UniProtKB - Q9H910 (JUPI2_HUMAN)
Protein
Jupiter microtubule associated homolog 2
Gene
JPT2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Jupiter microtubule associated homolog 2ImportedAlternative name(s): Hematological and neurological expressed 1-like protein1 Publication Short name: HN1-like protein |
Gene namesi | ORF Names:L11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000206053.12 |
HGNCi | HGNC:14137, JPT2 |
neXtProti | NX_Q9H910 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 90861 |
OpenTargetsi | ENSG00000206053 |
PharmGKBi | PA162391043 |
Miscellaneous databases
Pharosi | Q9H910, Tdark |
Chemistry databases
ChEMBLi | CHEMBL4295946 |
Polymorphism and mutation databases
BioMutai | JPT2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054921 | 1 – 190 | Jupiter microtubule associated homolog 2Add BLAST | 190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 30 | PhosphoserineCombined sources | 1 | |
Modified residuei | 35 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 45 | PhosphoserineCombined sources | 1 | |
Modified residuei | 69 | PhosphoserineCombined sources | 1 | |
Modified residuei | 97 | PhosphoserineCombined sources | 1 | |
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Modified residuei | 144 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9H910 |
jPOSTi | Q9H910 |
MassIVEi | Q9H910 |
MaxQBi | Q9H910 |
PaxDbi | Q9H910 |
PeptideAtlasi | Q9H910 |
PRIDEi | Q9H910 |
ProteomicsDBi | 4534 81270 [Q9H910-1] 81271 [Q9H910-2] |
TopDownProteomicsi | Q9H910-1 [Q9H910-1] |
PTM databases
iPTMneti | Q9H910 |
MetOSitei | Q9H910 |
PhosphoSitePlusi | Q9H910 |
Expressioni
Tissue specificityi
Expressed in liver, kidney, prostate, testis and uterus.1 Publication
Inductioni
Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC), bronchioalveolar carcinoma (BAC), breast and uterus tumors.1 Publication
Gene expression databases
Bgeei | ENSG00000206053, Expressed in C1 segment of cervical spinal cord and 245 other tissues |
ExpressionAtlasi | Q9H910, baseline and differential |
Genevisiblei | Q9H910, HS |
Organism-specific databases
HPAi | ENSG00000206053, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124774, 25 interactors |
IntActi | Q9H910, 11 interactors |
STRINGi | 9606.ENSP00000248098 |
Miscellaneous databases
RNActi | Q9H910, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the JUPITER family.Curated
Phylogenomic databases
eggNOGi | ENOG502S1G7, Eukaryota |
GeneTreei | ENSGT00390000007652 |
HOGENOMi | CLU_111612_0_0_1 |
InParanoidi | Q9H910 |
OMAi | DHEPRLG |
OrthoDBi | 1620782at2759 |
PhylomeDBi | Q9H910 |
TreeFami | TF327169 |
Family and domain databases
InterProi | View protein in InterPro IPR033335, JUPITER |
PANTHERi | PTHR34930, PTHR34930, 1 hit |
Pfami | View protein in Pfam PF17054, JUPITER, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H910-1) [UniParc]FASTAAdd to basket
Also known as: HN1LA
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFQVPDSEGG RAGSRAMKPP GGESSNLFGS PEEATPSSRP NRMASNIFGP
60 70 80 90 100
TEEPQNIPKR TNPPGGKGSG IFDESTPVQT RQHLNPPGGK TSDIFGSPVT
110 120 130 140 150
ATSRLAHPNK PKDHVFLCEG EEPKSDLKAA RSIPAGAEPG EKGSARKAGP
160 170 180 190
AKEQEPMPTV DSHEPRLGPR PRSHNKVLNP PGGKSSISFY
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BMT0 | H3BMT0_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 115 | Annotation score: | ||
H3BMV3 | H3BMV3_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 190 | Annotation score: | ||
H3BU16 | H3BU16_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 167 | Annotation score: | ||
A6NGP5 | A6NGP5_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 178 | Annotation score: | ||
H3BMM8 | H3BMM8_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 70 | Annotation score: | ||
B4E1P3 | B4E1P3_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 98 | Annotation score: | ||
H3BTV5 | H3BTV5_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 116 | Annotation score: | ||
H3BS08 | H3BS08_HUMAN | Jupiter microtubule-associated homo... | JPT2 | 77 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014706 | 1 – 17 | MFQVP…GSRAM → M in isoform 2. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_057423 | 14 | S → SRKWQLLTGSLASTSPSLLS GQGPWAPLQ in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY323831 Genomic DNA Translation: AAP72616.1 AY323978 mRNA Translation: AAP83791.1 AY323979 mRNA Translation: AAP83792.1 AY598330 mRNA Translation: AAT06741.1 AK023154 mRNA Translation: BAB14434.1 AE006639 Genomic DNA Translation: AAK61289.1 AK296998 mRNA Translation: BAG59536.1 AL031009 Genomic DNA No translation available. AL031710 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85635.1 CH471112 Genomic DNA Translation: EAW85638.1 BC014438 mRNA Translation: AAH14438.1 BC060853 mRNA Translation: AAH60853.1 |
CCDSi | CCDS10441.1 [Q9H910-1] |
RefSeqi | NP_653171.1, NM_144570.2 [Q9H910-1] |
Genome annotation databases
Ensembli | ENST00000248098; ENSP00000248098; ENSG00000206053 [Q9H910-1] ENST00000382711; ENSP00000372158; ENSG00000206053 [Q9H910-2] ENST00000562684; ENSP00000457694; ENSG00000206053 [Q9H910-3] |
GeneIDi | 90861 |
KEGGi | hsa:90861 |
UCSCi | uc002cmg.4, human [Q9H910-1] uc010uvi.3, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY323831 Genomic DNA Translation: AAP72616.1 AY323978 mRNA Translation: AAP83791.1 AY323979 mRNA Translation: AAP83792.1 AY598330 mRNA Translation: AAT06741.1 AK023154 mRNA Translation: BAB14434.1 AE006639 Genomic DNA Translation: AAK61289.1 AK296998 mRNA Translation: BAG59536.1 AL031009 Genomic DNA No translation available. AL031710 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85635.1 CH471112 Genomic DNA Translation: EAW85638.1 BC014438 mRNA Translation: AAH14438.1 BC060853 mRNA Translation: AAH60853.1 |
CCDSi | CCDS10441.1 [Q9H910-1] |
RefSeqi | NP_653171.1, NM_144570.2 [Q9H910-1] |
3D structure databases
SMRi | Q9H910 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124774, 25 interactors |
IntActi | Q9H910, 11 interactors |
STRINGi | 9606.ENSP00000248098 |
Chemistry databases
ChEMBLi | CHEMBL4295946 |
PTM databases
iPTMneti | Q9H910 |
MetOSitei | Q9H910 |
PhosphoSitePlusi | Q9H910 |
Polymorphism and mutation databases
BioMutai | JPT2 |
Proteomic databases
EPDi | Q9H910 |
jPOSTi | Q9H910 |
MassIVEi | Q9H910 |
MaxQBi | Q9H910 |
PaxDbi | Q9H910 |
PeptideAtlasi | Q9H910 |
PRIDEi | Q9H910 |
ProteomicsDBi | 4534 81270 [Q9H910-1] 81271 [Q9H910-2] |
TopDownProteomicsi | Q9H910-1 [Q9H910-1] |
Protocols and materials databases
Antibodypediai | 23196, 73 antibodies |
DNASUi | 90861 |
Genome annotation databases
Ensembli | ENST00000248098; ENSP00000248098; ENSG00000206053 [Q9H910-1] ENST00000382711; ENSP00000372158; ENSG00000206053 [Q9H910-2] ENST00000562684; ENSP00000457694; ENSG00000206053 [Q9H910-3] |
GeneIDi | 90861 |
KEGGi | hsa:90861 |
UCSCi | uc002cmg.4, human [Q9H910-1] uc010uvi.3, human |
Organism-specific databases
CTDi | 90861 |
DisGeNETi | 90861 |
EuPathDBi | HostDB:ENSG00000206053.12 |
GeneCardsi | JPT2 |
HGNCi | HGNC:14137, JPT2 |
HPAi | ENSG00000206053, Low tissue specificity |
neXtProti | NX_Q9H910 |
OpenTargetsi | ENSG00000206053 |
PharmGKBi | PA162391043 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1G7, Eukaryota |
GeneTreei | ENSGT00390000007652 |
HOGENOMi | CLU_111612_0_0_1 |
InParanoidi | Q9H910 |
OMAi | DHEPRLG |
OrthoDBi | 1620782at2759 |
PhylomeDBi | Q9H910 |
TreeFami | TF327169 |
Enzyme and pathway databases
PathwayCommonsi | Q9H910 |
Miscellaneous databases
BioGRID-ORCSi | 90861, 3 hits in 841 CRISPR screens |
ChiTaRSi | HN1L, human |
GeneWikii | HN1L |
GenomeRNAii | 90861 |
Pharosi | Q9H910, Tdark |
PROi | PR:Q9H910 |
RNActi | Q9H910, protein |
Gene expression databases
Bgeei | ENSG00000206053, Expressed in C1 segment of cervical spinal cord and 245 other tissues |
ExpressionAtlasi | Q9H910, baseline and differential |
Genevisiblei | Q9H910, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033335, JUPITER |
PANTHERi | PTHR34930, PTHR34930, 1 hit |
Pfami | View protein in Pfam PF17054, JUPITER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | JUPI2_HUMAN | |
Accessioni | Q9H910Primary (citable) accession number: Q9H910 Secondary accession number(s): B1AJY2, B4DLH4, Q6EIC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM