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Protein

COP9 signalosome complex subunit 7b

Gene

COPS7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.4 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7b
Short name:
SGN7b
Short name:
Signalosome subunit 7b
Alternative name(s):
JAB1-containing signalosome subunit 7b
Gene namesi
Name:COPS7B
Synonyms:CSN7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144524.17
HGNCiHGNC:16760 COPS7B
MIMi616010 gene
neXtProtiNX_Q9H9Q2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144524
PharmGKBiPA26759

Chemistry databases

ChEMBLiCHEMBL5706

Polymorphism and mutation databases

DMDMi55976598

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001209992 – 264COP9 signalosome complex subunit 7bAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Isoform 3 (identifier: Q9H9Q2-3)
Modified residuei261PhosphothreonineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H9Q2
MaxQBiQ9H9Q2
PaxDbiQ9H9Q2
PeptideAtlasiQ9H9Q2
PRIDEiQ9H9Q2
ProteomicsDBi81347
81348 [Q9H9Q2-2]
81349 [Q9H9Q2-3]

PTM databases

iPTMnetiQ9H9Q2
PhosphoSitePlusiQ9H9Q2

Expressioni

Gene expression databases

BgeeiENSG00000144524
CleanExiHS_COPS7B
ExpressionAtlasiQ9H9Q2 baseline and differential
GenevisibleiQ9H9Q2 HS

Organism-specific databases

HPAiHPA034675
HPA034676

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8 (PubMed:11337588, PubMed:18850735). Interacts with EIF3S6 (PubMed:12220626).4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122237, 79 interactors
ComplexPortaliCPX-1871 COP9 signalosome variant 2
DIPiDIP-53525N
IntActiQ9H9Q2, 23 interactors
STRINGi9606.ENSP00000272995

Structurei

3D structure databases

ProteinModelPortaliQ9H9Q2
SMRiQ9H9Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 159PCIPROSITE-ProRule annotationAdd BLAST158

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili188 – 237Sequence analysisAdd BLAST50

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3250 Eukaryota
ENOG410XP7W LUCA
GeneTreeiENSGT00390000013069
HOGENOMiHOG000006003
HOVERGENiHBG051138
InParanoidiQ9H9Q2
KOiK12180
PhylomeDBiQ9H9Q2
TreeFamiTF101149

Family and domain databases

InterProiView protein in InterPro
IPR027530 Csn7b
IPR000717 PCI_dom
PANTHERiPTHR15350:SF8 PTHR15350:SF8, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H9Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA
60 70 80 90 100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT
110 120 130 140 150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ
160 170 180 190 200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE
210 220 230 240 250
NHNRTQQQVE AEVTNIKKTL KATASSSAQE MEQQLAEREC PPHAEQRQPT
260
KKMSKVKGLV SSRH
Length:264
Mass (Da):29,622
Last modified:March 1, 2001 - v1
Checksum:iFF9279CEA6CB7707
GO
Isoform 2 (identifier: Q9H9Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):18,157
Checksum:i14EF8FC4F2AAB95E
GO
Isoform 3 (identifier: Q9H9Q2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-264: VTNIKKTLKA...KVKGLVSSRH → REKRDVPLLN...RGSPPRRCPK

Show »
Length:273
Mass (Da):30,959
Checksum:i5CC118D3000C1A92
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0119131 – 107Missing in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_040266213 – 264VTNIK…VSSRH → REKRDVPLLNLITTAFFWLP TSRRHSKPPHPPRLRRWSSS WLNGSVPLTLSRGSPPRRCP K in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022674 mRNA Translation: BAB14170.1
AK024273 mRNA Translation: BAB14868.1
AC073476 Genomic DNA Translation: AAY24152.1
CH471063 Genomic DNA Translation: EAW70980.1
BC010739 mRNA Translation: AAH10739.2
BC091493 mRNA Translation: AAH91493.1
CCDSiCCDS2488.1 [Q9H9Q2-1]
CCDS63153.1 [Q9H9Q2-3]
CCDS63154.1 [Q9H9Q2-2]
RefSeqiNP_001269879.1, NM_001282950.2 [Q9H9Q2-3]
NP_001269881.1, NM_001282952.2 [Q9H9Q2-2]
NP_073567.1, NM_022730.3 [Q9H9Q2-1]
XP_016860205.1, XM_017004716.1 [Q9H9Q2-1]
XP_016860206.1, XM_017004717.1 [Q9H9Q2-2]
UniGeneiHs.335061
Hs.611663

Genome annotation databases

EnsembliENST00000350033; ENSP00000272995; ENSG00000144524 [Q9H9Q2-1]
ENST00000373608; ENSP00000362710; ENSG00000144524 [Q9H9Q2-3]
ENST00000409091; ENSP00000386527; ENSG00000144524 [Q9H9Q2-2]
ENST00000410024; ENSP00000386567; ENSG00000144524 [Q9H9Q2-1]
ENST00000620578; ENSP00000484579; ENSG00000144524 [Q9H9Q2-2]
GeneIDi64708
KEGGihsa:64708
UCSCiuc002vsg.3 human [Q9H9Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSN7B_HUMAN
AccessioniPrimary (citable) accession number: Q9H9Q2
Secondary accession number(s): Q53S22, Q5BJG3, Q9H7V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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