UniProtKB - Q9H9Y6 (RPA2_HUMAN)
DNA-directed RNA polymerase I subunit RPA2
POLR1B
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
1 PublicationCatalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1070 – 1101 | C4-typeBy similarityAdd BLAST | 32 |
GO - Molecular functioni
- DNA binding Source: InterPro
- DNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- ribonucleoside binding Source: InterPro
GO - Biological processi
- embryo implantation Source: Ensembl
- neural crest formation Source: UniProtKB
- nucleologenesis Source: Ensembl
- rRNA transcription Source: Ensembl
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Transcription |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H9Y6 |
Reactomei | R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73863, RNA Polymerase I Transcription Termination |
SignaLinki | Q9H9Y6 |
SIGNORi | Q9H9Y6 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase I subunit RPA2 (EC:2.7.7.61 Publication)Short name: RNA polymerase I subunit 2 Alternative name(s): DNA-directed RNA polymerase I 135 kDa polypeptide Short name: RPA135 |
Gene namesi | Name:POLR1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20454, POLR1B |
MIMi | 602000, gene |
neXtProti | NX_Q9H9Y6 |
VEuPathDBi | HostDB:ENSG00000125630 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Other locations
- Chromosome By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: Reactome
- RNA polymerase I complex Source: GO_Central
Other locations
- chromosome Source: UniProtKB
Keywords - Cellular componenti
Chromosome, DNA-directed RNA polymerase, NucleusPathology & Biotechi
Involvement in diseasei
Treacher Collins syndrome 4 (TCS4)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084557 | 682 | S → R in TCS4; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_084558 | 1003 | R → C in TCS4. 1 Publication | 1 | |
Natural variantiVAR_084559 | 1003 | R → S in TCS4. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 84172 |
GeneReviewsi | POLR1B |
MalaCardsi | POLR1B |
MIMi | 618939, phenotype |
OpenTargetsi | ENSG00000125630 |
Orphaneti | 861, Treacher-Collins syndrome |
PharmGKBi | PA130601182 |
Miscellaneous databases
Pharosi | Q9H9Y6, Tbio |
Genetic variation databases
BioMutai | POLR1B |
DMDMi | 92090637 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048072 | 1 – 1135 | DNA-directed RNA polymerase I subunit RPA2Add BLAST | 1135 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1051 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H9Y6 |
jPOSTi | Q9H9Y6 |
MassIVEi | Q9H9Y6 |
MaxQBi | Q9H9Y6 |
PaxDbi | Q9H9Y6 |
PeptideAtlasi | Q9H9Y6 |
PRIDEi | Q9H9Y6 |
ProteomicsDBi | 25159 30108 81369 [Q9H9Y6-1] 81370 [Q9H9Y6-2] |
2D gel databases
SWISS-2DPAGEi | Q9H9Y6 |
PTM databases
GlyGeni | Q9H9Y6, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9H9Y6 |
PhosphoSitePlusi | Q9H9Y6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125630, Expressed in buccal mucosa cell and 252 other tissues |
ExpressionAtlasi | Q9H9Y6, baseline and differential |
Genevisiblei | Q9H9Y6, HS |
Organism-specific databases
HPAi | ENSG00000125630, Low tissue specificity |
Interactioni
Subunit structurei
Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.
1 PublicationBinary interactionsi
Q9H9Y6
With | #Exp. | IntAct |
---|---|---|
POLR1A [O95602] | 3 | EBI-355441,EBI-359472 |
Protein-protein interaction databases
BioGRIDi | 123926, 120 interactors |
CORUMi | Q9H9Y6 |
DIPi | DIP-27538N |
IntActi | Q9H9Y6, 35 interactors |
MINTi | Q9H9Y6 |
STRINGi | 9606.ENSP00000444136 |
Miscellaneous databases
RNActi | Q9H9Y6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1070 – 1101 | C4-typeBy similarityAdd BLAST | 32 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0216, Eukaryota |
GeneTreei | ENSGT00950000183132 |
HOGENOMi | CLU_000524_5_1_1 |
InParanoidi | Q9H9Y6 |
OMAi | FFGVVHY |
OrthoDBi | 42570at2759 |
PhylomeDBi | Q9H9Y6 |
TreeFami | TF103055 |
Family and domain databases
CDDi | cd00653, RNA_pol_B_RPB2, 1 hit |
Gene3Di | 2.40.270.10, 1 hit 2.40.50.150, 1 hit 3.90.1110.10, 1 hit |
InterProi | View protein in InterPro IPR015712, DNA-dir_RNA_pol_su2 IPR007120, DNA-dir_RNAP_su2_dom IPR037033, DNA-dir_RNAP_su2_hyb_sf IPR007121, RNA_pol_bsu_CS IPR007644, RNA_pol_bsu_protrusion IPR007642, RNA_pol_Rpb2_2 IPR037034, RNA_pol_Rpb2_2_sf IPR007645, RNA_pol_Rpb2_3 IPR007641, RNA_pol_Rpb2_7 IPR014724, RNA_pol_RPB2_OB-fold IPR009674, Rpa2_dom_4 |
PANTHERi | PTHR20856, PTHR20856, 1 hit |
Pfami | View protein in Pfam PF06883, RNA_pol_Rpa2_4, 1 hit PF04563, RNA_pol_Rpb2_1, 1 hit PF04561, RNA_pol_Rpb2_2, 1 hit PF04565, RNA_pol_Rpb2_3, 1 hit PF00562, RNA_pol_Rpb2_6, 1 hit PF04560, RNA_pol_Rpb2_7, 1 hit |
PROSITEi | View protein in PROSITE PS01166, RNA_POL_BETA, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPGSRWRNL PSGPSLKHLT DPSYGIPREQ QKAALQELTR AHVESFNYAV
60 70 80 90 100
HEGLGLAVQA IPPFEFAFKD ERISFTILDA VISPPTVPKG TICKEANVYP
110 120 130 140 150
AECRGRRSTY RGKLTADINW AVNGISKGII KQFLGYVPIM VKSKLCNLRN
160 170 180 190 200
LPPQALIEHH EEAEEMGGYF IINGIEKVIR MLIMPRRNFP IAMIRPKWKT
210 220 230 240 250
RGPGYTQYGV SMHCVREEHS AVNMNLHYLE NGTVMLNFIY RKELFFLPLG
260 270 280 290 300
FALKALVSFS DYQIFQELIK GKEDDSFLRN SVSQMLRIVM EEGCSTQKQV
310 320 330 340 350
LNYLGECFRV KLNVPDWYPN EQAAEFLFNQ CICIHLKSNT EKFYMLCLMT
360 370 380 390 400
RKLFALAKGE CMEDNPDSLV NQEVLTPGQL FLMFLKEKLE GWLVSIKIAF
410 420 430 440 450
DKKAQKTSVS MNTDNLMRIF TMGIDLTKPF EYLFATGNLR SKTGLGLLQD
460 470 480 490 500
SGLCVVADKL NFIRYLSHFR CVHRGADFAK MRTTTVRRLL PESWGFLCPV
510 520 530 540 550
HTPDGEPCGL MNHLTAVCEV VTQFVYTASI PALLCNLGVT PIDGAPHRSY
560 570 580 590 600
SECYPVLLDG VMVGWVDKDL APGIADSLRH FKVLREKRIP PWMEVVLIPM
610 620 630 640 650
TGKPSLYPGL FLFTTPCRLV RPVQNLALGK EELIGTMEQI FMNVAIFEDE
660 670 680 690 700
VFAGVTTHQE LFPHSLLSVI ANFIPFSDHN QSPRNMYQCQ MGKQTMGFPL
710 720 730 740 750
LTYQDRSDNK LYRLQTPQSP LVRPSMYDYY DMDNYPIGTN AIVAVISYTG
760 770 780 790 800
YDMEDAMIVN KASWERGFAH GSVYKSEFID LSEKIKQGDS SLVFGIKPGD
810 820 830 840 850
