COPS7B

Functionⁱ

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.4 Publications

GO - Biological processⁱ

nucleotide-excision repair, DNA damage recognition Source: Reactome
post-translational protein modification Source: Reactome
protein deneddylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19141280
transcription-coupled nucleotide-excision repair Source: Reactome

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5696394 DNA Damage Recognition in GG-NER R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664 Neddylation

Reactomeⁱ

R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: COP9 signalosome complex subunit 7b Short name: SGN7b Short name: Signalosome subunit 7b Alternative name(s): JAB1-containing signalosome subunit 7b
Gene namesⁱ	Name:COPS7B Synonyms:CSN7B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144524.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16760 COPS7B
MIMⁱ	616010 gene
neXtProtⁱ	NX_Q9H9Q2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000144524
PharmGKBⁱ	PA26759

Chemistry databases

ChEMBLⁱ	CHEMBL5706

ChEMBLⁱ

CHEMBL5706

Polymorphism and mutation databases

DMDMⁱ	55976598

DMDMⁱ

55976598

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000120999	2 – 264	COP9 signalosome complex subunit 7bAdd BLAST		263

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Isoform 3 (identifier: Q9H9Q2-3)
Modified residueⁱ	261	PhosphothreonineCombined sources	1
Modified residueⁱ	263	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H9Q2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H9Q2
PaxDbⁱ	Q9H9Q2
PeptideAtlas More...PeptideAtlasⁱ	Q9H9Q2
PRIDEⁱ	Q9H9Q2
ProteomicsDBⁱ	81347 81348 [Q9H9Q2-2] 81349 [Q9H9Q2-3]

PTM databases

iPTMnetⁱ	Q9H9Q2
PhosphoSitePlusⁱ	Q9H9Q2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000144524
CleanExⁱ	HS_COPS7B
ExpressionAtlasⁱ	Q9H9Q2 baseline and differential
Genevisibleⁱ	Q9H9Q2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA034675 HPA034676

HPAⁱ

HPA034675
HPA034676

Interactionⁱ

Subunit structureⁱ

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8 (PubMed:11337588, PubMed:18850735). Interacts with EIF3S6 (PubMed:12220626).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
COPS5	Q92905	4	EBI-2510162,EBI-594661
NMI	Q13287	8	EBI-2510162,EBI-372942

Show more details

Protein-protein interaction databases

BioGridⁱ	122237, 79 interactors
ComplexPortalⁱ	CPX-1871 COP9 signalosome variant 2
Database of interacting proteins More...DIPⁱ	DIP-53525N
IntActⁱ	Q9H9Q2, 23 interactors
STRINGⁱ	9606.ENSP00000272995

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H9Q2
SMRⁱ	Q9H9Q2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 159	PCIPROSITE-ProRule annotationAdd BLAST		158

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	188 – 237	Sequence analysisAdd BLAST		50

Sequence similaritiesⁱ

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3250 Eukaryota ENOG410XP7W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013069
HOGENOMⁱ	HOG000006003
HOVERGENⁱ	HBG051138
InParanoidⁱ	Q9H9Q2
KEGG Orthology (KO) More...KOⁱ	K12180
PhylomeDBⁱ	Q9H9Q2
TreeFamⁱ	TF101149

Family and domain databases

InterProⁱ	View protein in InterPro IPR027530 Csn7b IPR000717 PCI_dom
PANTHERⁱ	PTHR15350:SF8 PTHR15350:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9H9Q2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA 
        60         70         80         90        100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT 
       110        120        130        140        150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ 
       160        170        180        190        200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE 
       210        220        230        240        250
NHNRTQQQVE AEVTNIKKTL KATASSSAQE MEQQLAEREC PPHAEQRQPT 
       260 
KKMSKVKGLV SSRH

Length:264

Mass (Da):29,622

Last modified:March 1, 2001 - v1

Checksum:ⁱFF9279CEA6CB7707

GO

Isoform 2 (identifier: Q9H9Q2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-107: Missing.

« Hide

        10         20         30         40         50
MKCIPYSVLL KDLEMRNLRE LEDLIIEAVY TDIIQGKLDQ RNQLLEVDFC 
        60         70         80         90        100
IGRDIRKKDI NNIVKTLHEW CDGCEAVLLG IEQQVLRANQ YKENHNRTQQ 
       110        120        130        140        150
QVEAEVTNIK KTLKATASSS AQEMEQQLAE RECPPHAEQR QPTKKMSKVK 

GLVSSRH

Note: No experimental confirmation available.

