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Protein

GPN-loop GTPase 2

Gene

GPN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei78Stabilizes the phosphate intermediate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 24GTPBy similarity6
Nucleotide bindingi178 – 181GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GPN-loop GTPase 2Curated
Alternative name(s):
ATP-binding domain 1 family member B
Gene namesi
Name:GPN21 PublicationImported
Synonyms:ATPBD1B
ORF Names:UNQ5828/PRO19647
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142751.14
HGNCiHGNC:25513 GPN2
neXtProtiNX_Q9H9Y4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142751
PharmGKBiPA162390149

Polymorphism and mutation databases

BioMutaiGPN2
DMDMi110832767

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002478292 – 310GPN-loop GTPase 2Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H9Y4
MaxQBiQ9H9Y4
PaxDbiQ9H9Y4
PeptideAtlasiQ9H9Y4
PRIDEiQ9H9Y4
ProteomicsDBi81368

PTM databases

iPTMnetiQ9H9Y4
PhosphoSitePlusiQ9H9Y4

Expressioni

Gene expression databases

BgeeiENSG00000142751 Expressed in 199 organ(s), highest expression level in testis
CleanExiHS_GPN2
ExpressionAtlasiQ9H9Y4 baseline and differential
GenevisibleiQ9H9Y4 HS

Organism-specific databases

HPAiHPA028059

Interactioni

Subunit structurei

Heterodimers with GPN1 or GPN3 (By similarity). Binds to RNA polymerase II (RNAPII) (PubMed:20864038).By similarity1 Publication

Protein-protein interaction databases

BioGridi120104, 11 interactors
IntActiQ9H9Y4, 2 interactors
STRINGi9606.ENSP00000363250

Structurei

3D structure databases

ProteinModelPortaliQ9H9Y4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 78Gly-Pro-Asn (GPN)-loop; involved in dimer interfaceBy similarity3

Sequence similaritiesi

Belongs to the GPN-loop GTPase family.Curated

Phylogenomic databases

eggNOGiKOG1533 Eukaryota
ENOG410YRVC LUCA
GeneTreeiENSGT00550000075096
HOGENOMiHOG000207661
HOVERGENiHBG054729
InParanoidiQ9H9Y4
KOiK06883
OMAiCSIVNLD
OrthoDBiEOG091G0E07
PhylomeDBiQ9H9Y4
TreeFamiTF300828

Family and domain databases

InterProiView protein in InterPro
IPR004130 Gpn
IPR030231 Gpn2
IPR027417 P-loop_NTPase
PANTHERiPTHR21231 PTHR21231, 1 hit
PTHR21231:SF3 PTHR21231:SF3, 1 hit
PfamiView protein in Pfam
PF03029 ATP_bind_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H9Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAAPTTAF GQAVIGPPGS GKTTYCLGMS EFLRALGRRV AVVNLDPANE
60 70 80 90 100
GLPYECAVDV GELVGLGDVM DALRLGPNGG LLYCMEYLEA NLDWLRAKLD
110 120 130 140 150
PLRGHYFLFD CPGQVELCTH HGALRSIFSQ MAQWDLRLTA VHLVDSHYCT
160 170 180 190 200
DPAKFISVLC TSLATMLHVE LPHINLLSKM DLIEHYGKLA FNLDYYTEVL
210 220 230 240 250
DLSYLLDHLA SDPFFRHYRQ LNEKLVQLIE DYSLVSFIPL NIQDKESIQR
260 270 280 290 300
VLQAVDKANG YCFRAQEQRS LEAMMSAAMG ADFHFSSTLG IQEKYLAPSN
310
QSVEQEAMQL
Length:310
Mass (Da):34,561
Last modified:July 25, 2006 - v2
Checksum:iF73EAF808DA692CA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JYG4Q5JYG4_HUMAN
GPN-loop GTPase 2
GPN2
112Annotation score:
Q5JYG3Q5JYG3_HUMAN
GPN-loop GTPase 2
GPN2
131Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15I → T in AAQ76820 (PubMed:16533400).Curated1
Sequence conflicti15I → T in BAA91556 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027153227Q → R1 PublicationCorresponds to variant dbSNP:rs17856257Ensembl.1
Natural variantiVAR_027154264R → G3 PublicationsCorresponds to variant dbSNP:rs3170660Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364261 mRNA Translation: AAQ76820.1
AY358864 mRNA Translation: AAQ89223.1
AK001211 mRNA Translation: BAA91556.1
AK022535 mRNA Translation: BAB14084.1
AL034380 Genomic DNA No translation available.
BC007815 mRNA Translation: AAH07815.1
BC008634 mRNA Translation: AAH08634.1
CCDSiCCDS289.1
RefSeqiNP_060536.3, NM_018066.3
UniGeneiHs.14333

Genome annotation databases

EnsembliENST00000374135; ENSP00000363250; ENSG00000142751
GeneIDi54707
KEGGihsa:54707
UCSCiuc001bnd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364261 mRNA Translation: AAQ76820.1
AY358864 mRNA Translation: AAQ89223.1
AK001211 mRNA Translation: BAA91556.1
AK022535 mRNA Translation: BAB14084.1
AL034380 Genomic DNA No translation available.
BC007815 mRNA Translation: AAH07815.1
BC008634 mRNA Translation: AAH08634.1
CCDSiCCDS289.1
RefSeqiNP_060536.3, NM_018066.3
UniGeneiHs.14333

3D structure databases

ProteinModelPortaliQ9H9Y4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120104, 11 interactors
IntActiQ9H9Y4, 2 interactors
STRINGi9606.ENSP00000363250

PTM databases

iPTMnetiQ9H9Y4
PhosphoSitePlusiQ9H9Y4

Polymorphism and mutation databases

BioMutaiGPN2
DMDMi110832767

Proteomic databases

EPDiQ9H9Y4
MaxQBiQ9H9Y4
PaxDbiQ9H9Y4
PeptideAtlasiQ9H9Y4
PRIDEiQ9H9Y4
ProteomicsDBi81368

Protocols and materials databases

DNASUi54707
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374135; ENSP00000363250; ENSG00000142751
GeneIDi54707
KEGGihsa:54707
UCSCiuc001bnd.2 human

Organism-specific databases

CTDi54707
EuPathDBiHostDB:ENSG00000142751.14
GeneCardsiGPN2
HGNCiHGNC:25513 GPN2
HPAiHPA028059
neXtProtiNX_Q9H9Y4
OpenTargetsiENSG00000142751
PharmGKBiPA162390149
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1533 Eukaryota
ENOG410YRVC LUCA
GeneTreeiENSGT00550000075096
HOGENOMiHOG000207661
HOVERGENiHBG054729
InParanoidiQ9H9Y4
KOiK06883
OMAiCSIVNLD
OrthoDBiEOG091G0E07
PhylomeDBiQ9H9Y4
TreeFamiTF300828

Miscellaneous databases

ChiTaRSiGPN2 human
GenomeRNAii54707
PROiPR:Q9H9Y4

Gene expression databases

BgeeiENSG00000142751 Expressed in 199 organ(s), highest expression level in testis
CleanExiHS_GPN2
ExpressionAtlasiQ9H9Y4 baseline and differential
GenevisibleiQ9H9Y4 HS

Family and domain databases

InterProiView protein in InterPro
IPR004130 Gpn
IPR030231 Gpn2
IPR027417 P-loop_NTPase
PANTHERiPTHR21231 PTHR21231, 1 hit
PTHR21231:SF3 PTHR21231:SF3, 1 hit
PfamiView protein in Pfam
PF03029 ATP_bind_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H9Y4
Secondary accession number(s): Q96HG4, Q9NUE1, Q9NW30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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