UniProtKB - Q9H939 (PPIP2_HUMAN)
Protein
Proline-serine-threonine phosphatase-interacting protein 2
Gene
PSTPIP2
Organism
Homo sapiens (Human)
Status
Functioni
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).By similarity
GO - Molecular functioni
- actin filament binding Source: GO_Central
- cytoskeletal protein binding Source: GO_Central
GO - Biological processi
- actin filament polymerization Source: GO_Central
- cell migration Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9H939 |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-serine-threonine phosphatase-interacting protein 2Short name: PEST phosphatase-interacting protein 2 |
Gene namesi | Name:PSTPIP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9581, PSTPIP2 |
MIMi | 616046, gene |
neXtProti | NX_Q9H939 |
VEuPathDBi | HostDB:ENSG00000152229.18 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- Membrane By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- actin filament Source: GO_Central
- cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: Ensembl
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 9050 |
OpenTargetsi | ENSG00000152229 |
PharmGKBi | PA33932 |
Miscellaneous databases
Pharosi | Q9H939, Tbio |
Genetic variation databases
BioMutai | PSTPIP2 |
DMDMi | 294862539 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058541 | 1 – 334 | Proline-serine-threonine phosphatase-interacting protein 2Add BLAST | 334 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 323 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 329 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Phosphorylated on tyrosine.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H939 |
jPOSTi | Q9H939 |
MassIVEi | Q9H939 |
MaxQBi | Q9H939 |
PaxDbi | Q9H939 |
PeptideAtlasi | Q9H939 |
PRIDEi | Q9H939 |
ProteomicsDBi | 81278 [Q9H939-1] 81279 [Q9H939-2] |
PTM databases
iPTMneti | Q9H939 |
PhosphoSitePlusi | Q9H939 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152229, Expressed in spleen and 164 other tissues |
ExpressionAtlasi | Q9H939, baseline and differential |
Genevisiblei | Q9H939, HS |
Organism-specific databases
HPAi | ENSG00000152229, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
Interactioni
GO - Molecular functioni
- actin filament binding Source: GO_Central
- cytoskeletal protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114512, 12 interactors |
IntActi | Q9H939, 10 interactors |
MINTi | Q9H939 |
STRINGi | 9606.ENSP00000387261 |
Miscellaneous databases
RNActi | Q9H939, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 264 | F-BARPROSITE-ProRule annotationAdd BLAST | 261 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 66 – 166 | Sequence analysisAdd BLAST | 101 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2398, Eukaryota |
GeneTreei | ENSGT00940000158788 |
HOGENOMi | CLU_038196_1_1_1 |
InParanoidi | Q9H939 |
OMAi | AYMLHIN |
PhylomeDBi | Q9H939 |
TreeFami | TF313677 |
Family and domain databases
CDDi | cd07672, F-BAR_PSTPIP2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030106, PSTPIP2 IPR042694, PSTPIP2_F-BAR |
PANTHERi | PTHR23065:SF9, PTHR23065:SF9, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9H939-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE
60 70 80 90 100
RYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE
110 120 130 140 150
EARKMEEFRE KQKLQRKKTE LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD
160 170 180 190 200
KDEAEQAVSR SANLVNPKQQ EKLFVKLATS KTAVEDSDKA YMLHIGTLDK
210 220 230 240 250
VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ QCVTSDEMYE
260 270 280 290 300
QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA
310 320 330
TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ
Sequence cautioni
The sequence BAB14404 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 284 | Y → H in BAB14404 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059708 | 322 | N → D. Corresponds to variant dbSNP:rs2276199Ensembl. | 1 | |
Natural variantiVAR_059709 | 322 | N → S. Corresponds to variant dbSNP:rs16978507Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004070 | 248 – 334 | MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2. 1 PublicationAdd BLAST | 87 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012569 Genomic DNA No translation available. AC090355 Genomic DNA No translation available. BC035395 mRNA Translation: AAH35395.1 AK023100 mRNA Translation: BAB14404.1 Different initiation. |
CCDSi | CCDS32820.2 [Q9H939-1] |
RefSeqi | NP_077748.3, NM_024430.3 [Q9H939-1] |
Genome annotation databases
Ensembli | ENST00000409746; ENSP00000387261; ENSG00000152229 [Q9H939-1] ENST00000589328; ENSP00000468622; ENSG00000152229 [Q9H939-2] |
GeneIDi | 9050 |
KEGGi | hsa:9050 |
UCSCi | uc002lbp.5, human [Q9H939-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC012569 Genomic DNA No translation available. AC090355 Genomic DNA No translation available. BC035395 mRNA Translation: AAH35395.1 AK023100 mRNA Translation: BAB14404.1 Different initiation. |
CCDSi | CCDS32820.2 [Q9H939-1] |
RefSeqi | NP_077748.3, NM_024430.3 [Q9H939-1] |
3D structure databases
SMRi | Q9H939 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114512, 12 interactors |
IntActi | Q9H939, 10 interactors |
MINTi | Q9H939 |
STRINGi | 9606.ENSP00000387261 |
PTM databases
iPTMneti | Q9H939 |
PhosphoSitePlusi | Q9H939 |
Genetic variation databases
BioMutai | PSTPIP2 |
DMDMi | 294862539 |
Proteomic databases
EPDi | Q9H939 |
jPOSTi | Q9H939 |
MassIVEi | Q9H939 |
MaxQBi | Q9H939 |
PaxDbi | Q9H939 |
PeptideAtlasi | Q9H939 |
PRIDEi | Q9H939 |
ProteomicsDBi | 81278 [Q9H939-1] 81279 [Q9H939-2] |
Protocols and materials databases
Antibodypediai | 22437, 83 antibodies |
DNASUi | 9050 |
Genome annotation databases
Ensembli | ENST00000409746; ENSP00000387261; ENSG00000152229 [Q9H939-1] ENST00000589328; ENSP00000468622; ENSG00000152229 [Q9H939-2] |
GeneIDi | 9050 |
KEGGi | hsa:9050 |
UCSCi | uc002lbp.5, human [Q9H939-1] |
Organism-specific databases
CTDi | 9050 |
DisGeNETi | 9050 |
GeneCardsi | PSTPIP2 |
HGNCi | HGNC:9581, PSTPIP2 |
HPAi | ENSG00000152229, Tissue enhanced (blood, bone marrow, lymphoid tissue) |
MIMi | 616046, gene |
neXtProti | NX_Q9H939 |
OpenTargetsi | ENSG00000152229 |
PharmGKBi | PA33932 |
VEuPathDBi | HostDB:ENSG00000152229.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2398, Eukaryota |
GeneTreei | ENSGT00940000158788 |
HOGENOMi | CLU_038196_1_1_1 |
InParanoidi | Q9H939 |
OMAi | AYMLHIN |
PhylomeDBi | Q9H939 |
TreeFami | TF313677 |
Enzyme and pathway databases
PathwayCommonsi | Q9H939 |
Miscellaneous databases
BioGRID-ORCSi | 9050, 2 hits in 874 CRISPR screens |
ChiTaRSi | PSTPIP2, human |
GeneWikii | PSTPIP2 |
GenomeRNAii | 9050 |
Pharosi | Q9H939, Tbio |
PROi | PR:Q9H939 |
RNActi | Q9H939, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152229, Expressed in spleen and 164 other tissues |
ExpressionAtlasi | Q9H939, baseline and differential |
Genevisiblei | Q9H939, HS |
Family and domain databases
CDDi | cd07672, F-BAR_PSTPIP2, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030106, PSTPIP2 IPR042694, PSTPIP2_F-BAR |
PANTHERi | PTHR23065:SF9, PTHR23065:SF9, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPIP2_HUMAN | |
Accessioni | Q9H939Primary (citable) accession number: Q9H939 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot