UniProtKB - Q9H9K5 (MER34_HUMAN)
Protein
Endogenous retroviral envelope protein HEMO
Gene
ERVMER34-1
Organism
Homo sapiens (Human)
Status
Functioni
Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.Curated
Enzyme and pathway databases
PathwayCommonsi | Q9H9K5 |
Names & Taxonomyi
Protein namesi | Recommended name: Endogenous retroviral envelope protein HEMOCuratedAlternative name(s): Endogenous retrovirus group MER34 member 1 Env polyproteinCurated HERV-MER_4q12 provirus ancestral Env polyprotein Human endogenous MER34 (medium-reiteration-frequency-family-34) open reading frame1 Publication Human endogenous MER34 ORF1 Publication Short name: HEMO1 Publication Cleaved into the following chain: Alternative name(s): Endogenous retroviral envelope protein HEMO, 48 kDa form |
Gene namesi | ORF Names:LP9056 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000226887.7 |
HGNCi | HGNC:42970, ERVMER34-1 |
neXtProti | NX_Q9H9K5 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Note: This uncleaved form present at the cell surface represents the major form (PubMed:28739914).1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 488 | ExtracellularSequence analysisAdd BLAST | 462 | |
Transmembranei | 489 – 509 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 510 – 563 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 352 – 355 | CTQG → RTKR: Introduction of a furin cleavage site, promoting proteolytic cleavage of the protein by furin and release in the extracellular medium. 1 Publication | 4 | |
Mutagenesisi | 433 – 563 | Missing : Promotes release in the extracellular medium. 1 PublicationAdd BLAST | 131 | |
Mutagenesisi | 472 – 563 | Missing : Promotes release in the extracellular medium. 1 PublicationAdd BLAST | 92 | |
Mutagenesisi | 489 – 563 | Missing : Promotes release in the extracellular medium. 1 PublicationAdd BLAST | 75 |
Organism-specific databases
DisGeNETi | 100288413 |
OpenTargetsi | ENSG00000226887 |
Miscellaneous databases
Pharosi | Q9H9K5, Tdark |
Polymorphism and mutation databases
BioMutai | ERVMER34-1 |
DMDMi | 74734033 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 1 PublicationAdd BLAST | 26 | |
ChainiPRO_0000341352 | 27 – 563 | Endogenous retroviral envelope protein HEMOAdd BLAST | 537 | |
ChainiPRO_0000443800 | 27 – 432 | Endogenous retroviral envelope protein HEMO, secreted form1 PublicationAdd BLAST | 406 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 122 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Cleaved by some metalloproteinase at 432-Gln-Arg-433 (mainly) or 433-Arg-Gln-434, leading to release the secreted form (Endogenous retroviral envelope protein HEMO, secreted form) in the extracellular medium.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9H9K5 |
MassIVEi | Q9H9K5 |
PaxDbi | Q9H9K5 |
PeptideAtlasi | Q9H9K5 |
PRIDEi | Q9H9K5 |
ProteomicsDBi | 81327 |
TopDownProteomicsi | Q9H9K5 |
PTM databases
GlyGeni | Q9H9K5, 8 sites |
iPTMneti | Q9H9K5 |
PhosphoSitePlusi | Q9H9K5 |
Expressioni
Tissue specificityi
Expressed at high level in the placenta and stem cells (at protein level) (PubMed:28739914). Also expressed in the kidney but at a lower level (PubMed:28739914). Endogenous retroviral envelope protein HEMO, secreted form: Present in the blood of pregnant women (at protein level) (PubMed:28739914).1 Publication
Gene expression databases
Bgeei | ENSG00000226887, Expressed in chorionic villus and 112 other tissues |
Genevisiblei | Q9H9K5, HS |
Organism-specific databases
HPAi | ENSG00000226887, Group enriched (parathyroid gland, placenta) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000460602 |
Miscellaneous databases
RNActi | Q9H9K5, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 171 – 174 | Poly-Asp | 4 |
Sequence similaritiesi
Belongs to the gamma type-C retroviral envelope protein family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SD08, Eukaryota |
GeneTreei | ENSGT00870000136875 |
HOGENOMi | CLU_483911_0_0_1 |
InParanoidi | Q9H9K5 |
OMAi | GKWRCAD |
OrthoDBi | 389221at2759 |
TreeFami | TF344098 |
Family and domain databases
InterProi | View protein in InterPro IPR018154, TLV/ENV_coat_polyprotein |
PANTHERi | PTHR10424, PTHR10424, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9H9K5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSLSNYALL QLTLTAFLTI LVQPQHLLAP VFRTLSILTN QSNCWLCEHL
60 70 80 90 100
DNAEQPELVF VPASASTWWT YSGQWMYERV WYPQAEVQNH STSSYRKVTW
110 120 130 140 150
HWEASMEAQG LSFAQVRLLE GNFSLCVENK NGSGPFLGNI PKQYCNQILW
160 170 180 190 200
FDSTDGTFMP SIDVTNESRN DDDDTSVCLG TRQCSWFAGC TNRTWNSSAV
210 220 230 240 250
PLIGLPNTQD YKWVDRNSGL TWSGNDTCLY SCQNQTKGLL YQLFRNLFCS
260 270 280 290 300
YGLTEAHGKW RCADASITND KGHDGHRTPT WWLTGSNLTL SVNNSGLFFL
310 320 330 340 350
CGNGVYKGFP PKWSGRCGLG YLVPSLTRYL TLNASQITNL RSFIHKVTPH
360 370 380 390 400
RCTQGDTDNP PLYCNPKDNS TIRALFPSLG TYDLEKAILN ISKAMEQEFS
410 420 430 440 450
ATKQTLEAHQ SKVSSLASAS RKDHVLDIPT TQRQTACGTV GKQCCLYINY
460 470 480 490 500
SEEIKSNIQR LHEASENLKN VPLLDWQGIF AKVGDWFRSW GYVLLIVLFC
510 520 530 540 550
LFIFVLIYVR VFRKSRRSLN SQPLNLALSP QQSAQLLVSE TSCQVSNRAM
560
KGLTTHQYDT SLL
Sequence cautioni
The sequence AAH69998 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | T → A in AAH69998 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 81 | W → R in AAH67529 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 418 | S → P in AAH67529 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 434 | Q → R in AAH67529 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 459 | Q → H in AAH69998 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY189288 mRNA Translation: AAO86732.1 AK022746 mRNA Translation: BAB14220.1 AK095318 mRNA Translation: BAG53026.1 CH471057 Genomic DNA Translation: EAX05439.1 BC067526 mRNA Translation: AAH67526.1 BC067528 mRNA Translation: AAH67528.1 BC067529 mRNA Translation: AAH67529.1 BC069998 mRNA Translation: AAH69998.1 Frameshift. |
RefSeqi | NP_001229619.1, NM_001242690.1 NP_078810.1, NM_024534.5 |
Genome annotation databases
Ensembli | ENST00000440542; ENSP00000460255; ENSG00000226887 ENST00000443173; ENSP00000460602; ENSG00000226887 |
GeneIDi | 100288413 |
KEGGi | hsa:100288413 |
UCSCi | uc003gzr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY189288 mRNA Translation: AAO86732.1 AK022746 mRNA Translation: BAB14220.1 AK095318 mRNA Translation: BAG53026.1 CH471057 Genomic DNA Translation: EAX05439.1 BC067526 mRNA Translation: AAH67526.1 BC067528 mRNA Translation: AAH67528.1 BC067529 mRNA Translation: AAH67529.1 BC069998 mRNA Translation: AAH69998.1 Frameshift. |
RefSeqi | NP_001229619.1, NM_001242690.1 NP_078810.1, NM_024534.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000460602 |
PTM databases
GlyGeni | Q9H9K5, 8 sites |
iPTMneti | Q9H9K5 |
PhosphoSitePlusi | Q9H9K5 |
Polymorphism and mutation databases
BioMutai | ERVMER34-1 |
DMDMi | 74734033 |
Proteomic databases
EPDi | Q9H9K5 |
MassIVEi | Q9H9K5 |
PaxDbi | Q9H9K5 |
PeptideAtlasi | Q9H9K5 |
PRIDEi | Q9H9K5 |
ProteomicsDBi | 81327 |
TopDownProteomicsi | Q9H9K5 |
Protocols and materials databases
Antibodypediai | 63827, 4 antibodies |
Genome annotation databases
Ensembli | ENST00000440542; ENSP00000460255; ENSG00000226887 ENST00000443173; ENSP00000460602; ENSG00000226887 |
GeneIDi | 100288413 |
KEGGi | hsa:100288413 |
UCSCi | uc003gzr.4, human |
Organism-specific databases
CTDi | 100288413 |
DisGeNETi | 100288413 |
EuPathDBi | HostDB:ENSG00000226887.7 |
GeneCardsi | ERVMER34-1 |
HGNCi | HGNC:42970, ERVMER34-1 |
HPAi | ENSG00000226887, Group enriched (parathyroid gland, placenta) |
neXtProti | NX_Q9H9K5 |
OpenTargetsi | ENSG00000226887 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SD08, Eukaryota |
GeneTreei | ENSGT00870000136875 |
HOGENOMi | CLU_483911_0_0_1 |
InParanoidi | Q9H9K5 |
OMAi | GKWRCAD |
OrthoDBi | 389221at2759 |
TreeFami | TF344098 |
Enzyme and pathway databases
PathwayCommonsi | Q9H9K5 |
Miscellaneous databases
BioGRID-ORCSi | 100288413, 0 hits in 70 CRISPR screens |
ChiTaRSi | ERVMER34-1, human |
GenomeRNAii | 100288413 |
Pharosi | Q9H9K5, Tdark |
PROi | PR:Q9H9K5 |
RNActi | Q9H9K5, protein |
Gene expression databases
Bgeei | ENSG00000226887, Expressed in chorionic villus and 112 other tissues |
Genevisiblei | Q9H9K5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018154, TLV/ENV_coat_polyprotein |
PANTHERi | PTHR10424, PTHR10424, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MER34_HUMAN | |
Accessioni | Q9H9K5Primary (citable) accession number: Q9H9K5 Secondary accession number(s): B3KTB4, Q0P5R3, Q6NWN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
ERV, Reference proteome, Transposable elementDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families