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Entry version 164 (31 Jul 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Golgi reassembly-stacking protein 2

Gene

GORASP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262).By similarity7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H8Y8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi reassembly-stacking protein 2
Short name:
GRS2
Alternative name(s):
Golgi phosphoprotein 6
Short name:
GOLPH6
Golgi reassembly-stacking protein of 55 kDa
Short name:
GRASP55
p59
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GORASP2
Synonyms:GOLPH6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17500 GORASP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608693 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H8Y8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Abolishes myristoylation. Loss of its ability to mediate unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane. No effect on ER stress-induced relocalization from Golgi to ER. 2 Publications1
Mutagenesisi59L → A: Abolishes organelle clustering; when associated with S-100. 1 Publication1
Mutagenesisi100I → S: Abolishes organelle clustering; when associated with A-59. 1 Publication1
Mutagenesisi148D → N: Enhances homodimerization. Loss of ER stress-induced relocalization from Golgi to ER. 1 Publication1
Mutagenesisi189S → D: Phosphomimetic mutation that decreases the ability to promote organelle clustering. 1 Publication1
Mutagenesisi222T → A: Abolishes mitotic phosphorylation; when associated with A-225. 1 Publication1
Mutagenesisi225T → A: Abolishes mitotic phosphorylation; when associated with A-222. 1 Publication1
Mutagenesisi441S → A: Loss of phosphorylation and its ability to mediate unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane. Inhibits ER stress-mediated disruption of homodimerization. Loss of ER stress-induced relocalization from Golgi to ER. 2 Publications1
Mutagenesisi441S → D: Phosphomimetic mutant. No loss of its ability to mediate unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane. Disrupts homodimerization. No loss of ER stress-induced relocalization from Golgi to ER. 2 Publications1
Mutagenesisi449S → A: Loss of phosphorylation. Does not inhibit ER stress-mediated disruption of homodimerization. 1 Publication1
Mutagenesisi449S → D: Phosphomimetic mutant. No disruption of homodimerization. 1 Publication1
Mutagenesisi451S → A: Loss of phosphorylation. Does not inhibit ER stress-mediated disruption of homodimerization. 1 Publication1
Mutagenesisi451S → D: Phosphomimetic mutant. Partial disruption of homodimerization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
26003

Open Targets

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OpenTargetsi
ENSG00000115806

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38457

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GORASP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51316097

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875452 – 452Golgi reassembly-stacking protein 2Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication3 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30Dimethylated arginine; alternateBy similarity1
Modified residuei30Omega-N-methylated arginine; alternateBy similarity1
Modified residuei47Dimethylated arginine; alternateBy similarity1
Modified residuei47Omega-N-methylated arginine; alternateBy similarity1
Modified residuei214PhosphoserineCombined sources1
Modified residuei222PhosphothreonineCombined sources1
Modified residuei225PhosphothreonineCombined sources1 Publication1
Modified residuei409PhosphoserineBy similarity1
Modified residuei415PhosphothreonineCombined sources1
Modified residuei433PhosphothreonineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei441Phosphoserine2 Publications1
Modified residuei449PhosphoserineCombined sources1 Publication1
Modified residuei451PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Myristoylated (PubMed:11101516). Myristoylation is essential for the Golgi targeting (By similarity).By similarity1 Publication
Palmitoylated.1 Publication
Phosphorylated in mitotic cells (PubMed:11408587). ER stress-induced phosphorylation at Ser-441 induces monomerization and subsequent relocalization from Golgi to ER which is essential for mediating unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane (PubMed:21884936, PubMed:27062250).3 Publications

Keywords - PTMi

Lipoprotein, Methylation, Myristate, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H8Y8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H8Y8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H8Y8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H8Y8

PeptideAtlas

More...
PeptideAtlasi
Q9H8Y8

PRoteomics IDEntifications database

More...
PRIDEi
Q9H8Y8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
4483
81257 [Q9H8Y8-1]
81258 [Q9H8Y8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H8Y8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H8Y8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H8Y8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000115806 Expressed in 237 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H8Y8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H8Y8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB075758
HPA035274
HPA035275

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Homooligomer. ER stress induces phosphorylation-dependent monomerization (PubMed:27062250).

