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UniProtKB - Q9H9D4 (ZN408_HUMAN)

Protein

Zinc finger protein 408

Gene

ZNF408

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri353 – 375C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 408
Alternative name(s):
PR domain zinc finger protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF408
Synonyms:PFM14, PRDM17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000175213.2

Human Gene Nomenclature Database

More...HGNCi		HGNC:20041 ZNF408

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616454 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H9D4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Vitreoretinopathy, exudative 6 (EVR6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of exudative vitreoretinopathy, a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery.
See also OMIM:616468
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_074612126S → N in EVR6; unknown pathological significance; does not affect localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs536561101EnsemblClinVar.1
Natural variantiVAR_074613455H → Y in EVR6; severely decreased localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs373273223EnsemblClinVar.1
Retinitis pigmentosa 72 (RP72)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
See also OMIM:616469
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074615541R → C in RP72; decreased localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs781192528EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...DisGeNETi		79797

MalaCards human disease database

More...MalaCardsi		ZNF408
MIMi616468 phenotype
616469 phenotype

Open Targets

More...OpenTargetsi		ENSG00000175213

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		891 Familial exudative vitreoretinopathy
791 Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134936136

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF408

Domain mapping of disease mutations (DMDM)

More...DMDMi		17368963

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475691 – 720Zinc finger protein 408Add BLAST720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei322PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H9D4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H9D4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H9D4

PeptideAtlas

More...PeptideAtlasi		Q9H9D4

PRoteomics IDEntifications database

More...PRIDEi		Q9H9D4

ProteomicsDB human proteome resource

More...ProteomicsDBi		81314

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H9D4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H9D4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression is observed in adult retina; abundantly expressed in the fetal eye (PubMed:23716654). In the retina, it is detected in the outer nuclear layer, especially cone and rod photoreceptor cells, ganglion cell layer and both outer and inner plexiform layers (at protein level) (PubMed:25882705). Expressed in retinal blood vessels (at protein level) (PubMed:25882705).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175213 Expressed in 185 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

More...CleanExi		HS_ZNF408

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H9D4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA017892

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122894, 96 interactors

Protein interaction database and analysis system

More...IntActi		Q9H9D4, 77 interactors

Molecular INTeraction database

More...MINTi		Q9H9D4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309606

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9H9D4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H9D4

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 375C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri496 – 518C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri524 – 546C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00930000151062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231441

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG079382

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H9D4

Identification of Orthologs from Complete Genome Data

More...OMAi		QCPPRAK

Database of Orthologous Groups

More...OrthoDBi		EOG091G02KC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H9D4

TreeFam database of animal gene trees

More...TreeFami		TF331495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096 zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H9D4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEAEELLLE GKKALQLARE PRLGLDLGWN PSGEGCTQGL KDVPPEPTRD 
        60         70         80         90        100
ILALKSLPRG LALGPSLAKE QRLGVWCVGD PLQPGLLWGP LEEESASKEK 
       110        120        130        140        150
GEGVKPRQEE NLSLGPWGDV CACEQSSGWT SLVQRGRLES EGNVAPVRIS 
       160        170        180        190        200
ERLHLQVYQL VLPGSELLLW PQPSSEGPSL TQPGLDKEAA VAVVTEVESA 
       210        220        230        240        250
VQQEVASPGE DAAEPCIDPG SQSPSGIQAE NMVSPGLKFP TQDRISKDSQ 
       260        270        280        290        300
PLGPLLQDGD VDEECPAQAQ MPPELQSNSA TQQDPDGSGA SFSSSARGTQ 
       310        320        330        340        350
PHGYLAKKLH SPSDQCPPRA KTPEPGAQQS GFPTLSRSPP GPAGSSPKQG 
       360        370        380        390        400
RRYRCGECGK AFLQLCHLKK HAFVHTGHKP FLCTECGKSY SSEESFKAHM 
       410        420        430        440        450
LGHRGVRPFP CPQCDKAYGT QRDLKEHQVV HSGARPFACD QCGKAFARRP 
       460        470        480        490        500
SLRLHRKTHQ VPAAPAPCPC PVCGRPLANQ GSLRNHMRLH TGEKPFLCPH 
       510        520        530        540        550
CGRAFRQRGN LRGHLRLHTG ERPYRCPHCA DAFPQLPELR RHLISHTGEA 
       560        570        580        590        600
HLCPVCGKAL RDPHTLRAHE RLHSGERPFP CPQCGRAYTL ATKLRRHLKS 
       610        620        630        640        650
HLEDKPYRCP TCGMGYTLPQ SLRRHQLSHR PEAPCSPPSV PSAASEPTVV 
       660        670        680        690        700
LLQAEPQLLD THREEEVSPA RDVVEVTISE SQEKCFVVPE EPDAAPSLVL 
       710        720
IHKDMGLGAW AEVVEVEMGT
Length:720
Mass (Da):78,439
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D3CDA7572D17721
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074612126S → N in EVR6; unknown pathological significance; does not affect localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs536561101EnsemblClinVar.1
Natural variantiVAR_052823337R → P. Corresponds to variant dbSNP:rs36017347Ensembl.1
Natural variantiVAR_074613455H → Y in EVR6; severely decreased localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs373273223EnsemblClinVar.1
Natural variantiVAR_074614492G → R1 PublicationCorresponds to variant dbSNP:rs561740128Ensembl.1
Natural variantiVAR_074615541R → C in RP72; decreased localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs781192528EnsemblClinVar.1
Natural variantiVAR_074616583Q → K1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF346626 mRNA Translation: AAK29075.1
AK022889 mRNA Translation: BAB14295.1
BC013355 mRNA Translation: AAH13355.1
BC015708 mRNA Translation: AAH15708.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7923.1

NCBI Reference Sequences

More...RefSeqi		NP_001171680.1, NM_001184751.1
NP_079017.1, NM_024741.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.656931

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000311764; ENSP00000309606; ENSG00000175213

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79797

UCSC genome browser

More...UCSCi		uc001nde.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF346626 mRNA Translation: AAK29075.1
AK022889 mRNA Translation: BAB14295.1
BC013355 mRNA Translation: AAH13355.1
BC015708 mRNA Translation: AAH15708.1
CCDSiCCDS7923.1
RefSeqiNP_001171680.1, NM_001184751.1
NP_079017.1, NM_024741.2
UniGeneiHs.656931

3D structure databases

ProteinModelPortaliQ9H9D4
SMRiQ9H9D4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122894, 96 interactors
IntActiQ9H9D4, 77 interactors
MINTiQ9H9D4
STRINGi9606.ENSP00000309606

PTM databases

iPTMnetiQ9H9D4
PhosphoSitePlusiQ9H9D4

Polymorphism and mutation databases

BioMutaiZNF408
DMDMi17368963

Proteomic databases

EPDiQ9H9D4
MaxQBiQ9H9D4
PaxDbiQ9H9D4
PeptideAtlasiQ9H9D4
PRIDEiQ9H9D4
ProteomicsDBi81314

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		79797
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311764; ENSP00000309606; ENSG00000175213
GeneIDi79797
KEGGihsa:79797
UCSCiuc001nde.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79797
DisGeNETi79797
EuPathDBiHostDB:ENSG00000175213.2

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF408
HGNCiHGNC:20041 ZNF408
HPAiHPA017892
MalaCardsiZNF408
MIMi616454 gene
616468 phenotype
616469 phenotype
neXtProtiNX_Q9H9D4
OpenTargetsiENSG00000175213
Orphaneti891 Familial exudative vitreoretinopathy
791 Retinitis pigmentosa
PharmGKBiPA134936136

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000151062
HOGENOMiHOG000231441
HOVERGENiHBG079382
InParanoidiQ9H9D4
OMAiQCPPRAK
OrthoDBiEOG091G02KC
PhylomeDBiQ9H9D4
TreeFamiTF331495

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF408 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79797

Protein Ontology

More...PROi		PR:Q9H9D4

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175213 Expressed in 185 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ZNF408
GenevisibleiQ9H9D4 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN408_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H9D4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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