UniProtKB - Q9H9Q2 (CSN7B_HUMAN)
COP9 signalosome complex subunit 7b
COPS7B
Functioni
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
4 PublicationsGO - Biological processi
- COP9 signalosome assembly Source: InterPro
- protein deneddylation Source: UniProtKB
- protein neddylation Source: ComplexPortal
- regulation of protein neddylation Source: ComplexPortal
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q9H9Q2 |
Reactomei | R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664, Neddylation |
SignaLinki | Q9H9Q2 |
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 7bShort name: SGN7b Short name: Signalosome subunit 7b Alternative name(s): JAB1-containing signalosome subunit 7b |
Gene namesi | Name:COPS7B Synonyms:CSN7B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16760, COPS7B |
MIMi | 616010, gene |
neXtProti | NX_Q9H9Q2 |
VEuPathDBi | HostDB:ENSG00000144524 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- COP9 signalosome Source: UniProtKB
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, Nucleus, SignalosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 64708 |
OpenTargetsi | ENSG00000144524 |
PharmGKBi | PA26759 |
Miscellaneous databases
Pharosi | Q9H9Q2, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5706 |
Genetic variation databases
BioMutai | COPS7B |
DMDMi | 55976598 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000120999 | 2 – 264 | COP9 signalosome complex subunit 7bAdd BLAST | 263 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | ||
Isoform 3 (identifier: Q9H9Q2-3) | |||||
Modified residuei | 261 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 263 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9H9Q2 |
jPOSTi | Q9H9Q2 |
MassIVEi | Q9H9Q2 |
MaxQBi | Q9H9Q2 |
PaxDbi | Q9H9Q2 |
PeptideAtlasi | Q9H9Q2 |
PRIDEi | Q9H9Q2 |
ProteomicsDBi | 81347 [Q9H9Q2-1] 81348 [Q9H9Q2-2] 81349 [Q9H9Q2-3] |
PTM databases
GlyGeni | Q9H9Q2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9H9Q2 |
MetOSitei | Q9H9Q2 |
PhosphoSitePlusi | Q9H9Q2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000144524, Expressed in pituitary gland and 213 other tissues |
ExpressionAtlasi | Q9H9Q2, baseline and differential |
Genevisiblei | Q9H9Q2, HS |
Organism-specific databases
HPAi | ENSG00000144524, Low tissue specificity |
Interactioni
Subunit structurei
Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8 (PubMed:11337588, PubMed:18850735).
Interacts with EIF3S6 (PubMed:12220626).
4 Publications(Microbial infection) Interacts with vaccinia virus protein C9L.
1 PublicationBinary interactionsi
Q9H9Q2
With | #Exp. | IntAct |
---|---|---|
BEX5 [Q5H9J7] | 3 | EBI-2510162,EBI-10243741 |
CCT5 [P48643] | 3 | EBI-2510162,EBI-355710 |
HSPB1 [P04792] | 3 | EBI-2510162,EBI-352682 |
NMI [Q13287] | 9 | EBI-2510162,EBI-372942 |
Protein-protein interaction databases
BioGRIDi | 122237, 117 interactors |
ComplexPortali | CPX-1871, COP9 signalosome variant 2 |
DIPi | DIP-53525N |
IntActi | Q9H9Q2, 60 interactors |
MINTi | Q9H9Q2 |
STRINGi | 9606.ENSP00000362710 |
Miscellaneous databases
RNActi | Q9H9Q2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 159 | PCIPROSITE-ProRule annotationAdd BLAST | 158 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 223 – 264 | DisorderedSequence analysisAdd BLAST | 42 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 188 – 237 | Sequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 236 – 252 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3250, Eukaryota |
GeneTreei | ENSGT00940000157155 |