Interacts with BLZF1/Golgin 45 (PubMed:11739401).

Identified in a complex with RAB2 and GORASP2 (PubMed:11739401).

Interacts with JAM2 and JAM3 (By similarity).

Interacts with members of the p24 cargo receptors (PubMed:11739402). Intebracts with CNIH1 and the cytoplasmic domain of transmembrane TGFA, prior its transit in the trans-Golgi (PubMed:11101516, PubMed:17607000).

Interacts with KCTD5 (PubMed:19361449).

Interacts with TMED2 and TMED3 (By similarity).

Interacts with SEC16A in response to ER stress (PubMed:28067262).

Interacts (via PDZ GRASP-type 1 domain) with core-glycosylated CFTR in response to ER stress (PubMed:21884936).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB83EBI-739467,EBI-6927928From Hepatitis C virus genotype 2a (isolate JFH-1).
AAMDCQ9H7C93EBI-739467,EBI-10308705
ACY3Q96HD910EBI-739467,EBI-3916242
AESQ081173EBI-739467,EBI-717810
ARL6IP1Q150413EBI-739467,EBI-714543
BEND5Q7L4P63EBI-739467,EBI-724373
C1orf94Q6P1W55EBI-739467,EBI-946029
CBLBQ131916EBI-739467,EBI-744027
CCDC153Q494R43EBI-739467,EBI-10241443
CDC23Q9UJX27EBI-739467,EBI-396137
CFTRP135693EBI-739467,EBI-349854
CRYAAP024898EBI-739467,EBI-6875961
DCTDP323215EBI-739467,EBI-739870
DMC1Q145655EBI-739467,EBI-930865
DPYSL2Q165557EBI-739467,EBI-1104711
DUSP21Q9H5965EBI-739467,EBI-7357329
EIF2B1Q142325EBI-739467,EBI-491065
ENOX1Q8TC923EBI-739467,EBI-713221
GABPB2Q8TAK55EBI-739467,EBI-8468945
GOLGA2Q083796EBI-739467,EBI-618309
JADE2Q9NQC1-23EBI-739467,EBI-10311936
KCTD9Q7L2735EBI-739467,EBI-4397613
KIFC3Q9BVG83EBI-739467,EBI-2125614
LONRF1Q17RB87EBI-739467,EBI-2341787
MAP1LC3BQ9GZQ85EBI-739467,EBI-373144
MID2Q9UJV3-25EBI-739467,EBI-10172526
MORN2Q502X03EBI-739467,EBI-725982
NQO2P160833EBI-739467,EBI-358466
ODC1P119269EBI-739467,EBI-1044287
PCBD1P614573EBI-739467,EBI-740475
PDE9AO760833EBI-739467,EBI-742764
PNMA5Q96PV45EBI-739467,EBI-10171633
PRDX3P300483EBI-739467,EBI-748336
PRPS1P608913EBI-739467,EBI-749195
PSMA3P257883EBI-739467,EBI-348380
RGS3P49796-83EBI-739467,EBI-10211517
RPIAP492476EBI-739467,EBI-744831
SCAND1P570865EBI-739467,EBI-745846
STOX1Q6ZVD73EBI-739467,EBI-3923644
TCF4P158843EBI-739467,EBI-533224
TEKT3Q9BXF94EBI-739467,EBI-8644516
TRAF1Q130775EBI-739467,EBI-359224
TRAF2Q129336EBI-739467,EBI-355744
TRAF4Q9BUZ43EBI-739467,EBI-3650647
TRAF5O004633EBI-739467,EBI-523498
TRIM38O006355EBI-739467,EBI-2130415
TSC22D1Q15714-24EBI-739467,EBI-12034704
TSNQ156314EBI-739467,EBI-1044160
TXLNAP402225EBI-739467,EBI-359793
ZBTB14O438293EBI-739467,EBI-10176632
ZNF148Q9UQR13EBI-739467,EBI-2688184

