Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (05 Jun 2019)
Sequence version 2 (19 Jul 2005)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Succinate--hydroxymethylglutarate CoA-transferase

Gene

SUGCT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei212NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000175600-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Succinate--hydroxymethylglutarate CoA-transferase (EC:2.8.3.13)
Alternative name(s):
Dermal papilla-derived protein 13
SuccinylCoA:glutarate-CoA transferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUGCT
Synonyms:C7orf10, DERP13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16001 SUGCT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609187 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HAC7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glutaric aciduria 3 (GA3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder due to peroxisomal glutaryl-CoA oxidase deficiency and characterized by the excretion of abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054852336R → W in GA3; inactive enzyme; healthy individuals who have abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid. 2 PublicationsCorresponds to variant dbSNP:rs137852860Ensembl.1

Keywords - Diseasei

Disease mutation, Glutaricaciduria

Organism-specific databases

DisGeNET

More...
DisGeNETi
79783

MalaCards human disease database

More...
MalaCardsi
SUGCT
MIMi231690 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000175600

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
35706 Glutaric acidemia type 3

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25942

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SUGCT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152390

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000019472639 – 445Succinate--hydroxymethylglutarate CoA-transferaseAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei401N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HAC7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HAC7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HAC7

PeptideAtlas

More...
PeptideAtlasi
Q9HAC7

PRoteomics IDEntifications database

More...
PRIDEi
Q9HAC7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81391
81392 [Q9HAC7-2]
81393 [Q9HAC7-3]
81394 [Q9HAC7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HAC7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HAC7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175600 Expressed in 141 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HAC7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HAC7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026698
HPA026704
HPA026705

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TMLHEQ9NVH62EBI-20630203,EBI-395312

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122883, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HAC7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338475

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HAC7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CoA-transferase III family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157866

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000219745

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HAC7

KEGG Orthology (KO)

More...
KOi
K18703

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQVAANY

Database of Orthologous Groups

More...
OrthoDBi
983223at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HAC7

TreeFam database of animal gene trees

More...
TreeFami
TF314188

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10540, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003673 CoA-Trfase_fam_III
IPR023606 CoA-Trfase_III_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02515 CoA_transf_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89796 SSF89796, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HAC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSETHAMLA TLARVAALRR TCLFSGRGGG RGLWTGRPQS DMNNIKPLEG
60 70 80 90 100
VKILDLTRVL AGPFATMNLG DLGAEVIKVE RPGAGDDTRT WGPPFVGTES
110 120 130 140 150
TYYLSVNRNK KSIAVNIKDP KGVKIIKELA AVCDVFVENY VPGKLSAMGL
160 170 180 190 200
GYEDIDEIAP HIIYCSITGY GQTGPISQRA GYDAVASAVS GLMHITGPEN
210 220 230 240 250
GDPVRPGVAM TDLATGLYAY GAIMAGLIQK YKTGKGLFID CNLLSSQVAC
260 270 280 290 300
LSHIAANYLI GQKEAKRWGT AHGSIVPYQA FKTKDGYIVV GAGNNQQFAT
310 320 330 340 350
VCKILDLPEL IDNSKYKTNH LRVHNRKELI KILSERFEEE LTSKWLYLFE
360 370 380 390 400
GSGVPYGPIN NMKNVFAEPQ VLHNGLVMEM EHPTVGKISV PGPAVRYSKF
410 420 430 440
KMSEARPPPL LGQHTTHILK EVLRYDDRAI GELLSAGVVD QHETH
Length:445
Mass (Da):48,462
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1FE42D75787692A
GO
Isoform 2 (identifier: Q9HAC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-162: Missing.
     370-370: Q → QNAVSGFQSLLHSLAHGPFLHLQGSAR

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):47,186
Checksum:i7154D3E23618A883
GO
Isoform 3 (identifier: Q9HAC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-370: Q → QNAVSGFQSLLHSLAHGPFLHLQGSAR

Show »
Length:471
Mass (Da):51,189
Checksum:iF55613A9604F5D55
GO
Isoform 4 (identifier: Q9HAC7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     200-247: Missing.

