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Entry version 161 (13 Feb 2019)
Sequence version 3 (08 Feb 2011)
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Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

USP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei120NucleophilePROSITE-ProRule annotation1
Active sitei371Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • thiol-dependent ubiquitin-specific protease activity Source: FlyBase
  • thiol-dependent ubiquitinyl hydrolase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDifferentiation, Spermatogenesis, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.048

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP42
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000106346.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20068 USP42

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H9J4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84132

Open Targets

More...
OpenTargetsi
ENSG00000106346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134902515

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP42

Domain mapping of disease mutations (DMDM)

More...
DMDMi
322510098

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806721 – 1324Ubiquitin carboxyl-terminal hydrolase 42Add BLAST1324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1219PhosphoserineBy similarity1
Modified residuei1222PhosphoserineBy similarity1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H9J4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H9J4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H9J4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H9J4

PeptideAtlas

More...
PeptideAtlasi
Q9H9J4

PRoteomics IDEntifications database

More...
PRIDEi
Q9H9J4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81325
81326 [Q9H9J4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H9J4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H9J4

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9H9J4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106346 Expressed in 205 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H9J4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H9J4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006752
HPA064800

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046372EBI-2513638,EBI-366083

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123904, 41 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H9J4, 29 interactors

Molecular INTeraction database

More...
MINTi
Q9H9J4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301962

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H9J4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H9J4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 412USPAdd BLAST302

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi742 – 937Pro-richAdd BLAST196
Compositional biasi946 – 1118Arg-richAdd BLAST173
Compositional biasi1176 – 1246Lys-richAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1865 Eukaryota
ENOG410XQ92 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236355

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080724

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H9J4

KEGG Orthology (KO)

More...
KOi
K11855

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSQPVMN

Database of Orthologous Groups

More...
OrthoDBi
1469106at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H9J4

TreeFam database of animal gene trees

More...
TreeFami
TF315281

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H9J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH
60 70 80 90 100
TLSLGPVPGA VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC
110 120 130 140 150
LKWQQTHRVG AGLQNLGNTC FANAALQCLT YTPPLANYML SHEHSKTCHA
160 170 180 190 200
EGFCMMCTMQ AHITQALSNP GDVIKPMFVI NEMRRIARHF RFGNQEDAHE
210 220 230 240 250
FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS RVKCLNCKGV
260 270 280 290 300
SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA
310 320 330 340 350
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE
360 370 380 390 400
PIVYVLYAVL VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL
410 420 430 440 450
SQQAYVLFYI RSHDVKNGGE LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG
460 470 480 490 500
FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS MSSPNGNSSV NRASPVNASA
510 520 530 540 550
SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN LHSNSLENPT
560 570 580 590 600
KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN
610 620 630 640 650
SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE
660 670 680 690 700
LQEPMTLNGA NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP
710 720 730 740 750
GKLMPAPLLS LPEDKILETF RLSNKLKGST DEMSAPGAER GPPEDRDAEP
760 770 780 790 800
QPGSPAAESL EEPDAAAGLS STKKAPPPRD PGTPATKEGA WEAMAVAPEE
810 820 830 840 850
PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA EGPRDSALAE
860 870 880 890 900
APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP
910 920 930 940 950
APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR
960 970 980 990 1000
GHYRSRRERS SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP
1010 1020 1030 1040 1050
GHGDRLSPGE RRSLGRCSHH HSRHRSGVEL DWVRHHYTEG ERGWGREKFY
1060 1070 1080 1090 1100
PDRPRWDRCR YYHDRYALYA ARDWKPFHGG REHERAGLHE RPHKDHNRGR
1110 1120 1130 1140 1150
RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV AGDNCNLSDR
1160 1170 1180 1190 1200
FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK
1210 1220 1230 1240 1250
KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF
1260 1270 1280 1290 1300
VKDSELHLPR VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM
1310 1320
ESRDDRCRLF EYGQGKRRYL ELGR
Length:1,324
Mass (Da):145,392
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EB4975521ABF516
GO
Isoform 2 (identifier: Q9H9J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1316-1324: KRRYLELGR → D

