UniProtKB - Q9H9F9 (ARP5_HUMAN)
Protein
Actin-related protein 5
Gene
ACTR5
Organism
Homo sapiens (Human)
Status
Functioni
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.2 Publications
GO - Biological processi
- ATP-dependent chromatin remodeling Source: GO_Central
- DNA duplex unwinding Source: GOC
- DNA recombination Source: UniProtKB-KW
- double-strand break repair Source: UniProtKB
- protein deubiquitination Source: Reactome
- regulation of transcription, DNA-templated Source: GO_Central
- UV-damage excision repair Source: UniProtKB
Keywordsi
Biological process | DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9H9F9 |
Reactomei | R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER |
SignaLinki | Q9H9F9 |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein 5Short name: hARP5 Alternative name(s): Sarcoma antigen NY-SAR-16 |
Gene namesi | Name:ACTR5 Synonyms:ARP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000101442.9 |
HGNCi | HGNC:14671, ACTR5 |
neXtProti | NX_Q9H9F9 |
Subcellular locationi
Nucleus
- Ino80 complex Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79913 |
OpenTargetsi | ENSG00000101442 |
PharmGKBi | PA24490 |
Miscellaneous databases
Pharosi | Q9H9F9, Tbio |
Polymorphism and mutation databases
BioMutai | ACTR5 |
DMDMi | 110832751 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247842 | 1 – 607 | Actin-related protein 5Add BLAST | 607 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 283 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9H9F9 |
jPOSTi | Q9H9F9 |
MassIVEi | Q9H9F9 |
MaxQBi | Q9H9F9 |
PaxDbi | Q9H9F9 |
PeptideAtlasi | Q9H9F9 |
PRIDEi | Q9H9F9 |
ProteomicsDBi | 81319 |
PTM databases
iPTMneti | Q9H9F9 |
PhosphoSitePlusi | Q9H9F9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000101442, Expressed in epithelium of mammary gland and 217 other tissues |
Genevisiblei | Q9H9F9, HS |
Organism-specific databases
HPAi | ENSG00000101442, Low tissue specificity |
Interactioni
Subunit structurei
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80.
Interacts with DDB1.
Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells.
5 PublicationsBinary interactionsi
Hide detailsQ9H9F9
With | #Exp. | IntAct |
---|---|---|
ACTR8 [Q9H981] | 3 | EBI-769418,EBI-769597 |
DDB1 [Q16531] | 4 | EBI-769418,EBI-350322 |
INO80 [Q9ULG1] | 8 | EBI-769418,EBI-769345 |
PPL [O60437] | 3 | EBI-769418,EBI-368321 |
Protein-protein interaction databases
BioGRIDi | 122993, 49 interactors |
ComplexPortali | CPX-846, INO80 chromatin remodeling complex |
CORUMi | Q9H9F9 |
DIPi | DIP-34297N |
IntActi | Q9H9F9, 49 interactors |
MINTi | Q9H9F9 |
STRINGi | 9606.ENSP00000243903 |
Miscellaneous databases
RNActi | Q9H9F9, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 288 – 327 | Sequence analysisAdd BLAST | 40 | |
Coiled coili | 355 – 384 | Sequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0681, Eukaryota |
GeneTreei | ENSGT00720000108866 |
HOGENOMi | CLU_008246_2_0_1 |
InParanoidi | Q9H9F9 |
OMAi | ITNWNHQ |
OrthoDBi | 344271at2759 |
PhylomeDBi | Q9H9F9 |
TreeFami | TF324227 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR004001, Actin_CS IPR027664, Arp5 IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit PTHR11937:SF16, PTHR11937:SF16, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00432, ACTINS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H9F9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAANVFPFRD ARAAPDPVLE AGPVAHGPLP VPLVLDNGSF QVRAGWACPG
60 70 80 90 100
QDPGPEPRLQ FRAVCARGRG GARGASGPQV GNALGSLEPL RWMLRSPFDR
110 120 130 140 150
NVPVNLELQE LLLDYSFQHL GVSSQGCVDH PIVLTEAVCN PLYSRQMMSE
160 170 180 190 200
LLFECYGIPK VAYGIDSLFS FYHNKPKNSM CSGLIISSGY QCTHVLPILE
210 220 230 240 250
GRLDAKNCKR INLGGSQAAG YLQRLLQLKY PGHLAAITLS RMEEILHEHS
260 270 280 290 300
YIAEDYVEEL HKWRCPDYYE NNVHKMQLPF SSKLLGSTLT SEEKQERRQQ
310 320 330 340 350
QLRRLQELNA RRREEKLQLD QERLDRLLYV QELLEDGQMD QFHKALIELN
360 370 380 390 400
MDSPEELQSY IQKLSIAVEQ AKQKILQAEV NLEVDVVDSK PETPDLEQLE
410 420 430 440 450
PSLEDVESMN DFDPLFSEET PGVEKPVTTV QPVFNLAAYH QLFVGTERIR
460 470 480 490 500
APEIIFQPSL IGEEQAGIAE TLQYILDRYP KDIQEMLVQN VFLTGGNTMY
