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Protein

Proline-serine-threonine phosphatase-interacting protein 2

Gene

PSTPIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • cytoskeletal protein binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-serine-threonine phosphatase-interacting protein 2
Short name:
PEST phosphatase-interacting protein 2
Gene namesi
Name:PSTPIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000152229.18
HGNCiHGNC:9581 PSTPIP2
MIMi616046 gene
neXtProtiNX_Q9H939

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9050
OpenTargetsiENSG00000152229
PharmGKBiPA33932

Polymorphism and mutation databases

BioMutaiPSTPIP2
DMDMi294862539

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585411 – 334Proline-serine-threonine phosphatase-interacting protein 2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323PhosphotyrosineBy similarity1
Modified residuei329PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H939
MaxQBiQ9H939
PaxDbiQ9H939
PeptideAtlasiQ9H939
PRIDEiQ9H939
ProteomicsDBi81278
81279 [Q9H939-2]

PTM databases

iPTMnetiQ9H939
PhosphoSitePlusiQ9H939

Expressioni

Gene expression databases

BgeeiENSG00000152229 Expressed in 146 organ(s), highest expression level in spleen
CleanExiHS_PSTPIP2
ExpressionAtlasiQ9H939 baseline and differential
GenevisibleiQ9H939 HS

Organism-specific databases

HPAiHPA040923
HPA040944

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114512, 9 interactors
IntActiQ9H939, 5 interactors
MINTiQ9H939
STRINGi9606.ENSP00000387261

Structurei

3D structure databases

ProteinModelPortaliQ9H939
SMRiQ9H939
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 264F-BARPROSITE-ProRule annotationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili66 – 166Sequence analysisAdd BLAST101

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IU8M Eukaryota
ENOG411036U LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000294218
HOVERGENiHBG052960
InParanoidiQ9H939
KOiK20124
OMAiCRDKEEA
OrthoDBiEOG091G09F9
PhylomeDBiQ9H939
TreeFamiTF313677

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030106 PSTPIP2
PANTHERiPTHR23065:SF9 PTHR23065:SF9, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H939-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE
60 70 80 90 100
RYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE
110 120 130 140 150
EARKMEEFRE KQKLQRKKTE LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD
160 170 180 190 200
KDEAEQAVSR SANLVNPKQQ EKLFVKLATS KTAVEDSDKA YMLHIGTLDK
210 220 230 240 250
VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ QCVTSDEMYE
260 270 280 290 300
QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA
310 320 330
TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ
Length:334
Mass (Da):38,858
Last modified:April 20, 2010 - v4
Checksum:iDD7DC17EC3F6E165
GO
Isoform 2 (identifier: Q9H939-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):36,446
Checksum:i366C0F8B5A1CA272
GO

Sequence cautioni

The sequence BAB14404 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284Y → H in BAB14404 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059708322N → D. Corresponds to variant dbSNP:rs2276199Ensembl.1
Natural variantiVAR_059709322N → S. Corresponds to variant dbSNP:rs16978507Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004070248 – 334MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012569 Genomic DNA No translation available.
AC090355 Genomic DNA No translation available.
BC035395 mRNA Translation: AAH35395.1
AK023100 mRNA Translation: BAB14404.1 Different initiation.
CCDSiCCDS32820.2 [Q9H939-1]
RefSeqiNP_077748.3, NM_024430.3 [Q9H939-1]
UniGeneiHs.567384

Genome annotation databases

EnsembliENST00000409746; ENSP00000387261; ENSG00000152229 [Q9H939-1]
ENST00000589328; ENSP00000468622; ENSG00000152229 [Q9H939-2]
GeneIDi9050
KEGGihsa:9050
UCSCiuc002lbp.5 human [Q9H939-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012569 Genomic DNA No translation available.
AC090355 Genomic DNA No translation available.
BC035395 mRNA Translation: AAH35395.1
AK023100 mRNA Translation: BAB14404.1 Different initiation.
CCDSiCCDS32820.2 [Q9H939-1]
RefSeqiNP_077748.3, NM_024430.3 [Q9H939-1]
UniGeneiHs.567384

3D structure databases

ProteinModelPortaliQ9H939
SMRiQ9H939
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114512, 9 interactors
IntActiQ9H939, 5 interactors
MINTiQ9H939
STRINGi9606.ENSP00000387261

PTM databases

iPTMnetiQ9H939
PhosphoSitePlusiQ9H939

Polymorphism and mutation databases

BioMutaiPSTPIP2
DMDMi294862539

Proteomic databases

EPDiQ9H939
MaxQBiQ9H939
PaxDbiQ9H939
PeptideAtlasiQ9H939
PRIDEiQ9H939
ProteomicsDBi81278
81279 [Q9H939-2]

Protocols and materials databases

DNASUi9050
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409746; ENSP00000387261; ENSG00000152229 [Q9H939-1]
ENST00000589328; ENSP00000468622; ENSG00000152229 [Q9H939-2]
GeneIDi9050
KEGGihsa:9050
UCSCiuc002lbp.5 human [Q9H939-1]

Organism-specific databases

CTDi9050
DisGeNETi9050
EuPathDBiHostDB:ENSG00000152229.18
GeneCardsiPSTPIP2
H-InvDBiHIX0014425
HGNCiHGNC:9581 PSTPIP2
HPAiHPA040923
HPA040944
MIMi616046 gene
neXtProtiNX_Q9H939
OpenTargetsiENSG00000152229
PharmGKBiPA33932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IU8M Eukaryota
ENOG411036U LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000294218
HOVERGENiHBG052960
InParanoidiQ9H939
KOiK20124
OMAiCRDKEEA
OrthoDBiEOG091G09F9
PhylomeDBiQ9H939
TreeFamiTF313677

Miscellaneous databases

ChiTaRSiPSTPIP2 human
GeneWikiiPSTPIP2
GenomeRNAii9050
PROiPR:Q9H939
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152229 Expressed in 146 organ(s), highest expression level in spleen
CleanExiHS_PSTPIP2
ExpressionAtlasiQ9H939 baseline and differential
GenevisibleiQ9H939 HS

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030106 PSTPIP2
PANTHERiPTHR23065:SF9 PTHR23065:SF9, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 138 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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