Show »
Length:1,316
Mass (Da):144,335
Checksum:i28998E673C8EFE3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJP3E5RJP3_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DP25B4DP25_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPC9C9JPC9_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
1,043Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWZ4E7EWZ4_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD92F8WD92_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti655M → T in CAE53097 (PubMed:14715245).Curated1
Sequence conflicti655M → T in BAB14232 (PubMed:14702039).Curated1
Sequence conflicti1214R → RR in CAE53097 (PubMed:14715245).Curated1
Sequence conflicti1217Q → R in AAT67238 (PubMed:15489334).Curated1
Sequence conflicti1294K → E in AAT67238 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0597541030L → P. Corresponds to variant dbSNP:rs6463529Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0405291316 – 1324KRRYLELGR → D in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ601395 mRNA Translation: CAE53097.1
AY618868 mRNA Translation: AAT67238.1
AC004895 Genomic DNA No translation available.
BC060846 mRNA Translation: AAH60846.2
BC132862 mRNA Translation: AAI32863.1
AK022759 mRNA Translation: BAB14232.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47535.1 [Q9H9J4-2]

NCBI Reference Sequences

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RefSeqi
NP_115548.1, NM_032172.2 [Q9H9J4-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.31856

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000306177; ENSP00000301962; ENSG00000106346 [Q9H9J4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84132

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84132

UCSC genome browser

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UCSCi
uc011jwp.3 human [Q9H9J4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ601395 mRNA Translation: CAE53097.1
AY618868 mRNA Translation: AAT67238.1
AC004895 Genomic DNA No translation available.
BC060846 mRNA Translation: AAH60846.2
BC132862 mRNA Translation: AAI32863.1
AK022759 mRNA Translation: BAB14232.1
CCDSiCCDS47535.1 [Q9H9J4-2]
RefSeqiNP_115548.1, NM_032172.2 [Q9H9J4-2]
UniGeneiHs.31856

3D structure databases

ProteinModelPortaliQ9H9J4
SMRiQ9H9J4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123904, 41 interactors
IntActiQ9H9J4, 29 interactors
MINTiQ9H9J4
STRINGi9606.ENSP00000301962

Protein family/group databases

MEROPSiC19.048

PTM databases

iPTMnetiQ9H9J4
PhosphoSitePlusiQ9H9J4

Polymorphism and mutation databases

BioMutaiUSP42
DMDMi322510098

Proteomic databases

EPDiQ9H9J4
jPOSTiQ9H9J4
MaxQBiQ9H9J4
PaxDbiQ9H9J4
PeptideAtlasiQ9H9J4
PRIDEiQ9H9J4
ProteomicsDBi81325
81326 [Q9H9J4-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306177; ENSP00000301962; ENSG00000106346 [Q9H9J4-2]
GeneIDi84132
KEGGihsa:84132
UCSCiuc011jwp.3 human [Q9H9J4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84132
DisGeNETi84132
EuPathDBiHostDB:ENSG00000106346.11

GeneCards: human genes, protein and diseases

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GeneCardsi
USP42

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006462
HGNCiHGNC:20068 USP42
HPAiHPA006752
HPA064800
neXtProtiNX_Q9H9J4
OpenTargetsiENSG00000106346
PharmGKBiPA134902515

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00940000154596
HOGENOMiHOG000236355
HOVERGENiHBG080724
InParanoidiQ9H9J4
KOiK11855
OMAiCSQPVMN
OrthoDBi1469106at2759
PhylomeDBiQ9H9J4
TreeFamiTF315281

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
USP42 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
USP42

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84132
PMAP-CutDBiQ9H9J4

Protein Ontology

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PROi
PR:Q9H9J4

Gene expression databases

BgeeiENSG00000106346 Expressed in 205 organ(s), highest expression level in sperm
ExpressionAtlasiQ9H9J4 baseline and differential
GenevisibleiQ9H9J4 HS

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP42_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H9J4
Secondary accession number(s): A2RUE3
, B5MDA5, Q0VIN8, Q3C166, Q6P9B4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 8, 2011
Last modified: February 13, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
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