Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

WD repeat-containing protein 54

Gene

WDR54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H977

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 54Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR54Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25770 WDR54

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H977

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi107W → A: Decreases cross-linking. 1 Publication1
Mutagenesisi196W → A: Slightly decreases cross-linking. 1 Publication1
Mutagenesisi221W → A: Decreases cross-linking. 1 Publication1
Mutagenesisi279W → A: Abolishes cross-linking. Decreases ERK signaling pathway activation. Abolishes inhibition of EGF receptor degradation after EGF stimulation. 1 Publication1
Mutagenesisi280K → R: Decreases cross-linking. Abolishes ubiquitination. 1 Publication1
Mutagenesisi304Q → A: No effect on cross-linking. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000005448

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670589

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H977

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR54

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761551

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514151 – 334WD repeat-containing protein 54Add BLAST334

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cross-linked to tightly form both dimers and trimers by TGM2. Cross-linking enhances the activation of EGF receptor-mediated signaling pathway (PubMed:30458214). Cross-linking is inhibited by EGF (PubMed:30458214).1 Publication
Ubiquitinated. EGF increases ubiquitination.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H977

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H977

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H977

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H977

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H977

PeptideAtlas

More...
PeptideAtlasi
Q9H977

PRoteomics IDEntifications database

More...
PRIDEi
Q9H977

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
7498
81290

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H977

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H977

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epithelial cells (at protein level) (PubMed:29987896). Isoform 3 expression is highly increased in colorectal cancer cells (PubMed:29987896).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005448 Expressed in 163 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H977 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H977 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043257
HPA053558

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and homotrimer; forms tight forms of dimers and trimers.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123853, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H977, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000006526

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati6 – 47WD 1Add BLAST42
Repeati58 – 99WD 2Add BLAST42
Repeati105 – 147WD 3Add BLAST43
Repeati155 – 198WD 4Add BLAST44
Repeati243 – 281WD 5Add BLAST39
Repeati289 – 333WD 6Add BLAST45

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

WD6 repeat is required for cross-linking by TGM2.1 Publication

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHHY Eukaryota
ENOG410XS69 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014530

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007356

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H977

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLWQGIV

Database of Orthologous Groups

More...
OrthoDBi
839593at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H977

TreeFam database of animal gene trees

More...
TreeFami
TF329316

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H977-1) [UniParc]FASTAAdd to basket
Also known as: b2 Publications

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRWERSIPL RGSAAALCNN LSVLQLPARN LTYFGVVHGP SAQLLSAAPE
60 70 80 90 100
GVPLAQRQLH AKEGAGVSPP LITQVHWCVL PFRVLLVLTS HRGIQMYESN
110 120 130 140 150
GYTMVYWHAL DSGDASPVQA VFARGIAASG HFICVGTWSG RVLVFDIPAK
160 170 180 190 200
GPNIVLSEEL AGHQMPITDI ATEPAQGQDC VADMVTADDS GLLCVWRSGP
210 220 230 240 250
EFTLLTRIPG FGVPCPSVQL WQGIIAAGYG NGQVHLYEAT TGNLHVQINA
260 270 280 290 300
HARAICALDL ASEVGKLLSA GEDTFVHIWK LSRNPESGYI EVEHCHGECV
310 320 330
ADTQLCGARF CDSSGNSFAV TGYDLAEIRR FSSV
Length:334
Mass (Da):35,891
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0B10168F9C84D34
GO
Isoform 3 (identifier: Q9H977-3) [UniParc]FASTAAdd to basket
Also known as: c2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MFRWERSIPL...GAGVSPPLIT → MVAADLEGPYEPGVRRADLGL
     292-296: VEHCH → ATPLL
     297-334: Missing.

Show »
Length:244
Mass (Da):26,249
Checksum:iC6341C27B40C8BDE
GO
Isoform 2 (identifier: Q9H977-4) [UniParc]FASTAAdd to basket
Also known as: a2 Publications

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVAADLEGPYEPGVRM

Show »
Length:349
Mass (Da):37,477
Checksum:i26467F17710A4C61
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J016C9J016_HUMAN
WD repeat-containing protein 54
WDR54
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti243N → D in BAD96416 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0602921 – 73MFRWE…PPLIT → MVAADLEGPYEPGVRRADLG L in isoform 3. Add BLAST73
Alternative sequenceiVSP_0602931M → MVAADLEGPYEPGVRM in isoform 2. 1
Alternative sequenceiVSP_060294292 – 296VEHCH → ATPLL in isoform 3. 5
Alternative sequenceiVSP_060295297 – 334Missing in isoform 3. Add BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023015 mRNA Translation: BAB14358.1
AK222696 mRNA Translation: BAD96416.1
CH471053 Genomic DNA Translation: EAW99677.1
CH471053 Genomic DNA Translation: EAW99680.1
AC005041 Genomic DNA No translation available.
BC051848 mRNA Translation: AAH51848.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1940.1 [Q9H977-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001307752.1, NM_001320823.1 [Q9H977-4]
NP_001307753.1, NM_001320824.1 [Q9H977-1]
NP_001307754.1, NM_001320825.1 [Q9H977-3]
NP_115494.1, NM_032118.3 [Q9H977-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000348227; ENSP00000006526; ENSG00000005448

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84058

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84058

UCSC genome browser

More...
UCSCi
uc002slb.4 human [Q9H977-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023015 mRNA Translation: BAB14358.1
AK222696 mRNA Translation: BAD96416.1
CH471053 Genomic DNA Translation: EAW99677.1
CH471053 Genomic DNA Translation: EAW99680.1
AC005041 Genomic DNA No translation available.
BC051848 mRNA Translation: AAH51848.1
CCDSiCCDS1940.1 [Q9H977-1]
RefSeqiNP_001307752.1, NM_001320823.1 [Q9H977-4]
NP_001307753.1, NM_001320824.1 [Q9H977-1]
NP_001307754.1, NM_001320825.1 [Q9H977-3]
NP_115494.1, NM_032118.3 [Q9H977-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123853, 33 interactors
IntActiQ9H977, 23 interactors
STRINGi9606.ENSP00000006526

PTM databases

iPTMnetiQ9H977
PhosphoSitePlusiQ9H977

Polymorphism and mutation databases

BioMutaiWDR54
DMDMi74761551

Proteomic databases

EPDiQ9H977
jPOSTiQ9H977
MassIVEiQ9H977
MaxQBiQ9H977
PaxDbiQ9H977
PeptideAtlasiQ9H977
PRIDEiQ9H977
ProteomicsDBi7498
81290

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84058

Genome annotation databases

EnsembliENST00000348227; ENSP00000006526; ENSG00000005448
GeneIDi84058
KEGGihsa:84058
UCSCiuc002slb.4 human [Q9H977-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84058

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR54
HGNCiHGNC:25770 WDR54
HPAiHPA043257
HPA053558
neXtProtiNX_Q9H977
OpenTargetsiENSG00000005448
PharmGKBiPA142670589

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHHY Eukaryota
ENOG410XS69 LUCA
GeneTreeiENSGT00390000014530
HOGENOMiHOG000007356
InParanoidiQ9H977
OMAiQLWQGIV
OrthoDBi839593at2759
PhylomeDBiQ9H977
TreeFamiTF329316

Enzyme and pathway databases

SignaLinkiQ9H977

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WDR54 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84058
PharosiQ9H977

Protein Ontology

More...
PROi
PR:Q9H977

Gene expression databases

BgeeiENSG00000005448 Expressed in 163 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ9H977 baseline and differential
GenevisibleiQ9H977 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR54_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H977
Secondary accession number(s): B9A049
, D6W5I3, Q53H85, Q86V45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again