UniProtKB - Q9H987 (SYP2L_HUMAN)
Protein
Synaptopodin 2-like protein
Gene
SYNPO2L
Organism
Homo sapiens (Human)
Status
Functioni
Actin-associated protein that may play a role in modulating actin-based shape.By similarity
GO - Molecular functioni
- actin binding Source: GO_Central
GO - Biological processi
- heart morphogenesis Source: BHF-UCL
- positive regulation of actin filament bundle assembly Source: GO_Central
- positive regulation of Rho protein signal transduction Source: BHF-UCL
- positive regulation of stress fiber assembly Source: BHF-UCL
- sarcomere organization Source: BHF-UCL
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9H987 |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptopodin 2-like protein |
Gene namesi | Name:SYNPO2L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166317.11 |
HGNCi | HGNC:23532, SYNPO2L |
neXtProti | NX_Q9H987 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- actin cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cell junction Source: HPA
- Z disc Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 79933 |
OpenTargetsi | ENSG00000166317 |
PharmGKBi | PA134889033 |
Miscellaneous databases
Pharosi | Q9H987, Tdark |
Polymorphism and mutation databases
BioMutai | SYNPO2L |
DMDMi | 212276492 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187675 | 1 – 977 | Synaptopodin 2-like proteinAdd BLAST | 977 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | PhosphoserineBy similarity | 1 | |
Modified residuei | 111 | PhosphoserineBy similarity | 1 | |
Modified residuei | 141 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 143 | PhosphoserineBy similarity | 1 | |
Modified residuei | 178 | PhosphoserineBy similarity | 1 | |
Modified residuei | 180 | PhosphoserineBy similarity | 1 | |
Modified residuei | 345 | PhosphoserineBy similarity | 1 | |
Modified residuei | 350 | PhosphoserineBy similarity | 1 | |
Modified residuei | 374 | PhosphoserineBy similarity | 1 | |
Modified residuei | 381 | PhosphoserineBy similarity | 1 | |
Modified residuei | 384 | PhosphoserineBy similarity | 1 | |
Modified residuei | 386 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 466 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 469 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 479 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 670 | PhosphoserineBy similarity | 1 | |
Modified residuei | 678 | PhosphoserineBy similarity | 1 | |
Modified residuei | 705 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 713 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 757 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 788 | PhosphoserineBy similarity | 1 | |
Modified residuei | 790 | PhosphoserineBy similarity | 1 | |
Modified residuei | 792 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 806 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 826 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 889 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 891 | PhosphoserineBy similarity | 1 | |
Modified residuei | 892 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 898 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 910 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 921 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 921 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 955 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 957 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9H987 |
