PSTPIP2

Functionⁱ

Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).By similarity

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytoskeletal protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament polymerization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell migration Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proline-serine-threonine phosphatase-interacting protein 2 Short name: PEST phosphatase-interacting protein 2
Gene namesⁱ	Name:PSTPIP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152229.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9581 PSTPIP2
MIMⁱ	616046 gene
neXtProtⁱ	NX_Q9H939

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9050
Open Targets More...OpenTargetsⁱ	ENSG00000152229
PharmGKBⁱ	PA33932

Polymorphism and mutation databases

BioMutaⁱ	PSTPIP2
DMDMⁱ	294862539

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058541	1 – 334	Proline-serine-threonine phosphatase-interacting protein 2Add BLAST		334

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	323	PhosphotyrosineBy similarity		1
Modified residueⁱ	329	PhosphotyrosineBy similarity		1

Post-translational modificationⁱ

Phosphorylated on tyrosine.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9H939
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H939
PaxDbⁱ	Q9H939
PeptideAtlas More...PeptideAtlasⁱ	Q9H939
PRIDEⁱ	Q9H939
ProteomicsDBⁱ	81278 81279 [Q9H939-2]

PTM databases

iPTMnetⁱ	Q9H939
PhosphoSitePlusⁱ	Q9H939

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152229 Expressed in 146 organ(s), highest expression level in spleen
CleanExⁱ	HS_PSTPIP2
ExpressionAtlasⁱ	Q9H939 baseline and differential
Genevisibleⁱ	Q9H939 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040923 HPA040944

HPAⁱ

HPA040923
HPA040944

Interactionⁱ

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytoskeletal protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114512, 9 interactors
IntActⁱ	Q9H939, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q9H939
STRINGⁱ	9606.ENSP00000387261

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H939
SMRⁱ	Q9H939
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 264	F-BARPROSITE-ProRule annotationAdd BLAST		261

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	66 – 166	Sequence analysisAdd BLAST		101

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IU8M Eukaryota ENOG411036U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150876
HOGENOMⁱ	HOG000294218
HOVERGENⁱ	HBG052960
InParanoidⁱ	Q9H939
KEGG Orthology (KO) More...KOⁱ	K20124
OMAⁱ	CRDKEEA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09F9
PhylomeDBⁱ	Q9H939
TreeFamⁱ	TF313677

Family and domain databases

Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR030106 PSTPIP2
PANTHERⁱ	PTHR23065:SF9 PTHR23065:SF9, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9H939-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE 
        60         70         80         90        100
RYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE 
       110        120        130        140        150
EARKMEEFRE KQKLQRKKTE LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD 
       160        170        180        190        200
KDEAEQAVSR SANLVNPKQQ EKLFVKLATS KTAVEDSDKA YMLHIGTLDK 
       210        220        230        240        250
VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ QCVTSDEMYE 
       260        270        280        290        300
QVRKSLEMCS IQRDIEYFVN QRKTGQIPPA PIMYENFYSS QKNAVPAGKA 
       310        320        330 
TGPNLARRGP LPIPKSSPDD PNYSLVDDYS LLYQ

Length:334

Mass (Da):38,858

Last modified:April 20, 2010 - v4

Checksum:ⁱDD7DC17EC3F6E165

GO

Isoform 2 (identifier: Q9H939-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
248-334: MYEQVRKSLE...LVDDYSLLYQ → HPSCMRISTP...KINETRAFSG

« Hide

        10         20         30         40         50
MTRSLFKGNF WSADILSTIG YDNIIQHLNN GRKNCKEFED FLKERAAIEE 
        60         70         80         90        100
RYGKDLLNLS RKKPCGQSEI NTLKRALEVF KQQVDNVAQC HIQLAQSLRE 
       110        120        130        140        150
EARKMEEFRE KQKLQRKKTE LIMDAIHKQK SLQFKKTMDA KKNYEQKCRD 
       160        170        180        190        200
KDEAEQAVSR SANLVNPKQQ EKLFVKLATS KTAVEDSDKA YMLHIGTLDK 
       210        220        230        240        250
VREEWQSEHI KACEAFEAQE CERINFFRNA LWLHVNQLSQ QCVTSDEHPS 
       260        270        280        290        300
CMRISTPPRR MQSQQERLQG LTWQGEDPSQ FLKAHQMIPI TLWLMTTVCS 
       310 
ISKINETRAF SG

Note: No experimental confirmation available.

Show »

Length:312

Mass (Da):36,446

Checksum:ⁱ366C0F8B5A1CA272

GO

Sequence cautionⁱ

The sequence BAB14404 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	284	Y → H in BAB14404 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059708	322	N → D. Corresponds to variant dbSNP:rs2276199Ensembl.		1
Natural variantⁱVAR_059709	322	N → S. Corresponds to variant dbSNP:rs16978507Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004070	248 – 334	MYEQV…SLLYQ → HPSCMRISTPPRRMQSQQER LQGLTWQGEDPSQFLKAHQM IPITLWLMTTVCSISKINET RAFSG in isoform 2. 1 PublicationAdd BLAST		87

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC012569 Genomic DNA No translation available. AC090355 Genomic DNA No translation available. BC035395 mRNA Translation: AAH35395.1 AK023100 mRNA Translation: BAB14404.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32820.2 [Q9H939-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_077748.3, NM_024430.3 [Q9H939-1]
UniGeneⁱ	Hs.567384

Genome annotation databases

Ensemblⁱ	ENST00000409746; ENSP00000387261; ENSG00000152229 [Q9H939-1] ENST00000589328; ENSP00000468622; ENSG00000152229 [Q9H939-2]
GeneIDⁱ	9050
KEGGⁱ	hsa:9050
UCSC genome browser More...UCSCⁱ	uc002lbp.5 human [Q9H939-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H939	Proline-serine-threonine phosphatase interacting protein 2 isoform 2		HUMAN		334	UniRef100_Q9H939
Q9H939-2	Proline-serine-threonine phosphatase interacting protein 2 isoform 1 (Fragment)		HUMAN		312	UniRef100_Q9H939-2

Protein	Similar proteins		Species	Score	Length	Source
Q9H939	Proline-serine-threonine phosphatase interacting protein 2 isoform 2		HUMAN		334	UniRef90_Q9H939
Uncharacterized protein		PANPA		334
Uncharacterized protein		MYOLU		334
Proline-serine-threonine phosphatase interacting protein 2		GORGO		334
PSTPIP2 isoform 1		PANTR		334
+3
Q9H939-2	Proline-serine-threonine phosphatase interacting protein 2 isoform 1 (Fragment)		HUMAN		312	UniRef90_Q9H939-2
Proline-serine-threonine phosphatase interacting protein 2		SAIBB		313
Uncharacterized protein		MACMU		313
Uncharacterized protein		CERAT		313
Uncharacterized protein		MANLE		302
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9H939	Proline-serine-threonine phosphatase-interacting protein 2		MOUSE		334	UniRef50_Q99M15
Proline-serine-threonine phosphatase-interacting protein 2		CRIGR		344
proline-serine-threonine phosphatase-interacting protein 2		MESAU		334
Proline-serine-threonine phosphatase-interacting protein 2		RAT		334
Proline-serine-threonine phosphatase interacting protein 2		PIG		302
+114
Q9H939-2	Proline-serine-threonine phosphatase interacting protein 2 isoform 1 (Fragment)		HUMAN		312	UniRef50_Q9H939-2
Uncharacterized protein		MACNE		313
Proline-serine-threonine phosphatase interacting protein 2		SAIBB		313
Uncharacterized protein		PAPAN		313
Uncharacterized protein		MACFA		313
+50

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC012569 Genomic DNA No translation available. AC090355 Genomic DNA No translation available. BC035395 mRNA Translation: AAH35395.1 AK023100 mRNA Translation: BAB14404.1 Different initiation.
CCDSⁱ	CCDS32820.2 [Q9H939-1]
RefSeqⁱ	NP_077748.3, NM_024430.3 [Q9H939-1]
UniGeneⁱ	Hs.567384

3D structure databases

ProteinModelPortalⁱ	Q9H939
SMRⁱ	Q9H939
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114512, 9 interactors
IntActⁱ	Q9H939, 5 interactors
MINTⁱ	Q9H939
STRINGⁱ	9606.ENSP00000387261

PTM databases

iPTMnetⁱ	Q9H939
PhosphoSitePlusⁱ	Q9H939

Polymorphism and mutation databases

BioMutaⁱ	PSTPIP2
DMDMⁱ	294862539

Proteomic databases

EPDⁱ	Q9H939
MaxQBⁱ	Q9H939
PaxDbⁱ	Q9H939
PeptideAtlasⁱ	Q9H939
PRIDEⁱ	Q9H939
ProteomicsDBⁱ	81278 81279 [Q9H939-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9050
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000409746; ENSP00000387261; ENSG00000152229 [Q9H939-1] ENST00000589328; ENSP00000468622; ENSG00000152229 [Q9H939-2]
GeneIDⁱ	9050
KEGGⁱ	hsa:9050
UCSCⁱ	uc002lbp.5 human [Q9H939-1]

Organism-specific databases

CTDⁱ	9050
DisGeNETⁱ	9050
EuPathDBⁱ	HostDB:ENSG00000152229.18
GeneCardsⁱ	PSTPIP2
H-InvDBⁱ	HIX0014425
HGNCⁱ	HGNC:9581 PSTPIP2
HPAⁱ	HPA040923 HPA040944
MIMⁱ	616046 gene
neXtProtⁱ	NX_Q9H939
OpenTargetsⁱ	ENSG00000152229
PharmGKBⁱ	PA33932
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IU8M Eukaryota ENOG411036U LUCA
GeneTreeⁱ	ENSGT00930000150876
HOGENOMⁱ	HOG000294218
HOVERGENⁱ	HBG052960
InParanoidⁱ	Q9H939
KOⁱ	K20124
OMAⁱ	CRDKEEA
OrthoDBⁱ	EOG091G09F9
PhylomeDBⁱ	Q9H939
TreeFamⁱ	TF313677

Miscellaneous databases

ChiTaRSⁱ	PSTPIP2 human
GeneWikiⁱ	PSTPIP2
GenomeRNAiⁱ	9050
Protein Ontology More...PROⁱ	PR:Q9H939
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152229 Expressed in 146 organ(s), highest expression level in spleen
CleanExⁱ	HS_PSTPIP2
ExpressionAtlasⁱ	Q9H939 baseline and differential
Genevisibleⁱ	Q9H939 HS

Family and domain databases

Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR031160 F_BAR IPR001060 FCH_dom IPR030106 PSTPIP2
PANTHERⁱ	PTHR23065:SF9 PTHR23065:SF9, 1 hit
Pfamⁱ	View protein in Pfam PF00611 FCH, 1 hit
SMARTⁱ	View protein in SMART SM00055 FCH, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit
PROSITEⁱ	View protein in PROSITE PS51741 F_BAR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPIP2_HUMAN
Accessionⁱ	Q9H939Primary (citable) accession number: Q9H939
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM

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UniProtKB - Q9H939 (PPIP2_HUMAN)

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Proline-serine-threonine phosphatase-interacting protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