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Protein

RING finger protein 122

Gene

RNF122

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May induce necrosis and apoptosis. May play a role in cell viability.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 122
Gene namesi
Name:RNF122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000133874.1
HGNCiHGNC:21147 RNF122
neXtProtiNX_Q9H9V4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133874
PharmGKBiPA134892945

Polymorphism and mutation databases

DMDMi110816410

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478521 – 155RING finger protein 122Add BLAST155

Proteomic databases

MaxQBiQ9H9V4
PaxDbiQ9H9V4
PeptideAtlasiQ9H9V4
PRIDEiQ9H9V4
ProteomicsDBi81364

PTM databases

iPTMnetiQ9H9V4
PhosphoSitePlusiQ9H9V4

Expressioni

Tissue specificityi

Widely expressed in several tissues and cell lines.1 Publication

Gene expression databases

BgeeiENSG00000133874 Expressed in 155 organ(s), highest expression level in right ovary
CleanExiHS_RNF122
GenevisibleiQ9H9V4 HS

Organism-specific databases

HPAiHPA003888

Interactioni

Protein-protein interaction databases

BioGridi122936, 10 interactors
IntActiQ9H9V4, 11 interactors
STRINGi9606.ENSP00000256257

Structurei

3D structure databases

ProteinModelPortaliQ9H9V4
SMRiQ9H9V4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri93 – 134RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00710000106755
HOGENOMiHOG000004806
HOVERGENiHBG058899
InParanoidiQ9H9V4
KOiK15699
OMAiQHTFHRK
OrthoDBiEOG091G0PFG
PhylomeDBiQ9H9V4

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H9V4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM
60 70 80 90 100
LSLIFCCYFI SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF
110 120 130 140 150
KGKDELGVLP CQHAFHRKCL VKWLEVRCVC PMCNKPIASP SEATQNIGIL

LDELV
Length:155
Mass (Da):17,475
Last modified:July 25, 2006 - v2
Checksum:iE86B8E6F4954457B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70E → D in BAB14115 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022588 mRNA Translation: BAB14115.1
BC093884 mRNA Translation: AAH93884.1
BC101573 mRNA Translation: AAI01574.1
CCDSiCCDS6091.1
RefSeqiNP_079063.2, NM_024787.3
UniGeneiHs.151237

Genome annotation databases

EnsembliENST00000256257; ENSP00000256257; ENSG00000133874
GeneIDi79845
KEGGihsa:79845
UCSCiuc003xjo.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022588 mRNA Translation: BAB14115.1
BC093884 mRNA Translation: AAH93884.1
BC101573 mRNA Translation: AAI01574.1
CCDSiCCDS6091.1
RefSeqiNP_079063.2, NM_024787.3
UniGeneiHs.151237

3D structure databases

ProteinModelPortaliQ9H9V4
SMRiQ9H9V4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122936, 10 interactors
IntActiQ9H9V4, 11 interactors
STRINGi9606.ENSP00000256257

PTM databases

iPTMnetiQ9H9V4
PhosphoSitePlusiQ9H9V4

Polymorphism and mutation databases

DMDMi110816410

Proteomic databases

MaxQBiQ9H9V4
PaxDbiQ9H9V4
PeptideAtlasiQ9H9V4
PRIDEiQ9H9V4
ProteomicsDBi81364

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256257; ENSP00000256257; ENSG00000133874
GeneIDi79845
KEGGihsa:79845
UCSCiuc003xjo.3 human

Organism-specific databases

CTDi79845
EuPathDBiHostDB:ENSG00000133874.1
GeneCardsiRNF122
HGNCiHGNC:21147 RNF122
HPAiHPA003888
neXtProtiNX_Q9H9V4
OpenTargetsiENSG00000133874
PharmGKBiPA134892945
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00710000106755
HOGENOMiHOG000004806
HOVERGENiHBG058899
InParanoidiQ9H9V4
KOiK15699
OMAiQHTFHRK
OrthoDBiEOG091G0PFG
PhylomeDBiQ9H9V4

Miscellaneous databases

ChiTaRSiRNF122 human
GeneWikiiRNF122
GenomeRNAii79845
PROiPR:Q9H9V4

Gene expression databases

BgeeiENSG00000133874 Expressed in 155 organ(s), highest expression level in right ovary
CleanExiHS_RNF122
GenevisibleiQ9H9V4 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN122_HUMAN
AccessioniPrimary (citable) accession number: Q9H9V4
Secondary accession number(s): Q52LK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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