Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 172 (25 May 2022)
Sequence version 2 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Ceramide synthase 4

Gene

CERS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.

5 Publications

Caution

Some prediction bioinformatics tools predict the presence of a homeobox domain (By similarity). However, the domain is degenerate and residues that are important for DNA-binding are absent (By similarity).Sequence analysis

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.8 µM for sphinganine (with octadecanoyl-CoA as substrate)1 Publication
  2. KM=1.8 µM for sphinganine (with eicosanoyl-CoA as substrate)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.4 Publications
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.24, 2681
2.3.1.291, 2681
2.3.1.297, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9HA82

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660661, Sphingolipid de novo biosynthesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9HA82

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00222

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000699

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ceramide synthase 41 Publication (EC:2.3.1.-4 Publications)
Short name:
CerS41 Publication
Alternative name(s):
LAG1 longevity assurance homolog 4By similarity
Sphingosine N-acyltransferase CERS4Curated (EC:2.3.1.24By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CERS41 PublicationImported
Synonyms:LASS4By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23747, CERS4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615334, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HA82

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000090661

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31Lumenal1 PublicationAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 394Cytoplasmic1 PublicationAdd BLAST70

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi291 – 298ESISNRGP → YPLELYPA: Altered specificity toward acyl donor; generates C24 ceramides instead of C18-C22-ceramides. 1 Publication8
Mutagenesisi342 – 350SDVEESDSS → ADVEEADAA: Decreased phosphorylation. 1 Publication9

Organism-specific databases

DisGeNET

More...
DisGeNETi
79603

Open Targets

More...
OpenTargetsi
ENSG00000090661

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134915173

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9HA82, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CERS4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434561

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001855121 – 394Ceramide synthase 4Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei342PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at the C-terminus by CK2.1 Publication
N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HA82

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HA82

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HA82

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HA82

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HA82

PeptideAtlas

More...
PeptideAtlasi
Q9HA82

PRoteomics IDEntifications database

More...
PRIDEi
Q9HA82

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81384

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1106, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9HA82, 1 site, 3 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HA82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HA82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090661, Expressed in lower esophagus mucosa and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HA82, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HA82, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000090661, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9HA82
With#Exp.IntAct
C1QL4 [Q86Z23]3EBI-2622997,EBI-12062109
CCL4L2 [Q8NHW4]3EBI-2622997,EBI-10271156
CLEC1A [Q8NC01]3EBI-2622997,EBI-11996768
COL4A5 - isoform 2 [P29400-2]3EBI-2622997,EBI-12211159
CTXN3 [Q4LDR2]3EBI-2622997,EBI-12019274
CYB5R3 [P00387]3EBI-2622997,EBI-1046040
EMD [P50402]3EBI-2622997,EBI-489887
FATE1 [Q969F0]3EBI-2622997,EBI-743099
FXYD6 [Q9H0Q3]3EBI-2622997,EBI-713304
GPR151 [Q8TDV0]3EBI-2622997,EBI-11955647
IER3IP1 [Q9Y5U9]3EBI-2622997,EBI-725665
IGFBP5 [P24593]3EBI-2622997,EBI-720480
ITGAM [P11215]3EBI-2622997,EBI-2568251
JAGN1 [Q8N5M9]3EBI-2622997,EBI-10266796
LHFPL5 [Q8TAF8]3EBI-2622997,EBI-2820517
MS4A1 [P11836]3EBI-2622997,EBI-2808234
NAT8 [Q9UHE5]3EBI-2622997,EBI-2863634
NEU1 [Q99519]3EBI-2622997,EBI-721517
PLP2 [Q04941]3EBI-2622997,EBI-608347
PNLIPRP1 [P54315]3EBI-2622997,EBI-8652812
PTPN9 [P43378]3EBI-2622997,EBI-742898
SCAMP5 [Q8TAC9]3EBI-2622997,EBI-2695784
SCD [O00767]3EBI-2622997,EBI-2684237
SERF1B [O75920]3EBI-2622997,EBI-2115181
SERP2 [Q8N6R1]3EBI-2622997,EBI-749270
SLC13A4 [Q9UKG4]3EBI-2622997,EBI-12808018
SLC35A1 [P78382]3EBI-2622997,EBI-12870360
SLC35F6 [Q8N357]3EBI-2622997,EBI-713484
SLC7A1 [P30825]3EBI-2622997,EBI-4289564
SMIM11 [P58511]3EBI-2622997,EBI-1051936
STX7 [O15400]3EBI-2622997,EBI-3221827
STX8 [Q9UNK0]3EBI-2622997,EBI-727240
TEX264 [Q9Y6I9]3EBI-2622997,EBI-10329860
TMEM176A [Q96HP8]3EBI-2622997,EBI-2800645
TMEM254 [Q8TBM7]3EBI-2622997,EBI-11956809
TMEM72 [A0PK05]3EBI-2622997,EBI-12878352
TOMM6 [Q96B49]3EBI-2622997,EBI-10826510
TSPO2 [Q5TGU0]3EBI-2622997,EBI-12195249
UPK1B [O75841]3EBI-2622997,EBI-12237619
VAMP2 [P63027]3EBI-2622997,EBI-520113
Q96FB23EBI-2622997,EBI-2857623

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
122740, 70 interactors

Protein interaction database and analysis system

More...
IntActi
Q9HA82, 45 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251363

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9HA82, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9HA82

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HA82

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 332TLCPROSITE-ProRule annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 128Homeobox-likeCuratedAdd BLAST62
Regioni341 – 394DisorderedSequence analysisAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi291 – 301Last loop motif1 PublicationAdd BLAST11

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The last loop motif confers selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) to behenoyl-CoA (docosanoyl-CoA; C22:0-CoA) as acyl donors.1 Publication

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1607, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234515

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HA82

Identification of Orthologs from Complete Genome Data

More...
OMAi
DQGGDCY

Database of Orthologous Groups

More...
OrthoDBi
987268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HA82

TreeFam database of animal gene trees

More...
TreeFami
TF314319

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR016439, Lag1/Lac1-like
IPR006634, TLC-dom

The PANTHER Classification System

More...
PANTHERi
PTHR12560, PTHR12560, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 1 hit
PF03798, TRAM_LAG1_CLN8, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005225, LAG1_LAC1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00724, TLC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50922, TLC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9HA82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL
60 70 80 90 100
AMRLAFERFI GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL
110 120 130 140 150
SLLAAQCGLT LQQTQRWFRR RRNQDRPQLT KKFCEASWRF LFYLSSFVGG
160 170 180 190 200
LSVLYHESWL WAPVMCWDRY PNQTLKPSLY WWYLLELGFY LSLLIRLPFD
210 220 230 240 250
VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD SSDYLLEACK
260 270 280 290 300
MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF
310 320 330 340 350
GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS
360 370 380 390
EEAAAAQEPL QLKNGAAGGP RPAPTDGPRS RVAGRLTNRH TTAT
Length:394
Mass (Da):46,399
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDAA12AA386ED2802
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YN04H0YN04_HUMAN
Ceramide synthase 4
CERS4
306Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKC9H0YKC9_HUMAN
Ceramide synthase 4
CERS4
343Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNR6H0YNR6_HUMAN
Ceramide synthase 4
CERS4
192Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKR4H0YKR4_HUMAN
Ceramide synthase 4
CERS4
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLY3H0YLY3_HUMAN
Ceramide synthase 4
CERS4
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMY6H0YMY6_HUMAN
Ceramide synthase 4
CERS4
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKS3H0YKS3_HUMAN
Ceramide synthase 4
CERS4
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034065119R → Q. Corresponds to variant dbSNP:rs17159388Ensembl.1
Natural variantiVAR_019556301G → S. Corresponds to variant dbSNP:rs2288413Ensembl.1
Natural variantiVAR_060263353A → V2 PublicationsCorresponds to variant dbSNP:rs17160348Ensembl.1
Natural variantiVAR_019557366A → T1 PublicationCorresponds to variant dbSNP:rs36259Ensembl.1
Natural variantiVAR_060264379R → Q2 PublicationsCorresponds to variant dbSNP:rs17160349Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK022151 mRNA Translation: BAB13972.1
AC022146 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68940.1
CH471139 Genomic DNA Translation: EAW68941.1
CH471139 Genomic DNA Translation: EAW68942.1
CH471139 Genomic DNA Translation: EAW68945.1
BC009828 mRNA Translation: AAH09828.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12197.1