PRVLQKLDDD GLPFIGAKLQ YGDPYYSYLN LNTGESFVMY YKSKENCVVD
860 870 880 890 900
NIKVCSNDTG SGKFKCVCIT MRVPRNPTIG DKFASRHGQK GILSRLWPAE
910 920 930 940 950
DMPFTESGMV PDILFNPHGF PSRMTIGMLI ESMAGKSAAL HGLCHDATPF
960 970 980 990 1000
IFSEENSALE YFGEMLKAAG YNFYGTERLY SGISGLELEA DIFIGVVYYQ
1010 1020 1030 1040 1050
RLRHMVSDKF QVRTTGARDR VTNQPIGGRN VQGGIRFGEM ERDALLAHGT
1060 1070 1080 1090 1100
SFLLHDRLFN CSDRSVAHVC VKCGSLLSPL LEKPPPSWSA MRNRKYNCTL
1110 1120 1130
CSRSDTIDTV SVPYVFRYFV AELAAMNIKV KLDVV
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C0D9 | H7C0D9_HUMAN | DNA-directed RNA polymerase I subun... | POLR1B | 307 | Annotation score: | ||
C9JS83 | C9JS83_HUMAN | DNA-directed RNA polymerase | POLR1B | 128 | Annotation score: | ||
C9JJG2 | C9JJG2_HUMAN | DNA-directed RNA polymerase | POLR1B | 114 | Annotation score: | ||
F8WAK7 | F8WAK7_HUMAN | DNA-directed RNA polymerase I subun... | POLR1B | 73 | Annotation score: | ||
F8WBB9 | F8WBB9_HUMAN | DNA-directed RNA polymerase I subun... | POLR1B | 92 | Annotation score: | ||
F8WCS3 | F8WCS3_HUMAN | DNA-directed RNA polymerase I subun... | POLR1B | 105 | Annotation score: | ||
F8WDS4 | F8WDS4_HUMAN | DNA-directed RNA polymerase I subun... | POLR1B | 65 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 247 | L → R in BAB14082 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 360 | E → G in AAI10834 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 746 | I → T in BAB14296 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 800 | D → G in BAC87247 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 868 | C → R in BAB14082 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 889 | Q → R in BAB14082 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1039 | E → G in BAH13809 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034476 | 295 | S → L1 PublicationCorresponds to variant dbSNP:rs1545133Ensembl. | 1 | |
Natural variantiVAR_084557 | 682 | S → R in TCS4; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_071195 | 887 | H → R. | 1 | |
Natural variantiVAR_084558 | 1003 | R → C in TCS4. 1 Publication | 1 | |
Natural variantiVAR_084559 | 1003 | R → S in TCS4. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056749 | 1 – 211 | Missing in isoform 4. 1 PublicationAdd BLAST | 211 | |
Alternative sequenceiVSP_056750 | 1 | M → MRAKEAAETGLRPLLPACTE RLASGVYRETGVRCAGGHM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_017823 | 61 – 116 | Missing in isoform 2. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_056751 | 387 – 582 | EKLEG…LRHFK → GSLPLMELPTDHT in isoform 5. 1 PublicationAdd BLAST | 196 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022533 mRNA Translation: BAB14082.1 AK022890 mRNA Translation: BAB14296.1 AK128044 mRNA Translation: BAC87247.1 AK301178 mRNA Translation: BAH13423.1 AK302814 mRNA Translation: BAH13809.1 AC012442 Genomic DNA Translation: AAX81999.1 BC110833 mRNA Translation: AAI10834.1 |
