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Protein

Pantothenate kinase 3

Gene

PANK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Activity regulationi

Regulated by feedback inhibition by CoA and its thioesters.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 1 (PANK1), Pantothenate kinase 3 (PANK3), Pantothenate kinase 4 (PANK4), Pantothenate kinase 2, mitochondrial (PANK2), Pantothenate kinase 4 (PANK4), Pantothenate kinase 4, Pantothenate kinase 4
  2. Phosphopantothenate--cysteine ligase (PPCS)
  3. Phosphopantothenoylcysteine decarboxylase (PPCDC)
  4. Bifunctional coenzyme A synthase (COASY)
  5. Bifunctional coenzyme A synthase (COASY)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192Acetyl-CoA1 Publication1
Binding sitei195Acetyl-CoA1 Publication1
Binding sitei207Acetyl-CoA1 Publication1

GO - Molecular functioni

GO - Biological processi

  • coenzyme A biosynthetic process Source: UniProtKB
  • phosphorylation Source: UniProtKB

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS04372-MONOMER
BRENDAi2.7.1.33 2681
ReactomeiR-HSA-196783 Coenzyme A biosynthesis
UniPathwayi
UPA00241;UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase 3 (EC:2.7.1.33)
Short name:
hPanK3
Alternative name(s):
Pantothenic acid kinase 3
Gene namesi
Name:PANK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000120137.6
HGNCiHGNC:19365 PANK3
MIMi606161 gene
neXtProtiNX_Q9H999

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120137
PharmGKBiPA134903180

Chemistry databases

ChEMBLiCHEMBL3407328

Polymorphism and mutation databases

BioMutaiPANK3
DMDMi27805668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001618041 – 370Pantothenate kinase 3Add BLAST370

Proteomic databases

EPDiQ9H999
MaxQBiQ9H999
PaxDbiQ9H999
PeptideAtlasiQ9H999
PRIDEiQ9H999
ProteomicsDBi81299

PTM databases

iPTMnetiQ9H999
PhosphoSitePlusiQ9H999
SwissPalmiQ9H999

Expressioni

Tissue specificityi

Highly expressed in the liver.1 Publication

Gene expression databases

BgeeiENSG00000120137 Expressed in 231 organ(s), highest expression level in jejunal mucosa
CleanExiHS_PANK3
ExpressionAtlasiQ9H999 baseline and differential
GenevisibleiQ9H999 HS

Organism-specific databases

HPAiHPA062358

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122774, 2 interactors
STRINGi9606.ENSP00000239231

Chemistry databases

BindingDBiQ9H999

Structurei

Secondary structure

1370
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H999
SMRiQ9H999
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H999

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Phylogenomic databases

eggNOGiKOG2201 Eukaryota
COG5146 LUCA
GeneTreeiENSGT00390000020719
HOGENOMiHOG000194690
HOVERGENiHBG053495
InParanoidiQ9H999
KOiK09680
OMAiHDLPTFI
OrthoDBiEOG091G0851
PhylomeDBiQ9H999
TreeFamiTF314866

Family and domain databases

InterProiView protein in InterPro
IPR004567 Type_II_PanK
PfamiView protein in Pfam
PF03630 Fumble, 1 hit
TIGRFAMsiTIGR00555 panK_eukar, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H999-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIKDAKKPS FPWFGMDIGG TLVKLSYFEP IDITAEEEQE EVESLKSIRK
60 70 80 90 100
YLTSNVAYGS TGIRDVHLEL KDLTLFGRRG NLHFIRFPTQ DLPTFIQMGR
110 120 130 140 150
DKNFSTLQTV LCATGGGAYK FEKDFRTIGN LHLHKLDELD CLVKGLLYID
160 170 180 190 200
SVSFNGQAEC YYFANASEPE RCQKMPFNLD DPYPLLVVNI GSGVSILAVH
210 220 230 240 250
SKDNYKRVTG TSLGGGTFLG LCSLLTGCES FEEALEMASK GDSTQADKLV
260 270 280 290 300
RDIYGGDYER FGLPGWAVAS SFGNMIYKEK RESVSKEDLA RATLVTITNN
310 320 330 340 350
IGSVARMCAV NEKINRVVFV GNFLRVNTLS MKLLAYALDY WSKGQLKALF
360 370
LEHEGYFGAV GALLGLPNFS
Length:370
Mass (Da):41,094
Last modified:March 1, 2001 - v1
Checksum:i71EEFA56079F352D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHA5E5RHA5_HUMAN
Pantothenate kinase 3
PANK3
122Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335A → V in BAD97005 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022961 mRNA Translation: BAB14333.1
AK223285 mRNA Translation: BAD97005.1
CH471062 Genomic DNA Translation: EAW61503.1
CH471062 Genomic DNA Translation: EAW61505.1
BC013705 mRNA Translation: AAH13705.1
BK000011 mRNA Translation: DAA00005.1
CCDSiCCDS4368.1
RefSeqiNP_078870.1, NM_024594.3
UniGeneiHs.388400
Hs.591729