HOGENOMi | CLU_054426_1_0_1 |
InParanoidi | Q9H9Q2 |
OMAi | GTYKQFR |
PhylomeDBi | Q9H9Q2 |
TreeFami | TF101149 |
Family and domain databases
InterProi | View protein in InterPro IPR045237, COPS7/eIF3m IPR041481, CSN7_helixI IPR027530, Csn7B IPR000717, PCI_dom |
PANTHERi | PTHR15350, PTHR15350, 1 hit PTHR15350:SF8, PTHR15350:SF8, 1 hit |
Pfami | View protein in Pfam PF18392, CSN7a_helixI, 1 hit PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA
60 70 80 90 100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT
110 120 130 140 150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ
160 170 180 190 200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE
210 220 230 240 250
NHNRTQQQVE AEVTNIKKTL KATASSSAQE MEQQLAEREC PPHAEQRQPT
260
KKMSKVKGLV SSRH
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KQ34 | J3KQ34_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 230 | Annotation score: | ||
A0A087X1P5 | A0A087X1P5_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 209 | Annotation score: | ||
J3QT73 | J3QT73_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 172 | Annotation score: | ||
J3KQ41 | J3KQ41_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 278 | Annotation score: | ||
J3QT95 | J3QT95_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 150 | Annotation score: | ||
J3QT50 | J3QT50_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 78 | Annotation score: | ||
J3QT43 | J3QT43_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 103 | Annotation score: | ||
J3QT67 | J3QT67_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 62 | Annotation score: | ||
J3QT69 | J3QT69_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 68 | Annotation score: | ||
J3QT65 | J3QT65_HUMAN | COP9 signalosome complex subunit 7b | COPS7B | 49 | Annotation score: | ||
There are more potential isoformsShow all |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011913 | 1 – 107 | Missing in isoform 2. 1 PublicationAdd BLAST | 107 | |
Alternative sequenceiVSP_040266 | 213 – 264 | VTNIK…VSSRH → REKRDVPLLNLITTAFFWLP TSRRHSKPPHPPRLRRWSSS WLNGSVPLTLSRGSPPRRCP K in isoform 3. 1 PublicationAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022674 mRNA Translation: BAB14170.1 AK024273 mRNA Translation: BAB14868.1 AC073476 Genomic DNA Translation: AAY24152.1 CH471063 Genomic DNA Translation: EAW70980.1 BC010739 mRNA Translation: AAH10739.2 BC091493 mRNA Translation: AAH91493.1 |
CCDSi | CCDS2488.1 [Q9H9Q2-1] CCDS63153.1 [Q9H9Q2-3] CCDS63154.1 [Q9H9Q2-2] |
RefSeqi | NP_001269879.1, NM_001282950.2 [Q9H9Q2-3] NP_001269881.1, NM_001282952.2 [Q9H9Q2-2] NP_073567.1, NM_022730.3 [Q9H9Q2-1] XP_016860205.1, XM_017004716.1 XP_016860206.1, XM_017004717.1 [Q9H9Q2-2] |
Genome annotation databases
Ensembli | ENST00000350033.8; ENSP00000272995.5; ENSG00000144524.18 ENST00000373608.7; ENSP00000362710.3; ENSG00000144524.18 [Q9H9Q2-3] ENST00000409091.5; ENSP00000386527.1; ENSG00000144524.18 [Q9H9Q2-2] ENST00000410024.5; ENSP00000386567.1; ENSG00000144524.18 ENST00000620578.4; ENSP00000484579.1; ENSG00000144524.18 [Q9H9Q2-2] |
GeneIDi | 64708 |
KEGGi | hsa:64708 |
MANE-Selecti | ENST00000350033.8; ENSP00000272995.5; NM_022730.4; NP_073567.1 |
UCSCi | uc002vsg.3, human [Q9H9Q2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022674 mRNA Translation: BAB14170.1 AK024273 mRNA Translation: BAB14868.1 AC073476 Genomic DNA Translation: AAY24152.1 CH471063 Genomic DNA Translation: EAW70980.1 BC010739 mRNA Translation: AAH10739.2 BC091493 mRNA Translation: AAH91493.1 |
CCDSi | CCDS2488.1 [Q9H9Q2-1] CCDS63153.1 [Q9H9Q2-3] CCDS63154.1 [Q9H9Q2-2] |