CCDSi | CCDS2097.1 [Q9H9Y6-1] CCDS46395.1 [Q9H9Y6-2] CCDS62988.1 [Q9H9Y6-3] CCDS62989.1 [Q9H9Y6-5] CCDS62990.1 [Q9H9Y6-4] |
RefSeqi | NP_001131076.1, NM_001137604.2 [Q9H9Y6-2] NP_001269701.1, NM_001282772.1 [Q9H9Y6-3] NP_001269703.1, NM_001282774.1 [Q9H9Y6-5] NP_001269705.1, NM_001282776.1 [Q9H9Y6-4] NP_001269706.1, NM_001282777.1 NP_001269708.1, NM_001282779.1 NP_061887.2, NM_019014.5 [Q9H9Y6-1] |
Genome annotation databases
Ensembli | ENST00000263331; ENSP00000263331; ENSG00000125630 ENST00000409894; ENSP00000387143; ENSG00000125630 [Q9H9Y6-5] ENST00000417433; ENSP00000405358; ENSG00000125630 [Q9H9Y6-2] ENST00000537335; ENSP00000437914; ENSG00000125630 [Q9H9Y6-4] ENST00000541869; ENSP00000444136; ENSG00000125630 [Q9H9Y6-3] |
GeneIDi | 84172 |
KEGGi | hsa:84172 |
MANE-Selecti | ENST00000263331.10; ENSP00000263331.5; NM_019014.6; NP_061887.2 |
UCSCi | uc002thw.4, human [Q9H9Y6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022533 mRNA Translation: BAB14082.1 AK022890 mRNA Translation: BAB14296.1 AK128044 mRNA Translation: BAC87247.1 AK301178 mRNA Translation: BAH13423.1 AK302814 mRNA Translation: BAH13809.1 AC012442 Genomic DNA Translation: AAX81999.1 BC110833 mRNA Translation: AAI10834.1 |
CCDSi | CCDS2097.1 [Q9H9Y6-1] CCDS46395.1 [Q9H9Y6-2] CCDS62988.1 [Q9H9Y6-3] CCDS62989.1 [Q9H9Y6-5] CCDS62990.1 [Q9H9Y6-4] |
RefSeqi | NP_001131076.1, NM_001137604.2 [Q9H9Y6-2] NP_001269701.1, NM_001282772.1 [Q9H9Y6-3] NP_001269703.1, NM_001282774.1 [Q9H9Y6-5] NP_001269705.1, NM_001282776.1 [Q9H9Y6-4] NP_001269706.1, NM_001282777.1 NP_001269708.1, NM_001282779.1 NP_061887.2, NM_019014.5 [Q9H9Y6-1] |
3D structure databases
SMRi | Q9H9Y6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123926, 120 interactors |
CORUMi | Q9H9Y6 |
DIPi | DIP-27538N |
IntActi | Q9H9Y6, 35 interactors |
MINTi | Q9H9Y6 |
STRINGi | 9606.ENSP00000444136 |
PTM databases
GlyGeni | Q9H9Y6, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9H9Y6 |
PhosphoSitePlusi | Q9H9Y6 |
Genetic variation databases
BioMutai | POLR1B |
DMDMi | 92090637 |
2D gel databases
SWISS-2DPAGEi | Q9H9Y6 |
Proteomic databases
EPDi | Q9H9Y6 |
jPOSTi | Q9H9Y6 |
MassIVEi | Q9H9Y6 |
MaxQBi | Q9H9Y6 |
PaxDbi | Q9H9Y6 |
PeptideAtlasi | Q9H9Y6 |
PRIDEi | Q9H9Y6 |
ProteomicsDBi | 25159 30108 81369 [Q9H9Y6-1] 81370 [Q9H9Y6-2] |
Protocols and materials databases
Antibodypediai | 18109, 125 antibodies from 23 providers |
DNASUi | 84172 |
Genome annotation databases