510 520 530 540 550
PGMKARMEKE LLEMRPFRSS FQVQLASNPV LDAWYGARDW ALNHLDDNEV
560 570 580 590 600
WITRKEYEEK GGEYLKEHCA SNIYVPIRLP KQASRSSDAQ ASSKGSAAGG
GGAGEQA
Sequence cautioni
The sequence AAO65164 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 – 70 | RG → AR in AAO65164 (PubMed:12601173).Curated | 2 | |
Sequence conflicti | 481 | K → E in BAB14270 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027158 | 298 | R → L1 PublicationCorresponds to variant dbSNP:rs17853829Ensembl. | 1 | |
Natural variantiVAR_048189 | 461 | I → L. Corresponds to variant dbSNP:rs35805905Ensembl. | 1 | |
Natural variantiVAR_027159 | 483 | I → V1 PublicationCorresponds to variant dbSNP:rs2245231Ensembl. | 1 | |
Natural variantiVAR_027160 | 580 | P → L. Corresponds to variant dbSNP:rs3752289Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022847 mRNA Translation: BAB14270.1 AL133519 Genomic DNA No translation available. BC001324 mRNA Translation: AAH01324.1 BC006162 mRNA Translation: AAH06162.1 BC038402 mRNA Translation: AAH38402.1 AY211911 mRNA Translation: AAO65164.1 Frameshift. |
CCDSi | CCDS13308.1 |
RefSeqi | NP_079131.3, NM_024855.3 |
Genome annotation databases
Ensembli | ENST00000243903; ENSP00000243903; ENSG00000101442 |
GeneIDi | 79913 |
KEGGi | hsa:79913 |
UCSCi | uc002xjd.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022847 mRNA Translation: BAB14270.1 AL133519 Genomic DNA No translation available. BC001324 mRNA Translation: AAH01324.1 BC006162 mRNA Translation: AAH06162.1 BC038402 mRNA Translation: AAH38402.1 AY211911 mRNA Translation: AAO65164.1 Frameshift. |
CCDSi | CCDS13308.1 |
RefSeqi | NP_079131.3, NM_024855.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6HTS | electron microscopy | 4.80 | H | 1-607 | [»] | |
SMRi | Q9H9F9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122993, 49 interactors |
ComplexPortali | CPX-846, INO80 chromatin remodeling complex |
CORUMi | Q9H9F9 |
DIPi | DIP-34297N |
IntActi | Q9H9F9, 49 interactors |
MINTi | Q9H9F9 |
STRINGi | 9606.ENSP00000243903 |
PTM databases
iPTMneti | Q9H9F9 |
PhosphoSitePlusi | Q9H9F9 |
Polymorphism and mutation databases
BioMutai | ACTR5 |
DMDMi | 110832751 |
Proteomic databases
EPDi | Q9H9F9 |
jPOSTi | Q9H9F9 |
MassIVEi | Q9H9F9 |
MaxQBi | Q9H9F9 |
PaxDbi | Q9H9F9 |
PeptideAtlasi | Q9H9F9 |
PRIDEi | Q9H9F9 |
ProteomicsDBi | 81319 |
Protocols and materials databases
Antibodypediai | 43543, 124 antibodies |
Genome annotation databases
Ensembli | ENST00000243903; ENSP00000243903; ENSG00000101442 |
GeneIDi | 79913 |
KEGGi | hsa:79913 |
UCSCi | uc002xjd.3, human |
Organism-specific databases
CTDi | 79913 |
DisGeNETi | 79913 |
EuPathDBi | HostDB:ENSG00000101442.9 |
GeneCardsi | ACTR5 |
HGNCi | HGNC:14671, ACTR5 |
HPAi | ENSG00000101442, Low tissue specificity |
neXtProti | NX_Q9H9F9 |
OpenTargetsi | ENSG00000101442 |
PharmGKBi | PA24490 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0681, Eukaryota |
GeneTreei | ENSGT00720000108866 |
HOGENOMi | CLU_008246_2_0_1 |
InParanoidi | Q9H9F9 |
OMAi | ITNWNHQ |
OrthoDBi | 344271at2759 |
PhylomeDBi | Q9H9F9 |
TreeFami | TF324227 |
Enzyme and pathway databases
PathwayCommonsi | Q9H9F9 |
Reactomei | R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER |
SignaLinki | Q9H9F9 |
Miscellaneous databases
BioGRID-ORCSi | 79913, 132 hits in 853 CRISPR screens |
ChiTaRSi | ACTR5, human |
GenomeRNAii | 79913 |
Pharosi | Q9H9F9, Tbio |
PROi | PR:Q9H9F9 |
RNActi | Q9H9F9, protein |
Gene expression databases
Bgeei | ENSG00000101442, Expressed in epithelium of mammary gland and 217 other tissues |
Genevisiblei | Q9H9F9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR004001, Actin_CS IPR027664, Arp5 IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit PTHR11937:SF16, PTHR11937:SF16, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00432, ACTINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARP5_HUMAN | |
Accessioni | Q9H9F9Primary (citable) accession number: Q9H9F9 Secondary accession number(s): Q86WF7 Q9BVB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | July 25, 2006 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations