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UniProtKB - Q9H987 (SYP2L_HUMAN)

Entry version 145 (02 Dec 2020)
Sequence version 3 (04 Nov 2008)
Previous versions | rss
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Protein

Synaptopodin 2-like protein

Gene

SYNPO2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin-associated protein that may play a role in modulating actin-based shape.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H987

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptopodin 2-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNPO2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000166317.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:23532, SYNPO2L

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H987

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79933

Open Targets

More...OpenTargetsi		ENSG00000166317

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134889033

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H987, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYNPO2L

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276492

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001876751 – 977Synaptopodin 2-like proteinAdd BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei108PhosphoserineBy similarity1
Modified residuei111PhosphoserineBy similarity1
Modified residuei141PhosphothreonineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei178PhosphoserineBy similarity1
Modified residuei180PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei374PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei384PhosphoserineBy similarity1
Modified residuei386Omega-N-methylarginineBy similarity1
Modified residuei466Omega-N-methylarginineBy similarity1
Modified residuei469Omega-N-methylarginineBy similarity1
Modified residuei479Omega-N-methylarginineBy similarity1
Modified residuei670PhosphoserineBy similarity1
Modified residuei678PhosphoserineBy similarity1
Modified residuei705PhosphothreonineBy similarity1
Modified residuei713PhosphothreonineBy similarity1
Modified residuei757Omega-N-methylarginineBy similarity1
Modified residuei788PhosphoserineBy similarity1
Modified residuei790PhosphoserineBy similarity1
Modified residuei792PhosphothreonineBy similarity1
Modified residuei806Omega-N-methylarginineBy similarity1
Modified residuei826Omega-N-methylarginineBy similarity1
Modified residuei889Omega-N-methylarginineBy similarity1
Modified residuei891PhosphoserineBy similarity1
Modified residuei892PhosphothreonineBy similarity1
Modified residuei898PhosphothreonineBy similarity1
Modified residuei910Omega-N-methylarginineBy similarity1
Modified residuei921Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei921Omega-N-methylarginine; alternateBy similarity1
Modified residuei955Omega-N-methylarginineBy similarity1
Modified residuei957Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H987

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H987

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H987

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H987

PeptideAtlas

More...PeptideAtlasi		Q9H987

PRoteomics IDEntifications database

More...PRIDEi		Q9H987

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81295 [Q9H987-1]
81296 [Q9H987-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H987

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H987

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166317, Expressed in cardiac ventricle and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H987, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H987, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166317, Group enriched (heart muscle, skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123008, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q9H987, 8 interactors

Molecular INTeraction database

More...MINTi		Q9H987

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378289

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H987, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H987

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 88PDZPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 241Pro-richAdd BLAST150
Compositional biasi422 – 939Pro-richAdd BLAST518

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptopodin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1703, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183054

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007120_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H987

Identification of Orthologs from Complete Genome Data

More...OMAi		TTYAQKA

Database of Orthologous Groups

More...OrthoDBi		109454at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H987

TreeFam database of animal gene trees

More...TreeFami		TF330867

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50106, PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H987-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAEEEVLVT LSGGAPWGFR LHGGAEQRKP LQVSKIRRRS QAGRAGLRER 
        60         70         80         90        100
DQLLAINGVS CTNLSHASAM SLIDASGNQL VLTVQRLADE GPVQSPSPHE 
       110        120        130        140        150
LQVLSPLSPL SPEPPGAPVP QPLQPGSLRS PPDSEAYYGE TDSDADGPAT 
       160        170        180        190        200
QEKPRRPRRR GPTRPTPPGA PPDEVYLSDS PAEPAPTIPG PPSQGDSRVS 
       210        220        230        240        250
SPSWEDGAAL QPPPAEALLL PHGPLRPGPH LIPMVGPVPH PVAEDLTTTY 
       260        270        280        290        300
TQKAKQAKLQ RAESLQEKSI KEAKTKCRTI ASLLTAAPNP HSKGVLMFKK 
       310        320        330        340        350
RRQRAKKYTL VSFGAAAGTG AEEEDGVPPT SESELDEEAF SDARSLTNQS 
       360        370        380        390        400
DWDSPYLDME LARAGSRASE GQGSGLGGQL SEVSGRGVQL FEQQRQRADS 
       410        420        430        440        450
STQELARVEP AAMLNGEGLQ SPPRAQSAPP EAAVLPPSPL PAPVASPRPF 
       460        470        480        490        500
QPGGGAPTPA PSIFNRSARP FTPGLQGQRP TTTSVIFRPL APKRANDSLG 
       510        520        530        540        550
GLSPAPPPFL SSQGPTPLPS FTSGVPSHAP VSGSPSTPRS SGPVTATSSL 
       560        570        580        590        600
YIPAPSRPVT PGGAPEPPAP PSAAAMTSTA SIFLSAPLRP SARPEAPAPG 
       610        620        630        640        650
PGAPEPPSAR EQRISVPAAR TGILQEARRR GTRKQMFRPG KEETKNSPNP 
       660        670        680        690        700
ELLSLVQNLD EKPRAGGAES GPEEDALSLG AEACNFMQPV GARSYKTLPH 
       710        720        730        740        750
VTPKTPPPMA PKTPPPMTPK TPPPVAPKPP SRGLLDGLVN GAASSAGIPE 
       760        770        780        790        800
PPRLQGRGGE LFAKRQSRAD RYVVEGTPGP GLGPRPRSPS PTPSLPPSWK 
       810        820        830        840        850
YSPNIRAPPP IAYNPLLSPF FPQAARTLPK AQSQGPRATP KQGIKALDFM 
       860        870        880        890        900
RHQPYQLKTA MFCFDEVPPT PGPIASGSPK TARVQEIRRF STPAPQPTAE 
       910        920        930        940        950
PLAPTVLAPR AATTLDEPIW RTELASAPVP SPAPPPEAPR GLGASPSSCG 
       960        970 
FQVARPRFSA TRTGLQAHVW RPGAGHQ
Length:977
Mass (Da):102,481
Last modified:November 4, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i885B28CEE3C5B3D7
GO
Isoform 2 (identifier: Q9H987-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.
     225-258: LRPGPHLIPMVGPVPHPVAEDLTTTYTQKAKQAK → METFEPISQEPLSQASYDKAPDPVPELQDSFYAE

