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Protein

Ankyrin repeat and zinc finger domain-containing protein 1

Gene

ANKZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 96C2H2-typeAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and zinc finger domain-containing protein 1
Alternative name(s):
Zinc finger protein 744
Gene namesi
Name:ANKZF1
Synonyms:ZNF744
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163516.13
HGNCiHGNC:25527 ANKZF1
MIMi617541 gene
neXtProtiNX_Q9H8Y5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi661 – 662AA → LL: Abolishes interaction with VCP. 1 Publication2

Organism-specific databases

OpenTargetsiENSG00000163516
PharmGKBiPA143485305

Polymorphism and mutation databases

BioMutaiANKZF1
DMDMi74761542

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472781 – 726Ankyrin repeat and zinc finger domain-containing protein 1Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei607PhosphothreonineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8Y5
MaxQBiQ9H8Y5
PaxDbiQ9H8Y5
PeptideAtlasiQ9H8Y5
PRIDEiQ9H8Y5
ProteomicsDBi81256

PTM databases

iPTMnetiQ9H8Y5
PhosphoSitePlusiQ9H8Y5
SwissPalmiQ9H8Y5

Expressioni

Gene expression databases

BgeeiENSG00000163516 Expressed in 175 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ANKZF1
ExpressionAtlasiQ9H8Y5 baseline and differential
GenevisibleiQ9H8Y5 HS

Organism-specific databases

HPAiHPA035208

Interactioni

Subunit structurei

Interacts (via VIM motif) with VCP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G42EBI-724848,EBI-6248094From Human immunodeficiency virus 1.

Protein-protein interaction databases

BioGridi120443, 10 interactors
IntActiQ9H8Y5, 10 interactors
MINTiQ9H8Y5
STRINGi9606.ENSP00000321617

Structurei

3D structure databases

ProteinModelPortaliQ9H8Y5
SMRiQ9H8Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati493 – 526ANK 1Add BLAST34
Repeati534 – 563ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni654 – 666VCP/p97-interacting motif (VIM)1 PublicationAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili609 – 659Sequence analysisAdd BLAST51

Sequence similaritiesi

Belongs to the ANKZF1/VMS1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 96C2H2-typeAdd BLAST25

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2505 Eukaryota
ENOG410XQAG LUCA
GeneTreeiENSGT00390000005911
HOGENOMiHOG000033947
HOVERGENiHBG080842
InParanoidiQ9H8Y5
OMAiSFCSTRC
OrthoDBiEOG091G06FM
PhylomeDBiQ9H8Y5
TreeFamiTF313431

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.iShow all

Q9H8Y5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPAPDAAPA PASISLFDLS ADAPVFQGLS LVSHAPGEAL ARAPRTSCSG
60 70 80 90 100
SGERESPERK LLQGPMDISE KLFCSTCDQT FQNHQEQREH YKLDWHRFNL
110 120 130 140 150
KQRLKDKPLL SALDFEKQSS TGDLSSISGS EDSDSASEED LQTLDRERAT
160 170 180 190 200
FEKLSRPPGF YPHRVLFQNA QGQFLYAYRC VLGPHQDPPE EAELLLQNLQ
210 220 230 240 250
SRGPRDCVVL MAAAGHFAGA IFQGREVVTH KTFHRYTVRA KRGTAQGLRD
260 270 280 290 300
ARGGPSHSAG ANLRRYNEAT LYKDVRDLLA GPSWAKALEE AGTILLRAPR
310 320 330 340 350
SGRSLFFGGK GAPLQRGDPR LWDIPLATRR PTFQELQRVL HKLTTLHVYE
360 370 380 390 400
EDPREAVRLH SPQTHWKTVR EERKKPTEEE IRKICRDEKE ALGQNEESPK
410 420 430 440 450
QGSGSEGEDG FQVELELVEL TVGTLDLCES EVLPKRRRRK RNKKEKSRDQ
460 470 480 490 500
EAGAHRTLLQ QTQEEEPSTQ SSQAVAAPLG PLLDEAKAPG QPELWNALLA
510 520 530 540 550
ACRAGDVGVL KLQLAPSPAD PRVLSLLSAP LGSGGFTLLH AAAAAGRGSV
560 570 580 590 600
VRLLLEAGAD PTVQDSRARP PYTVAADKST RNEFRRFMEK NPDAYDYNKA
610 620 630 640 650
QVPGPLTPEM EARQATRKRE QKAARRQREE QQQRQQEQEE REREEQRRFA
660 670 680 690 700
ALSDREKRAL AAERRLAAQL GAPTSPIPDS AIVNTRRCWS CGASLQGLTP
710 720
FHYLDFSFCS TRCLQDHRRQ AGRPSS
Length:726
Mass (Da):80,927
Last modified:March 1, 2001 - v1
Checksum:i44F7930A530F1355
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZS4B8ZZS4_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
516Annotation score:
C9K022C9K022_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
140Annotation score:
C9JS61C9JS61_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
115Annotation score:
C9JQZ3C9JQZ3_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
90Annotation score:
F8WD44F8WD44_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
53Annotation score:
C9J5H7C9J5H7_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
59Annotation score:

Sequence cautioni

The sequence ABD65410 differs from that shown. Reason: Frameshift at position 318.Curated
The sequence BAA91596 differs from that shown. Reason: Frameshift at position 318.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07913632 – 87Missing Found in a patient with infantile-onset inflammatory bowel disease; unknown pathological significance. 1 PublicationAdd BLAST56
Natural variantiVAR_079137152E → K Found in a patient with infantile-onset inflammatory bowel disease; unknown pathological significance; decreased function in cellular response to hydrogen peroxide; does not affect protein abundance; does not affect interaction with VCP. 1 PublicationCorresponds to variant dbSNP:rs149382949Ensembl.1
Natural variantiVAR_048269569R → W. Corresponds to variant dbSNP:rs2293076Ensembl.1
Natural variantiVAR_079138585R → Q Found in a patient with infantile-onset inflammatory bowel disease; unknown pathological significance; decreased function in cellular response to hydrogen peroxide; decreased protein abundance; does not affect interaction with VCP. 1 PublicationCorresponds to variant dbSNP:rs189875478Ensembl.1
Natural variantiVAR_079139638Q → P1 Publication1
Natural variantiVAR_048270676P → L. Corresponds to variant dbSNP:rs2293079Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ412564 mRNA Translation: ABD65410.1 Frameshift.
AK001277 mRNA Translation: BAA91596.1 Frameshift.
AK023206 mRNA Translation: BAB14462.1
BC000238 mRNA Translation: AAH00238.1
BC008948 mRNA Translation: AAH08948.1
CCDSiCCDS42821.1
RefSeqiNP_001035869.1, NM_001042410.1
NP_060559.2, NM_018089.2
UniGeneiHs.437647

Genome annotation databases

EnsembliENST00000323348; ENSP00000321617; ENSG00000163516
ENST00000410034; ENSP00000386337; ENSG00000163516
GeneIDi55139
KEGGihsa:55139
UCSCiuc002vkg.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ412564 mRNA Translation: ABD65410.1 Frameshift.
AK001277 mRNA Translation: BAA91596.1 Frameshift.
AK023206 mRNA Translation: BAB14462.1
BC000238 mRNA Translation: AAH00238.1
BC008948 mRNA Translation: AAH08948.1
CCDSiCCDS42821.1
RefSeqiNP_001035869.1, NM_001042410.1
NP_060559.2, NM_018089.2
UniGeneiHs.437647

3D structure databases

ProteinModelPortaliQ9H8Y5
SMRiQ9H8Y5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120443, 10 interactors
IntActiQ9H8Y5, 10 interactors
MINTiQ9H8Y5
STRINGi9606.ENSP00000321617

PTM databases

iPTMnetiQ9H8Y5
PhosphoSitePlusiQ9H8Y5
SwissPalmiQ9H8Y5

Polymorphism and mutation databases

BioMutaiANKZF1
DMDMi74761542

Proteomic databases

EPDiQ9H8Y5
MaxQBiQ9H8Y5
PaxDbiQ9H8Y5
PeptideAtlasiQ9H8Y5
PRIDEiQ9H8Y5
ProteomicsDBi81256

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323348; ENSP00000321617; ENSG00000163516
ENST00000410034; ENSP00000386337; ENSG00000163516
GeneIDi55139
KEGGihsa:55139
UCSCiuc002vkg.3 human

Organism-specific databases

CTDi55139
EuPathDBiHostDB:ENSG00000163516.13
GeneCardsiANKZF1
HGNCiHGNC:25527 ANKZF1
HPAiHPA035208
MIMi617541 gene
neXtProtiNX_Q9H8Y5
OpenTargetsiENSG00000163516
PharmGKBiPA143485305
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2505 Eukaryota
ENOG410XQAG LUCA
GeneTreeiENSGT00390000005911
HOGENOMiHOG000033947
HOVERGENiHBG080842
InParanoidiQ9H8Y5
OMAiSFCSTRC
OrthoDBiEOG091G06FM
PhylomeDBiQ9H8Y5
TreeFamiTF313431

Miscellaneous databases

ChiTaRSiANKZF1 human
GeneWikiiANKZF1
GenomeRNAii55139
PROiPR:Q9H8Y5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163516 Expressed in 175 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_ANKZF1
ExpressionAtlasiQ9H8Y5 baseline and differential
GenevisibleiQ9H8Y5 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANKZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9H8Y5
Secondary accession number(s): Q9NVZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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