UniProtKB - Q9H972 (CN093_HUMAN)
Protein
Uncharacterized protein C14orf93
Gene
C14orf93
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Uncharacterized protein C14orf93 |
Gene namesi | Name:C14orf93 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20162 C14orf93 |
neXtProti | NX_Q9H972 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 60686 |
OpenTargetsi | ENSG00000100802 |
PharmGKBi | PA134982493 |
Miscellaneous databases
Pharosi | Q9H972 |
Polymorphism and mutation databases
BioMutai | C14orf93 |
DMDMi | 33301115 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000020950 | 18 – 538 | Uncharacterized protein C14orf93Add BLAST | 521 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 128 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 221 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 224 | PhosphoserineCombined sources | 1 | |
Modified residuei | 285 | PhosphoserineCombined sources | 1 | |
Modified residuei | 428 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9H972 |
MassIVEi | Q9H972 |
MaxQBi | Q9H972 |
PaxDbi | Q9H972 |
PeptideAtlasi | Q9H972 |
PRIDEi | Q9H972 |
ProteomicsDBi | 81287 [Q9H972-1] 81288 [Q9H972-2] |
PTM databases
iPTMneti | Q9H972 |
PhosphoSitePlusi | Q9H972 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100802 Expressed in 174 organ(s), highest expression level in blood |
ExpressionAtlasi | Q9H972 baseline and differential |
Genevisiblei | Q9H972 HS |
Organism-specific databases
HPAi | HPA002569 |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Q9Y605 | 3 | EBI-10329620,EBI-995714 |
Protein-protein interaction databases
BioGridi | 121959, 6 interactors |
IntActi | Q9H972, 3 interactors |
MINTi | Q9H972 |
STRINGi | 9606.ENSP00000299088 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 19 – 24 | Poly-Cys | 6 | |
Compositional biasi | 257 – 260 | Poly-Ala | 4 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410II26 Eukaryota ENOG410YVIZ LUCA |
GeneTreei | ENSGT00390000012708 |
InParanoidi | Q9H972 |
OMAi | FDQSHKT |
OrthoDBi | 961389at2759 |
PhylomeDBi | Q9H972 |
TreeFami | TF336941 |
Family and domain databases
InterProi | View protein in InterPro IPR028101 DUF4616 |
PANTHERi | PTHR14375 PTHR14375, 1 hit |
Pfami | View protein in Pfam PF15394 DUF4616, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H972-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSFSATILFS PPSGSEARCC CCACKSETNG GNTGSQGGNP PPSTPITVTG
60 70 80 90 100
HGLAVQSSEQ LLHVIYQRVD KAVGLAEAAL GLARANNELL KRLQEEVGDL
110 120 130 140 150
RQGKVSIPDE DGESRAHSSP PEEPGPLKES PGEAFKALSA VEEECDSVGS
160 170 180 190 200
GVQVVIEELR QLGAASVGPG PLGFPATQRD MRLPGCTLAA SEAAPLLNPL
210 220 230 240 250
VDDYVASEGA VQRVLVPAYA KQLSPATQLA IQRATPETGP ENGTKLPPPR
260 270 280 290 300
PEDMLNAAAA LDSALEESGP GSTGELRHSL GLTVSPCRTR GSGQKNSRRK
310 320 330 340 350
RDLVLSKLVH NVHNHITNDK RFNGSESIKS SWNISVVKFL LEKLKQELVT
360 370 380 390 400
SPHNYTDKEL KGACVAYFLT KRREYRNSLN PFKGLKEKEE KKLRSRRYRL
410 420 430 440 450
FANRSSIMRH FGPEDQRLWN DVTEELMSDE EDSLNEPGVW VARPPRFRAQ
460 470 480 490 500
RLTELCYHLD ANSKHGTKAN RVYGPPSDRL PSAEAQLLPP ELYNPNFQEE
510 520 530
EDEGGDENAP GSPSFDQPHK TCCPDLNSFI EIKVEKDE
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2P0 | G3V2P0_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 199 | Annotation score: | ||
G3V4W6 | G3V4W6_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 136 | Annotation score: | ||
J3KPV9 | J3KPV9_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 208 | Annotation score: | ||
A0A0C4DFZ6 | A0A0C4DFZ6_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 358 | Annotation score: | ||
G5E9D9 | G5E9D9_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 126 | Annotation score: | ||
G3V4L9 | G3V4L9_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 49 | Annotation score: | ||
G3V396 | G3V396_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 106 | Annotation score: | ||
G3V2U2 | G3V2U2_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 78 | Annotation score: | ||
G3V3W0 | G3V3W0_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 83 | Annotation score: | ||
G3V4F1 | G3V4F1_HUMAN | Uncharacterized protein C14orf93 | C14orf93 | 11 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 394 | R → L in AAH14299 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 438 | G → S in BAB13988 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050875 | 190 | A → V. Corresponds to variant dbSNP:rs3829409Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007850 | 438 – 477 | Missing in isoform 2. 1 PublicationAdd BLAST | 40 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000299088; ENSP00000299088; ENSG00000100802 [Q9H972-1] ENST00000341470; ENSP00000341353; ENSG00000100802 [Q9H972-2] ENST00000397379; ENSP00000380535; ENSG00000100802 [Q9H972-1] ENST00000397382; ENSP00000380538; ENSG00000100802 [Q9H972-1] |
GeneIDi | 60686 |
KEGGi | hsa:60686 |
UCSCi | uc001wia.6 human [Q9H972-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 121959, 6 interactors |
IntActi | Q9H972, 3 interactors |
MINTi | Q9H972 |
STRINGi | 9606.ENSP00000299088 |
PTM databases
iPTMneti | Q9H972 |
PhosphoSitePlusi | Q9H972 |
Polymorphism and mutation databases
BioMutai | C14orf93 |
DMDMi | 33301115 |
Proteomic databases
jPOSTi | Q9H972 |
MassIVEi | Q9H972 |
MaxQBi | Q9H972 |
PaxDbi | Q9H972 |
PeptideAtlasi | Q9H972 |
PRIDEi | Q9H972 |
ProteomicsDBi | 81287 [Q9H972-1] 81288 [Q9H972-2] |
Genome annotation databases
Ensembli | ENST00000299088; ENSP00000299088; ENSG00000100802 [Q9H972-1] ENST00000341470; ENSP00000341353; ENSG00000100802 [Q9H972-2] ENST00000397379; ENSP00000380535; ENSG00000100802 [Q9H972-1] ENST00000397382; ENSP00000380538; ENSG00000100802 [Q9H972-1] |
GeneIDi | 60686 |
KEGGi | hsa:60686 |
UCSCi | uc001wia.6 human [Q9H972-1] |
Organism-specific databases
CTDi | 60686 |
DisGeNETi | 60686 |
GeneCardsi | C14orf93 |
HGNCi | HGNC:20162 C14orf93 |
HPAi | HPA002569 |
neXtProti | NX_Q9H972 |
OpenTargetsi | ENSG00000100802 |
PharmGKBi | PA134982493 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410II26 Eukaryota ENOG410YVIZ LUCA |
GeneTreei | ENSGT00390000012708 |
InParanoidi | Q9H972 |
OMAi | FDQSHKT |
OrthoDBi | 961389at2759 |
PhylomeDBi | Q9H972 |
TreeFami | TF336941 |
Miscellaneous databases
ChiTaRSi | C14orf93 human |
GenomeRNAii | 60686 |
Pharosi | Q9H972 |
PROi | PR:Q9H972 |
Gene expression databases
Bgeei | ENSG00000100802 Expressed in 174 organ(s), highest expression level in blood |
ExpressionAtlasi | Q9H972 baseline and differential |
Genevisiblei | Q9H972 HS |
Family and domain databases
InterProi | View protein in InterPro IPR028101 DUF4616 |
PANTHERi | PTHR14375 PTHR14375, 1 hit |
Pfami | View protein in Pfam PF15394 DUF4616, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CN093_HUMAN | |
Accessioni | Q9H972Primary (citable) accession number: Q9H972 Secondary accession number(s): B7WP03 Q9HA68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | September 18, 2019 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations