Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 175 (29 Sep 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

Sideroflexin-1

Gene

SFXN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778).

Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778).

Transports both D-serine and L-serine (PubMed:30442778).

Also able to transport other amino-acids, such as alanine (PubMed:30442778).

May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity).

By similarity1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=170 µM for serine1 Publication
  2. KM=371 µM for alanine1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, One-carbon metabolism, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H9B4

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.54.1.1, the sideroflexin (sfxn) family (formerly the mitochondrial tricarboxylate carrier (mtc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sideroflexin-1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFXN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16085, SFXN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615569, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H9B4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000164466

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 102Mitochondrial matrix1 PublicationAdd BLAST101
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei103 – 120HelicalSequence analysisAdd BLAST18
Topological domaini121 – 146Mitochondrial intermembraneCuratedAdd BLAST26
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 174Mitochondrial matrixCurated7
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 228Mitochondrial intermembraneCuratedAdd BLAST33
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 266Mitochondrial matrixCuratedAdd BLAST17
Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
Topological domaini288 – 322Mitochondrial intermembrane1 PublicationAdd BLAST35

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
94081

Open Targets

More...
OpenTargetsi
ENSG00000164466

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38090

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H9B4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SFXN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001770322 – 322Sideroflexin-1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H9B4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H9B4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H9B4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H9B4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H9B4

PeptideAtlas

More...
PeptideAtlasi
Q9H9B4

PRoteomics IDEntifications database

More...
PRIDEi
Q9H9B4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81311

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9H9B4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H9B4

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9H9B4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H9B4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H9B4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164466, Expressed in liver and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H9B4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H9B4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164466, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125107, 281 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H9B4, 176 interactors

Molecular INTeraction database

More...
MINTi
Q9H9B4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316905

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H9B4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H9B4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3767, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039425_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H9B4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PELWHAK

Database of Orthologous Groups

More...
OrthoDBi
881974at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H9B4

TreeFam database of animal gene trees

More...
TreeFami
TF313205

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004686, Mtc

The PANTHER Classification System

More...
PANTHERi
PTHR11153, PTHR11153, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03820, SFXNs, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00798, mtc, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9H9B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGELPPNIN IKEPRWDQST FIGRANHFFT VTDPRNILLT NEQLESARKI
60 70 80 90 100
VHDYRQGIVP PGLTENELWR AKYIYDSAFH PDTGEKMILI GRMSAQVPMN
110 120 130 140 150
MTITGCMMTF YRTTPAVLFW QWINQSFNAV VNYTNRSGDA PLTVNELGTA
160 170 180 190 200
YVSATTGAVA TALGLNALTK HVSPLIGRFV PFAAVAAANC INIPLMRQRE
210 220 230 240 250
LKVGIPVTDE NGNRLGESAN AAKQAITQVV VSRILMAAPG MAIPPFIMNT
260 270 280 290 300
LEKKAFLKRF PWMSAPIQVG LVGFCLVFAT PLCCALFPQK SSMSVTSLEA
310 320
ELQAKIQESH PELRRVYFNK GL
Length:322
Mass (Da):35,619
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47E03172F27990DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RDG7D6RDG7_HUMAN
Sideroflexin-1
SFXN1
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFI0D6RFI0_HUMAN
Sideroflexin-1
SFXN1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2X2S4R2X2_HUMAN
Sideroflexin-1
SFXN1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAE9D6RAE9_HUMAN
Sideroflexin-1
SFXN1
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9J5H0Y9J5_HUMAN
Sideroflexin-1
SFXN1
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH20517 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14003 differs from that shown. Cloning artifact.Curated
The sequence BAB14318 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73Y → K in BAB14318 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05196626N → S. Corresponds to variant dbSNP:rs17065105EnsemblClinVar.1
Natural variantiVAR_051967266P → S. Corresponds to variant dbSNP:rs34907038Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF327346 mRNA Translation: AAL56007.1
AK022287 mRNA Translation: BAB14003.1 Sequence problems.
AK022938 mRNA Translation: BAB14318.1 Different initiation.
AK056915 mRNA Translation: BAG51825.1
BX648188 mRNA No translation available.
AC091393 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61370.1
CH471062 Genomic DNA Translation: EAW61372.1
CH471062 Genomic DNA Translation: EAW61374.1
CH471062 Genomic DNA Translation: EAW61375.1
BC020517 mRNA Translation: AAH20517.1 Different initiation.
BC063241 mRNA Translation: AAH63241.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4394.1

NCBI Reference Sequences

More...
RefSeqi
NP_001309906.1, NM_001322977.1
NP_073591.2, NM_022754.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321442; ENSP00000316905; ENSG00000164466

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:94081

UCSC genome browser

More...
UCSCi
uc003mda.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327346 mRNA Translation: AAL56007.1
AK022287 mRNA Translation: BAB14003.1 Sequence problems.
AK022938 mRNA Translation: BAB14318.1 Different initiation.
AK056915 mRNA Translation: BAG51825.1
BX648188 mRNA No translation available.
AC091393 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61370.1
CH471062 Genomic DNA Translation: EAW61372.1
CH471062 Genomic DNA Translation: EAW61374.1
CH471062 Genomic DNA Translation: EAW61375.1
BC020517 mRNA Translation: AAH20517.1 Different initiation.
BC063241 mRNA Translation: AAH63241.1
CCDSiCCDS4394.1
RefSeqiNP_001309906.1, NM_001322977.1
NP_073591.2, NM_022754.6

3D structure databases

SMRiQ9H9B4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125107, 281 interactors
IntActiQ9H9B4, 176 interactors
MINTiQ9H9B4
STRINGi9606.ENSP00000316905

Protein family/group databases

TCDBi2.A.54.1.1, the sideroflexin (sfxn) family (formerly the mitochondrial tricarboxylate carrier (mtc) family

PTM databases

iPTMnetiQ9H9B4
MetOSiteiQ9H9B4
PhosphoSitePlusiQ9H9B4
SwissPalmiQ9H9B4

Genetic variation databases

BioMutaiSFXN1

Proteomic databases

EPDiQ9H9B4
jPOSTiQ9H9B4
MassIVEiQ9H9B4
MaxQBiQ9H9B4
PaxDbiQ9H9B4
PeptideAtlasiQ9H9B4
PRIDEiQ9H9B4
ProteomicsDBi81311
TopDownProteomicsiQ9H9B4

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17087, 166 antibodies

The DNASU plasmid repository

More...
DNASUi
94081

Genome annotation databases

EnsembliENST00000321442; ENSP00000316905; ENSG00000164466
GeneIDi94081
KEGGihsa:94081
UCSCiuc003mda.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94081
DisGeNETi94081

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SFXN1
HGNCiHGNC:16085, SFXN1
HPAiENSG00000164466, Tissue enhanced (liver)
MIMi615569, gene
neXtProtiNX_Q9H9B4
OpenTargetsiENSG00000164466
PharmGKBiPA38090
VEuPathDBiHostDB:ENSG00000164466

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3767, Eukaryota
GeneTreeiENSGT01030000234641
HOGENOMiCLU_039425_1_0_1
InParanoidiQ9H9B4
OMAiPELWHAK
OrthoDBi881974at2759
PhylomeDBiQ9H9B4
TreeFamiTF313205

Enzyme and pathway databases

PathwayCommonsiQ9H9B4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
94081, 23 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SFXN1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SFXN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
94081
PharosiQ9H9B4, Tbio

Protein Ontology

More...
PROi
PR:Q9H9B4
RNActiQ9H9B4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164466, Expressed in liver and 236 other tissues
ExpressionAtlasiQ9H9B4, baseline and differential
GenevisibleiQ9H9B4, HS

Family and domain databases

InterProiView protein in InterPro
IPR004686, Mtc
PANTHERiPTHR11153, PTHR11153, 1 hit
PfamiView protein in Pfam
PF03820, SFXNs, 1 hit
TIGRFAMsiTIGR00798, mtc, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFXN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H9B4
Secondary accession number(s): B3KPW3, D3DQN2, Q9HA53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 175 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again