MassIVEi | Q9H987 |
MaxQBi | Q9H987 |
PaxDbi | Q9H987 |
PeptideAtlasi | Q9H987 |
PRIDEi | Q9H987 |
ProteomicsDBi | 81295 [Q9H987-1] 81296 [Q9H987-2] |
PTM databases
iPTMneti | Q9H987 |
PhosphoSitePlusi | Q9H987 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166317, Expressed in cardiac ventricle and 140 other tissues |
ExpressionAtlasi | Q9H987, baseline and differential |
Genevisiblei | Q9H987, HS |
Organism-specific databases
HPAi | ENSG00000166317, Group enriched (heart muscle, skeletal muscle, tongue) |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q9H987-2]
GO - Molecular functioni
- actin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 123008, 7 interactors |
IntActi | Q9H987, 8 interactors |
MINTi | Q9H987 |
STRINGi | 9606.ENSP00000378289 |
Miscellaneous databases
RNActi | Q9H987, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 88 | PDZPROSITE-ProRule annotationAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 92 – 241 | Pro-richAdd BLAST | 150 | |
Compositional biasi | 422 – 939 | Pro-richAdd BLAST | 518 |
Sequence similaritiesi
Belongs to the synaptopodin family.Curated
Phylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00950000183054 |
HOGENOMi | CLU_007120_1_0_1 |
InParanoidi | Q9H987 |
OMAi | TTYAQKA |
OrthoDBi | 109454at2759 |
PhylomeDBi | Q9H987 |
TreeFami | TF330867 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H987-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAEEEVLVT LSGGAPWGFR LHGGAEQRKP LQVSKIRRRS QAGRAGLRER
60 70 80 90 100
DQLLAINGVS CTNLSHASAM SLIDASGNQL VLTVQRLADE GPVQSPSPHE
110 120 130 140 150
LQVLSPLSPL SPEPPGAPVP QPLQPGSLRS PPDSEAYYGE TDSDADGPAT
160 170 180 190 200
QEKPRRPRRR GPTRPTPPGA PPDEVYLSDS PAEPAPTIPG PPSQGDSRVS
210 220 230 240 250
SPSWEDGAAL QPPPAEALLL PHGPLRPGPH LIPMVGPVPH PVAEDLTTTY
260 270 280 290 300
TQKAKQAKLQ RAESLQEKSI KEAKTKCRTI ASLLTAAPNP HSKGVLMFKK
310 320 330 340 350
RRQRAKKYTL VSFGAAAGTG AEEEDGVPPT SESELDEEAF SDARSLTNQS
360 370 380 390 400
DWDSPYLDME LARAGSRASE GQGSGLGGQL SEVSGRGVQL FEQQRQRADS
410 420 430 440 450
STQELARVEP AAMLNGEGLQ SPPRAQSAPP EAAVLPPSPL PAPVASPRPF
460 470 480 490 500
QPGGGAPTPA PSIFNRSARP FTPGLQGQRP TTTSVIFRPL APKRANDSLG
510 520 530 540 550
GLSPAPPPFL SSQGPTPLPS FTSGVPSHAP VSGSPSTPRS SGPVTATSSL
560 570 580 590 600
YIPAPSRPVT PGGAPEPPAP PSAAAMTSTA SIFLSAPLRP SARPEAPAPG
610 620 630 640 650
PGAPEPPSAR EQRISVPAAR TGILQEARRR GTRKQMFRPG KEETKNSPNP
660 670 680 690 700
ELLSLVQNLD EKPRAGGAES GPEEDALSLG AEACNFMQPV GARSYKTLPH
710 720 730 740 750
VTPKTPPPMA PKTPPPMTPK TPPPVAPKPP SRGLLDGLVN GAASSAGIPE
760 770 780 790 800
PPRLQGRGGE LFAKRQSRAD RYVVEGTPGP GLGPRPRSPS PTPSLPPSWK
810 820 830 840 850
YSPNIRAPPP IAYNPLLSPF FPQAARTLPK AQSQGPRATP KQGIKALDFM
860 870 880 890 900
RHQPYQLKTA MFCFDEVPPT PGPIASGSPK TARVQEIRRF STPAPQPTAE
910 920 930 940 950
PLAPTVLAPR AATTLDEPIW RTELASAPVP SPAPPPEAPR GLGASPSSCG
960 970
FQVARPRFSA TRTGLQAHVW RPGAGHQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketU3KQD0 | U3KQD0_HUMAN | Synaptopodin 2-like protein | SYNPO2L | 115 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 748 | I → T in BAB14346 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061835 | 508 | P → H. Corresponds to variant dbSNP:rs57006992Ensembl. | 1 | |
Natural variantiVAR_019671 | 707 | P → L. Corresponds to variant dbSNP:rs3812629Ensembl. | 1 | |
Natural variantiVAR_047065 | 833 | S → Y. Corresponds to variant dbSNP:rs34163229Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011495 | 1 – 224 | Missing in isoform 2. 2 PublicationsAdd BLAST | 224 | |
Alternative sequenceiVSP_011496 | 225 – 258 | LRPGP…AKQAK → METFEPISQEPLSQASYDKA PDPVPELQDSFYAE in isoform 2. 2 PublicationsAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB188489 mRNA Translation: BAD37139.1 AK022983 mRNA Translation: BAB14346.1 AC073389 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54507.1 BC142635 mRNA Translation: AAI42636.1 |
CCDSi | CCDS44438.1 [Q9H987-1] CCDS7331.1 [Q9H987-2] |
RefSeqi | NP_001107605.1, NM_001114133.2 [Q9H987-1] NP_079151.2, NM_024875.4 [Q9H987-2] |
Genome annotation databases
Ensembli | ENST00000372873; ENSP00000361964; ENSG00000166317 [Q9H987-2] ENST00000394810; ENSP00000378289; ENSG00000166317 [Q9H987-1] |
GeneIDi | 79933 |
KEGGi | hsa:79933 |
UCSCi | uc001jus.6, human [Q9H987-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB188489 mRNA Translation: BAD37139.1 AK022983 mRNA Translation: BAB14346.1 AC073389 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54507.1 BC142635 mRNA Translation: AAI42636.1 |
CCDSi | CCDS44438.1 [Q9H987-1] CCDS7331.1 [Q9H987-2] |
RefSeqi | NP_001107605.1, NM_001114133.2 [Q9H987-1] NP_079151.2, NM_024875.4 [Q9H987-2] |
3D structure databases
SMRi | Q9H987 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123008, 7 interactors |
IntActi | Q9H987, 8 interactors |
MINTi | Q9H987 |
STRINGi | 9606.ENSP00000378289 |
PTM databases
iPTMneti | Q9H987 |
PhosphoSitePlusi | Q9H987 |
Polymorphism and mutation databases
BioMutai | SYNPO2L |
DMDMi | 212276492 |
Proteomic databases
EPDi | Q9H987 |
MassIVEi | Q9H987 |
MaxQBi | Q9H987 |
PaxDbi | Q9H987 |
PeptideAtlasi | Q9H987 |
PRIDEi | Q9H987 |
ProteomicsDBi | 81295 [Q9H987-1] 81296 [Q9H987-2] |
Protocols and materials databases
Antibodypediai | 45402, 67 antibodies |
Genome annotation databases
Ensembli | ENST00000372873; ENSP00000361964; ENSG00000166317 [Q9H987-2] ENST00000394810; ENSP00000378289; ENSG00000166317 [Q9H987-1] |
GeneIDi | 79933 |
KEGGi | hsa:79933 |
UCSCi | uc001jus.6, human [Q9H987-1] |
Organism-specific databases
CTDi | 79933 |
DisGeNETi | 79933 |
EuPathDBi | HostDB:ENSG00000166317.11 |
GeneCardsi | SYNPO2L |
HGNCi | HGNC:23532, SYNPO2L |
HPAi | ENSG00000166317, Group enriched (heart muscle, skeletal muscle, tongue) |
neXtProti | NX_Q9H987 |
OpenTargetsi | ENSG00000166317 |
PharmGKBi | PA134889033 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00950000183054 |
HOGENOMi | CLU_007120_1_0_1 |
InParanoidi | Q9H987 |
OMAi | TTYAQKA |
OrthoDBi | 109454at2759 |
PhylomeDBi | Q9H987 |
TreeFami | TF330867 |
Enzyme and pathway databases
PathwayCommonsi | Q9H987 |
Miscellaneous databases
BioGRID-ORCSi | 79933, 49 hits in 839 CRISPR screens |
ChiTaRSi | SYNPO2L, human |
GenomeRNAii | 79933 |
Pharosi | Q9H987, Tdark |
PROi | PR:Q9H987 |
RNActi | Q9H987, protein |
Gene expression databases
Bgeei | ENSG00000166317, Expressed in cardiac ventricle and 140 other tissues |
ExpressionAtlasi | Q9H987, baseline and differential |
Genevisiblei | Q9H987, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYP2L_HUMAN | |
Accessioni | Q9H987Primary (citable) accession number: Q9H987 Secondary accession number(s): A5PKV9, Q68A20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | November 4, 2008 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations