UniProtKB - Q9HAC8 (UBTD1_HUMAN)
Protein
Ubiquitin domain-containing protein 1
Gene
UBTD1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.1 Publication
Enzyme and pathway databases
PathwayCommonsi | Q9HAC8 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin domain-containing protein 1 |
Gene namesi | Name:UBTD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25683, UBTD1 |
MIMi | 616388, gene |
neXtProti | NX_Q9HAC8 |
VEuPathDBi | HostDB:ENSG00000165886.4 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 80019 |
OpenTargetsi | ENSG00000165886 |
PharmGKBi | PA134976337 |
Miscellaneous databases
Pharosi | Q9HAC8, Tdark |
Genetic variation databases
BioMutai | UBTD1 |
DMDMi | 74752759 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000242674 | 1 – 227 | Ubiquitin domain-containing protein 1Add BLAST | 227 |
Proteomic databases
EPDi | Q9HAC8 |
jPOSTi | Q9HAC8 |
MassIVEi | Q9HAC8 |
MaxQBi | Q9HAC8 |
PaxDbi | Q9HAC8 |
PeptideAtlasi | Q9HAC8 |
PRIDEi | Q9HAC8 |
ProteomicsDBi | 81395 |
PTM databases
iPTMneti | Q9HAC8 |
PhosphoSitePlusi | Q9HAC8 |
SwissPalmi | Q9HAC8 |
Expressioni
Inductioni
Induced by cytotoxic agents, it is also increased during premature senescence. the induction seems to be mediated by TP53.1 Publication
Gene expression databases
Bgeei | ENSG00000165886, Expressed in right testis and 186 other tissues |
Genevisiblei | Q9HAC8, HS |
Organism-specific databases
HPAi | ENSG00000165886, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with UBTD1.
1 PublicationBinary interactionsi
Hide detailsQ9HAC8
Protein-protein interaction databases
BioGRIDi | 123073, 35 interactors |
IntActi | Q9HAC8, 20 interactors |
STRINGi | 9606.ENSP00000359698 |
Miscellaneous databases
RNActi | Q9HAC8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 224 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 76 |
Phylogenomic databases
eggNOGi | KOG0013, Eukaryota |
GeneTreei | ENSGT00940000158630 |
HOGENOMi | CLU_070348_0_0_1 |
InParanoidi | Q9HAC8 |
OMAi | AWQRWFF |
OrthoDBi | 1221075at2759 |
PhylomeDBi | Q9HAC8 |
TreeFami | TF323925 |
Family and domain databases
Gene3Di | 1.20.225.20, 1 hit |
InterProi | View protein in InterPro IPR032752, DC-UbP/UBTD2_N IPR038169, DC-UbP/UBTD2_N_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019956, Ubiquitin_dom IPR039869, UBTD1/2 |
PANTHERi | PTHR13609, PTHR13609, 1 hit |
Pfami | View protein in Pfam PF16455, UBD, 1 hit PF00240, ubiquitin, 1 hit |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9HAC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNCVGRQRR ERPAAPGHPR KRAGRNEPLK KERLKWKSDY PMTDGQLRSK
60 70 80 90 100
RDEFWDTAPA FEGRKEIWDA LKAAAYAAEA NDHELAQAIL DGASITLPHG
110 120 130 140 150
TLCECYDELG NRYQLPIYCL SPPVNLLLEH TEEESLEPPE PPPSVRREFP
160 170 180 190 200
LKVRLSTGKD VRLSASLPDT VGQLKRQLHA QEGIEPSWQR WFFSGKLLTD
210 220
RTRLQETKIQ KDFVIQVIIN QPPPPQD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | E → G in BAD96317 (Ref. 2) Curated | 1 | |
Sequence conflicti | 173 | Q → L in BAD96317 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021869 mRNA Translation: BAB13921.1 AK222597 mRNA Translation: BAD96317.1 AL359388 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49918.1 CH471066 Genomic DNA Translation: EAW49919.1 BC007331 mRNA Translation: AAH07331.1 |
CCDSi | CCDS7465.1 |
RefSeqi | NP_079230.1, NM_024954.4 |
Genome annotation databases
Ensembli | ENST00000370664; ENSP00000359698; ENSG00000165886 |
GeneIDi | 80019 |
KEGGi | hsa:80019 |
UCSCi | uc001knv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK021869 mRNA Translation: BAB13921.1 AK222597 mRNA Translation: BAD96317.1 AL359388 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49918.1 CH471066 Genomic DNA Translation: EAW49919.1 BC007331 mRNA Translation: AAH07331.1 |
CCDSi | CCDS7465.1 |
RefSeqi | NP_079230.1, NM_024954.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123073, 35 interactors |
IntActi | Q9HAC8, 20 interactors |
STRINGi | 9606.ENSP00000359698 |
PTM databases
iPTMneti | Q9HAC8 |
PhosphoSitePlusi | Q9HAC8 |
SwissPalmi | Q9HAC8 |
Genetic variation databases
BioMutai | UBTD1 |
DMDMi | 74752759 |
Proteomic databases
EPDi | Q9HAC8 |
jPOSTi | Q9HAC8 |
MassIVEi | Q9HAC8 |
MaxQBi | Q9HAC8 |
PaxDbi | Q9HAC8 |
PeptideAtlasi | Q9HAC8 |
PRIDEi | Q9HAC8 |
ProteomicsDBi | 81395 |
Protocols and materials databases
Antibodypediai | 30969, 311 antibodies |
DNASUi | 80019 |
Genome annotation databases
Ensembli | ENST00000370664; ENSP00000359698; ENSG00000165886 |
GeneIDi | 80019 |
KEGGi | hsa:80019 |
UCSCi | uc001knv.2, human |
Organism-specific databases
CTDi | 80019 |
DisGeNETi | 80019 |
GeneCardsi | UBTD1 |
HGNCi | HGNC:25683, UBTD1 |
HPAi | ENSG00000165886, Low tissue specificity |
MIMi | 616388, gene |
neXtProti | NX_Q9HAC8 |
OpenTargetsi | ENSG00000165886 |
PharmGKBi | PA134976337 |
VEuPathDBi | HostDB:ENSG00000165886.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0013, Eukaryota |
GeneTreei | ENSGT00940000158630 |
HOGENOMi | CLU_070348_0_0_1 |
InParanoidi | Q9HAC8 |
OMAi | AWQRWFF |
OrthoDBi | 1221075at2759 |
PhylomeDBi | Q9HAC8 |
TreeFami | TF323925 |
Enzyme and pathway databases
PathwayCommonsi | Q9HAC8 |
Miscellaneous databases
BioGRID-ORCSi | 80019, 6 hits in 878 CRISPR screens |
ChiTaRSi | UBTD1, human |
GenomeRNAii | 80019 |
Pharosi | Q9HAC8, Tdark |
PROi | PR:Q9HAC8 |
RNActi | Q9HAC8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165886, Expressed in right testis and 186 other tissues |
Genevisiblei | Q9HAC8, HS |
Family and domain databases
Gene3Di | 1.20.225.20, 1 hit |
InterProi | View protein in InterPro IPR032752, DC-UbP/UBTD2_N IPR038169, DC-UbP/UBTD2_N_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019956, Ubiquitin_dom IPR039869, UBTD1/2 |
PANTHERi | PTHR13609, PTHR13609, 1 hit |
Pfami | View protein in Pfam PF16455, UBD, 1 hit PF00240, ubiquitin, 1 hit |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBTD1_HUMAN | |
Accessioni | Q9HAC8Primary (citable) accession number: Q9HAC8 Secondary accession number(s): D3DR57, Q53HI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot