UniProtKB - Q9H910 (JUPI2_HUMAN)

BLAST

>sp|Q9H910|JUPI2_HUMAN Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1
MFQVPDSEGGRAGSRAMKPPGGESSNLFGSPEEATPSSRPNRMASNIFGPTEEPQNIPKR
TNPPGGKGSGIFDESTPVQTRQHLNPPGGKTSDIFGSPVTATSRLAHPNKPKDHVFLCEG
EEPKSDLKAARSIPAGAEPGEKGSARKAGPAKEQEPMPTVDSHEPRLGPRPRSHNKVLNP
PGGKSSISFY

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History
Entry version 136 (12 Sep 2018)
Sequence version 1 (01 Mar 2001)
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Protein

Jupiter microtubule associated homolog 2

Gene

JPT2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Jupiter microtubule associated homolog 2Imported Alternative name(s): Hematological and neurological expressed 1-like protein1 Publication Short name: HN1-like protein
Gene namesⁱ	Name:JPT2Imported Synonyms:C16orf34, HN1L1 Publication ORF Names:L11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000206053.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14137 JPT2
neXtProtⁱ	NX_Q9H910

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	90861
Open Targets More...OpenTargetsⁱ	ENSG00000206053
PharmGKBⁱ	PA162391043

Polymorphism and mutation databases

BioMutaⁱ	HN1L

BioMutaⁱ

HN1L

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000054921	1 – 190	Jupiter microtubule associated homolog 2Add BLAST		190

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	30	PhosphoserineCombined sources	1
Modified residueⁱ	35	PhosphothreonineCombined sources	1
Modified residueⁱ	45	PhosphoserineCombined sources	1
Modified residueⁱ	69	PhosphoserineCombined sources	1
Modified residueⁱ	97	PhosphoserineCombined sources	1
Modified residueⁱ	132	PhosphoserineCombined sources	1
Modified residueⁱ	144	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H910
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H910
PaxDbⁱ	Q9H910
PeptideAtlas More...PeptideAtlasⁱ	Q9H910
PRIDEⁱ	Q9H910
ProteomicsDBⁱ	81270 81271 [Q9H910-2]
TopDownProteomicsⁱ	Q9H910-1 [Q9H910-1]

PTM databases

iPTMnetⁱ	Q9H910
PhosphoSitePlusⁱ	Q9H910

Expressionⁱ

Tissue specificityⁱ

Expressed in liver, kidney, prostate, testis and uterus.1 Publication

Inductionⁱ

Up-regulated in squamous cell carcinoma (SCC) adenocarcinoma (AC), adenosquamous cell carcinoma (ASCC), bronchioalveolar carcinoma (BAC), breast and uterus tumors.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000206053 Expressed in 233 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_HN1L
ExpressionAtlasⁱ	Q9H910 baseline and differential
Genevisibleⁱ	Q9H910 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA041888 HPA041908

HPAⁱ

HPA041888
HPA041908

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	124774, 16 interactors
IntActⁱ	Q9H910, 8 interactors
STRINGⁱ	9606.ENSP00000248098

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H910
SMRⁱ	Q9H910
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the JUPITER family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IY2U Eukaryota ENOG4111V7S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007652
HOGENOMⁱ	HOG000231170
HOVERGENⁱ	HBG055006
InParanoidⁱ	Q9H910
OMAⁱ	RSHNRVL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NGB
PhylomeDBⁱ	Q9H910
TreeFamⁱ	TF327169

Family and domain databases

InterProⁱ	View protein in InterPro IPR033335 JUPITER
PANTHERⁱ	PTHR34930 PTHR34930, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17054 JUPITER, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9H910-1) [UniParc]FASTA Add to basket

Also known as: HN1LA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQVPDSEGG RAGSRAMKPP GGESSNLFGS PEEATPSSRP NRMASNIFGP 
        60         70         80         90        100
TEEPQNIPKR TNPPGGKGSG IFDESTPVQT RQHLNPPGGK TSDIFGSPVT 
       110        120        130        140        150
ATSRLAHPNK PKDHVFLCEG EEPKSDLKAA RSIPAGAEPG EKGSARKAGP 
       160        170        180        190
AKEQEPMPTV DSHEPRLGPR PRSHNKVLNP PGGKSSISFY

Length:190

Mass (Da):20,063

Last modified:March 1, 2001 - v1

Checksum:ⁱ9132F17687193192

Isoform 2 (identifier: Q9H910-2) [UniParc]FASTA Add to basket

Also known as: HN1LB, HN1LC

The sequence of this isoform differs from the canonical sequence as follows:
1-17: MFQVPDSEGGRAGSRAM → M

« Hide

        10         20         30         40         50
MKPPGGESSN LFGSPEEATP SSRPNRMASN IFGPTEEPQN IPKRTNPPGG 
        60         70         80         90        100
KGSGIFDEST PVQTRQHLNP PGGKTSDIFG SPVTATSRLA HPNKPKDHVF 
       110        120        130        140        150
LCEGEEPKSD LKAARSIPAG AEPGEKGSAR KAGPAKEQEP MPTVDSHEPR 
       160        170 
LGPRPRSHNK VLNPPGGKSS ISFY

Show »

Length:174

Mass (Da):18,416

Checksum:ⁱD8555196DA197D09

Isoform 3 (identifier: Q9H910-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
14-14: S → SRKWQLLTGSLASTSPSLLSGQGPWAPLQ

« Hide

        10         20         30         40         50
MFQVPDSEGG RAGSRKWQLL TGSLASTSPS LLSGQGPWAP LQRAMKPPGG 
        60         70         80         90        100
ESSNLFGSPE EATPSSRPNR MASNIFGPTE EPQNIPKRTN PPGGKGSGIF 
       110        120        130        140        150
DESTPVQTRQ HLNPPGGKTS DIFGSPVTAT SRLAHPNKPK DHVFLCEGEE 
       160        170        180        190        200
PKSDLKAARS IPAGAEPGEK GSARKAGPAK EQEPMPTVDS HEPRLGPRPR 
       210 
SHNKVLNPPG GKSSISFY

Note: No experimental confirmation available.

