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Entry version 147 (05 Jun 2019)
Sequence version 1 (01 Mar 2001)
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Protein

E3 ubiquitin-protein ligase MARCH7

Gene

MARCH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri544 – 614RING-CH-typePROSITE-ProRule annotationAdd BLAST71

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.3.2.19 2681

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MARCH7 (EC:2.3.2.27)
Alternative name(s):
Axotrophin
Membrane-associated RING finger protein 7
Membrane-associated RING-CH protein VII
Short name:
MARCH-VII
RING finger protein 177
RING-type E3 ubiquitin transferase MARCH7Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARCH7
Synonyms:AXOT, RNF177
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17393 MARCH7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613334 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H992

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64844

Open Targets

More...
OpenTargetsi
ENSG00000136536

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25198

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MARCH7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762745

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002744151 – 704E3 ubiquitin-protein ligase MARCH7Add BLAST704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei686PhosphothreonineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H992

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H992

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H992

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H992

PeptideAtlas

More...
PeptideAtlasi
Q9H992

PRoteomics IDEntifications database

More...
PRIDEi
Q9H992

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81297

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H992

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H992

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136536 Expressed in 238 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H992 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H992 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014275
HPA022152

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MAPRE3Q9UPY84EBI-949983,EBI-726739

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122319, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H992, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H992

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 421Ser-richAdd BLAST409

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-CH-type zinc finger domain is required for E3 ligase activity.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri544 – 614RING-CH-typePROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1609 Eukaryota
COG5183 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063836

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232048

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H992

KEGG Orthology (KO)

More...
KOi
K10662

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLEAQSD

Database of Orthologous Groups

More...
OrthoDBi
517602at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H992

TreeFam database of animal gene trees

More...
TreeFami
TF330816

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011016 Znf_RING-CH
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12906 RINGv, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00744 RINGv, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51292 ZF_RING_CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H992-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESKPSRIPR RISVQPSSSL SARMMSGSRG SSLNDTYHSR DSSFRLDSEY
60 70 80 90 100
QSTSASASAS PFQSAWYSES EITQGARSRS QNQQRDHDSK RPKLSCTNCT
110 120 130 140 150
TSAGRNVGNG LNTLSDSSWR HSQVPRSSSM VLGSFGTDLM RERRDLERRT
160 170 180 190 200
DSSISNLMDY SHRSGDFTTS SYVQDRVPSY SQGARPKENS MSTLQLNTSS
210 220 230 240 250
TNHQLPSEHQ TILSSRDSRN SLRSNFSSRE SESSRSNTQP GFSYSSSRDE
260 270 280 290 300
APIISNSERV VSSQRPFQES SDNEGRRTTR RLLSRIASSM SSTFFSRRSS
310 320 330 340 350
QDSLNTRSLN SENSYVSPRI LTASQSRSNV PSASEVPDNR ASEASQGFRF
360 370 380 390 400
LRRRWGLSSL SHNHSSESDS ENFNQESEGR NTGPWLSSSL RNRCTPLFSR
410 420 430 440 450
RRREGRDESS RIPTSDTSSR SHIFRRESNE VVHLEAQNDP LGAAANRPQA
460 470 480 490 500
SAASSSATTG GSTSDSAQGG RNTGISGILP GSLFRFAVPP ALGSNLTDNV
510 520 530 540 550
MITVDIIPSG WNSADGKSDK TKSAPSRDPE RLQKIKESLL LEDSEEEEGD
560 570 580 590 600
LCRICQMAAA SSSNLLIEPC KCTGSLQYVH QDCMKKWLQA KINSGSSLEA
610 620 630 640 650
VTTCELCKEK LELNLEDFDI HELHRAHANE QAEYEFISSG LYLVVLLHLC
660 670 680 690 700
EQSFSDMMGN TNEPSTRVRF INLARTLQAH MEDLETSEDD SEEDGDHNRT

FDIA
Length:704
Mass (Da):78,051
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1271F74D7F389130
GO
Isoform 2 (identifier: Q9H992-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQ → MIGNYDHLMSLVT

Note: No experimental confirmation available.
Show »
Length:666
Mass (Da):73,778
Checksum:iA553FF5F219A65D2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6W4F5H6W4_HUMAN
E3 ubiquitin-protein ligase MARCH7
MARCH7
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J159C9J159_HUMAN
E3 ubiquitin-protein ligase MARCH7
MARCH7
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZU7H7BZU7_HUMAN
E3 ubiquitin-protein ligase MARCH7
MARCH7
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti376E → G in BAD96600 (Ref. 2) Curated1
Sequence conflicti412I → V in BAD96600 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030284100T → S. Corresponds to variant dbSNP:rs17813964Ensembl.1
Natural variantiVAR_030285193T → I. Corresponds to variant dbSNP:rs16844275Ensembl.1
Natural variantiVAR_030286379G → S1 PublicationCorresponds to variant dbSNP:rs13024801Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0544061 – 51MESKP…DSEYQ → MIGNYDHLMSLVT in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK022973 mRNA Translation: BAB14340.1
AK292836 mRNA Translation: BAF85525.1
AK302347 mRNA Translation: BAH13681.1
AK222880 mRNA Translation: BAD96600.1
AC009961 Genomic DNA Translation: AAY14941.1
CH471058 Genomic DNA Translation: EAX11402.1
BC003404 mRNA Translation: AAH03404.1
BC065014 mRNA Translation: AAH65014.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2210.1 [Q9H992-1]
CCDS63039.1 [Q9H992-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001269734.1, NM_001282805.1 [Q9H992-1]
NP_001269735.1, NM_001282806.1
NP_001269736.1, NM_001282807.1 [Q9H992-2]
NP_073737.1, NM_022826.3 [Q9H992-1]
XP_005246830.1, XM_005246773.2 [Q9H992-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259050; ENSP00000259050; ENSG00000136536 [Q9H992-1]
ENST00000409175; ENSP00000386830; ENSG00000136536 [Q9H992-1]
ENST00000409591; ENSP00000387238; ENSG00000136536 [Q9H992-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64844

UCSC genome browser

More...
UCSCi
uc002uax.5 human [Q9H992-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022973 mRNA Translation: BAB14340.1
AK292836 mRNA Translation: BAF85525.1
AK302347 mRNA Translation: BAH13681.1
AK222880 mRNA Translation: BAD96600.1
AC009961 Genomic DNA Translation: AAY14941.1
CH471058 Genomic DNA Translation: EAX11402.1
BC003404 mRNA Translation: AAH03404.1
BC065014 mRNA Translation: AAH65014.1
CCDSiCCDS2210.1 [Q9H992-1]
CCDS63039.1 [Q9H992-2]
RefSeqiNP_001269734.1, NM_001282805.1 [Q9H992-1]
NP_001269735.1, NM_001282806.1
NP_001269736.1, NM_001282807.1 [Q9H992-2]
NP_073737.1, NM_022826.3 [Q9H992-1]
XP_005246830.1, XM_005246773.2 [Q9H992-1]

3D structure databases

SMRiQ9H992
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122319, 33 interactors
IntActiQ9H992, 15 interactors
STRINGi9606.ENSP00000259050

PTM databases

iPTMnetiQ9H992
PhosphoSitePlusiQ9H992

Polymorphism and mutation databases

BioMutaiMARCH7
DMDMi74762745

Proteomic databases

EPDiQ9H992
jPOSTiQ9H992
MaxQBiQ9H992
PaxDbiQ9H992
PeptideAtlasiQ9H992
PRIDEiQ9H992
ProteomicsDBi81297

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259050; ENSP00000259050; ENSG00000136536 [Q9H992-1]
ENST00000409175; ENSP00000386830; ENSG00000136536 [Q9H992-1]
ENST00000409591; ENSP00000387238; ENSG00000136536 [Q9H992-2]
GeneIDi64844
KEGGihsa:64844
UCSCiuc002uax.5 human [Q9H992-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64844
DisGeNETi64844

GeneCards: human genes, protein and diseases

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GeneCardsi
MARCH7
HGNCiHGNC:17393 MARCH7
HPAiHPA014275
HPA022152
MIMi613334 gene
neXtProtiNX_Q9H992
OpenTargetsiENSG00000136536
PharmGKBiPA25198

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1609 Eukaryota
COG5183 LUCA
GeneTreeiENSGT00530000063836
HOGENOMiHOG000232048
InParanoidiQ9H992
KOiK10662
OMAiHLEAQSD
OrthoDBi517602at2759
PhylomeDBiQ9H992
TreeFamiTF330816

Enzyme and pathway databases

UniPathwayiUPA00143
BRENDAi6.3.2.19 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MARCH7 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MARCH7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64844

Protein Ontology

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PROi
PR:Q9H992

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136536 Expressed in 238 organ(s), highest expression level in kidney
ExpressionAtlasiQ9H992 baseline and differential
GenevisibleiQ9H992 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011016 Znf_RING-CH
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12906 RINGv, 1 hit
SMARTiView protein in SMART
SM00744 RINGv, 1 hit
PROSITEiView protein in PROSITE
PS51292 ZF_RING_CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARH7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H992
Secondary accession number(s): A8K9X1
, B7Z7P5, D3DPB0, Q53GQ1, Q9BTR9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2001
Last modified: June 5, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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