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Protein

WD repeat-containing protein 54

Gene

WDR54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9H977

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 54
Gene namesi
Name:WDR54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000005448.16
HGNCiHGNC:25770 WDR54
neXtProtiNX_Q9H977

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000005448
PharmGKBiPA142670589

Polymorphism and mutation databases

BioMutaiWDR54
DMDMi74761551

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514151 – 334WD repeat-containing protein 54Add BLAST334

Proteomic databases

EPDiQ9H977
MaxQBiQ9H977
PaxDbiQ9H977
PeptideAtlasiQ9H977
PRIDEiQ9H977
ProteomicsDBi81290

PTM databases

iPTMnetiQ9H977
PhosphoSitePlusiQ9H977

Expressioni

Gene expression databases

BgeeiENSG00000005448 Expressed in 163 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_WDR54
ExpressionAtlasiQ9H977 baseline and differential
GenevisibleiQ9H977 HS

Organism-specific databases

HPAiHPA043257
HPA053558

Interactioni

Protein-protein interaction databases

BioGridi123853, 33 interactors
IntActiQ9H977, 2 interactors
STRINGi9606.ENSP00000006526

Structurei

3D structure databases

ProteinModelPortaliQ9H977
SMRiQ9H977
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 47WD 1Add BLAST42
Repeati58 – 99WD 2Add BLAST42
Repeati105 – 147WD 3Add BLAST43
Repeati155 – 198WD 4Add BLAST44
Repeati243 – 281WD 5Add BLAST39
Repeati289 – 333WD 6Add BLAST45

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IHHY Eukaryota
ENOG410XS69 LUCA
GeneTreeiENSGT00390000014530
HOGENOMiHOG000007356
HOVERGENiHBG061221
InParanoidiQ9H977
OMAiHVQISAH
OrthoDBiEOG091G0FN3
PhylomeDBiQ9H977
TreeFamiTF329316

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H977-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRWERSIPL RGSAAALCNN LSVLQLPARN LTYFGVVHGP SAQLLSAAPE
60 70 80 90 100
GVPLAQRQLH AKEGAGVSPP LITQVHWCVL PFRVLLVLTS HRGIQMYESN
110 120 130 140 150
GYTMVYWHAL DSGDASPVQA VFARGIAASG HFICVGTWSG RVLVFDIPAK
160 170 180 190 200
GPNIVLSEEL AGHQMPITDI ATEPAQGQDC VADMVTADDS GLLCVWRSGP
210 220 230 240 250
EFTLLTRIPG FGVPCPSVQL WQGIIAAGYG NGQVHLYEAT TGNLHVQINA
260 270 280 290 300
HARAICALDL ASEVGKLLSA GEDTFVHIWK LSRNPESGYI EVEHCHGECV
310 320 330
ADTQLCGARF CDSSGNSFAV TGYDLAEIRR FSSV
Length:334
Mass (Da):35,891
Last modified:March 1, 2001 - v1
Checksum:iF0B10168F9C84D34
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9A049B9A049_HUMAN
WD repeat-containing protein 54
WDR54
244Annotation score:
C9J016C9J016_HUMAN
WD repeat-containing protein 54
WDR54
162Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243N → D in BAD96416 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023015 mRNA Translation: BAB14358.1
AK222696 mRNA Translation: BAD96416.1
CH471053 Genomic DNA Translation: EAW99677.1
CH471053 Genomic DNA Translation: EAW99680.1
BC051848 mRNA Translation: AAH51848.1
CCDSiCCDS1940.1
RefSeqiNP_001307752.1, NM_001320823.1
NP_001307753.1, NM_001320824.1
NP_001307754.1, NM_001320825.1
NP_115494.1, NM_032118.3
UniGeneiHs.643480

Genome annotation databases

EnsembliENST00000348227; ENSP00000006526; ENSG00000005448
GeneIDi84058
KEGGihsa:84058
UCSCiuc002slb.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023015 mRNA Translation: BAB14358.1
AK222696 mRNA Translation: BAD96416.1
CH471053 Genomic DNA Translation: EAW99677.1
CH471053 Genomic DNA Translation: EAW99680.1
BC051848 mRNA Translation: AAH51848.1
CCDSiCCDS1940.1
RefSeqiNP_001307752.1, NM_001320823.1
NP_001307753.1, NM_001320824.1
NP_001307754.1, NM_001320825.1
NP_115494.1, NM_032118.3
UniGeneiHs.643480

3D structure databases

ProteinModelPortaliQ9H977
SMRiQ9H977
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123853, 33 interactors
IntActiQ9H977, 2 interactors
STRINGi9606.ENSP00000006526

PTM databases

iPTMnetiQ9H977
PhosphoSitePlusiQ9H977

Polymorphism and mutation databases

BioMutaiWDR54
DMDMi74761551

Proteomic databases

EPDiQ9H977
MaxQBiQ9H977
PaxDbiQ9H977
PeptideAtlasiQ9H977
PRIDEiQ9H977
ProteomicsDBi81290

Protocols and materials databases

DNASUi84058
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348227; ENSP00000006526; ENSG00000005448
GeneIDi84058
KEGGihsa:84058
UCSCiuc002slb.4 human

Organism-specific databases

CTDi84058
EuPathDBiHostDB:ENSG00000005448.16
GeneCardsiWDR54
HGNCiHGNC:25770 WDR54
HPAiHPA043257
HPA053558
neXtProtiNX_Q9H977
OpenTargetsiENSG00000005448
PharmGKBiPA142670589
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHHY Eukaryota
ENOG410XS69 LUCA
GeneTreeiENSGT00390000014530
HOGENOMiHOG000007356
HOVERGENiHBG061221
InParanoidiQ9H977
OMAiHVQISAH
OrthoDBiEOG091G0FN3
PhylomeDBiQ9H977
TreeFamiTF329316

Enzyme and pathway databases

SignaLinkiQ9H977

Miscellaneous databases

ChiTaRSiWDR54 human
GenomeRNAii84058
PROiPR:Q9H977

Gene expression databases

BgeeiENSG00000005448 Expressed in 163 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_WDR54
ExpressionAtlasiQ9H977 baseline and differential
GenevisibleiQ9H977 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR54_HUMAN
AccessioniPrimary (citable) accession number: Q9H977
Secondary accession number(s): D6W5I3, Q53H85, Q86V45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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