Show »

Length:157

Mass (Da):18,157

Checksum:ⁱ14EF8FC4F2AAB95E

GO

Isoform 3 (identifier: Q9H9Q2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
213-264: VTNIKKTLKA...KVKGLVSSRH → REKRDVPLLN...RGSPPRRCPK

« Hide

        10         20         30         40         50
MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA 
        60         70         80         90        100
NVQELAEGAN AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT 
       110        120        130        140        150
IVSLASRMKC IPYSVLLKDL EMRNLRELED LIIEAVYTDI IQGKLDQRNQ 
       160        170        180        190        200
LLEVDFCIGR DIRKKDINNI VKTLHEWCDG CEAVLLGIEQ QVLRANQYKE 
       210        220        230        240        250
NHNRTQQQVE AEREKRDVPL LNLITTAFFW LPTSRRHSKP PHPPRLRRWS 
       260        270 
SSWLNGSVPL TLSRGSPPRR CPK

Show »

Length:273

Mass (Da):30,959

Checksum:ⁱ5CC118D3000C1A92

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011913	1 – 107	Missing in isoform 2. 1 PublicationAdd BLAST		107
Alternative sequenceⁱVSP_040266	213 – 264	VTNIK…VSSRH → REKRDVPLLNLITTAFFWLP TSRRHSKPPHPPRLRRWSSS WLNGSVPLTLSRGSPPRRCP K in isoform 3. 1 PublicationAdd BLAST		52

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022674 mRNA Translation: BAB14170.1 AK024273 mRNA Translation: BAB14868.1 AC073476 Genomic DNA Translation: AAY24152.1 CH471063 Genomic DNA Translation: EAW70980.1 BC010739 mRNA Translation: AAH10739.2 BC091493 mRNA Translation: AAH91493.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2488.1 [Q9H9Q2-1] CCDS63153.1 [Q9H9Q2-3] CCDS63154.1 [Q9H9Q2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001269879.1, NM_001282950.2 [Q9H9Q2-3] NP_001269881.1, NM_001282952.2 [Q9H9Q2-2] NP_073567.1, NM_022730.3 [Q9H9Q2-1] XP_016860205.1, XM_017004716.1 [Q9H9Q2-1] XP_016860206.1, XM_017004717.1 [Q9H9Q2-2]
UniGeneⁱ	Hs.335061 Hs.611663

Genome annotation databases

Ensemblⁱ	ENST00000350033; ENSP00000272995; ENSG00000144524 [Q9H9Q2-1] ENST00000373608; ENSP00000362710; ENSG00000144524 [Q9H9Q2-3] ENST00000409091; ENSP00000386527; ENSG00000144524 [Q9H9Q2-2] ENST00000410024; ENSP00000386567; ENSG00000144524 [Q9H9Q2-1] ENST00000620578; ENSP00000484579; ENSG00000144524 [Q9H9Q2-2]
GeneIDⁱ	64708
KEGGⁱ	hsa:64708
UCSC genome browser More...UCSCⁱ	uc002vsg.3 human [Q9H9Q2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9H9Q2	COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), isoform CRA_b		HUMAN		264
COP9 signalosome complex subunit 7b		CALJA		264
COP9 constitutive photomorphogenic homolog subunit 7B		PANTR		264
COPS7B isoform 14		PONAB		264
COP9 signalosome subunit 7B		SAIBB		264
+5
Q9H9Q2-2	COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), isoform CRA_a		HUMAN		157
COPS7B isoform 19		PANTR		157
COPS7B isoform 18		PONAB		157
Uncharacterized protein		MACFA		157
UPI000C7ED791		OTOGA		301
+1

Protein	Similar proteins		Species	Score	Length
Q9H9Q2	COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), isoform CRA_b		HUMAN		264
COP9 signalosome complex subunit 7b		CALJA		264
COP9 constitutive photomorphogenic homolog subunit 7B		PANTR		264
COPS7B isoform 14		PONAB		264
COP9 signalosome subunit 7B		SAIBB		264
+129
Q9H9Q2-2	COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), isoform CRA_a		HUMAN		157
COPS7B isoform 19		PANTR		157
COPS7B isoform 18		PONAB		157
Uncharacterized protein		MACFA		157
UPI000C7ED791		OTOGA		301
+8
Q9H9Q2-3	COP9 signalosome subunit 7B		MACMU		278
COP9 signalosome subunit 7B		MACFA		278
COP9 signalosome subunit 7B		MACNE		278
COP9 signalosome subunit 7B		CALJA		279
Uncharacterized protein (Fragment)		AILME		279
+27

Protein	Similar proteins		Species	Score	Length
Q9H9Q2	COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), isoform CRA_b		HUMAN		264
COP9 signalosome complex subunit 7b		CALJA		264
COP9 constitutive photomorphogenic homolog subunit 7B		PANTR		264
COPS7B isoform 14		PONAB		264
COP9 signalosome subunit 7B		SAIBB		264
+241
Q9H9Q2-2	COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), isoform CRA_a		HUMAN		157
COPS7B isoform 19		PANTR		157
COPS7B isoform 18		PONAB		157
Uncharacterized protein		MACFA		157
UPI000C7ED791		OTOGA		301
+24
Q9H9Q2-3	COP9 signalosome subunit 7B		MACMU		278
COP9 signalosome subunit 7B		MACFA		278
COP9 signalosome subunit 7B		MACNE		278
COP9 signalosome subunit 7B		CALJA		279
Uncharacterized protein (Fragment)		AILME		279
+70