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):43,446
Checksum:i067AC010C8F7DD46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0H3H7C0H3_HUMAN
Succinate--hydroxymethylglutarate C...
SUGCT
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4N1H0Y4N1_HUMAN
Succinate--hydroxymethylglutarate C...
SUGCT
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1N0H7C1N0_HUMAN
Succinate--hydroxymethylglutarate C...
SUGCT
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99E → G in BAB87807 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054852336R → W in GA3; inactive enzyme; healthy individuals who have abnormal quantities of glutaric acid but low 3-hydroxyglutaric acid. 2 PublicationsCorresponds to variant dbSNP:rs137852860Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014721126 – 162Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_043291200 – 247Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_014722370Q → QNAVSGFQSLLHSLAHGPFL HLQGSAR in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK021870 mRNA Translation: BAB13922.1
AK299133 mRNA Translation: BAG61185.1
AC004988 Genomic DNA No translation available.
AC005030 Genomic DNA No translation available.
AC005160 Genomic DNA No translation available.
AC006023 Genomic DNA No translation available.
AC025536 Genomic DNA No translation available.
AC026866 Genomic DNA No translation available.
AC079149 Genomic DNA No translation available.
AC092030 Genomic DNA No translation available.
CH236951 Genomic DNA Translation: EAL24000.1
CH471073 Genomic DNA Translation: EAW94136.1
BC098117 mRNA Translation: AAH98117.1
BC098261 mRNA Translation: AAH98261.1
BC098310 mRNA Translation: AAH98310.1
BC098318 mRNA Translation: AAH98318.1
AF397013 mRNA Translation: AAL76418.1
AB014767 mRNA Translation: BAB87807.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55104.1 [Q9HAC7-3]
CCDS55105.1 [Q9HAC7-1]
CCDS55106.1 [Q9HAC7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001180240.1, NM_001193311.1 [Q9HAC7-3]
NP_001180241.1, NM_001193312.1 [Q9HAC7-4]
NP_001180242.1, NM_001193313.1 [Q9HAC7-1]
NP_079004.1, NM_024728.2 [Q9HAC7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335693; ENSP00000338475; ENSG00000175600 [Q9HAC7-1]
ENST00000401647; ENSP00000385222; ENSG00000175600 [Q9HAC7-4]
ENST00000628514; ENSP00000486291; ENSG00000175600 [Q9HAC7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79783

UCSC genome browser

More...
UCSCi
uc003thn.3 human [Q9HAC7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021870 mRNA Translation: BAB13922.1
AK299133 mRNA Translation: BAG61185.1
AC004988 Genomic DNA No translation available.
AC005030 Genomic DNA No translation available.
AC005160 Genomic DNA No translation available.
AC006023 Genomic DNA No translation available.
AC025536 Genomic DNA No translation available.
AC026866 Genomic DNA No translation available.
AC079149 Genomic DNA No translation available.
AC092030 Genomic DNA No translation available.
CH236951 Genomic DNA Translation: EAL24000.1
CH471073 Genomic DNA Translation: EAW94136.1
BC098117 mRNA Translation: AAH98117.1
BC098261 mRNA Translation: AAH98261.1
BC098310 mRNA Translation: AAH98310.1
BC098318 mRNA Translation: AAH98318.1
AF397013 mRNA Translation: AAL76418.1
AB014767 mRNA Translation: BAB87807.1
CCDSiCCDS55104.1 [Q9HAC7-3]
CCDS55105.1 [Q9HAC7-1]
CCDS55106.1 [Q9HAC7-4]
RefSeqiNP_001180240.1, NM_001193311.1 [Q9HAC7-3]
NP_001180241.1, NM_001193312.1 [Q9HAC7-4]
NP_001180242.1, NM_001193313.1 [Q9HAC7-1]
NP_079004.1, NM_024728.2 [Q9HAC7-2]

3D structure databases

SMRiQ9HAC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122883, 15 interactors
IntActiQ9HAC7, 2 interactors
STRINGi9606.ENSP00000338475

PTM databases

iPTMnetiQ9HAC7
PhosphoSitePlusiQ9HAC7

Polymorphism and mutation databases

BioMutaiSUGCT
DMDMi71152390

Proteomic databases

EPDiQ9HAC7
jPOSTiQ9HAC7
MaxQBiQ9HAC7
PeptideAtlasiQ9HAC7
PRIDEiQ9HAC7
ProteomicsDBi81391
81392 [Q9HAC7-2]
81393 [Q9HAC7-3]
81394 [Q9HAC7-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335693; ENSP00000338475; ENSG00000175600 [Q9HAC7-1]
ENST00000401647; ENSP00000385222; ENSG00000175600 [Q9HAC7-4]
ENST00000628514; ENSP00000486291; ENSG00000175600 [Q9HAC7-3]
GeneIDi79783
KEGGihsa:79783
UCSCiuc003thn.3 human [Q9HAC7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79783
DisGeNETi79783

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SUGCT
HGNCiHGNC:16001 SUGCT
HPAiHPA026698
HPA026704
HPA026705
MalaCardsiSUGCT
MIMi231690 phenotype
609187 gene
neXtProtiNX_Q9HAC7
OpenTargetsiENSG00000175600
Orphaneti35706 Glutaric acidemia type 3
PharmGKBiPA25942

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000157866
HOGENOMiHOG000219745
InParanoidiQ9HAC7
KOiK18703
OMAiTQVAANY
OrthoDBi983223at2759
PhylomeDBiQ9HAC7
TreeFamiTF314188

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000175600-MONOMER

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SUGCT human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79783

Protein Ontology

More...
PROi
PR:Q9HAC7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175600 Expressed in 141 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiQ9HAC7 baseline and differential
GenevisibleiQ9HAC7 HS

Family and domain databases

Gene3Di3.40.50.10540, 1 hit
InterProiView protein in InterPro
IPR003673 CoA-Trfase_fam_III
IPR023606 CoA-Trfase_III_dom_sf
PfamiView protein in Pfam
PF02515 CoA_transf_3, 1 hit
SUPFAMiSSF89796 SSF89796, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUCHY_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HAC7
Secondary accession number(s): A4D1W5
, B4DR73, Q4KMW4, Q4KMW8, Q4KMZ0, Q8TE00, Q8TEY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 5, 2019
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again