UniProtKB - Q9H9P2 (CHODL_HUMAN)
Chondrolectin
CHODL
Functioni
Miscellaneous
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
GO - Biological processi
- muscle organ development Source: HGNC-UCL
- positive regulation of axonogenesis Source: GO_Central
Keywordsi
Biological process | Neurogenesis |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q9H9P2 |
Names & Taxonomyi
Protein namesi | Recommended name: ChondrolectinAlternative name(s): Transmembrane protein MT75 |
Gene namesi | Name:CHODL Synonyms:C21orf68 ORF Names:PRED12, UNQ872/PRO1890 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000154645.13 |
HGNCi | HGNC:17807, CHODL |
MIMi | 607247, gene |
neXtProti | NX_Q9H9P2 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
- Membrane Curated; Single-pass type I membrane protein Curated
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
- Endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Other locations
- Cytoplasm 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: HGNC-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 216 | ExtracellularSequence analysisAdd BLAST | 195 | |
Transmembranei | 217 – 237 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 238 – 273 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 140578 |
OpenTargetsi | ENSG00000154645 |
PharmGKBi | PA26475 |
Miscellaneous databases
Pharosi | Q9H9P2, Tbio |
Polymorphism and mutation databases
BioMutai | CHODL |
DMDMi | 18202949 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000017415 | 22 – 273 | ChondrolectinAdd BLAST | 252 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 61 ↔ 178 | PROSITE-ProRule annotation | ||
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 144 ↔ 170 | PROSITE-ProRule annotation |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q9H9P2 |
PaxDbi | Q9H9P2 |
PeptideAtlasi | Q9H9P2 |
PRIDEi | Q9H9P2 |
ProteomicsDBi | 81335 [Q9H9P2-1] 81336 [Q9H9P2-2] 81337 [Q9H9P2-3] 81338 [Q9H9P2-4] |
PTM databases
GlyGeni | Q9H9P2, 1 site |
iPTMneti | Q9H9P2 |
PhosphoSitePlusi | Q9H9P2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000154645, Expressed in calcaneal tendon and 144 other tissues |
ExpressionAtlasi | Q9H9P2, baseline and differential |
Genevisiblei | Q9H9P2, HS |
Organism-specific databases
HPAi | ENSG00000154645, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with RABGGTB.
By similarityBinary interactionsi
Hide detailsQ9H9P2
Protein-protein interaction databases
BioGRIDi | 126628, 10 interactors |
IntActi | Q9H9P2, 10 interactors |
STRINGi | 9606.ENSP00000299295 |
Miscellaneous databases
RNActi | Q9H9P2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 179 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 145 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00390000001844 |
HOGENOMi | CLU_045492_1_0_1 |
InParanoidi | Q9H9P2 |
OMAi | VASATCC |
PhylomeDBi | Q9H9P2 |
TreeFami | TF330715 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRVVSLLLG AALLCGHGAF CRRVVSGQKV CFADFKHPCY KMAYFHELSS
60 70 80 90 100
RVSFQEARLA CESEGGVLLS LENEAEQKLI ESMLQNLTKP GTGISDGDFW
110 120 130 140 150
IGLWRNGDGQ TSGACPDLYQ WSDGSNSQYR NWYTDEPSCG SEKCVVMYHQ
160 170 180 190 200
PTANPGLGGP YLYQWNDDRC NMKHNYICKY EPEINPTAPV EKPYLTNQPG
210 220 230 240 250
DTHQNVVVTE AGIIPNLIYV VIPTIPLLLL ILVAFGTCCF QMLHKSKGRT
260 270
KTSPNQSTLW ISKSTRKESG MEV
The sequence of this isoform differs from the canonical sequence as follows:
1-41: Missing.
212-273: GIIPNLIYVV...STRKESGMEV → VKEEQKLVQT...EITKDLQDEL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DFS2 | A0A0C4DFS2_HUMAN | Chondrolectin | CHODL | 236 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | E → G in AAP43902 (PubMed:12621022).Curated | 1 | |
Sequence conflicti | 159 | G → S in AAP43902 (PubMed:12621022).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017275 | 1 – 41 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 41 | |
Alternative sequenceiVSP_043300 | 1 – 27 | MSRVV…RVVSG → MTAGSAHS in isoform 4. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_017276 | 212 – 273 | GIIPN…SGMEV → VKEEQKLVQTSLHCGFQRVP EKKAAWKYNNSLTWFQNFVI LDLYKEWHQNNSLEWLEITK DLQDEL in isoform 3. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF257472 mRNA Translation: AAL05981.1 AF523313 mRNA Translation: AAP43902.1 AF523314 mRNA Translation: AAP43903.1 AF523315 mRNA Translation: AAP43904.1 AY358608 mRNA Translation: AAQ88971.1 AK022689 mRNA Translation: BAB14181.1 AK296009 mRNA Translation: BAG58780.1 AK313725 mRNA Translation: BAG36467.1 AF130417 Genomic DNA No translation available. AL078474 Genomic DNA No translation available. AL109761 Genomic DNA No translation available. AL163217 Genomic DNA Translation: CAB90388.1 AP000404 Genomic DNA No translation available. AP000656 Genomic DNA No translation available. AP000745 Genomic DNA No translation available. AP000998 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX10018.1 BC009418 mRNA Translation: AAH09418.1 |
