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UniProtKB - Q9H9J4 (UBP42_HUMAN)
Protein
Ubiquitin carboxyl-terminal hydrolase 42
Gene
USP42
Organism
Homo sapiens (Human)
Status
Functioni
Deubiquitinating enzyme which may play an important role during spermatogenesis.
By similarityCatalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 120 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 371 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: GO_Central
- thiol-dependent deubiquitinase Source: FlyBase
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- protein deubiquitination Source: FlyBase
- regulation of apoptotic process Source: GO_Central
- spermatogenesis Source: UniProtKB-KW
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Differentiation, Spermatogenesis, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9H9J4 |
Reactomei | R-HSA-5689880, Ub-specific processing proteases |
SignaLinki | Q9H9J4 |
Protein family/group databases
MEROPSi | C19.048 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolase 42 (EC:3.4.19.12)Alternative name(s): Deubiquitinating enzyme 42 Ubiquitin thioesterase 42 Ubiquitin-specific-processing protease 42 |
Gene namesi | Name:USP42 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20068, USP42 |
neXtProti | NX_Q9H9J4 |
VEuPathDBi | HostDB:ENSG00000106346 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84132 |
OpenTargetsi | ENSG00000106346 |
PharmGKBi | PA134902515 |
Miscellaneous databases
Pharosi | Q9H9J4, Tbio |
Genetic variation databases
BioMutai | USP42 |
DMDMi | 322510098 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080672 | 1 – 1324 | Ubiquitin carboxyl-terminal hydrolase 42Add BLAST | 1324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 75 | PhosphoserineCombined sources | 1 | |
Modified residuei | 483 | PhosphoserineCombined sources | 1 | |
Modified residuei | 754 | PhosphoserineCombined sources | 1 | |
Modified residuei | 856 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1181 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1219 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1222 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1226 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1247 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H9J4 |
jPOSTi | Q9H9J4 |
MassIVEi | Q9H9J4 |
MaxQBi | Q9H9J4 |
PaxDbi | Q9H9J4 |
PeptideAtlasi | Q9H9J4 |
PRIDEi | Q9H9J4 |
ProteomicsDBi | 81325 [Q9H9J4-1] 81326 [Q9H9J4-2] |
PTM databases
iPTMneti | Q9H9J4 |
PhosphoSitePlusi | Q9H9J4 |
Expressioni
Tissue specificityi
Broadly expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000106346, Expressed in sperm and 219 other tissues |
ExpressionAtlasi | Q9H9J4, baseline and differential |
Genevisiblei | Q9H9J4, HS |
Organism-specific databases
HPAi | ENSG00000106346, Low tissue specificity |
Interactioni
Binary interactionsi
Q9H9J4
With | #Exp. | IntAct |
---|---|---|
TP53 [P04637] | 2 | EBI-2513638,EBI-366083 |
Isoform 2 [Q9H9J4-2]
With | #Exp. | IntAct |
---|---|---|
TP53 [P04637] | 2 | EBI-9118105,EBI-366083 |
Protein-protein interaction databases
BioGRIDi | 123904, 55 interactors |
IntActi | Q9H9J4, 30 interactors |
MINTi | Q9H9J4 |
STRINGi | 9606.ENSP00000301962 |
Miscellaneous databases
RNActi | Q9H9J4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 111 – 412 | USPAdd BLAST | 302 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 63 – 87 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 452 – 494 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 536 – 707 | DisorderedSequence analysisAdd BLAST | 172 | |
Regioni | 722 – 1026 | DisorderedSequence analysisAdd BLAST | 305 | |
Regioni | 1085 – 1131 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 1149 – 1254 | DisorderedSequence analysisAdd BLAST | 106 | |
Regioni | 1275 – 1294 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 25 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 472 – 494 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 536 – 608 | Polar residuesSequence analysisAdd BLAST | 73 | |
Compositional biasi | 654 – 668 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 942 – 972 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 985 – 1015 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 1085 – 1117 | Basic and acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1149 – 1192 | Basic and acidic residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 1193 – 1209 | Basic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1231 – 1245 | Basic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the peptidase C19 family.Curated
Phylogenomic databases
eggNOGi | KOG1865, Eukaryota |
GeneTreei | ENSGT00940000154596 |
HOGENOMi | CLU_005541_1_0_1 |
InParanoidi | Q9H9J4 |
OMAi | HVEKKAW |
OrthoDBi | 929408at2759 |
PhylomeDBi | Q9H9J4 |
TreeFami | TF315281 |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00443, UCH, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H9J4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH
60 70 80 90 100
TLSLGPVPGA VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC
110 120 130 140 150
LKWQQTHRVG AGLQNLGNTC FANAALQCLT YTPPLANYML SHEHSKTCHA
160 170 180 190 200
EGFCMMCTMQ AHITQALSNP GDVIKPMFVI NEMRRIARHF RFGNQEDAHE
210 220 230 240 250
FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS RVKCLNCKGV
260 270 280 290 300
SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA
310 320 330 340 350
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE
360 370 380 390 400
PIVYVLYAVL VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL
410 420 430 440 450
SQQAYVLFYI RSHDVKNGGE LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG
460 470 480 490 500
FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS MSSPNGNSSV NRASPVNASA
510 520 530 540 550
SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN LHSNSLENPT
560 570 580 590 600
KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN
610 620 630 640 650
SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE
660 670 680 690 700
LQEPMTLNGA NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP
710 720 730 740 750
GKLMPAPLLS LPEDKILETF RLSNKLKGST DEMSAPGAER GPPEDRDAEP
760 770 780 790 800
QPGSPAAESL EEPDAAAGLS STKKAPPPRD PGTPATKEGA WEAMAVAPEE
810 820 830 840 850
PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA EGPRDSALAE
860 870 880 890 900
APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP
910 920 930 940 950
APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR
960 970 980 990 1000
GHYRSRRERS SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP
1010 1020 1030 1040 1050
GHGDRLSPGE RRSLGRCSHH HSRHRSGVEL DWVRHHYTEG ERGWGREKFY
1060 1070 1080 1090 1100
PDRPRWDRCR YYHDRYALYA ARDWKPFHGG REHERAGLHE RPHKDHNRGR
1110 1120 1130 1140 1150
RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV AGDNCNLSDR
1160 1170 1180 1190 1200
FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK
1210 1220 1230 1240 1250
KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF
1260 1270 1280 1290 1300
VKDSELHLPR VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM
1310 1320
ESRDDRCRLF EYGQGKRRYL ELGR
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JPC9 | C9JPC9_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP42 | 1,043 | Annotation score: | ||
E5RJP3 | E5RJP3_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP42 | 219 | Annotation score: | ||
E7EWZ4 | E7EWZ4_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP42 | 475 | Annotation score: | ||
B4DP25 | B4DP25_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP42 | 174 | Annotation score: | ||
F8WD92 | F8WD92_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP42 | 98 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 655 | M → T in CAE53097 (PubMed:14715245).Curated | 1 | |
