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Protein

Calcium-binding protein 39-like

Gene

CAB39L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).By similarity

Miscellaneous

Found in serum of 50% of patients with acute monocytic leukemia.

GO - Biological processi

  • cell cycle arrest Source: Reactome
  • signal transduction by protein phosphorylation Source: GO_Central

Enzyme and pathway databases

ReactomeiR-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39-like
Alternative name(s):
Antigen MLAA-34
MO25beta
Mo25-like protein
Gene namesi
Name:CAB39L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102547.18
HGNCiHGNC:20290 CAB39L
MIMi612175 gene
neXtProtiNX_Q9H9S4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi81617
OpenTargetsiENSG00000102547
PharmGKBiPA134913801

Polymorphism and mutation databases

DMDMi51338824

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098261 – 337Calcium-binding protein 39-likeAdd BLAST337

Proteomic databases

EPDiQ9H9S4
MaxQBiQ9H9S4
PaxDbiQ9H9S4
PeptideAtlasiQ9H9S4
PRIDEiQ9H9S4
ProteomicsDBi81359

PTM databases

iPTMnetiQ9H9S4
PhosphoSitePlusiQ9H9S4
SwissPalmiQ9H9S4

Expressioni

Gene expression databases

BgeeiENSG00000102547 Expressed in 205 organ(s), highest expression level in decidua
CleanExiHS_CAB39L
ExpressionAtlasiQ9H9S4 baseline and differential
GenevisibleiQ9H9S4 HS

Organism-specific databases

HPAiCAB003686
HPA045954

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MX1P205913EBI-1047244,EBI-929476

Protein-protein interaction databases

BioGridi123552, 9 interactors
IntActiQ9H9S4, 5 interactors
STRINGi9606.ENSP00000261669

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H9S4
SMRiQ9H9S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiKOG1566 Eukaryota
ENOG410XP4S LUCA
GeneTreeiENSGT00390000004360
HOGENOMiHOG000234711
HOVERGENiHBG050757
InParanoidiQ9H9S4
KOiK08272
OMAiNFQKERT
OrthoDBiEOG091G0DTL
PhylomeDBiQ9H9S4
TreeFamiTF314910

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013878 Mo25
PANTHERiPTHR10182 PTHR10182, 1 hit
PfamiView protein in Pfam
PF08569 Mo25, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9H9S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKMPLFSKS HKNPAEIVKI LKDNLAILEK QDKKTDKASE EVSKSLQAMK
60 70 80 90 100
EILCGTNEKE PPTEAVAQLA QELYSSGLLV TLIADLQLID FEGKKDVTQI
110 120 130 140 150
FNNILRRQIG TRSPTVEYIS AHPHILFMLL KGYEAPQIAL RCGIMLRECI
160 170 180 190 200
RHEPLAKIIL FSNQFRDFFK YVELSTFDIA SDAFATFKDL LTRHKVLVAD
210 220 230 240 250
FLEQNYDTIF EDYEKLLQSE NYVTKRQSLK LLGELILDRH NFAIMTKYIS
260 270 280 290 300
KPENLKLMMN LLRDKSPNIQ FEAFHVFKVF VASPHKTQPI VEILLKNQPK
310 320 330
LIEFLSSFQK ERTDDEQFAD EKNYLIKQIR DLKKTAP
Length:337
Mass (Da):39,088
Last modified:August 16, 2004 - v3
Checksum:i5C6C7A83B9B4CA2D
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBJ4B7ZBJ4_HUMAN
Calcium-binding protein 39-like
CAB39L
193Annotation score:
B7ZBJ5B7ZBJ5_HUMAN
Calcium-binding protein 39-like
CAB39L
188Annotation score:
B7ZBJ6B7ZBJ6_HUMAN
Calcium-binding protein 39-like
CAB39L
128Annotation score:
Q5TAW7Q5TAW7_HUMAN
Calcium-binding protein 39-like
CAB39L
280Annotation score:
B7ZBJ7B7ZBJ7_HUMAN
Calcium-binding protein 39-like
CAB39L
93Annotation score:

