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UniProtKB - Q9H9T3 (ELP3_HUMAN)

Entry version 176 (07 Apr 2021)
Sequence version 2 (17 Apr 2007)
Previous versions | rss
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Protein

Elongator complex protein 3

Gene

ELP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (PubMed:11714725, PubMed:11818576, PubMed:15902492, PubMed:16713582). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity).By similarity6 Publications

Caution

The relevance of the protein lysine acetyltransferase activity is unclear and growing evidence shows that ELP3 is primarily involved in tRNA modification.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis

This protein is involved in the pathway 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis, which is part of tRNA modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi99Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi109Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi112Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei164Acetyl-CoABy similarity1
Binding sitei530Acetyl-CoABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation, tRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H9T3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847, HATs acetylate histones

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00988

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elongator complex protein 31 Publication
Short name:
hELP31 Publication
Alternative name(s):
Protein lysine acetyltransferase ELP3Curated (EC:2.3.1.-1 Publication)
tRNA uridine(34) acetyltransferaseCurated (EC:2.3.1.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELP31 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20696, ELP3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612722, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H9T3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134014.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyotrophic lateral sclerosis (ALS)1 Publication1 Publication
The gene represented in this entry may act as a disease modifier.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Related information in OMIM

Keywords - Diseasei

Amyotrophic lateral sclerosis, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		55140
MIMi105400, phenotype

Open Targets

More...OpenTargetsi		ENSG00000134014

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992603

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H9T3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ELP3

Domain mapping of disease mutations (DMDM)

More...DMDMi		145558902

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002839861 – 547Elongator complex protein 3Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei161PhosphoserineBy similarity1
Modified residuei202PhosphotyrosineCombined sources1
Modified residuei229N6-methyllysineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H9T3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H9T3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H9T3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H9T3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H9T3

PeptideAtlas

More...PeptideAtlasi		Q9H9T3

PRoteomics IDEntifications database

More...PRIDEi		Q9H9T3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3914
4303
81361 [Q9H9T3-1]
81362 [Q9H9T3-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9H9T3

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H9T3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H9T3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the cerebellum and spinal motor neurons.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134014, Expressed in amniotic fluid and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H9T3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H9T3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134014, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex (PubMed:11714725, PubMed:11818576, PubMed:22854966). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (PubMed:11714725, PubMed:11818576, PubMed:22854966).

Interacts with ELP1 (PubMed:11818576, PubMed:19185337).

Interacts with alpha-tubulin (PubMed:19185337).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120444, 82 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1949, Elongator holoenzyme complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9H9T3

Database of interacting proteins

More...DIPi		DIP-53227N

Protein interaction database and analysis system

More...IntActi		Q9H9T3, 31 interactors

Molecular INTeraction database

More...MINTi		Q9H9T3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256398

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H9T3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H9T3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 372Radical SAM corePROSITE-ProRule annotationAdd BLAST291
Domaini396 – 547N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni474 – 477Acetyl-CoA bindingBy similarity4
Regioni497 – 499Acetyl-CoA bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ELP3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2535, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013141

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H9T3

Identification of Orthologs from Complete Genome Data

More...OMAi		TFETRPD

Database of Orthologous Groups

More...OrthoDBi		320059at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H9T3

TreeFam database of animal gene trees

More...TreeFami		TF105752

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.30.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR039661, ELP3
IPR034687, ELP3-like
IPR006638, Elp3/MiaB/NifB
IPR000182, GNAT_dom
IPR032432, Radical_SAM_C
IPR007197, rSAM
IPR023404, rSAM_horseshoe

The PANTHER Classification System

More...PANTHERi		PTHR11135, PTHR11135, 1 hit
PTHR11135:SF0, PTHR11135:SF0, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00583, Acetyltransf_1, 1 hit
PF04055, Radical_SAM, 1 hit
PF16199, Radical_SAM_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005669, Hist_AcTrfase_ELP3, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDF00344, ELP3-like, 1 hit
SFLDS00029, Radical_SAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00729, Elp3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55729, SSF55729, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01211, ELP3, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51186, GNAT, 1 hit
PS51918, RADICAL_SAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H9T3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRQKRKGDLS PAELMMLTIG DVIKQLIEAH EQGKDIDLNK VKTKTAAKYG 
        60         70         80         90        100
LSAQPRLVDI IAAVPPQYRK VLMPKLKAKP IRTASGIAVV AVMCKPHRCP 
       110        120        130        140        150
HISFTGNICV YCPGGPDSDF EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH 
       160        170        180        190        200
RIEQLKQLGH SVDKVEFIVM GGTFMALPEE YRDYFIRNLH DALSGHTSNN 
       210        220        230        240        250
IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC TRLEIGVQSV 
       260        270        280        290        300
YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ 
       310        320        330        340        350
FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLVELVA 
       360        370        380        390        400
RILALVPPWT RVYRVQRDIP MPLVSSGVEH GNLRELALAR MKDLGIQCRD 
       410        420        430        440        450
VRTREVGIQE IHHKVRPYQV ELVRRDYVAN GGWETFLSYE DPDQDILIGL 
       460        470        480        490        500
LRLRKCSEET FRFELGGGVS IVRELHVYGS VVPVSSRDPT KFQHQGFGML 
       510        520        530        540 
LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP YMVKMLK
Length:547
Mass (Da):62,259
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60898ADD3DBAD035
GO
Isoform 2 (identifier: Q9H9T3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:533
Mass (Da):60,648
Checksum:iDF8E71D8D401B90C
GO
Isoform 3 (identifier: Q9H9T3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MRQKRKGDLSPA → MSTHQFYRKYMC
     13-131: Missing.

