UniProtKB - Q9H8Y1 (VRTN_HUMAN)
Protein
Vertnin
Gene
VRTN
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- sequence-specific DNA binding Source: InterPro
- transposase activity Source: InterPro
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- transposition, DNA-mediated Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Vertnin |
Gene namesi | Name:VRTN Synonyms:C14orf115 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20223 VRTN |
neXtProti | NX_Q9H8Y1 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55237 |
OpenTargetsi | ENSG00000133980 |
PharmGKBi | PA134899928 |
Miscellaneous databases
Pharosi | Q9H8Y1 |
Polymorphism and mutation databases
BioMutai | VRTN |
DMDMi | 41016925 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089926 | 1 – 702 | VertninAdd BLAST | 702 |
Proteomic databases
EPDi | Q9H8Y1 |
jPOSTi | Q9H8Y1 |
MassIVEi | Q9H8Y1 |
PaxDbi | Q9H8Y1 |
PeptideAtlasi | Q9H8Y1 |
PRIDEi | Q9H8Y1 |
ProteomicsDBi | 81255 |
PTM databases
iPTMneti | Q9H8Y1 |
PhosphoSitePlusi | Q9H8Y1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000133980 Expressed in 101 organ(s), highest expression level in buccal mucosa cell |
ExpressionAtlasi | Q9H8Y1 baseline and differential |
Genevisiblei | Q9H8Y1 HS |
Organism-specific databases
HPAi | HPA001460 |
Interactioni
Protein-protein interaction databases
BioGridi | 120530, 8 interactors |
IntActi | Q9H8Y1, 8 interactors |
STRINGi | 9606.ENSP00000256362 |
Family & Domainsi
Sequence similaritiesi
Belongs to the vertnin family.Curated
Phylogenomic databases
eggNOGi | ENOG410IJNH Eukaryota ENOG4110HRD LUCA |
GeneTreei | ENSGT00390000007874 |
InParanoidi | Q9H8Y1 |
OMAi | VLQRNIY |
OrthoDBi | 570582at2759 |
PhylomeDBi | Q9H8Y1 |
TreeFami | TF332015 |
Family and domain databases
InterProi | View protein in InterPro IPR002514 Transposase_8 IPR010921 Trp_repressor/repl_initiator IPR038822 Vertnin-like |
PANTHERi | PTHR16081 PTHR16081, 1 hit |
Pfami | View protein in Pfam PF01527 HTH_Tnp_1, 1 hit |
SUPFAMi | SSF48295 SSF48295, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9H8Y1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSRNQLVQK VLQELQEAVE CEGLEGLIGA SLEAKQVLSS FTLPTCREGG
60 70 80 90 100
PGLQVLEVDS VALSLYPEDA PRNMLPLVCK GEGSLLFEAA SMLLWGDAGL
110 120 130 140 150
SLELRARTVV EMLLHRHYYL QGMIDSKVML QAVRYSLCSE ESPEMTSLPP
160 170 180 190 200
ATLEAIFDAD VKASCFPSSF SNVWHLYALA SVLQRNIYSI YPMRNLKIRP
210 220 230 240 250
YFNRVIRPRR CDHVPSTLHI MWAGQPLTSH FFRHQYFAPV VGLEEVEAEG
260 270 280 290 300
APGVAPALPA LAPLSSPAKT LELLNREPGL SYSHLCERYS VTKSTFYRWR
310 320 330 340 350
RQSQEHRQKV AARFSAKHFL QDSFHRGGVV PLQQFLQRFP EISRSTYYAW
360 370 380 390 400
KHELLGSGTC PALPPREVLG MEELEKLPEE QVAEEELECS ALAVSSPGMV
410 420 430 440 450
LMQRAKLYLE HCISLNTLVP YRCFKRRFPG ISRSTYYNWR RKALRRNPSF
460 470 480 490 500
KPAPALSAAG TPQLASVGEG AVIPWKSEAE EGAGNATGED PPAPGELLPL
510 520 530 540 550
RMPLSRWQRR LRRAARRQVL SGHLPFCRFR LRYPSLSPSA FWVWKSLARG
560 570 580 590 600
WPRGLSKLQV PVPTLGKGGQ EAEEKQEKEA GRDVTAVMAP PVGASSEDVE
610 620 630 640 650
GGPSREGALQ EGATAQGQPH SGPLLSQPVV AAAGGRDGRM LVMDMIATTK