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117479, 122 interactors

Protein interaction database and analysis system

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IntActi
Q9H8Y8, 144 interactors

Molecular INTeraction database

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MINTi
Q9H8Y8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000234160

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H8Y8

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H8Y8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 105PDZ GRASP-type 1PROSITE-ProRule annotationAdd BLAST91
Domaini111 – 199PDZ GRASP-type 2PROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 215GRASPPROSITE-ProRule annotationAdd BLAST201
Regioni194 – 199Important for membrane binding6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi277 – 372Pro-richAdd BLAST96

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GORASP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3834 Eukaryota
COG5233 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008686

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231920

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H8Y8

Identification of Orthologs from Complete Genome Data

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OMAi
MPSEFLP

Database of Orthologous Groups

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OrthoDBi
1366434at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H8Y8

TreeFam database of animal gene trees

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TreeFami
TF314053

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024958 GRASP55/65_PDZ
IPR007583 GRASP55_65
IPR036034 PDZ_sf

The PANTHER Classification System

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PANTHERi
PTHR12893 PTHR12893, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04495 GRASP55_65, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50156 SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51865 PDZ_GRASP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H8Y8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSSQSVEIP GGGTEGYHVL RVQENSPGHR AGLEPFFDFI VSINGSRLNK
60 70 80 90 100
DNDTLKDLLK ANVEKPVKML IYSSKTLELR ETSVTPSNLW GGQGLLGVSI
110 120 130 140 150
RFCSFDGANE NVWHVLEVES NSPAALAGLR PHSDYIIGAD TVMNESEDLF
160 170 180 190 200
SLIETHEAKP LKLYVYNTDT DNCREVIITP NSAWGGEGSL GCGIGYGYLH
210 220 230 240 250
RIPTRPFEEG KKISLPGQMA GTPITPLKDG FTEVQLSSVN PPSLSPPGTT
260 270 280 290 300
GIEQSLTGLS ISSTPPAVSS VLSTGVPTVP LLPPQVNQSL TSVPPMNPAT
310 320 330 340 350
TLPGLMPLPA GLPNLPNLNL NLPAPHIMPG VGLPELVNPG LPPLPSMPPR
360 370 380 390 400
NLPGIAPLPL PSEFLPSFPL VPESSSAASS GELLSSLPPT SNAPSDPATT
410 420 430 440 450
TAKADAASSL TVDVTPPTAK APTTVEDRVG DSTPVSEKPV SAAVDANASE

SP
Length:452
Mass (Da):47,145
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i326EA6C107D2EA8B
GO
Isoform 2 (identifier: Q9H8Y8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Show »
Length:384
Mass (Da):39,768
Checksum:i707E11F2C55B7BDA
GO
Isoform 3 (identifier: Q9H8Y8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MGSSQSVEIPGGGTEGYHVLR → MREGSSTLSEIRKLKPGIMVCTCNPSYSNQETE

Note: No experimental confirmation available.
Show »
Length:464
Mass (Da):48,674
Checksum:iF6A0C68893A94434
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEG2F8WEG2_HUMAN
Golgi reassembly-stacking protein 2
GORASP2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF79F8WF79_HUMAN
Golgi reassembly-stacking protein 2
GORASP2
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEH9F8WEH9_HUMAN
Golgi reassembly-stacking protein 2
GORASP2
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBR9F8WBR9_HUMAN
Golgi reassembly-stacking protein 2
GORASP2
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20L → Q in BAB14459 (PubMed:14702039).Curated1
Sequence conflicti34E → G in BAB14395 (PubMed:14702039).Curated1
Sequence conflicti83S → P AA sequence (PubMed:11101516).Curated1
Sequence conflicti299A → T in BAB14395 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051013432S → F1 PublicationCorresponds to variant dbSNP:rs3770436Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0113001 – 68Missing in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_0543641 – 21MGSSQ…YHVLR → MREGSSTLSEIRKLKPGIMV CTCNPSYSNQETE in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027349 mRNA Translation: BAB55054.1
AK023082 mRNA Translation: BAB14395.1
AK023201 mRNA Translation: BAB14459.1
AK296698 mRNA Translation: BAG59292.1
AL117430 mRNA Translation: CAB55919.1
AC010092 Genomic DNA Translation: AAY15076.1
CH471058 Genomic DNA Translation: EAX11227.1
BC007770 mRNA Translation: AAH07770.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33325.1 [Q9H8Y8-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17229

NCBI Reference Sequences

More...
RefSeqi
NP_001188357.1, NM_001201428.1 [Q9H8Y8-2]
NP_056345.3, NM_015530.4 [Q9H8Y8-1]
XP_006712471.1, XM_006712408.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234160; ENSP00000234160; ENSG00000115806 [Q9H8Y8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26003

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26003

UCSC genome browser

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UCSCi
uc002ugk.4 human [Q9H8Y8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027349 mRNA Translation: BAB55054.1
AK023082 mRNA Translation: BAB14395.1
AK023201 mRNA Translation: BAB14459.1
AK296698 mRNA Translation: BAG59292.1
AL117430 mRNA Translation: CAB55919.1
AC010092 Genomic DNA Translation: AAY15076.1
CH471058 Genomic DNA Translation: EAX11227.1
BC007770 mRNA Translation: AAH07770.1
CCDSiCCDS33325.1 [Q9H8Y8-1]
PIRiT17229
RefSeqiNP_001188357.1, NM_001201428.1 [Q9H8Y8-2]
NP_056345.3, NM_015530.4 [Q9H8Y8-1]
XP_006712471.1, XM_006712408.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RLEX-ray1.65A2-208[»]
4EDJX-ray1.90A/B1-208[»]
SMRiQ9H8Y8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117479, 122 interactors
IntActiQ9H8Y8, 144 interactors
MINTiQ9H8Y8
STRINGi9606.ENSP00000234160

PTM databases

iPTMnetiQ9H8Y8
PhosphoSitePlusiQ9H8Y8
SwissPalmiQ9H8Y8

Polymorphism and mutation databases

BioMutaiGORASP2
DMDMi51316097

Proteomic databases

EPDiQ9H8Y8
jPOSTiQ9H8Y8
MaxQBiQ9H8Y8
PaxDbiQ9H8Y8
PeptideAtlasiQ9H8Y8
PRIDEiQ9H8Y8
ProteomicsDBi4483
81257 [Q9H8Y8-1]
81258 [Q9H8Y8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26003
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234160; ENSP00000234160; ENSG00000115806 [Q9H8Y8-1]
GeneIDi26003
KEGGihsa:26003
UCSCiuc002ugk.4 human [Q9H8Y8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26003
DisGeNETi26003

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GORASP2
HGNCiHGNC:17500 GORASP2
HPAiCAB075758
HPA035274
HPA035275
MIMi608693 gene
neXtProtiNX_Q9H8Y8
OpenTargetsiENSG00000115806
PharmGKBiPA38457

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3834 Eukaryota
COG5233 LUCA
GeneTreeiENSGT00390000008686
HOGENOMiHOG000231920
InParanoidiQ9H8Y8
OMAiMPSEFLP
OrthoDBi1366434at2759
PhylomeDBiQ9H8Y8
TreeFamiTF314053

Enzyme and pathway databases

ReactomeiR-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
SIGNORiQ9H8Y8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GORASP2 human
EvolutionaryTraceiQ9H8Y8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GORASP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26003

Protein Ontology

More...
PROi
PR:Q9H8Y8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115806 Expressed in 237 organ(s), highest expression level in sperm
ExpressionAtlasiQ9H8Y8 baseline and differential
GenevisibleiQ9H8Y8 HS

Family and domain databases

InterProiView protein in InterPro
IPR024958 GRASP55/65_PDZ
IPR007583 GRASP55_65
IPR036034 PDZ_sf
PANTHERiPTHR12893 PTHR12893, 1 hit
PfamiView protein in Pfam
PF04495 GRASP55_65, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS51865 PDZ_GRASP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGORS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8Y8
Secondary accession number(s): B4DKT0
, Q53TE3, Q96I74, Q96K84, Q9H946, Q9UFW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 31, 2019
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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