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UniProtKB - Q9H9J4 (UBP42_HUMAN)

Entry version 177 (23 Feb 2022)
Sequence version 3 (08 Feb 2011)
Previous versions | rss
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Protein

Ubiquitin carboxyl-terminal hydrolase 42

Gene

USP42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinating enzyme which may play an important role during spermatogenesis.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei120NucleophilePROSITE-ProRule annotation1
Active sitei371Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDifferentiation, Spermatogenesis, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H9J4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5689880, Ub-specific processing proteases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H9J4

Protein family/group databases

MEROPS protease database

More...MEROPSi		C19.048

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 42
Ubiquitin thioesterase 42
Ubiquitin-specific-processing protease 42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20068, USP42

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H9J4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106346

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84132

Open Targets

More...OpenTargetsi		ENSG00000106346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134902515

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H9J4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		USP42

Domain mapping of disease mutations (DMDM)

More...DMDMi		322510098

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806721 – 1324Ubiquitin carboxyl-terminal hydrolase 42Add BLAST1324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1219PhosphoserineBy similarity1
Modified residuei1222PhosphoserineBy similarity1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H9J4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H9J4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H9J4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H9J4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H9J4

PeptideAtlas

More...PeptideAtlasi		Q9H9J4

PRoteomics IDEntifications database

More...PRIDEi		Q9H9J4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81325 [Q9H9J4-1]
81326 [Q9H9J4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H9J4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H9J4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106346, Expressed in sperm and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H9J4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H9J4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106346, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123904, 55 interactors

Protein interaction database and analysis system

More...IntActi		Q9H9J4, 30 interactors

Molecular INTeraction database

More...MINTi		Q9H9J4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000301962

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H9J4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H9J4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 412USPAdd BLAST302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni63 – 87DisorderedSequence analysisAdd BLAST25
Regioni452 – 494DisorderedSequence analysisAdd BLAST43
Regioni536 – 707DisorderedSequence analysisAdd BLAST172
Regioni722 – 1026DisorderedSequence analysisAdd BLAST305
Regioni1085 – 1131DisorderedSequence analysisAdd BLAST47
Regioni1149 – 1254DisorderedSequence analysisAdd BLAST106
Regioni1275 – 1294DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 25Polar residuesSequence analysisAdd BLAST25
Compositional biasi472 – 494Polar residuesSequence analysisAdd BLAST23
Compositional biasi536 – 608Polar residuesSequence analysisAdd BLAST73
Compositional biasi654 – 668Polar residuesSequence analysisAdd BLAST15
Compositional biasi942 – 972Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi985 – 1015Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1085 – 1117Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi1149 – 1192Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi1193 – 1209Basic residuesSequence analysisAdd BLAST17
Compositional biasi1231 – 1245Basic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1865, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005541_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H9J4

Identification of Orthologs from Complete Genome Data

More...OMAi		HVEKKAW

Database of Orthologous Groups

More...OrthoDBi		929408at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H9J4

TreeFam database of animal gene trees

More...TreeFami		TF315281

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H9J4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH 
        60         70         80         90        100
TLSLGPVPGA VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC 
       110        120        130        140        150
LKWQQTHRVG AGLQNLGNTC FANAALQCLT YTPPLANYML SHEHSKTCHA 
       160        170        180        190        200
EGFCMMCTMQ AHITQALSNP GDVIKPMFVI NEMRRIARHF RFGNQEDAHE 
       210        220        230        240        250
FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS RVKCLNCKGV 
       260        270        280        290        300
SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA 
       310        320        330        340        350
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE 
       360        370        380        390        400
PIVYVLYAVL VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL 
       410        420        430        440        450
SQQAYVLFYI RSHDVKNGGE LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG 
       460        470        480        490        500
FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS MSSPNGNSSV NRASPVNASA 
       510        520        530        540        550
SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN LHSNSLENPT 
       560        570        580        590        600
KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN 
       610        620        630        640        650
SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE 
       660        670        680        690        700
LQEPMTLNGA NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP 
       710        720        730        740        750
GKLMPAPLLS LPEDKILETF RLSNKLKGST DEMSAPGAER GPPEDRDAEP 
       760        770        780        790        800
QPGSPAAESL EEPDAAAGLS STKKAPPPRD PGTPATKEGA WEAMAVAPEE 
       810        820        830        840        850
PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA EGPRDSALAE 
       860        870        880        890        900
APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP 
       910        920        930        940        950
APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR 
       960        970        980        990       1000
GHYRSRRERS SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP 
      1010       1020       1030       1040       1050
GHGDRLSPGE RRSLGRCSHH HSRHRSGVEL DWVRHHYTEG ERGWGREKFY 
      1060       1070       1080       1090       1100
PDRPRWDRCR YYHDRYALYA ARDWKPFHGG REHERAGLHE RPHKDHNRGR 
      1110       1120       1130       1140       1150
RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV AGDNCNLSDR 
      1160       1170       1180       1190       1200
FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK 
      1210       1220       1230       1240       1250
KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF 
      1260       1270       1280       1290       1300
VKDSELHLPR VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM 
      1310       1320 
ESRDDRCRLF EYGQGKRRYL ELGR
Length:1,324
Mass (Da):145,392
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EB4975521ABF516
GO
Isoform 2 (identifier: Q9H9J4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1316-1324: KRRYLELGR → D