Show »
Length:753
Mass (Da):79,146
Checksum:i46F0797C216316B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQD0U3KQD0_HUMAN
Synaptopodin 2-like protein
SYNPO2L
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti748I → T in BAB14346 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061835508P → H. Corresponds to variant dbSNP:rs57006992Ensembl.1
Natural variantiVAR_019671707P → L. Corresponds to variant dbSNP:rs3812629Ensembl.1
Natural variantiVAR_047065833S → Y. Corresponds to variant dbSNP:rs34163229Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0114951 – 224Missing in isoform 2. 2 PublicationsAdd BLAST224
Alternative sequenceiVSP_011496225 – 258LRPGP…AKQAK → METFEPISQEPLSQASYDKA PDPVPELQDSFYAE in isoform 2. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB188489 mRNA Translation: BAD37139.1
AK022983 mRNA Translation: BAB14346.1
AC073389 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54507.1
BC142635 mRNA Translation: AAI42636.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44438.1 [Q9H987-1]
CCDS7331.1 [Q9H987-2]

NCBI Reference Sequences

More...RefSeqi		NP_001107605.1, NM_001114133.2 [Q9H987-1]
NP_079151.2, NM_024875.4 [Q9H987-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372873; ENSP00000361964; ENSG00000166317 [Q9H987-2]
ENST00000394810; ENSP00000378289; ENSG00000166317 [Q9H987-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79933

UCSC genome browser

More...UCSCi		uc001jus.6, human [Q9H987-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB188489 mRNA Translation: BAD37139.1
AK022983 mRNA Translation: BAB14346.1
AC073389 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54507.1
BC142635 mRNA Translation: AAI42636.1
CCDSiCCDS44438.1 [Q9H987-1]
CCDS7331.1 [Q9H987-2]
RefSeqiNP_001107605.1, NM_001114133.2 [Q9H987-1]
NP_079151.2, NM_024875.4 [Q9H987-2]

3D structure databases

SMRiQ9H987
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123008, 7 interactors
IntActiQ9H987, 8 interactors
MINTiQ9H987
STRINGi9606.ENSP00000378289

PTM databases

iPTMnetiQ9H987
PhosphoSitePlusiQ9H987

Polymorphism and mutation databases

BioMutaiSYNPO2L
DMDMi212276492

Proteomic databases

EPDiQ9H987
MassIVEiQ9H987
MaxQBiQ9H987
PaxDbiQ9H987
PeptideAtlasiQ9H987
PRIDEiQ9H987
ProteomicsDBi81295 [Q9H987-1]
81296 [Q9H987-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45402, 67 antibodies

Genome annotation databases

EnsembliENST00000372873; ENSP00000361964; ENSG00000166317 [Q9H987-2]
ENST00000394810; ENSP00000378289; ENSG00000166317 [Q9H987-1]
GeneIDi79933
KEGGihsa:79933
UCSCiuc001jus.6, human [Q9H987-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79933
DisGeNETi79933
EuPathDBiHostDB:ENSG00000166317.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYNPO2L
HGNCiHGNC:23532, SYNPO2L
HPAiENSG00000166317, Group enriched (heart muscle, skeletal muscle, tongue)
neXtProtiNX_Q9H987
OpenTargetsiENSG00000166317
PharmGKBiPA134889033

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1703, Eukaryota
GeneTreeiENSGT00950000183054
HOGENOMiCLU_007120_1_0_1
InParanoidiQ9H987
OMAiTTYAQKA
OrthoDBi109454at2759
PhylomeDBiQ9H987
TreeFamiTF330867

Enzyme and pathway databases

PathwayCommonsiQ9H987

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79933, 49 hits in 839 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYNPO2L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79933
PharosiQ9H987, Tdark

Protein Ontology

More...PROi		PR:Q9H987
RNActiQ9H987, protein

Gene expression databases

BgeeiENSG00000166317, Expressed in cardiac ventricle and 140 other tissues
ExpressionAtlasiQ9H987, baseline and differential
GenevisibleiQ9H987, HS

Family and domain databases

Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYP2L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H987
Secondary accession number(s): A5PKV9, Q68A20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 4, 2008
Last modified: December 2, 2020
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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