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Protein

Ketosamine-3-kinase

Gene

FN3KRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000141560-MONOMER
BRENDAi2.7.1.171 2681
2.7.1.172 2681
ReactomeiR-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ketosamine-3-kinase (EC:2.7.1.-)
Alternative name(s):
Fructosamine-3-kinase-related protein
Short name:
FN3K-RP
Short name:
FN3K-related protein
Gene namesi
Name:FN3KRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141560.14
HGNCiHGNC:25700 FN3KRP
MIMi611683 gene
neXtProtiNX_Q9HA64

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000141560
PharmGKBiPA164720079

Polymorphism and mutation databases

BioMutaiFN3KRP
DMDMi47606765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002163391 – 309Ketosamine-3-kinaseAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HA64
MaxQBiQ9HA64
PaxDbiQ9HA64
PeptideAtlasiQ9HA64
PRIDEiQ9HA64
ProteomicsDBi81378

2D gel databases

REPRODUCTION-2DPAGEiIPI00099986

PTM databases

iPTMnetiQ9HA64
PhosphoSitePlusiQ9HA64

Expressioni

Tissue specificityi

Expressed in erythrocytes.1 Publication

Gene expression databases

BgeeiENSG00000141560
ExpressionAtlasiQ9HA64 baseline and differential
GenevisibleiQ9HA64 HS

Organism-specific databases

HPAiHPA056172
HPA065831

Interactioni

Protein-protein interaction databases

BioGridi122797, 14 interactors
IntActiQ9HA64, 3 interactors
STRINGi9606.ENSP00000269373

Structurei

3D structure databases

ProteinModelPortaliQ9HA64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fructosamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG3021 Eukaryota
COG3001 LUCA
GeneTreeiENSGT00390000005730
HOGENOMiHOG000023913
HOVERGENiHBG005740
InParanoidiQ9HA64
KOiK15523
OMAiPFVDQFG
OrthoDBiEOG091G0KFO
PhylomeDBiQ9HA64
TreeFamiTF313452

Family and domain databases

InterProiView protein in InterPro
IPR016477 Fructo-/Ketosamine-3-kinase
IPR011009 Kinase-like_dom_sf
PANTHERiPTHR12149 PTHR12149, 1 hit
PfamiView protein in Pfam
PF03881 Fructosamin_kin, 1 hit
PIRSFiPIRSF006221 Ketosamine-3-kinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HA64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELLRRELG CSSVRATGHS GGGCISQGRS YDTDQGRVFV KVNPKAEARR
60 70 80 90 100
MFEGEMASLT AILKTNTVKV PKPIKVLDAP GGGSVLVMEH MDMRHLSSHA
110 120 130 140 150
AKLGAQLADL HLDNKKLGEM RLKEAGTVGR GGGQEERPFV ARFGFDVVTC
160 170 180 190 200
CGYLPQVNDW QEDWVVFYAR QRIQPQMDMV EKESGDREAL QLWSALQLKI
210 220 230 240 250
PDLFRDLEII PALLHGDLWG GNVAEDSSGP VIFDPASFYG HSEYELAIAG
260 270 280 290 300
MFGGFSSSFY SAYHGKIPKA PGFEKRLQLY QLFHYLNHWN HFGSGYRGSS

LNIMRNLVK
Length:309
Mass (Da):34,412
Last modified:May 24, 2004 - v2
Checksum:iEE6101C5BB2A7FF3
GO

Sequence cautioni

The sequence CAB66566 differs from that shown. Reason: Erroneous termination at position 198. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129G → W in CAB66566 (PubMed:11230166).Curated1
Sequence conflicti265G → C in AAH01458 (PubMed:15489334).Curated1
Sequence conflicti278Q → R in BAB13992 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03405757A → V. Corresponds to variant dbSNP:rs3748811Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360465 mRNA Translation: AAQ72344.1
AL136631 mRNA Translation: CAB66566.1 Sequence problems.
AK022233 mRNA Translation: BAB13992.1
BC001458 mRNA Translation: AAH01458.2
BC007611 mRNA Translation: AAH07611.1
BC014408 mRNA Translation: AAH14408.1
CCDSiCCDS11817.1
RefSeqiNP_078895.2, NM_024619.3
UniGeneiHs.31431

Genome annotation databases

EnsembliENST00000269373; ENSP00000269373; ENSG00000141560
GeneIDi79672
KEGGihsa:79672
UCSCiuc002kfu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKT3K_HUMAN
AccessioniPrimary (citable) accession number: Q9HA64
Secondary accession number(s): Q969F4, Q9H0U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 24, 2004
Last modified: June 20, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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