RefSeqi | NP_001269879.1, NM_001282950.2 [Q9H9Q2-3] NP_001269881.1, NM_001282952.2 [Q9H9Q2-2] NP_073567.1, NM_022730.3 [Q9H9Q2-1] XP_016860205.1, XM_017004716.1 XP_016860206.1, XM_017004717.1 [Q9H9Q2-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6R6H | electron microscopy | 8.40 | G | 9-214 | [»] | |
6R7F | electron microscopy | 8.20 | G | 8-215 | [»] | |
6R7H | electron microscopy | 8.80 | G | 8-215 | [»] | |
6R7I | electron microscopy | 5.90 | G | 1-215 | [»] | |
6R7N | electron microscopy | 6.50 | G | 1-215 | [»] | |
AlphaFoldDBi | Q9H9Q2 | |||||
SMRi | Q9H9Q2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122237, 117 interactors |
ComplexPortali | CPX-1871, COP9 signalosome variant 2 |
DIPi | DIP-53525N |
IntActi | Q9H9Q2, 60 interactors |
MINTi | Q9H9Q2 |
STRINGi | 9606.ENSP00000362710 |
Chemistry databases
ChEMBLi | CHEMBL5706 |
PTM databases
GlyGeni | Q9H9Q2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9H9Q2 |
MetOSitei | Q9H9Q2 |
PhosphoSitePlusi | Q9H9Q2 |
Genetic variation databases
BioMutai | COPS7B |
DMDMi | 55976598 |
Proteomic databases
EPDi | Q9H9Q2 |
jPOSTi | Q9H9Q2 |
MassIVEi | Q9H9Q2 |
MaxQBi | Q9H9Q2 |
PaxDbi | Q9H9Q2 |
PeptideAtlasi | Q9H9Q2 |
PRIDEi | Q9H9Q2 |
ProteomicsDBi | 81347 [Q9H9Q2-1] 81348 [Q9H9Q2-2] 81349 [Q9H9Q2-3] |
Protocols and materials databases
Antibodypediai | 20213, 102 antibodies from 20 providers |
DNASUi | 64708 |
Genome annotation databases
Ensembli | ENST00000350033.8; ENSP00000272995.5; ENSG00000144524.18 ENST00000373608.7; ENSP00000362710.3; ENSG00000144524.18 [Q9H9Q2-3] ENST00000409091.5; ENSP00000386527.1; ENSG00000144524.18 [Q9H9Q2-2] ENST00000410024.5; ENSP00000386567.1; ENSG00000144524.18 ENST00000620578.4; ENSP00000484579.1; ENSG00000144524.18 [Q9H9Q2-2] |
GeneIDi | 64708 |
KEGGi | hsa:64708 |
MANE-Selecti | ENST00000350033.8; ENSP00000272995.5; NM_022730.4; NP_073567.1 |
UCSCi | uc002vsg.3, human [Q9H9Q2-1] |
Organism-specific databases
CTDi | 64708 |
DisGeNETi | 64708 |
GeneCardsi | COPS7B |
HGNCi | HGNC:16760, COPS7B |
HPAi | ENSG00000144524, Low tissue specificity |
MIMi | 616010, gene |
neXtProti | NX_Q9H9Q2 |
OpenTargetsi | ENSG00000144524 |
PharmGKBi | PA26759 |
VEuPathDBi | HostDB:ENSG00000144524 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3250, Eukaryota |
GeneTreei | ENSGT00940000157155 |
HOGENOMi | CLU_054426_1_0_1 |
InParanoidi | Q9H9Q2 |
OMAi | GTYKQFR |
PhylomeDBi | Q9H9Q2 |
TreeFami | TF101149 |
Enzyme and pathway databases
PathwayCommonsi | Q9H9Q2 |
Reactomei | R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664, Neddylation |
SignaLinki | Q9H9Q2 |
Miscellaneous databases
BioGRID-ORCSi | 64708, 20 hits in 1089 CRISPR screens |
ChiTaRSi | COPS7B, human |
GeneWikii | COPS7B |
GenomeRNAii | 64708 |
Pharosi | Q9H9Q2, Tbio |
PROi | PR:Q9H9Q2 |
RNActi | Q9H9Q2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144524, Expressed in pituitary gland and 213 other tissues |
ExpressionAtlasi | Q9H9Q2, baseline and differential |
Genevisiblei | Q9H9Q2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR045237, COPS7/eIF3m IPR041481, CSN7_helixI IPR027530, Csn7B IPR000717, PCI_dom |
PANTHERi | PTHR15350, PTHR15350, 1 hit PTHR15350:SF8, PTHR15350:SF8, 1 hit |
Pfami | View protein in Pfam PF18392, CSN7a_helixI, 1 hit PF01399, PCI, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSN7B_HUMAN | |
Accessioni | Q9H9Q2Primary (citable) accession number: Q9H9Q2 Secondary accession number(s): Q53S22, Q5BJG3, Q9H7V6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families