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Protein

Ribosome production factor 1

Gene

RPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be required for ribosome biogenesis.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • rRNA primary transcript binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 1
Alternative name(s):
Brix domain-containing protein 5
Ribosome biogenesis protein RPF1
Gene namesi
Name:RPF1
Synonyms:BXDC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117133.10
HGNCiHGNC:30350 RPF1
neXtProtiNX_Q9H9Y2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117133
PharmGKBiPA165752348

Polymorphism and mutation databases

BioMutaiRPF1
DMDMi71153718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202481 – 349Ribosome production factor 1Add BLAST349

Proteomic databases

EPDiQ9H9Y2
MaxQBiQ9H9Y2
PaxDbiQ9H9Y2
PeptideAtlasiQ9H9Y2
PRIDEiQ9H9Y2
ProteomicsDBi81367

2D gel databases

SWISS-2DPAGEiQ9H9Y2

PTM databases

iPTMnetiQ9H9Y2
PhosphoSitePlusiQ9H9Y2

Expressioni

Gene expression databases

BgeeiENSG00000117133
CleanExiHS_BXDC5
ExpressionAtlasiQ9H9Y2 baseline and differential
GenevisibleiQ9H9Y2 HS

Organism-specific databases

HPAiHPA024642

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-9996007,EBI-10172290

Protein-protein interaction databases

BioGridi123133, 47 interactors
IntActiQ9H9Y2, 6 interactors
STRINGi9606.ENSP00000359688

Structurei

3D structure databases

ProteinModelPortaliQ9H9Y2
SMRiQ9H9Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 325BrixPROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni303 – 320RNA-bindingBy similarityAdd BLAST18

Phylogenomic databases

eggNOGiKOG2780 Eukaryota
COG2136 LUCA
GeneTreeiENSGT00550000074691
HOGENOMiHOG000172062
HOVERGENiHBG083559
InParanoidiQ9H9Y2
KOiK14846
OMAiAWIISNK
OrthoDBiEOG091G0CQ2
PhylomeDBiQ9H9Y2
TreeFamiTF105897

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H9Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAGDKSSS SGKKSLKRKA AAEELQEAAG AGDGATENGV QPPKAAAFPP
60 70 80 90 100
GFSISEIKNK QRRHLMFTRW KQQQRKEKLA AKKKLKKERE ALGDKAPPKP
110 120 130 140 150
VPKTIDNQRV YDETTVDPND EEVAYDEATD EFASYFNKQT SPKILITTSD
160 170 180 190 200
RPHGRTVRLC EQLSTVIPNS HVYYRRGLAL KKIIPQCIAR DFTDLIVINE
210 220 230 240 250
DRKTPNGLIL SHLPNGPTAH FKMSSVRLRK EIKRRGKDPT EHIPEIILNN
260 270 280 290 300
FTTRLGHSIG RMFASLFPHN PQFIGRQVAT FHNQRDYIFF RFHRYIFRSE
310 320 330 340
KKVGIQELGP RFTLKLRSLQ KGTFDSKYGE YEWVHKPREM DTSRRKFHL
Length:349
Mass (Da):40,111
Last modified:July 19, 2005 - v2
Checksum:iF939904B3AB79890
GO

Sequence cautioni

The sequence CAH71915 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0228719S → G2 PublicationsCorresponds to variant dbSNP:rs2292191Ensembl.1
Natural variantiVAR_048421223M → I. Corresponds to variant dbSNP:rs7528067Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322053 mRNA Translation: AAL37236.1
AK022537 mRNA Translation: BAB14086.1
AL359762, AL844170 Genomic DNA Translation: CAH70204.1
AL844170, AL359762 Genomic DNA Translation: CAH71914.1
AL844170 Genomic DNA Translation: CAH71915.1 Sequence problems.
BC016051 mRNA Translation: AAH16051.1
CR627468 mRNA Translation: CAH10670.1
AL359584 mRNA Translation: CAH10671.1
CCDSiCCDS695.1
PIRiT50616
RefSeqiNP_079341.2, NM_025065.6
UniGeneiHs.481202

Genome annotation databases

EnsembliENST00000370654; ENSP00000359688; ENSG00000117133
GeneIDi80135
KEGGihsa:80135
UCSCiuc001djv.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPF1_HUMAN
AccessioniPrimary (citable) accession number: Q9H9Y2
Secondary accession number(s): Q5VSK7, Q6AHX1, Q8WXZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 20, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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