Show »

Length:218

Mass (Da):23,026

Checksum:ⁱF191DB78D1D0FA62

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A6NGP5	A6NGP5_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2 (cDNA FLJ50401, highly similar to Hematological and neurological expressed1-like protein) (cDNA, FLJ79413, highly similar to Hematological and neurological expressed 1-like protein)	JPT2	178	Annotation score:
H3BMV3	H3BMV3_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2	JPT2	190	Annotation score:
H3BU16	H3BU16_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2	JPT2	167	Annotation score:
H3BMT0	H3BMT0_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2	JPT2	115	Annotation score:
B4E1P3	B4E1P3_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2 (cDNA FLJ52046, moderately similar to Hematological and neurological expressed1-like protein)	JPT2	98	Annotation score:
H3BMM8	H3BMM8_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2	JPT2	70	Annotation score:
H3BTV5	H3BTV5_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2	JPT2	116	Annotation score:
H3BS08	H3BS08_HUMAN	Jupiter microtubule-associated homo... Jupiter microtubule-associated homolog 2	JPT2	77	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_014706	1 – 17	MFQVP…GSRAM → M in isoform 2. 1 PublicationAdd BLAST		17
Alternative sequenceⁱVSP_057423	14	S → SRKWQLLTGSLASTSPSLLS GQGPWAPLQ in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY323831 Genomic DNA Translation: AAP72616.1 AY323978 mRNA Translation: AAP83791.1 AY323979 mRNA Translation: AAP83792.1 AY598330 mRNA Translation: AAT06741.1 AK023154 mRNA Translation: BAB14434.1 AE006639 Genomic DNA Translation: AAK61289.1 AK296998 mRNA Translation: BAG59536.1 AL031009 Genomic DNA No translation available. AL031710 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85635.1 CH471112 Genomic DNA Translation: EAW85638.1 BC014438 mRNA Translation: AAH14438.1 BC060853 mRNA Translation: AAH60853.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10441.1 [Q9H910-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_653171.1, NM_144570.2 [Q9H910-1]
UniGeneⁱ	Hs.513261

Genome annotation databases

Ensemblⁱ	ENST00000248098; ENSP00000248098; ENSG00000206053 [Q9H910-1] ENST00000382711; ENSP00000372158; ENSG00000206053 [Q9H910-2] ENST00000562684; ENSP00000457694; ENSG00000206053 [Q9H910-3]
GeneIDⁱ	90861
KEGGⁱ	hsa:90861
UCSC genome browser More...UCSCⁱ	uc002cmg.4 human [Q9H910-1] uc010uvi.3 human

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H910	Jupiter microtubule associated homolog 2		MANLE		197	UniRef90_Q9H910
Jupiter microtubule associated homolog 2		MACFA		197
Jupiter microtubule associated homolog 2		CHLSB		190
Hematological and neurological expressed 1-like		PANTR		190
Jupiter microtubule associated homolog 2		GORGO		190
+29
Q9H910-2	Isoform 3 of Jupiter microtubule associated homolog 2		HUMAN		218	UniRef90_Q9H910-3
JPT2 isoform 3		PANTR		218
Jupiter microtubule associated homolog 2		GORGO		218
Uncharacterized protein		NOMLE		79
Jupiter microtubule associated homolog 2		PANPA		203
+33
Q9H910-3	Isoform 2 of Jupiter microtubule associated homolog 2		HUMAN		174	UniRef90_Q9H910-3
JPT2 isoform 3		PANTR		218
Jupiter microtubule associated homolog 2		GORGO		218
Uncharacterized protein		NOMLE		79
Jupiter microtubule associated homolog 2		PANPA		203
+33

Protein	Similar proteins		Species	Score	Length	Source
Q9H910	Jupiter microtubule associated homolog 2		MANLE		197	UniRef50_Q9H910
Jupiter microtubule associated homolog 2		MACFA		197
Uncharacterized protein		AOTNA		190
Jupiter microtubule associated homolog 2		SAIBB		190
Jupiter microtubule associated homolog 2		CHLSB		190
+95
Q9H910-2	Isoform 3 of Jupiter microtubule associated homolog 2		HUMAN		218	UniRef50_Q9H910-3
Jupiter microtubule associated homolog 2		MACNE		218
Jupiter microtubule associated homolog 2		SAIBB		218
Uncharacterized protein		CALJA		218
JPT2 isoform 4		PONAB		218
+44
Q9H910-3	Isoform 2 of Jupiter microtubule associated homolog 2		HUMAN		174	UniRef50_Q9H910-3
Jupiter microtubule associated homolog 2		MACNE		218
Jupiter microtubule associated homolog 2		SAIBB		218
Uncharacterized protein		CALJA		218
JPT2 isoform 4		PONAB		218
+44

Entry informationⁱ

Entry nameⁱ	JUPI2_HUMAN
Accessionⁱ	Q9H910Primary (citable) accession number: Q9H910 Secondary accession number(s): B1AJY2, B4DLH4, Q6EIC7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
	Last sequence update:	March 1, 2001
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

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Supporting data

UniProtKB - Q9H910 (JUPI2_HUMAN)

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Jupiter microtubule associated homolog 2

JPT2

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