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Protein

Ankyrin repeat family A protein 2

Gene

ANKRA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).By similarity1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: UniProtKB
  • low-density lipoprotein particle receptor binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat family A protein 2
Alternative name(s):
RFXANK-like protein 2
Gene namesi
Name:ANKRA2
Synonyms:ANKRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164331.9
HGNCiHGNC:13208 ANKRA2
MIMi605787 gene
neXtProtiNX_Q9H9E1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31K → R: No effect on interaction with CCDC8. 1 Publication1
Mutagenesisi188W → A: Loss of interaction with CCDC8. Decreased affinity for HDAC4. 2 Publications1
Mutagenesisi254Y → A: Decreased affinity for HDAC4. 1 Publication1

Organism-specific databases

DisGeNETi57763
OpenTargetsiENSG00000164331
PharmGKBiPA24803

Polymorphism and mutation databases

BioMutaiANKRA2
DMDMi27734215

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668951 – 313Ankyrin repeat family A protein 2Add BLAST313

Proteomic databases

EPDiQ9H9E1
MaxQBiQ9H9E1
PaxDbiQ9H9E1
PeptideAtlasiQ9H9E1
PRIDEiQ9H9E1
ProteomicsDBi81315

PTM databases

iPTMnetiQ9H9E1
PhosphoSitePlusiQ9H9E1

Expressioni

Gene expression databases

BgeeiENSG00000164331 Expressed in 218 organ(s), highest expression level in ectocervix
CleanExiHS_ANKRA2
ExpressionAtlasiQ9H9E1 baseline and differential
GenevisibleiQ9H9E1 HS

Organism-specific databases

HPAiHPA065263

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CCDC8 (via PxLPxI/L motif); mediates the interaction with the 3M complex which is composed of CCDC8, CUL7 and OBSL1 (PubMed:25752541). Interacts (via ANK repeats) with HDAC4 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with HDAC5 (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with LRP2/megalin (via PxLPxI/L motif) (PubMed:22649097). Interacts (via ANK repeats) with RFX7 (via PxLPxI/L motif) (PubMed:25752541). Interacts with AHRR (By similarity). Interacts with NEK6 (PubMed:20873783).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HDAC4P565243EBI-10215533,EBI-308629

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121758, 32 interactors
CORUMiQ9H9E1
ELMiQ9H9E1
IntActiQ9H9E1, 4 interactors
STRINGi9606.ENSP00000296785

Structurei

Secondary structure

1313
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H9E1
SMRiQ9H9E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati148 – 180ANK 1Add BLAST33
Repeati181 – 213ANK 2Add BLAST33
Repeati214 – 246ANK 3Add BLAST33
Repeati247 – 279ANK 4Add BLAST33
Repeati280 – 313ANK 5Add BLAST34

Domaini

The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2.2 Publications

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0502 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150856
HOGENOMiHOG000033969
HOVERGENiHBG017718
InParanoidiQ9H9E1
KOiK21486
OMAiMEGICVM
OrthoDBiEOG091G0BD5
PhylomeDBiQ9H9E1
TreeFamiTF333112

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H9E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSTNLDIG AQLIVEECPS TYSLTGMPDI KIEHPLDPNS EEGSAQGVAM
60 70 80 90 100
GMKFILPNRF DMNVCSRFVK SLNEEDSKNI QDQVNSDLEV ASVLFKAECN
110 120 130 140 150
IHTSPSPGIQ VRHVYTPSTT KHFSPIKQST TLTNKHRGNE VSTTPLLANS
160 170 180 190 200
LSVHQLAAQG EMLYLATRIE QENVINHTDE EGFTPLMWAA AHGQIAVVEF
210 220 230 240 250
LLQNGADPQL LGKGRESALS LACSKGYTDI VKMLLDCGVD VNEYDWNGGT
260 270 280 290 300
PLLYAVHGNH VKCVKMLLES GADPTIETDS GYNSMDLAVA LGYRSVQQVI
310
ESHLLKLLQN IKE
Length:313
Mass (Da):34,272
Last modified:March 1, 2001 - v1
Checksum:i31C653B10B4ED6E1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBK8D6RBK8_HUMAN
Ankyrin repeat family A protein 2
ANKRA2
177Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314032 mRNA Translation: AAK01621.1
AK022876 mRNA Translation: BAB14288.1
AF251051 mRNA Translation: AAK34941.1
BC012917 mRNA Translation: AAH12917.1
CCDSiCCDS4020.1
RefSeqiNP_075526.1, NM_023039.4
UniGeneiHs.239154

Genome annotation databases

EnsembliENST00000296785; ENSP00000296785; ENSG00000164331
GeneIDi57763
KEGGihsa:57763
UCSCiuc003kcu.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314032 mRNA Translation: AAK01621.1
AK022876 mRNA Translation: BAB14288.1
AF251051 mRNA Translation: AAK34941.1
BC012917 mRNA Translation: AAH12917.1
CCDSiCCDS4020.1
RefSeqiNP_075526.1, NM_023039.4
UniGeneiHs.239154

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SO8X-ray1.90A149-310[»]
3V2OX-ray1.89A148-313[»]
3V2XX-ray1.85A148-313[»]
3V31X-ray1.57A148-313[»]
4LG6X-ray1.80A142-313[»]
4QQIX-ray2.03A142-313[»]
ProteinModelPortaliQ9H9E1
SMRiQ9H9E1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121758, 32 interactors
CORUMiQ9H9E1
ELMiQ9H9E1
IntActiQ9H9E1, 4 interactors
STRINGi9606.ENSP00000296785

PTM databases

iPTMnetiQ9H9E1
PhosphoSitePlusiQ9H9E1

Polymorphism and mutation databases

BioMutaiANKRA2
DMDMi27734215

Proteomic databases

EPDiQ9H9E1
MaxQBiQ9H9E1
PaxDbiQ9H9E1
PeptideAtlasiQ9H9E1
PRIDEiQ9H9E1
ProteomicsDBi81315

Protocols and materials databases

DNASUi57763
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296785; ENSP00000296785; ENSG00000164331
GeneIDi57763
KEGGihsa:57763
UCSCiuc003kcu.3 human

Organism-specific databases

CTDi57763
DisGeNETi57763
EuPathDBiHostDB:ENSG00000164331.9
GeneCardsiANKRA2
HGNCiHGNC:13208 ANKRA2
HPAiHPA065263
MIMi605787 gene
neXtProtiNX_Q9H9E1
OpenTargetsiENSG00000164331
PharmGKBiPA24803
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0502 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150856
HOGENOMiHOG000033969
HOVERGENiHBG017718
InParanoidiQ9H9E1
KOiK21486
OMAiMEGICVM
OrthoDBiEOG091G0BD5
PhylomeDBiQ9H9E1
TreeFamiTF333112

Miscellaneous databases

GenomeRNAii57763
PROiPR:Q9H9E1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164331 Expressed in 218 organ(s), highest expression level in ectocervix
CleanExiHS_ANKRA2
ExpressionAtlasiQ9H9E1 baseline and differential
GenevisibleiQ9H9E1 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANRA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H9E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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