Sequence conflicti | 655 | M → T in BAB14232 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1214 | R → RR in CAE53097 (PubMed:14715245).Curated | 1 | |
Sequence conflicti | 1217 | Q → R in AAT67238 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1294 | K → E in AAT67238 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059754 | 1030 | L → P. Corresponds to variant dbSNP:rs6463529Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040529 | 1316 – 1324 | KRRYLELGR → D in isoform 2. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ601395 mRNA Translation: CAE53097.1 AY618868 mRNA Translation: AAT67238.1 AC004895 Genomic DNA No translation available. BC060846 mRNA Translation: AAH60846.2 BC132862 mRNA Translation: AAI32863.1 AK022759 mRNA Translation: BAB14232.1 |
CCDSi | CCDS47535.1 [Q9H9J4-2] |
RefSeqi | NP_115548.1, NM_032172.2 [Q9H9J4-2] |
Genome annotation databases
Ensembli | ENST00000306177; ENSP00000301962; ENSG00000106346 [Q9H9J4-2] |
GeneIDi | 84132 |
KEGGi | hsa:84132 |
MANE-Selecti | ENST00000306177.10; ENSP00000301962.5; NM_032172.3; NP_115548.1 [Q9H9J4-2] |
UCSCi | uc011jwp.3, human [Q9H9J4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ601395 mRNA Translation: CAE53097.1 AY618868 mRNA Translation: AAT67238.1 AC004895 Genomic DNA No translation available. BC060846 mRNA Translation: AAH60846.2 BC132862 mRNA Translation: AAI32863.1 AK022759 mRNA Translation: BAB14232.1 |
CCDSi | CCDS47535.1 [Q9H9J4-2] |
RefSeqi | NP_115548.1, NM_032172.2 [Q9H9J4-2] |
3D structure databases
SMRi | Q9H9J4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123904, 55 interactors |
IntActi | Q9H9J4, 30 interactors |
MINTi | Q9H9J4 |
STRINGi | 9606.ENSP00000301962 |
Protein family/group databases
MEROPSi | C19.048 |
PTM databases
iPTMneti | Q9H9J4 |
PhosphoSitePlusi | Q9H9J4 |
Genetic variation databases
BioMutai | USP42 |
DMDMi | 322510098 |
Proteomic databases
EPDi | Q9H9J4 |
jPOSTi | Q9H9J4 |
MassIVEi | Q9H9J4 |
MaxQBi | Q9H9J4 |
PaxDbi | Q9H9J4 |
PeptideAtlasi | Q9H9J4 |
PRIDEi | Q9H9J4 |
ProteomicsDBi | 81325 [Q9H9J4-1] 81326 [Q9H9J4-2] |
Protocols and materials databases
Antibodypediai | 1719, 107 antibodies from 27 providers |
DNASUi | 84132 |
Genome annotation databases
Ensembli | ENST00000306177; ENSP00000301962; ENSG00000106346 [Q9H9J4-2] |
GeneIDi | 84132 |
KEGGi | hsa:84132 |
MANE-Selecti | ENST00000306177.10; ENSP00000301962.5; NM_032172.3; NP_115548.1 [Q9H9J4-2] |
UCSCi | uc011jwp.3, human [Q9H9J4-1] |
Organism-specific databases
CTDi | 84132 |
DisGeNETi | 84132 |
GeneCardsi | USP42 |
HGNCi | HGNC:20068, USP42 |
HPAi | ENSG00000106346, Low tissue specificity |
neXtProti | NX_Q9H9J4 |
OpenTargetsi | ENSG00000106346 |
PharmGKBi | PA134902515 |
VEuPathDBi | HostDB:ENSG00000106346 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1865, Eukaryota |
GeneTreei | ENSGT00940000154596 |
HOGENOMi | CLU_005541_1_0_1 |
InParanoidi | Q9H9J4 |
OMAi | HVEKKAW |
OrthoDBi | 929408at2759 |
PhylomeDBi | Q9H9J4 |
TreeFami | TF315281 |
Enzyme and pathway databases
PathwayCommonsi | Q9H9J4 |
Reactomei | R-HSA-5689880, Ub-specific processing proteases |
SignaLinki | Q9H9J4 |
Miscellaneous databases
BioGRID-ORCSi | 84132, 16 hits in 1089 CRISPR screens |
ChiTaRSi | USP42, human |
GeneWikii | USP42 |
GenomeRNAii | 84132 |
Pharosi | Q9H9J4, Tbio |
PROi | PR:Q9H9J4 |
RNActi | Q9H9J4, protein |
Gene expression databases
Bgeei | ENSG00000106346, Expressed in sperm and 219 other tissues |
ExpressionAtlasi | Q9H9J4, baseline and differential |
Genevisiblei | Q9H9J4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF00443, UCH, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBP42_HUMAN | |
Accessioni | Q9H9J4Primary (citable) accession number: Q9H9J4 Secondary accession number(s): A2RUE3 Q6P9B4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | February 8, 2011 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families