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UniProtKB - Q9H9Q2 (CSN7B_HUMAN)

Entry version 143 (22 Apr 2020)
Sequence version 1 (01 Mar 2001)
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Protein

COP9 signalosome complex subunit 7b

Gene

COPS7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
COP9 signalosome complex subunit 7b
Short name:
SGN7b
Short name:
Signalosome subunit 7b
Alternative name(s):
JAB1-containing signalosome subunit 7b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COPS7B
Synonyms:CSN7B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16760 COPS7B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616010 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H9Q2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000144524

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26759

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H9Q2 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5706

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		COPS7B

Domain mapping of disease mutations (DMDM)

More...DMDMi		55976598

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001209992 – 264COP9 signalosome complex subunit 7bAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Isoform 3 (identifier: Q9H9Q2-3)
Modified residuei261PhosphothreonineCombined sources1
Modified residuei263PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H9Q2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H9Q2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H9Q2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H9Q2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H9Q2

PeptideAtlas

More...PeptideAtlasi		Q9H9Q2

PRoteomics IDEntifications database

More...PRIDEi		Q9H9Q2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81347 [Q9H9Q2-1]
81348 [Q9H9Q2-2]
81349 [Q9H9Q2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H9Q2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H9Q2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H9Q2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144524 Expressed in pituitary gland and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H9Q2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H9Q2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144524 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8 (PubMed:11337588, PubMed:18850735).

Interacts with EIF3S6 (PubMed:12220626).

4 Publications

(Microbial infection) Interacts with vaccinia virus protein C9L.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122237, 85 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1871 COP9 signalosome variant 2

Database of interacting proteins

More...DIPi		DIP-53525N

Protein interaction database and analysis system

More...IntActi		Q9H9Q2, 58 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362710

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H9Q2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H9Q2

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 159PCIPROSITE-ProRule annotationAdd BLAST158

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili188 – 237Sequence analysisAdd BLAST50

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3250 Eukaryota
ENOG410XP7W LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157155

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_054426_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H9Q2

KEGG Orthology (KO)

More...KOi		K12180

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H9Q2

TreeFam database of animal gene trees

More...TreeFami		TF101149

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041481 CSN7_helixI
IPR027530 Csn7b
IPR000717 PCI_dom

The PANTHER Classification System

More...PANTHERi		PTHR15350:SF8 PTHR15350:SF8, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18392 CSN7a_helixI, 1 hit
PF01399 PCI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00088 PINT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50250 PCI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H9Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA 
        60         70         80         90        100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT 
       110        120        130        140        150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ 
       160        170        180        190        200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE 
       210        220        230        240        250
NHNRTQQQVE AEVTNIKKTL KATASSSAQE MEQQLAEREC PPHAEQRQPT 
       260 
KKMSKVKGLV SSRH
Length:264
Mass (Da):29,622
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF9279CEA6CB7707
GO
Isoform 2 (identifier: Q9H9Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.

Show »
Length:157
Mass (Da):18,157
Checksum:i14EF8FC4F2AAB95E
GO
Isoform 3 (identifier: Q9H9Q2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-264: VTNIKKTLKA...KVKGLVSSRH → REKRDVPLLN...RGSPPRRCPK

Show »
Length:273
Mass (Da):30,959
Checksum:i5CC118D3000C1A92
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQ34J3KQ34_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
230Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1P5A0A087X1P5_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
209Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT73J3QT73_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
172Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQ41J3KQ41_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT95J3QT95_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT50J3QT50_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT43J3QT43_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT67J3QT67_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT69J3QT69_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT65J3QT65_HUMAN
COP9 signalosome complex subunit 7b
COPS7B
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0119131 – 107Missing in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_040266213 – 264VTNIK…VSSRH → REKRDVPLLNLITTAFFWLP TSRRHSKPPHPPRLRRWSSS WLNGSVPLTLSRGSPPRRCP K in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK022674 mRNA Translation: BAB14170.1
AK024273 mRNA Translation: BAB14868.1
AC073476 Genomic DNA Translation: AAY24152.1
CH471063 Genomic DNA Translation: EAW70980.1
BC010739 mRNA Translation: AAH10739.2
BC091493 mRNA Translation: AAH91493.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2488.1 [Q9H9Q2-1]
CCDS63153.1 [Q9H9Q2-3]
CCDS63154.1 [Q9H9Q2-2]

NCBI Reference Sequences

More...RefSeqi		NP_001269879.1, NM_001282950.2 [Q9H9Q2-3]
NP_001269881.1, NM_001282952.2 [Q9H9Q2-2]
NP_073567.1, NM_022730.3 [Q9H9Q2-1]
XP_016860205.1, XM_017004716.1
XP_016860206.1, XM_017004717.1 [Q9H9Q2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000350033; ENSP00000272995; ENSG00000144524 [Q9H9Q2-1]
ENST00000373608; ENSP00000362710; ENSG00000144524 [Q9H9Q2-3]
ENST00000409091; ENSP00000386527; ENSG00000144524 [Q9H9Q2-2]
ENST00000410024; ENSP00000386567; ENSG00000144524 [Q9H9Q2-1]
ENST00000620578; ENSP00000484579; ENSG00000144524 [Q9H9Q2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64708

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64708

UCSC genome browser

More...UCSCi		uc002vsg.3 human [Q9H9Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022674 mRNA Translation: BAB14170.1
AK024273 mRNA Translation: BAB14868.1
AC073476 Genomic DNA Translation: AAY24152.1
CH471063 Genomic DNA Translation: EAW70980.1
BC010739 mRNA Translation: AAH10739.2
BC091493 mRNA Translation: AAH91493.1
CCDSiCCDS2488.1 [Q9H9Q2-1]
CCDS63153.1 [Q9H9Q2-3]
CCDS63154.1 [Q9H9Q2-2]
RefSeqiNP_001269879.1, NM_001282950.2 [Q9H9Q2-3]
NP_001269881.1, NM_001282952.2 [Q9H9Q2-2]
NP_073567.1, NM_022730.3 [Q9H9Q2-1]
XP_016860205.1, XM_017004716.1
XP_016860206.1, XM_017004717.1 [Q9H9Q2-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6R6Helectron microscopy8.40G9-214[»]
6R7Felectron microscopy8.20G8-215[»]
6R7Helectron microscopy8.80G8-215[»]
6R7Ielectron microscopy5.90G1-215[»]
6R7Nelectron microscopy6.50G1-215[»]
SMRiQ9H9Q2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122237, 85 interactors
ComplexPortaliCPX-1871 COP9 signalosome variant 2
DIPiDIP-53525N
IntActiQ9H9Q2, 58 interactors
STRINGi9606.ENSP00000362710

Chemistry databases

ChEMBLiCHEMBL5706

PTM databases

iPTMnetiQ9H9Q2
MetOSiteiQ9H9Q2
PhosphoSitePlusiQ9H9Q2

Polymorphism and mutation databases

BioMutaiCOPS7B
DMDMi55976598

Proteomic databases

EPDiQ9H9Q2
jPOSTiQ9H9Q2
MassIVEiQ9H9Q2
MaxQBiQ9H9Q2
PaxDbiQ9H9Q2
PeptideAtlasiQ9H9Q2
PRIDEiQ9H9Q2
ProteomicsDBi81347 [Q9H9Q2-1]
81348 [Q9H9Q2-2]
81349 [Q9H9Q2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20213 92 antibodies

The DNASU plasmid repository

More...DNASUi		64708

Genome annotation databases

EnsembliENST00000350033; ENSP00000272995; ENSG00000144524 [Q9H9Q2-1]
ENST00000373608; ENSP00000362710; ENSG00000144524 [Q9H9Q2-3]
ENST00000409091; ENSP00000386527; ENSG00000144524 [Q9H9Q2-2]
ENST00000410024; ENSP00000386567; ENSG00000144524 [Q9H9Q2-1]
ENST00000620578; ENSP00000484579; ENSG00000144524 [Q9H9Q2-2]
GeneIDi64708
KEGGihsa:64708
UCSCiuc002vsg.3 human [Q9H9Q2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64708

GeneCards: human genes, protein and diseases

More...GeneCardsi		COPS7B
HGNCiHGNC:16760 COPS7B
HPAiENSG00000144524 Low tissue specificity
MIMi616010 gene
neXtProtiNX_Q9H9Q2
OpenTargetsiENSG00000144524
PharmGKBiPA26759

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3250 Eukaryota
ENOG410XP7W LUCA
GeneTreeiENSGT00940000157155
HOGENOMiCLU_054426_1_0_1
InParanoidiQ9H9Q2
KOiK12180
PhylomeDBiQ9H9Q2
TreeFamiTF101149

Enzyme and pathway databases

ReactomeiR-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		COPS7B human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		COPS7B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64708
PharosiQ9H9Q2 Tbio

Protein Ontology

More...PROi		PR:Q9H9Q2
RNActiQ9H9Q2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144524 Expressed in pituitary gland and 198 other tissues
ExpressionAtlasiQ9H9Q2 baseline and differential
GenevisibleiQ9H9Q2 HS

Family and domain databases

InterProiView protein in InterPro
IPR041481 CSN7_helixI
IPR027530 Csn7b
IPR000717 PCI_dom
PANTHERiPTHR15350:SF8 PTHR15350:SF8, 1 hit
PfamiView protein in Pfam
PF18392 CSN7a_helixI, 1 hit
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSN7B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H9Q2
Secondary accession number(s): Q53S22, Q5BJG3, Q9H7V6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: April 22, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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