Show »
Length:1,316
Mass (Da):144,335
Checksum:i28998E673C8EFE3B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JPC9C9JPC9_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
1,043Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJP3E5RJP3_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWZ4E7EWZ4_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DP25B4DP25_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD92F8WD92_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP42
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti655M → T in CAE53097 (PubMed:14715245).Curated1
Sequence conflicti655M → T in BAB14232 (PubMed:14702039).Curated1
Sequence conflicti1214R → RR in CAE53097 (PubMed:14715245).Curated1
Sequence conflicti1217Q → R in AAT67238 (PubMed:15489334).Curated1
Sequence conflicti1294K → E in AAT67238 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0597541030L → P. Corresponds to variant dbSNP:rs6463529Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0405291316 – 1324KRRYLELGR → D in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ601395 mRNA Translation: CAE53097.1
AY618868 mRNA Translation: AAT67238.1
AC004895 Genomic DNA No translation available.
BC060846 mRNA Translation: AAH60846.2
BC132862 mRNA Translation: AAI32863.1
AK022759 mRNA Translation: BAB14232.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47535.1 [Q9H9J4-2]

NCBI Reference Sequences

More...RefSeqi		NP_115548.1, NM_032172.2 [Q9H9J4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306177; ENSP00000301962; ENSG00000106346 [Q9H9J4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84132

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000306177.10; ENSP00000301962.5; NM_032172.3; NP_115548.1 [Q9H9J4-2]

UCSC genome browser

More...UCSCi		uc011jwp.3, human [Q9H9J4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ601395 mRNA Translation: CAE53097.1
AY618868 mRNA Translation: AAT67238.1
AC004895 Genomic DNA No translation available.
BC060846 mRNA Translation: AAH60846.2
BC132862 mRNA Translation: AAI32863.1
AK022759 mRNA Translation: BAB14232.1
CCDSiCCDS47535.1 [Q9H9J4-2]
RefSeqiNP_115548.1, NM_032172.2 [Q9H9J4-2]

3D structure databases

SMRiQ9H9J4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123904, 55 interactors
IntActiQ9H9J4, 30 interactors
MINTiQ9H9J4
STRINGi9606.ENSP00000301962

Protein family/group databases

MEROPSiC19.048

PTM databases

iPTMnetiQ9H9J4
PhosphoSitePlusiQ9H9J4

Genetic variation databases

BioMutaiUSP42
DMDMi322510098

Proteomic databases

EPDiQ9H9J4
jPOSTiQ9H9J4
MassIVEiQ9H9J4
MaxQBiQ9H9J4
PaxDbiQ9H9J4
PeptideAtlasiQ9H9J4
PRIDEiQ9H9J4
ProteomicsDBi81325 [Q9H9J4-1]
81326 [Q9H9J4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1719, 107 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		84132

Genome annotation databases

EnsembliENST00000306177; ENSP00000301962; ENSG00000106346 [Q9H9J4-2]
GeneIDi84132
KEGGihsa:84132
MANE-SelectiENST00000306177.10; ENSP00000301962.5; NM_032172.3; NP_115548.1 [Q9H9J4-2]
UCSCiuc011jwp.3, human [Q9H9J4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84132
DisGeNETi84132

GeneCards: human genes, protein and diseases

More...GeneCardsi		USP42
HGNCiHGNC:20068, USP42
HPAiENSG00000106346, Low tissue specificity
neXtProtiNX_Q9H9J4
OpenTargetsiENSG00000106346
PharmGKBiPA134902515
VEuPathDBiHostDB:ENSG00000106346

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1865, Eukaryota
GeneTreeiENSGT00940000154596
HOGENOMiCLU_005541_1_0_1
InParanoidiQ9H9J4
OMAiHVEKKAW
OrthoDBi929408at2759
PhylomeDBiQ9H9J4
TreeFamiTF315281

Enzyme and pathway databases

PathwayCommonsiQ9H9J4
ReactomeiR-HSA-5689880, Ub-specific processing proteases
SignaLinkiQ9H9J4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84132, 16 hits in 1089 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		USP42, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		USP42

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84132
PharosiQ9H9J4, Tbio

Protein Ontology

More...PROi		PR:Q9H9J4
RNActiQ9H9J4, protein

Gene expression databases

BgeeiENSG00000106346, Expressed in sperm and 219 other tissues
ExpressionAtlasiQ9H9J4, baseline and differential
GenevisibleiQ9H9J4, HS

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP42_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H9J4
Secondary accession number(s): A2RUE3
, B5MDA5, Q0VIN8, Q3C166, Q6P9B4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 8, 2011
Last modified: February 23, 2022
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. SIMILARITY comments
    Index of protein domains and families
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