Show »
Length:428
Mass (Da):49,405
Checksum:iF11EEC322AAE8964
GO
Isoform 4 (identifier: Q9H9T3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:455
Mass (Da):52,202
Checksum:iC64BAB6FED06D973
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DKA4B4DKA4_HUMAN
Elongator complex protein 3
ELP3
475Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAP7H0YAP7_HUMAN
Elongator complex protein 3
ELP3
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC54H0YC54_HUMAN
Elongator complex protein 3
ELP3
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHR2E5RHR2_HUMAN
Elongator complex protein 3
ELP3
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHY2E5RHY2_HUMAN
Elongator complex protein 3
ELP3
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIZ7E5RIZ7_HUMAN
Elongator complex protein 3
ELP3
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIC0E5RIC0_HUMAN
Elongator complex protein 3
ELP3
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIU1E5RIU1_HUMAN
Elongator complex protein 3
ELP3
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG26E5RG26_HUMAN
Elongator complex protein 3
ELP3
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91600 differs from that shown. Aberrant splicing.Curated
The sequence CAH10573 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10S → G in BAA91600 (PubMed:14702039).Curated1
Sequence conflicti30H → Y in BAD96767 (Ref. 5) Curated1
Sequence conflicti179E → K in CAH10573 (PubMed:17974005).Curated1
Sequence conflicti265K → M in BAB14138 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552841 – 92Missing in isoform 4. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0244061 – 14Missing in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0552851 – 12MRQKR…DLSPA → MSTHQFYRKYMC in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_05528613 – 131Missing in isoform 3. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001284 mRNA Translation: BAA91600.1 Sequence problems.
AK022626 mRNA Translation: BAB14138.1
AK293424 mRNA Translation: BAG56930.1
AK295574 mRNA Translation: BAG58473.1
AK315985 mRNA Translation: BAH14356.1
AL834273 mRNA Translation: CAD38948.1
BX648011 mRNA Translation: CAH10573.1 Frameshift.
AC019031 Genomic DNA No translation available.
AC021678 Genomic DNA No translation available.
BC001240 mRNA Translation: AAH01240.1
AK223047 mRNA Translation: BAD96767.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6065.1 [Q9H9T3-1]
CCDS64860.1 [Q9H9T3-5]
CCDS64861.1 [Q9H9T3-4]
CCDS75717.1 [Q9H9T3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001271151.1, NM_001284222.1 [Q9H9T3-2]
NP_001271153.1, NM_001284224.1 [Q9H9T3-4]
NP_001271154.1, NM_001284225.1 [Q9H9T3-4]
NP_001271155.1, NM_001284226.1 [Q9H9T3-5]
NP_060561.3, NM_018091.5 [Q9H9T3-1]
XP_006716417.1, XM_006716354.2 [Q9H9T3-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256398; ENSP00000256398; ENSG00000134014 [Q9H9T3-1]
ENST00000380353; ENSP00000369711; ENSG00000134014 [Q9H9T3-5]
ENST00000521015; ENSP00000428449; ENSG00000134014 [Q9H9T3-2]
ENST00000537665; ENSP00000445558; ENSG00000134014 [Q9H9T3-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55140