CCDSi | CCDS13570.1 [Q9H9P2-1] CCDS56208.1 [Q9H9P2-4] CCDS56209.1 [Q9H9P2-2] CCDS56210.1 [Q9H9P2-3] |
RefSeqi | NP_001191103.1, NM_001204174.1 [Q9H9P2-4] NP_001191104.1, NM_001204175.1 [Q9H9P2-2] NP_001191105.1, NM_001204176.1 [Q9H9P2-2] NP_001191106.1, NM_001204177.1 NP_001191107.1, NM_001204178.1 NP_079220.2, NM_024944.2 [Q9H9P2-1] XP_011527759.1, XM_011529457.2 [Q9H9P2-2] |
Genome annotation databases
Ensembli | ENST00000299295; ENSP00000299295; ENSG00000154645 [Q9H9P2-1] ENST00000400127; ENSP00000382992; ENSG00000154645 [Q9H9P2-2] ENST00000400128; ENSP00000382993; ENSG00000154645 [Q9H9P2-2] ENST00000543733; ENSP00000443566; ENSG00000154645 [Q9H9P2-4] |
GeneIDi | 140578 |
KEGGi | hsa:140578 |
UCSCi | uc002ykr.5, human [Q9H9P2-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Chondrolectin |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF257472 mRNA Translation: AAL05981.1 AF523313 mRNA Translation: AAP43902.1 AF523314 mRNA Translation: AAP43903.1 AF523315 mRNA Translation: AAP43904.1 AY358608 mRNA Translation: AAQ88971.1 AK022689 mRNA Translation: BAB14181.1 AK296009 mRNA Translation: BAG58780.1 AK313725 mRNA Translation: BAG36467.1 AF130417 Genomic DNA No translation available. AL078474 Genomic DNA No translation available. AL109761 Genomic DNA No translation available. AL163217 Genomic DNA Translation: CAB90388.1 AP000404 Genomic DNA No translation available. AP000656 Genomic DNA No translation available. AP000745 Genomic DNA No translation available. AP000998 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX10018.1 BC009418 mRNA Translation: AAH09418.1 |
CCDSi | CCDS13570.1 [Q9H9P2-1] CCDS56208.1 [Q9H9P2-4] CCDS56209.1 [Q9H9P2-2] CCDS56210.1 [Q9H9P2-3] |
RefSeqi | NP_001191103.1, NM_001204174.1 [Q9H9P2-4] NP_001191104.1, NM_001204175.1 [Q9H9P2-2] NP_001191105.1, NM_001204176.1 [Q9H9P2-2] NP_001191106.1, NM_001204177.1 NP_001191107.1, NM_001204178.1 NP_079220.2, NM_024944.2 [Q9H9P2-1] XP_011527759.1, XM_011529457.2 [Q9H9P2-2] |
3D structure databases
SMRi | Q9H9P2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126628, 10 interactors |
IntActi | Q9H9P2, 10 interactors |
STRINGi | 9606.ENSP00000299295 |
PTM databases
GlyGeni | Q9H9P2, 1 site |
iPTMneti | Q9H9P2 |
PhosphoSitePlusi | Q9H9P2 |
Polymorphism and mutation databases
BioMutai | CHODL |
DMDMi | 18202949 |
Proteomic databases
MassIVEi | Q9H9P2 |
PaxDbi | Q9H9P2 |
PeptideAtlasi | Q9H9P2 |
PRIDEi | Q9H9P2 |
ProteomicsDBi | 81335 [Q9H9P2-1] 81336 [Q9H9P2-2] 81337 [Q9H9P2-3] 81338 [Q9H9P2-4] |
Protocols and materials databases
Antibodypediai | 2518, 130 antibodies |
DNASUi | 140578 |
Genome annotation databases
Ensembli | ENST00000299295; ENSP00000299295; ENSG00000154645 [Q9H9P2-1] ENST00000400127; ENSP00000382992; ENSG00000154645 [Q9H9P2-2] ENST00000400128; ENSP00000382993; ENSG00000154645 [Q9H9P2-2] ENST00000543733; ENSP00000443566; ENSG00000154645 [Q9H9P2-4] |
GeneIDi | 140578 |
KEGGi | hsa:140578 |
UCSCi | uc002ykr.5, human [Q9H9P2-1] |
Organism-specific databases
CTDi | 140578 |
DisGeNETi | 140578 |
EuPathDBi | HostDB:ENSG00000154645.13 |
GeneCardsi | CHODL |
HGNCi | HGNC:17807, CHODL |
HPAi | ENSG00000154645, Tissue enriched (testis) |
MIMi | 607247, gene |
neXtProti | NX_Q9H9P2 |
OpenTargetsi | ENSG00000154645 |
PharmGKBi | PA26475 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00390000001844 |
HOGENOMi | CLU_045492_1_0_1 |
InParanoidi | Q9H9P2 |
OMAi | VASATCC |
PhylomeDBi | Q9H9P2 |
TreeFami | TF330715 |
Enzyme and pathway databases
PathwayCommonsi | Q9H9P2 |
Miscellaneous databases
BioGRID-ORCSi | 140578, 1 hit in 837 CRISPR screens |
ChiTaRSi | CHODL, human |
GeneWikii | CHODL |
GenomeRNAii | 140578 |
Pharosi | Q9H9P2, Tbio |
PROi | PR:Q9H9P2 |
RNActi | Q9H9P2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154645, Expressed in calcaneal tendon and 144 other tissues |
ExpressionAtlasi | Q9H9P2, baseline and differential |
Genevisiblei | Q9H9P2, HS |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CHODL_HUMAN | |
Accessioni | Q9H9P2Primary (citable) accession number: Q9H9P2 Secondary accession number(s): B2R9C0 Q9HCY3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 18, 2001 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM