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Entry version 177 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Leucine-rich repeat-containing protein 40

Gene

LRRC40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H9A6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26004, LRRC40

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H9A6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000066557.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000066557

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671528

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H9A6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LRRC40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761553

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002262571 – 602Leucine-rich repeat-containing protein 40Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei71PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H9A6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H9A6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H9A6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H9A6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H9A6

PeptideAtlas

More...
PeptideAtlasi
Q9H9A6

PRoteomics IDEntifications database

More...
PRIDEi
Q9H9A6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81305

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00152998

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H9A6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H9A6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H9A6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000066557, Expressed in frontal cortex and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H9A6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H9A6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000066557, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120770, 40 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H9A6, 25 interactors

Molecular INTeraction database

More...
MINTi
Q9H9A6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359990

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H9A6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati83 – 104LRR 1Add BLAST22
Repeati106 – 127LRR 2Add BLAST22
Repeati129 – 150LRR 3Add BLAST22
Repeati152 – 173LRR 4Add BLAST22
Repeati175 – 196LRR 5Add BLAST22
Repeati198 – 219LRR 6Add BLAST22
Repeati221 – 242LRR 7Add BLAST22
Repeati244 – 265LRR 8Add BLAST22
Repeati266 – 286LRR 9Add BLAST21
Repeati290 – 311LRR 10Add BLAST22
Repeati313 – 335LRR 11Add BLAST23
Repeati336 – 356LRR 12Add BLAST21
Repeati400 – 421LRR 13Add BLAST22
Repeati426 – 447LRR 14Add BLAST22
Repeati450 – 472LRR 15Add BLAST23
Repeati473 – 494LRR 16Add BLAST22
Repeati496 – 517LRR 17Add BLAST22
Repeati519 – 540LRR 18Add BLAST22
Repeati543 – 564LRR 19Add BLAST22
Repeati566 – 586LRR 20Add BLAST21

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0472, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_18_23_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H9A6

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRFQFIP

Database of Orthologous Groups

More...
OrthoDBi
826997at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H9A6

TreeFam database of animal gene trees

More...
TreeFami
TF354310

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855, LRR_8, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 13 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H9A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLKRIAGQ DLRAGFKAGG RDCGTSVPQG LLKAARKSGQ LNLSGRNLSE
60 70 80 90 100
VPQCVWRINV DIPEEANQNL SFGATERWWE QTDLTKLIIS NNKLQSLTDD
110 120 130 140 150
LRLLPALTVL DIHDNQLTSL PSAIRELENL QKLNVSHNKL KILPEEITNL
160 170 180 190 200
RNLKCLYLQH NELTCISEGF EQLSNLEDLD LSNNHLTTVP ASFSSLSSLV
210 220 230 240 250
RLNLSSNELK SLPAEINRMK RLKHLDCNSN LLETIPPELA GMESLELLYL
260 270 280 290 300
RRNKLRFLPE FPSCSLLKEL HVGENQIEML EAEHLKHLNS ILVLDLRDNK
310 320 330 340 350
LKSVPDEIIL LRSLERLDLS NNDISSLPYS LGNLHLKFLA LEGNPLRTIR
360 370 380 390 400
REIISKGTQE VLKYLRSKIK DDGPSQSESA TETAMTLPSE SRVNIHAIIT
410 420 430 440 450
LKILDYSDKQ ATLIPDEVFD AVKSNIVTSI NFSKNQLCEI PKRMVELKEM
460 470 480 490 500
VSDVDLSFNK LSFISLELCV LQKLTFLDLR NNFLNSLPEE MESLVRLQTI
510 520 530 540 550
NLSFNRFKML PEVLYRIFTL ETILISNNQV GSVDPQKMKM MENLTTLDLQ
560 570 580 590 600
NNDLLQIPPE LGNCVNLRTL LLDGNPFRVP RAAILMKGTA AILEYLRDRI

PT
Length:602
Mass (Da):68,250
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB126CAC02749C8A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91094 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti368K → T in BAA91094 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03408853Q → P. Corresponds to variant dbSNP:rs270495Ensembl.1
Natural variantiVAR_034089500I → V. Corresponds to variant dbSNP:rs3180401Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000338 mRNA Translation: BAA91094.1 Different initiation.
AK022951 mRNA Translation: BAB14326.1
AL353771 Genomic DNA No translation available.
BC003407 mRNA Translation: AAH03407.2
BC008586 mRNA Translation: AAH08586.1
AL162076 mRNA Translation: CAB82410.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS646.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T47176

NCBI Reference Sequences

More...
RefSeqi
NP_060238.3, NM_017768.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370952; ENSP00000359990; ENSG00000066557

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55631

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55631

UCSC genome browser

More...
UCSCi
uc001der.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000338 mRNA Translation: BAA91094.1 Different initiation.
AK022951 mRNA Translation: BAB14326.1
AL353771 Genomic DNA No translation available.
BC003407 mRNA Translation: AAH03407.2
BC008586 mRNA Translation: AAH08586.1
AL162076 mRNA Translation: CAB82410.1
CCDSiCCDS646.1
PIRiT47176
RefSeqiNP_060238.3, NM_017768.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120770, 40 interactors
IntActiQ9H9A6, 25 interactors
MINTiQ9H9A6
STRINGi9606.ENSP00000359990

PTM databases

iPTMnetiQ9H9A6
PhosphoSitePlusiQ9H9A6
SwissPalmiQ9H9A6

Genetic variation databases

BioMutaiLRRC40
DMDMi74761553

2D gel databases

REPRODUCTION-2DPAGEiIPI00152998

Proteomic databases

EPDiQ9H9A6
jPOSTiQ9H9A6
MassIVEiQ9H9A6
MaxQBiQ9H9A6
PaxDbiQ9H9A6
PeptideAtlasiQ9H9A6
PRIDEiQ9H9A6
ProteomicsDBi81305

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19653, 118 antibodies

The DNASU plasmid repository

More...
DNASUi
55631

Genome annotation databases

EnsembliENST00000370952; ENSP00000359990; ENSG00000066557
GeneIDi55631
KEGGihsa:55631
UCSCiuc001der.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55631

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LRRC40
HGNCiHGNC:26004, LRRC40
HPAiENSG00000066557, Low tissue specificity
neXtProtiNX_Q9H9A6
OpenTargetsiENSG00000066557
PharmGKBiPA142671528
VEuPathDBiHostDB:ENSG00000066557.5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0472, Eukaryota
GeneTreeiENSGT00940000156968
HOGENOMiCLU_000288_18_23_1
InParanoidiQ9H9A6
OMAiNRFQFIP
OrthoDBi826997at2759
PhylomeDBiQ9H9A6
TreeFamiTF354310

Enzyme and pathway databases

PathwayCommonsiQ9H9A6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55631, 5 hits in 995 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LRRC40, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LRRC40

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55631
PharosiQ9H9A6, Tdark

Protein Ontology

More...
PROi
PR:Q9H9A6
RNActiQ9H9A6, protein

Gene expression databases

BgeeiENSG00000066557, Expressed in frontal cortex and 240 other tissues
ExpressionAtlasiQ9H9A6, baseline and differential
GenevisibleiQ9H9A6, HS

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF13855, LRR_8, 4 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 13 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 17 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H9A6
Secondary accession number(s): Q9BTR7, Q9NSK1, Q9NXC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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