UCSC genome browser

More...UCSCi		uc003xgn.6, human [Q9H9T3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001284 mRNA Translation: BAA91600.1 Sequence problems.
AK022626 mRNA Translation: BAB14138.1
AK293424 mRNA Translation: BAG56930.1
AK295574 mRNA Translation: BAG58473.1
AK315985 mRNA Translation: BAH14356.1
AL834273 mRNA Translation: CAD38948.1
BX648011 mRNA Translation: CAH10573.1 Frameshift.
AC019031 Genomic DNA No translation available.
AC021678 Genomic DNA No translation available.
BC001240 mRNA Translation: AAH01240.1
AK223047 mRNA Translation: BAD96767.1
CCDSiCCDS6065.1 [Q9H9T3-1]
CCDS64860.1 [Q9H9T3-5]
CCDS64861.1 [Q9H9T3-4]
CCDS75717.1 [Q9H9T3-2]
RefSeqiNP_001271151.1, NM_001284222.1 [Q9H9T3-2]
NP_001271153.1, NM_001284224.1 [Q9H9T3-4]
NP_001271154.1, NM_001284225.1 [Q9H9T3-4]
NP_001271155.1, NM_001284226.1 [Q9H9T3-5]
NP_060561.3, NM_018091.5 [Q9H9T3-1]
XP_006716417.1, XM_006716354.2 [Q9H9T3-4]

3D structure databases

SMRiQ9H9T3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120444, 82 interactors
ComplexPortaliCPX-1949, Elongator holoenzyme complex
CORUMiQ9H9T3
DIPiDIP-53227N
IntActiQ9H9T3, 31 interactors
MINTiQ9H9T3
STRINGi9606.ENSP00000256398

PTM databases

CarbonylDBiQ9H9T3
iPTMnetiQ9H9T3
PhosphoSitePlusiQ9H9T3

Genetic variation databases

BioMutaiELP3
DMDMi145558902

Proteomic databases

EPDiQ9H9T3
jPOSTiQ9H9T3
MassIVEiQ9H9T3
MaxQBiQ9H9T3
PaxDbiQ9H9T3
PeptideAtlasiQ9H9T3
PRIDEiQ9H9T3
ProteomicsDBi3914
4303
81361 [Q9H9T3-1]
81362 [Q9H9T3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23089, 215 antibodies

The DNASU plasmid repository

More...DNASUi		55140

Genome annotation databases

EnsembliENST00000256398; ENSP00000256398; ENSG00000134014 [Q9H9T3-1]
ENST00000380353; ENSP00000369711; ENSG00000134014 [Q9H9T3-5]
ENST00000521015; ENSP00000428449; ENSG00000134014 [Q9H9T3-2]
ENST00000537665; ENSP00000445558; ENSG00000134014 [Q9H9T3-4]
GeneIDi55140
KEGGihsa:55140
UCSCiuc003xgn.6, human [Q9H9T3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55140
DisGeNETi55140

GeneCards: human genes, protein and diseases

More...GeneCardsi		ELP3
HGNCiHGNC:20696, ELP3
HPAiENSG00000134014, Low tissue specificity
MIMi105400, phenotype
612722, gene
neXtProtiNX_Q9H9T3
OpenTargetsiENSG00000134014
PharmGKBiPA134992603
VEuPathDBiHostDB:ENSG00000134014.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2535, Eukaryota
GeneTreeiENSGT00390000013141
InParanoidiQ9H9T3
OMAiTFETRPD
OrthoDBi320059at2759
PhylomeDBiQ9H9T3
TreeFamiTF105752

Enzyme and pathway databases

UniPathwayiUPA00988
PathwayCommonsiQ9H9T3
ReactomeiR-HSA-3214847, HATs acetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55140, 670 hits in 982 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ELP3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ELP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55140
PharosiQ9H9T3, Tbio

Protein Ontology

More...PROi		PR:Q9H9T3
RNActiQ9H9T3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134014, Expressed in amniotic fluid and 235 other tissues
ExpressionAtlasiQ9H9T3, baseline and differential
GenevisibleiQ9H9T3, HS

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR039661, ELP3
IPR034687, ELP3-like
IPR006638, Elp3/MiaB/NifB
IPR000182, GNAT_dom
IPR032432, Radical_SAM_C
IPR007197, rSAM
IPR023404, rSAM_horseshoe
PANTHERiPTHR11135, PTHR11135, 1 hit
PTHR11135:SF0, PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583, Acetyltransf_1, 1 hit
PF04055, Radical_SAM, 1 hit
PF16199, Radical_SAM_C, 1 hit
PIRSFiPIRSF005669, Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344, ELP3-like, 1 hit
SFLDS00029, Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729, Elp3, 1 hit
SUPFAMiSSF55729, SSF55729, 1 hit
TIGRFAMsiTIGR01211, ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186, GNAT, 1 hit
PS51918, RADICAL_SAM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H9T3
Secondary accession number(s): B4DE19
, B4DIG1, E2QRI5, Q53G84, Q6AWB0, Q9BVF7, Q9NVZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: April 7, 2021
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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