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Protein

Jupiter microtubule associated homolog 2

Gene

JPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Jupiter microtubule associated homolog 2Imported
Alternative name(s):
Hematological and neurological expressed 1-like protein1 Publication
Short name:
HN1-like protein
Gene namesi
Name:JPT2Imported
Synonyms:C16orf34, HN1L1 Publication
ORF Names:L11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000206053.12
HGNCiHGNC:14137 JPT2
neXtProtiNX_Q9H910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90861
OpenTargetsiENSG00000206053
PharmGKBiPA162391043

Polymorphism and mutation databases

BioMutaiHN1L

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549211 – 190Jupiter microtubule associated homolog 2Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei35PhosphothreonineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H910
MaxQBiQ9H910
PaxDbiQ9H910
PeptideAtlasiQ9H910
PRIDEiQ9H910
ProteomicsDBi81270
81271 [Q9H910-2]
TopDownProteomicsiQ9H910-1 [Q9H910-1]

PTM databases

iPTMnetiQ9H910
PhosphoSitePlusiQ9H910

Expressioni

Tissue specificityi

Expressed in liver, kidney, prostate, testis and uterus.1 Publication

Inductioni

Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC), bronchioalveolar carcinoma (BAC), breast and uterus tumors.1 Publication

Gene expression databases

BgeeiENSG00000206053 Expressed in 233 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_HN1L
ExpressionAtlasiQ9H910 baseline and differential
GenevisibleiQ9H910 HS

Organism-specific databases

HPAiHPA041888
HPA041908

Interactioni

Protein-protein interaction databases

BioGridi124774, 16 interactors
IntActiQ9H910, 8 interactors
STRINGi9606.ENSP00000248098

Structurei

3D structure databases

ProteinModelPortaliQ9H910
SMRiQ9H910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JUPITER family.Curated

Phylogenomic databases

eggNOGiENOG410IY2U Eukaryota
ENOG4111V7S LUCA
GeneTreeiENSGT00390000007652
HOGENOMiHOG000231170
HOVERGENiHBG055006
InParanoidiQ9H910
OMAiRSHNRVL
OrthoDBiEOG091G0NGB
PhylomeDBiQ9H910
TreeFamiTF327169

Family and domain databases

InterProiView protein in InterPro
IPR033335 JUPITER
PANTHERiPTHR34930 PTHR34930, 1 hit
PfamiView protein in Pfam
PF17054 JUPITER, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9H910-1) [UniParc]FASTAAdd to basket
Also known as: HN1LA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQVPDSEGG RAGSRAMKPP GGESSNLFGS PEEATPSSRP NRMASNIFGP
60 70 80 90 100
TEEPQNIPKR TNPPGGKGSG IFDESTPVQT RQHLNPPGGK TSDIFGSPVT
110 120 130 140 150
ATSRLAHPNK PKDHVFLCEG EEPKSDLKAA RSIPAGAEPG EKGSARKAGP
160 170 180 190
AKEQEPMPTV DSHEPRLGPR PRSHNKVLNP PGGKSSISFY
Length:190
Mass (Da):20,063
Last modified:March 1, 2001 - v1
Checksum:i9132F17687193192
GO
Isoform 2 (identifier: Q9H910-2) [UniParc]FASTAAdd to basket
Also known as: HN1LB, HN1LC

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MFQVPDSEGGRAGSRAM → M

Show »
Length:174
Mass (Da):18,416
Checksum:iD8555196DA197D09
GO
Isoform 3 (identifier: Q9H910-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-14: S → SRKWQLLTGSLASTSPSLLSGQGPWAPLQ

Note: No experimental confirmation available.
Show »
Length:218
Mass (Da):23,026
Checksum:iF191DB78D1D0FA62
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NGP5A6NGP5_HUMAN
Jupiter microtubule-associated homo...
JPT2
178Annotation score:
H3BMV3H3BMV3_HUMAN
Jupiter microtubule-associated homo...
JPT2
190Annotation score:
H3BU16H3BU16_HUMAN
Jupiter microtubule-associated homo...
JPT2
167Annotation score:
H3BMT0H3BMT0_HUMAN
Jupiter microtubule-associated homo...
JPT2
115Annotation score:
B4E1P3B4E1P3_HUMAN
Jupiter microtubule-associated homo...
JPT2
98Annotation score:
H3BMM8H3BMM8_HUMAN
Jupiter microtubule-associated homo...
JPT2
70Annotation score:
H3BTV5H3BTV5_HUMAN
Jupiter microtubule-associated homo...
JPT2
116Annotation score:
H3BS08H3BS08_HUMAN
Jupiter microtubule-associated homo...
JPT2
77Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147061 – 17MFQVP…GSRAM → M in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05742314S → SRKWQLLTGSLASTSPSLLS GQGPWAPLQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323831 Genomic DNA Translation: AAP72616.1
AY323978 mRNA Translation: AAP83791.1
AY323979 mRNA Translation: AAP83792.1
AY598330 mRNA Translation: AAT06741.1
AK023154 mRNA Translation: BAB14434.1
AE006639 Genomic DNA Translation: AAK61289.1
AK296998 mRNA Translation: BAG59536.1
AL031009 Genomic DNA No translation available.
AL031710 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85635.1
CH471112 Genomic DNA Translation: EAW85638.1
BC014438 mRNA Translation: AAH14438.1
BC060853 mRNA Translation: AAH60853.1
CCDSiCCDS10441.1 [Q9H910-1]
RefSeqiNP_653171.1, NM_144570.2 [Q9H910-1]
UniGeneiHs.513261

Genome annotation databases

EnsembliENST00000248098; ENSP00000248098; ENSG00000206053 [Q9H910-1]
ENST00000382711; ENSP00000372158; ENSG00000206053 [Q9H910-2]
ENST00000562684; ENSP00000457694; ENSG00000206053 [Q9H910-3]
GeneIDi90861
KEGGihsa:90861
UCSCiuc002cmg.4 human [Q9H910-1]
uc010uvi.3 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiJUPI2_HUMAN
AccessioniPrimary (citable) accession number: Q9H910
Secondary accession number(s): B1AJY2, B4DLH4, Q6EIC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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