Sequence cautioni

The sequence BAB14147 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93G → E in AAH10993 (PubMed:15489334).Curated1
Sequence conflicti156A → V in BAB14147 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288977 mRNA Translation: AAQ93064.2
AL136218 Genomic DNA No translation available.
AL138875 Genomic DNA No translation available.
BC010993 mRNA Translation: AAH10993.2
AK022639 mRNA Translation: BAB14147.1 Different initiation.
CCDSiCCDS9416.2
RefSeqiNP_001073138.1, NM_001079670.2
NP_001274266.1, NM_001287337.1
NP_001274267.1, NM_001287338.1
NP_001274268.1, NM_001287339.1
NP_112187.2, NM_030925.3
XP_011533556.1, XM_011535254.2
XP_011533557.1, XM_011535255.2
XP_011533558.1, XM_011535256.2
XP_016876274.1, XM_017020785.1
XP_016876275.1, XM_017020786.1
XP_016876276.1, XM_017020787.1
XP_016876277.1, XM_017020788.1
UniGeneiHs.742971
Hs.87159

Genome annotation databases

EnsembliENST00000347776; ENSP00000261669; ENSG00000102547
ENST00000355854; ENSP00000348113; ENSG00000102547
ENST00000409308; ENSP00000386375; ENSG00000102547
ENST00000410043; ENSP00000386328; ENSG00000102547
ENST00000610540; ENSP00000479669; ENSG00000102547
GeneIDi81617
KEGGihsa:81617
UCSCiuc001vcw.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288977 mRNA Translation: AAQ93064.2
AL136218 Genomic DNA No translation available.
AL138875 Genomic DNA No translation available.
BC010993 mRNA Translation: AAH10993.2
AK022639 mRNA Translation: BAB14147.1 Different initiation.
CCDSiCCDS9416.2
RefSeqiNP_001073138.1, NM_001079670.2
NP_001274266.1, NM_001287337.1
NP_001274267.1, NM_001287338.1
NP_001274268.1, NM_001287339.1
NP_112187.2, NM_030925.3
XP_011533556.1, XM_011535254.2
XP_011533557.1, XM_011535255.2
XP_011533558.1, XM_011535256.2
XP_016876274.1, XM_017020785.1
XP_016876275.1, XM_017020786.1
XP_016876276.1, XM_017020787.1
XP_016876277.1, XM_017020788.1
UniGeneiHs.742971
Hs.87159

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZHPX-ray2.90A/B5-337[»]
ProteinModelPortaliQ9H9S4
SMRiQ9H9S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123552, 9 interactors
IntActiQ9H9S4, 5 interactors
STRINGi9606.ENSP00000261669

PTM databases

iPTMnetiQ9H9S4
PhosphoSitePlusiQ9H9S4
SwissPalmiQ9H9S4

Polymorphism and mutation databases

DMDMi51338824

Proteomic databases

EPDiQ9H9S4
MaxQBiQ9H9S4
PaxDbiQ9H9S4
PeptideAtlasiQ9H9S4
PRIDEiQ9H9S4
ProteomicsDBi81359

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347776; ENSP00000261669; ENSG00000102547
ENST00000355854; ENSP00000348113; ENSG00000102547
ENST00000409308; ENSP00000386375; ENSG00000102547
ENST00000410043; ENSP00000386328; ENSG00000102547
ENST00000610540; ENSP00000479669; ENSG00000102547
GeneIDi81617
KEGGihsa:81617
UCSCiuc001vcw.5 human

Organism-specific databases

CTDi81617
DisGeNETi81617
EuPathDBiHostDB:ENSG00000102547.18
GeneCardsiCAB39L
H-InvDBiHIX0011314
HGNCiHGNC:20290 CAB39L
HPAiCAB003686
HPA045954
MIMi612175 gene
neXtProtiNX_Q9H9S4
OpenTargetsiENSG00000102547
PharmGKBiPA134913801
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1566 Eukaryota
ENOG410XP4S LUCA
GeneTreeiENSGT00390000004360
HOGENOMiHOG000234711
HOVERGENiHBG050757
InParanoidiQ9H9S4
KOiK08272
OMAiNFQKERT
OrthoDBiEOG091G0DTL
PhylomeDBiQ9H9S4
TreeFamiTF314910

Enzyme and pathway databases

ReactomeiR-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Miscellaneous databases

GeneWikiiCAB39L
GenomeRNAii81617
PROiPR:Q9H9S4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102547 Expressed in 205 organ(s), highest expression level in decidua
CleanExiHS_CAB39L
ExpressionAtlasiQ9H9S4 baseline and differential
GenevisibleiQ9H9S4 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013878 Mo25
PANTHERiPTHR10182 PTHR10182, 1 hit
PfamiView protein in Pfam
PF08569 Mo25, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCB39L_HUMAN
AccessioniPrimary (citable) accession number: Q9H9S4
Secondary accession number(s): Q5TAW6
, Q6WG71, Q96FG1, Q9BZ33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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