PeptideAtlasiQ9HAC8
PRIDEiQ9HAC8
ProteomicsDBi81395

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80019

Genome annotation databases

EnsembliENST00000370664; ENSP00000359698; ENSG00000165886
GeneIDi80019
KEGGihsa:80019
UCSCiuc001knv.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80019
DisGeNETi80019

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UBTD1
HGNCiHGNC:25683 UBTD1
HPAiHPA034825
MIMi616388 gene
neXtProtiNX_Q9HAC8
OpenTargetsiENSG00000165886
PharmGKBiPA134976337

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0013 Eukaryota
ENOG410XRPV LUCA
GeneTreeiENSGT00940000158630
HOGENOMiHOG000231205
InParanoidiQ9HAC8
OMAiLGDKMHI
OrthoDBi1221075at2759
PhylomeDBiQ9HAC8
TreeFamiTF323925

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
UBTD1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80019
PharosiQ9HAC8

Protein Ontology

More...
PROi
PR:Q9HAC8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165886 Expressed in 171 organ(s), highest expression level in right testis
GenevisibleiQ9HAC8 HS

Family and domain databases

Gene3Di1.20.225.20, 1 hit
InterProiView protein in InterPro
IPR032752 DC-UbP/UBTD2_N
IPR038169 DC-UbP/UBTD2_N_sf
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
IPR039869 UBTD1/2
PANTHERiPTHR13609 PTHR13609, 1 hit
PfamiView protein in Pfam
PF16455 UBD, 1 hit
PF00240 ubiquitin, 1 hit
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBTD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAC8
Secondary accession number(s): D3DR57, Q53HI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: September 18, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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