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK022674 mRNA Translation: BAB14170.1 AK024273 mRNA Translation: BAB14868.1 AC073476 Genomic DNA Translation: AAY24152.1 CH471063 Genomic DNA Translation: EAW70980.1 BC010739 mRNA Translation: AAH10739.2 BC091493 mRNA Translation: AAH91493.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2488.1 [Q9H9Q2-1] CCDS63153.1 [Q9H9Q2-3] CCDS63154.1 [Q9H9Q2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001269879.1, NM_001282950.2 [Q9H9Q2-3] NP_001269881.1, NM_001282952.2 [Q9H9Q2-2] NP_073567.1, NM_022730.3 [Q9H9Q2-1] XP_016860205.1, XM_017004716.1 [Q9H9Q2-1] XP_016860206.1, XM_017004717.1 [Q9H9Q2-2]
UniGeneⁱ	Hs.335061 Hs.611663

3D structure databases

ProteinModelPortalⁱ	Q9H9Q2
SMRⁱ	Q9H9Q2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122237, 79 interactors
ComplexPortalⁱ	CPX-1871 COP9 signalosome variant 2
Database of interacting proteins More...DIPⁱ	DIP-53525N
IntActⁱ	Q9H9Q2, 23 interactors
STRINGⁱ	9606.ENSP00000272995

Chemistry databases

ChEMBLⁱ	CHEMBL5706

ChEMBLⁱ

CHEMBL5706

PTM databases

iPTMnetⁱ	Q9H9Q2
PhosphoSitePlusⁱ	Q9H9Q2

Polymorphism and mutation databases

DMDMⁱ	55976598

DMDMⁱ

55976598

Proteomic databases

EPDⁱ	Q9H9Q2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H9Q2
PaxDbⁱ	Q9H9Q2
PeptideAtlas More...PeptideAtlasⁱ	Q9H9Q2
PRIDEⁱ	Q9H9Q2
ProteomicsDBⁱ	81347 81348 [Q9H9Q2-2] 81349 [Q9H9Q2-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64708
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000350033; ENSP00000272995; ENSG00000144524 [Q9H9Q2-1] ENST00000373608; ENSP00000362710; ENSG00000144524 [Q9H9Q2-3] ENST00000409091; ENSP00000386527; ENSG00000144524 [Q9H9Q2-2] ENST00000410024; ENSP00000386567; ENSG00000144524 [Q9H9Q2-1] ENST00000620578; ENSP00000484579; ENSG00000144524 [Q9H9Q2-2]
GeneIDⁱ	64708
KEGGⁱ	hsa:64708
UCSC genome browser More...UCSCⁱ	uc002vsg.3 human [Q9H9Q2-1]

Organism-specific databases

CTDⁱ	64708
EuPathDBⁱ	HostDB:ENSG00000144524.17
GeneCardsⁱ	COPS7B
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16760 COPS7B
Human Protein Atlas More...HPAⁱ	HPA034675 HPA034676
MIMⁱ	616010 gene
neXtProtⁱ	NX_Q9H9Q2
Open Targets More...OpenTargetsⁱ	ENSG00000144524
PharmGKBⁱ	PA26759
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3250 Eukaryota ENOG410XP7W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013069
HOGENOMⁱ	HOG000006003
HOVERGENⁱ	HBG051138
InParanoidⁱ	Q9H9Q2
KEGG Orthology (KO) More...KOⁱ	K12180
PhylomeDBⁱ	Q9H9Q2
TreeFamⁱ	TF101149

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5696394 DNA Damage Recognition in GG-NER R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8951664 Neddylation

Reactomeⁱ

R-HSA-5696394 DNA Damage Recognition in GG-NER
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8951664 Neddylation

Miscellaneous databases

ChiTaRSⁱ	COPS7B human
GeneWikiⁱ	COPS7B
GenomeRNAiⁱ	64708
Protein Ontology More...PROⁱ	PR:Q9H9Q2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144524
CleanExⁱ	HS_COPS7B
ExpressionAtlasⁱ	Q9H9Q2 baseline and differential
Genevisibleⁱ	Q9H9Q2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027530 Csn7b IPR000717 PCI_dom
PANTHERⁱ	PTHR15350:SF8 PTHR15350:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSN7B_HUMAN
Accessionⁱ	Q9H9Q2Primary (citable) accession number: Q9H9Q2 Secondary accession number(s): Q53S22, Q5BJG3, Q9H7V6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
	Last sequence update:	March 1, 2001
	Last modified:	July 18, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9H9Q2 (CSN7B_HUMAN)

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COP9 signalosome complex subunit 7b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