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Protein

RING finger protein 121

Gene

RNF121

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri226 – 276RING-type; atypicalPROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 121
Gene namesi
Name:RNF121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137522.17
HGNCiHGNC:21070 RNF121
neXtProtiNX_Q9H920

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137522
PharmGKBiPA134985388

Polymorphism and mutation databases

BioMutaiRNF121

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002614072 – 327RING finger protein 121Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H920
MaxQBiQ9H920
PaxDbiQ9H920
PeptideAtlasiQ9H920
PRIDEiQ9H920
ProteomicsDBi81272

PTM databases

iPTMnetiQ9H920
PhosphoSitePlusiQ9H920

Expressioni

Gene expression databases

BgeeiENSG00000137522 Expressed in 97 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_RNF121
ExpressionAtlasiQ9H920 baseline and differential
GenevisibleiQ9H920 HS

Organism-specific databases

HPAiHPA046041

Interactioni

Protein-protein interaction databases

BioGridi120585, 3 interactors
STRINGi9606.ENSP00000354571

Structurei

3D structure databases

ProteinModelPortaliQ9H920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNF121 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri226 – 276RING-type; atypicalPROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1734 Eukaryota
ENOG410XP8B LUCA
GeneTreeiENSGT00390000013075
HOGENOMiHOG000021822
HOVERGENiHBG061177
InParanoidiQ9H920
KOiK15698
OMAiRMRAEHQ
OrthoDBiEOG091G09YK
PhylomeDBiQ9H920
TreeFamiTF314357

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H920-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVVEVEVG GGAAGERELD EVDMSDLSPE EQWRVEHARM HAKHRGHEAM
60 70 80 90 100
HAEMVLILIA TLVVAQLLLV QWKQRHPRSY NMVTLFQMWV VPLYFTVKLH
110 120 130 140 150
WWRFLVIWIL FSAVTAFVTF RATRKPLVQT TPRLVYKWFL LIYKISYATG
160 170 180 190 200
IVGYMAVMFT LFGLNLLFKI KPEDAMDFGI SLLFYGLYYG VLERDFAEMC
210 220 230 240 250
ADYMASTIGF YSESGMPTKH LSDSVCAVCG QQIFVDVSEE GIIENTYRLS
260 270 280 290 300
CNHVFHEFCI RGWCIVGKKQ TCPYCKEKVD LKRMFSNPWE RPHVMYGQLL
310 320
DWLRYLVAWQ PVIIGVVQGI NYILGLE
Length:327
Mass (Da):37,882
Last modified:March 1, 2001 - v1
Checksum:iFFC170FF52AB15CD
GO
Isoform 2 (identifier: Q9H920-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:246
Mass (Da):28,736
Checksum:i6EDD49B9924630B7
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKE9E9PKE9_HUMAN
RING finger protein 121
RNF121
167Annotation score:
C9JQY5C9JQY5_HUMAN
RING finger protein 121
RNF121
205Annotation score:
G3V148G3V148_HUMAN
RING finger protein 121
RNF121 hCG_1811369
295Annotation score:
F8WDV7F8WDV7_HUMAN
RING finger protein 121
RNF121
113Annotation score:
H0YEH6H0YEH6_HUMAN
RING finger protein 121
RNF121
146Annotation score:
E9PLR7E9PLR7_HUMAN
RING finger protein 121
RNF121
81Annotation score:
E9PN80E9PN80_HUMAN
RING finger protein 121
RNF121
52Annotation score:
E9PRV6E9PRV6_HUMAN
RING finger protein 121
RNF121
49Annotation score:

Sequence cautioni

The sequence AAH09672 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH63680 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti327E → D in CAG33579 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0541331 – 81Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023139 mRNA Translation: BAB14423.1
AK094508 mRNA Translation: BAG52880.1
CR457298 mRNA Translation: CAG33579.1
AP002490 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74810.1
BC009672 mRNA Translation: AAH09672.2 Different initiation.
BC063680 mRNA Translation: AAH63680.1 Different initiation.
CCDSiCCDS8203.1 [Q9H920-1]
RefSeqiNP_060790.2, NM_018320.4 [Q9H920-1]
XP_006718693.1, XM_006718630.1 [Q9H920-2]
XP_011543452.1, XM_011545150.1 [Q9H920-2]
UniGeneiHs.368554

Genome annotation databases

EnsembliENST00000361756; ENSP00000354571; ENSG00000137522 [Q9H920-1]
GeneIDi55298
KEGGihsa:55298
UCSCiuc001ora.4 human [Q9H920-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023139 mRNA Translation: BAB14423.1
AK094508 mRNA Translation: BAG52880.1
CR457298 mRNA Translation: CAG33579.1
AP002490 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74810.1
BC009672 mRNA Translation: AAH09672.2 Different initiation.
BC063680 mRNA Translation: AAH63680.1 Different initiation.
CCDSiCCDS8203.1 [Q9H920-1]
RefSeqiNP_060790.2, NM_018320.4 [Q9H920-1]
XP_006718693.1, XM_006718630.1 [Q9H920-2]
XP_011543452.1, XM_011545150.1 [Q9H920-2]
UniGeneiHs.368554

3D structure databases

ProteinModelPortaliQ9H920
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120585, 3 interactors
STRINGi9606.ENSP00000354571

PTM databases

iPTMnetiQ9H920
PhosphoSitePlusiQ9H920

Polymorphism and mutation databases

BioMutaiRNF121

Proteomic databases

EPDiQ9H920
MaxQBiQ9H920
PaxDbiQ9H920
PeptideAtlasiQ9H920
PRIDEiQ9H920
ProteomicsDBi81272

Protocols and materials databases

DNASUi55298
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361756; ENSP00000354571; ENSG00000137522 [Q9H920-1]
GeneIDi55298
KEGGihsa:55298
UCSCiuc001ora.4 human [Q9H920-1]

Organism-specific databases

CTDi55298
EuPathDBiHostDB:ENSG00000137522.17
GeneCardsiRNF121
HGNCiHGNC:21070 RNF121
HPAiHPA046041
neXtProtiNX_Q9H920
OpenTargetsiENSG00000137522
PharmGKBiPA134985388
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1734 Eukaryota
ENOG410XP8B LUCA
GeneTreeiENSGT00390000013075
HOGENOMiHOG000021822
HOVERGENiHBG061177
InParanoidiQ9H920
KOiK15698
OMAiRMRAEHQ
OrthoDBiEOG091G09YK
PhylomeDBiQ9H920
TreeFamiTF314357

Miscellaneous databases

ChiTaRSiRNF121 human
GenomeRNAii55298
PROiPR:Q9H920

Gene expression databases

BgeeiENSG00000137522 Expressed in 97 organ(s), highest expression level in skeletal muscle tissue
CleanExiHS_RNF121
ExpressionAtlasiQ9H920 baseline and differential
GenevisibleiQ9H920 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN121_HUMAN
AccessioniPrimary (citable) accession number: Q9H920
Secondary accession number(s): B3KSW8
, Q6IA57, Q6P449, Q96DB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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