Genome annotation databases

EnsembliENST00000239231; ENSP00000239231; ENSG00000120137
GeneIDi79646
KEGGihsa:79646
UCSCiuc003lzy.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022961 mRNA Translation: BAB14333.1
AK223285 mRNA Translation: BAD97005.1
CH471062 Genomic DNA Translation: EAW61503.1
CH471062 Genomic DNA Translation: EAW61505.1
BC013705 mRNA Translation: AAH13705.1
BK000011 mRNA Translation: DAA00005.1
CCDSiCCDS4368.1
RefSeqiNP_078870.1, NM_024594.3
UniGeneiHs.388400
Hs.591729

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I7PX-ray2.05A/B/C/D12-368[»]
3MK6X-ray1.98A/B/C/D12-368[»]
3SMSX-ray2.20A10-370[»]
5KPRX-ray1.83A12-370[»]
5KPTX-ray2.30A12-370[»]
5KPZX-ray2.40A12-370[»]
5KQ8X-ray2.00A12-370[»]
5KQDX-ray2.60A12-370[»]
6B3VX-ray1.60A12-370[»]
ProteinModelPortaliQ9H999
SMRiQ9H999
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122774, 2 interactors
STRINGi9606.ENSP00000239231

Chemistry databases

BindingDBiQ9H999
ChEMBLiCHEMBL3407328

PTM databases

iPTMnetiQ9H999
PhosphoSitePlusiQ9H999
SwissPalmiQ9H999

Polymorphism and mutation databases

BioMutaiPANK3
DMDMi27805668

Proteomic databases

EPDiQ9H999
MaxQBiQ9H999
PaxDbiQ9H999
PeptideAtlasiQ9H999
PRIDEiQ9H999
ProteomicsDBi81299

Protocols and materials databases

DNASUi79646
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239231; ENSP00000239231; ENSG00000120137
GeneIDi79646
KEGGihsa:79646
UCSCiuc003lzy.4 human

Organism-specific databases

CTDi79646
EuPathDBiHostDB:ENSG00000120137.6
GeneCardsiPANK3
HGNCiHGNC:19365 PANK3
HPAiHPA062358
MIMi606161 gene
neXtProtiNX_Q9H999
OpenTargetsiENSG00000120137
PharmGKBiPA134903180
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2201 Eukaryota
COG5146 LUCA
GeneTreeiENSGT00390000020719
HOGENOMiHOG000194690
HOVERGENiHBG053495
InParanoidiQ9H999
KOiK09680
OMAiHDLPTFI
OrthoDBiEOG091G0851
PhylomeDBiQ9H999
TreeFamiTF314866

Enzyme and pathway databases

UniPathwayi
UPA00241;UER00352

BioCyciMetaCyc:HS04372-MONOMER
BRENDAi2.7.1.33 2681
ReactomeiR-HSA-196783 Coenzyme A biosynthesis

Miscellaneous databases

ChiTaRSiPANK3 human
EvolutionaryTraceiQ9H999
GenomeRNAii79646
PROiPR:Q9H999
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120137 Expressed in 231 organ(s), highest expression level in jejunal mucosa
CleanExiHS_PANK3
ExpressionAtlasiQ9H999 baseline and differential
GenevisibleiQ9H999 HS

Family and domain databases

InterProiView protein in InterPro
IPR004567 Type_II_PanK
PfamiView protein in Pfam
PF03630 Fumble, 1 hit
TIGRFAMsiTIGR00555 panK_eukar, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPANK3_HUMAN
AccessioniPrimary (citable) accession number: Q9H999
Secondary accession number(s): D3DQL1, Q53FJ9, Q7RTX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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