NCBI Reference Sequences

More...
RefSeqi
NP_078828.2, NM_024552.2
XP_011526592.1, XM_011528290.2
XP_011526593.1, XM_011528291.2
XP_011526594.1, XM_011528292.2
XP_011526595.1, XM_011528293.2
XP_011526596.1, XM_011528294.2
XP_011526597.1, XM_011528295.2
XP_016882792.1, XM_017027303.1
XP_016882793.1, XM_017027304.1
XP_016882794.1, XM_017027305.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251363.10; ENSP00000251363.5; ENSG00000090661.12
ENST00000559450.5; ENSP00000453509.1; ENSG00000090661.12

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79603

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79603

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000251363.10; ENSP00000251363.5; NM_024552.3; NP_078828.2

UCSC genome browser

More...
UCSCi
uc002mjg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022151 mRNA Translation: BAB13972.1
AC022146 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW68940.1
CH471139 Genomic DNA Translation: EAW68941.1
CH471139 Genomic DNA Translation: EAW68942.1
CH471139 Genomic DNA Translation: EAW68945.1
BC009828 mRNA Translation: AAH09828.1
CCDSiCCDS12197.1
RefSeqiNP_078828.2, NM_024552.2
XP_011526592.1, XM_011528290.2
XP_011526593.1, XM_011528291.2
XP_011526594.1, XM_011528292.2
XP_011526595.1, XM_011528293.2
XP_011526596.1, XM_011528294.2
XP_011526597.1, XM_011528295.2
XP_016882792.1, XM_017027303.1
XP_016882793.1, XM_017027304.1
XP_016882794.1, XM_017027305.1

3D structure databases

AlphaFoldDBiQ9HA82
SMRiQ9HA82
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122740, 70 interactors
IntActiQ9HA82, 45 interactors
STRINGi9606.ENSP00000251363

Chemistry databases

SwissLipidsiSLP:000000699

PTM databases

GlyConnecti1106, 3 N-Linked glycans (1 site)
GlyGeniQ9HA82, 1 site, 3 N-linked glycans (1 site)
iPTMnetiQ9HA82
PhosphoSitePlusiQ9HA82

Genetic variation databases

BioMutaiCERS4
DMDMi296434561

Proteomic databases

EPDiQ9HA82
jPOSTiQ9HA82
MassIVEiQ9HA82
MaxQBiQ9HA82
PaxDbiQ9HA82
PeptideAtlasiQ9HA82
PRIDEiQ9HA82
ProteomicsDBi81384

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24821, 290 antibodies from 29 providers

The DNASU plasmid repository

More...
DNASUi
79603

Genome annotation databases

EnsembliENST00000251363.10; ENSP00000251363.5; ENSG00000090661.12
ENST00000559450.5; ENSP00000453509.1; ENSG00000090661.12
GeneIDi79603
KEGGihsa:79603
MANE-SelectiENST00000251363.10; ENSP00000251363.5; NM_024552.3; NP_078828.2
UCSCiuc002mjg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79603
DisGeNETi79603

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CERS4
HGNCiHGNC:23747, CERS4
HPAiENSG00000090661, Low tissue specificity
MIMi615334, gene
neXtProtiNX_Q9HA82
OpenTargetsiENSG00000090661
PharmGKBiPA134915173
VEuPathDBiHostDB:ENSG00000090661

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1607, Eukaryota
GeneTreeiENSGT01030000234515
InParanoidiQ9HA82
OMAiDQGGDCY
OrthoDBi987268at2759
PhylomeDBiQ9HA82
TreeFamiTF314319

Enzyme and pathway databases

UniPathwayiUPA00222
BRENDAi2.3.1.24, 2681
2.3.1.291, 2681
2.3.1.297, 2681
PathwayCommonsiQ9HA82
ReactomeiR-HSA-1660661, Sphingolipid de novo biosynthesis
SignaLinkiQ9HA82

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79603, 25 hits in 1093 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CERS4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79603
PharosiQ9HA82, Tbio

Protein Ontology

More...
PROi
PR:Q9HA82
RNActiQ9HA82, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090661, Expressed in lower esophagus mucosa and 172 other tissues
ExpressionAtlasiQ9HA82, baseline and differential
GenevisibleiQ9HA82, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR016439, Lag1/Lac1-like
IPR006634, TLC-dom
PANTHERiPTHR12560, PTHR12560, 1 hit
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PF03798, TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005225, LAG1_LAC1, 1 hit
SMARTiView protein in SMART
SM00724, TLC, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50922, TLC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCERS4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HA82
Secondary accession number(s): D6W665
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again