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Entry version 162 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Ankyrin repeat and zinc finger domain-containing protein 1

Gene

ANKZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (PubMed:28302725). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri72 – 96C2H2-typeAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and zinc finger domain-containing protein 1
Alternative name(s):
Zinc finger protein 744
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKZF1
Synonyms:ZNF744
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25527 ANKZF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617541 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H8Y5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi661 – 662AA → LL: Abolishes interaction with VCP. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
55139

Open Targets

More...
OpenTargetsi
ENSG00000163516

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485305

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H8Y5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKZF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761542

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002472781 – 726Ankyrin repeat and zinc finger domain-containing protein 1Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei258PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei607PhosphothreonineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H8Y5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H8Y5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H8Y5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H8Y5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H8Y5

PeptideAtlas

More...
PeptideAtlasi
Q9H8Y5

PRoteomics IDEntifications database

More...
PRIDEi
Q9H8Y5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81256

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H8Y5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H8Y5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H8Y5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163516 Expressed in 175 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H8Y5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H8Y5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035208

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via VIM motif) with VCP.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ORFQ9Q2G42EBI-724848,EBI-6248094From Human immunodeficiency virus 1.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120443, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H8Y5, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9H8Y5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321617

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H8Y5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati493 – 526ANK 1Add BLAST34
Repeati534 – 563ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni654 – 666VCP/p97-interacting motif (VIM)1 PublicationAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili609 – 659Sequence analysisAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ANKZF1/VMS1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri72 – 96C2H2-typeAdd BLAST25

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2505 Eukaryota
ENOG410XQAG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005911

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033947

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H8Y5

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPFHYLD

Database of Orthologous Groups

More...
OrthoDBi
1495271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H8Y5

TreeFam database of animal gene trees

More...
TreeFami
TF313431

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR041540 VATC
IPR041175 VLRF1/Vms1
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF18826 bVLRF1, 1 hit
PF18716 VATC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9H8Y5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPAPDAAPA PASISLFDLS ADAPVFQGLS LVSHAPGEAL ARAPRTSCSG
60 70 80 90 100
SGERESPERK LLQGPMDISE KLFCSTCDQT FQNHQEQREH YKLDWHRFNL
110 120 130 140 150
KQRLKDKPLL SALDFEKQSS TGDLSSISGS EDSDSASEED LQTLDRERAT
160 170 180 190 200
FEKLSRPPGF YPHRVLFQNA QGQFLYAYRC VLGPHQDPPE EAELLLQNLQ
210 220 230 240 250
SRGPRDCVVL MAAAGHFAGA IFQGREVVTH KTFHRYTVRA KRGTAQGLRD
260 270 280 290 300
ARGGPSHSAG ANLRRYNEAT LYKDVRDLLA GPSWAKALEE AGTILLRAPR
310 320 330 340 350
SGRSLFFGGK GAPLQRGDPR LWDIPLATRR PTFQELQRVL HKLTTLHVYE
360 370 380 390 400
EDPREAVRLH SPQTHWKTVR EERKKPTEEE IRKICRDEKE ALGQNEESPK
410 420 430 440 450
QGSGSEGEDG FQVELELVEL TVGTLDLCES EVLPKRRRRK RNKKEKSRDQ
460 470 480 490 500
EAGAHRTLLQ QTQEEEPSTQ SSQAVAAPLG PLLDEAKAPG QPELWNALLA
510 520 530 540 550
ACRAGDVGVL KLQLAPSPAD PRVLSLLSAP LGSGGFTLLH AAAAAGRGSV
560 570 580 590 600
VRLLLEAGAD PTVQDSRARP PYTVAADKST RNEFRRFMEK NPDAYDYNKA
610 620 630 640 650
QVPGPLTPEM EARQATRKRE QKAARRQREE QQQRQQEQEE REREEQRRFA
660 670 680 690 700
ALSDREKRAL AAERRLAAQL GAPTSPIPDS AIVNTRRCWS CGASLQGLTP
710 720
FHYLDFSFCS TRCLQDHRRQ AGRPSS
Length:726
Mass (Da):80,927
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44F7930A530F1355
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZS4B8ZZS4_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
516Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K022C9K022_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JS61C9JS61_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQZ3C9JQZ3_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD44F8WD44_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5H7C9J5H7_HUMAN
Ankyrin repeat and zinc finger doma...
ANKZF1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABD65410 differs from that shown. Reason: Frameshift.Curated
The sequence BAA91596 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07913632 – 87Missing Found in a patient with infantile-onset inflammatory bowel disease; unknown pathological significance. 1 PublicationAdd BLAST56
Natural variantiVAR_079137152E → K Found in a patient with infantile-onset inflammatory bowel disease; unknown pathological significance; decreased function in cellular response to hydrogen peroxide; does not affect protein abundance; does not affect interaction with VCP. 1 PublicationCorresponds to variant dbSNP:rs149382949Ensembl.1
Natural variantiVAR_048269569R → W. Corresponds to variant dbSNP:rs2293076Ensembl.1
Natural variantiVAR_079138585R → Q Found in a patient with infantile-onset inflammatory bowel disease; unknown pathological significance; decreased function in cellular response to hydrogen peroxide; decreased protein abundance; does not affect interaction with VCP. 1 PublicationCorresponds to variant dbSNP:rs189875478Ensembl.1
Natural variantiVAR_079139638Q → P1 Publication1
Natural variantiVAR_048270676P → L. Corresponds to variant dbSNP:rs2293079Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ412564 mRNA Translation: ABD65410.1 Frameshift.
AK001277 mRNA Translation: BAA91596.1 Frameshift.
AK023206 mRNA Translation: BAB14462.1
BC000238 mRNA Translation: AAH00238.1
BC008948 mRNA Translation: AAH08948.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42821.1

NCBI Reference Sequences

More...
RefSeqi
NP_001035869.1, NM_001042410.1
NP_060559.2, NM_018089.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323348; ENSP00000321617; ENSG00000163516
ENST00000410034; ENSP00000386337; ENSG00000163516

Database of genes from NCBI RefSeq genomes

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GeneIDi
55139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55139

UCSC genome browser

More...
UCSCi
uc002vkg.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ412564 mRNA Translation: ABD65410.1 Frameshift.
AK001277 mRNA Translation: BAA91596.1 Frameshift.
AK023206 mRNA Translation: BAB14462.1
BC000238 mRNA Translation: AAH00238.1
BC008948 mRNA Translation: AAH08948.1
CCDSiCCDS42821.1
RefSeqiNP_001035869.1, NM_001042410.1
NP_060559.2, NM_018089.2

3D structure databases

SMRiQ9H8Y5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120443, 16 interactors
IntActiQ9H8Y5, 11 interactors
MINTiQ9H8Y5
STRINGi9606.ENSP00000321617

PTM databases

iPTMnetiQ9H8Y5
PhosphoSitePlusiQ9H8Y5
SwissPalmiQ9H8Y5

Polymorphism and mutation databases

BioMutaiANKZF1
DMDMi74761542

Proteomic databases

EPDiQ9H8Y5
jPOSTiQ9H8Y5
MassIVEiQ9H8Y5
MaxQBiQ9H8Y5
PaxDbiQ9H8Y5
PeptideAtlasiQ9H8Y5
PRIDEiQ9H8Y5
ProteomicsDBi81256

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q9H8Y5

Genome annotation databases

EnsembliENST00000323348; ENSP00000321617; ENSG00000163516
ENST00000410034; ENSP00000386337; ENSG00000163516
GeneIDi55139
KEGGihsa:55139
UCSCiuc002vkg.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55139
DisGeNETi55139

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKZF1
HGNCiHGNC:25527 ANKZF1
HPAiHPA035208
MIMi617541 gene
neXtProtiNX_Q9H8Y5
OpenTargetsiENSG00000163516
PharmGKBiPA143485305

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2505 Eukaryota
ENOG410XQAG LUCA
GeneTreeiENSGT00390000005911
HOGENOMiHOG000033947
InParanoidiQ9H8Y5
OMAiVPFHYLD
OrthoDBi1495271at2759
PhylomeDBiQ9H8Y5
TreeFamiTF313431

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKZF1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANKZF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55139
PharosiQ9H8Y5

Protein Ontology

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PROi
PR:Q9H8Y5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163516 Expressed in 175 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ9H8Y5 baseline and differential
GenevisibleiQ9H8Y5 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR041540 VATC
IPR041175 VLRF1/Vms1
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF18826 bVLRF1, 1 hit
PF18716 VATC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANKZ1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8Y5
Secondary accession number(s): Q9NVZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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