Ensembli | ENST00000263331; ENSP00000263331; ENSG00000125630 ENST00000409894; ENSP00000387143; ENSG00000125630 [Q9H9Y6-5] ENST00000417433; ENSP00000405358; ENSG00000125630 [Q9H9Y6-2] ENST00000537335; ENSP00000437914; ENSG00000125630 [Q9H9Y6-4] ENST00000541869; ENSP00000444136; ENSG00000125630 [Q9H9Y6-3] |
GeneIDi | 84172 |
KEGGi | hsa:84172 |
MANE-Selecti | ENST00000263331.10; ENSP00000263331.5; NM_019014.6; NP_061887.2 |
UCSCi | uc002thw.4, human [Q9H9Y6-1] |
Organism-specific databases
CTDi | 84172 |
DisGeNETi | 84172 |
GeneCardsi | POLR1B |
GeneReviewsi | POLR1B |
HGNCi | HGNC:20454, POLR1B |
HPAi | ENSG00000125630, Low tissue specificity |
MalaCardsi | POLR1B |
MIMi | 602000, gene 618939, phenotype |
neXtProti | NX_Q9H9Y6 |
OpenTargetsi | ENSG00000125630 |
Orphaneti | 861, Treacher-Collins syndrome |
PharmGKBi | PA130601182 |
VEuPathDBi | HostDB:ENSG00000125630 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0216, Eukaryota |
GeneTreei | ENSGT00950000183132 |
HOGENOMi | CLU_000524_5_1_1 |
InParanoidi | Q9H9Y6 |
OMAi | FFGVVHY |
OrthoDBi | 42570at2759 |
PhylomeDBi | Q9H9Y6 |
TreeFami | TF103055 |
Enzyme and pathway databases
PathwayCommonsi | Q9H9Y6 |
Reactomei | R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73863, RNA Polymerase I Transcription Termination |
SignaLinki | Q9H9Y6 |
SIGNORi | Q9H9Y6 |
Miscellaneous databases
BioGRID-ORCSi | 84172, 773 hits in 1023 CRISPR screens |
ChiTaRSi | POLR1B, human |
GeneWikii | POLR1B |
GenomeRNAii | 84172 |
Pharosi | Q9H9Y6, Tbio |
PROi | PR:Q9H9Y6 |
RNActi | Q9H9Y6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125630, Expressed in buccal mucosa cell and 252 other tissues |
ExpressionAtlasi | Q9H9Y6, baseline and differential |
Genevisiblei | Q9H9Y6, HS |
Family and domain databases
CDDi | cd00653, RNA_pol_B_RPB2, 1 hit |
Gene3Di | 2.40.270.10, 1 hit 2.40.50.150, 1 hit 3.90.1110.10, 1 hit |
InterProi | View protein in InterPro IPR015712, DNA-dir_RNA_pol_su2 IPR007120, DNA-dir_RNAP_su2_dom IPR037033, DNA-dir_RNAP_su2_hyb_sf IPR007121, RNA_pol_bsu_CS IPR007644, RNA_pol_bsu_protrusion IPR007642, RNA_pol_Rpb2_2 IPR037034, RNA_pol_Rpb2_2_sf IPR007645, RNA_pol_Rpb2_3 IPR007641, RNA_pol_Rpb2_7 IPR014724, RNA_pol_RPB2_OB-fold IPR009674, Rpa2_dom_4 |
PANTHERi | PTHR20856, PTHR20856, 1 hit |
Pfami | View protein in Pfam PF06883, RNA_pol_Rpa2_4, 1 hit PF04563, RNA_pol_Rpb2_1, 1 hit PF04561, RNA_pol_Rpb2_2, 1 hit PF04565, RNA_pol_Rpb2_3, 1 hit PF00562, RNA_pol_Rpb2_6, 1 hit PF04560, RNA_pol_Rpb2_7, 1 hit |
PROSITEi | View protein in PROSITE PS01166, RNA_POL_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RPA2_HUMAN | |
Accessioni | Q9H9Y6Primary (citable) accession number: Q9H9Y6 Secondary accession number(s): B7Z6Y7 Q9H9D3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 4, 2001 |
Last sequence update: | April 4, 2006 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families