660 670 680 690 700
FKAQAKLFLQ KRFQSKSFPS YKEFSALFPL TARSTYYMWK RALYDGLTLV
DG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V537 | G3V537_HUMAN | Vertnin | VRTN | 83 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 349 | A → V in BAA91826 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050876 | 53 | L → F. Corresponds to variant dbSNP:rs2232032Ensembl. | 1 | |
Natural variantiVAR_035677 | 133 | V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773509797Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023213 mRNA Translation: BAB14466.1 AK001673 mRNA Translation: BAA91826.1 BC053325 mRNA Translation: AAH53325.1 |
CCDSi | CCDS9830.1 |
RefSeqi | NP_060698.2, NM_018228.2 XP_011535213.1, XM_011536911.1 |
Genome annotation databases
Ensembli | ENST00000256362; ENSP00000256362; ENSG00000133980 |
GeneIDi | 55237 |
KEGGi | hsa:55237 |
UCSCi | uc001xpw.5 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023213 mRNA Translation: BAB14466.1 AK001673 mRNA Translation: BAA91826.1 BC053325 mRNA Translation: AAH53325.1 |
CCDSi | CCDS9830.1 |
RefSeqi | NP_060698.2, NM_018228.2 XP_011535213.1, XM_011536911.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 120530, 8 interactors |
IntActi | Q9H8Y1, 8 interactors |
STRINGi | 9606.ENSP00000256362 |
PTM databases
iPTMneti | Q9H8Y1 |
PhosphoSitePlusi | Q9H8Y1 |
Polymorphism and mutation databases
BioMutai | VRTN |
DMDMi | 41016925 |
Proteomic databases
EPDi | Q9H8Y1 |
jPOSTi | Q9H8Y1 |
MassIVEi | Q9H8Y1 |
PaxDbi | Q9H8Y1 |
PeptideAtlasi | Q9H8Y1 |
PRIDEi | Q9H8Y1 |
ProteomicsDBi | 81255 |
Genome annotation databases
Ensembli | ENST00000256362; ENSP00000256362; ENSG00000133980 |
GeneIDi | 55237 |
KEGGi | hsa:55237 |
UCSCi | uc001xpw.5 human |
Organism-specific databases
CTDi | 55237 |
DisGeNETi | 55237 |
GeneCardsi | VRTN |
HGNCi | HGNC:20223 VRTN |
HPAi | HPA001460 |
neXtProti | NX_Q9H8Y1 |
OpenTargetsi | ENSG00000133980 |
PharmGKBi | PA134899928 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IJNH Eukaryota ENOG4110HRD LUCA |
GeneTreei | ENSGT00390000007874 |
InParanoidi | Q9H8Y1 |
OMAi | VLQRNIY |
OrthoDBi | 570582at2759 |
PhylomeDBi | Q9H8Y1 |
TreeFami | TF332015 |
Miscellaneous databases
ChiTaRSi | VRTN human |
GenomeRNAii | 55237 |
Pharosi | Q9H8Y1 |
PROi | PR:Q9H8Y1 |
Gene expression databases
Bgeei | ENSG00000133980 Expressed in 101 organ(s), highest expression level in buccal mucosa cell |
ExpressionAtlasi | Q9H8Y1 baseline and differential |
Genevisiblei | Q9H8Y1 HS |
Family and domain databases
InterProi | View protein in InterPro IPR002514 Transposase_8 IPR010921 Trp_repressor/repl_initiator IPR038822 Vertnin-like |
PANTHERi | PTHR16081 PTHR16081, 1 hit |
Pfami | View protein in Pfam PF01527 HTH_Tnp_1, 1 hit |
SUPFAMi | SSF48295 SSF48295, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VRTN_HUMAN | |
Accessioni | Q9H8Y1Primary (citable) accession number: Q9H8Y1 Secondary accession number(s): Q9NVC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | March 1, 2001 | |
Last modified: | October 16, 2019 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations