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UniProtKB - Q9H8Y1 (VRTN_HUMAN)

Entry version 119 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Vertnin

Gene

VRTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vertnin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VRTN
Synonyms:C14orf115
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20223 VRTN

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H8Y1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55237

Open Targets

More...OpenTargetsi		ENSG00000133980

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134899928

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H8Y1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VRTN

Domain mapping of disease mutations (DMDM)

More...DMDMi		41016925

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899261 – 702VertninAdd BLAST702

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H8Y1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H8Y1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H8Y1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H8Y1

PeptideAtlas

More...PeptideAtlasi		Q9H8Y1

PRoteomics IDEntifications database

More...PRIDEi		Q9H8Y1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81255

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H8Y1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H8Y1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133980 Expressed in 101 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H8Y1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H8Y1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA001460

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		120530, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q9H8Y1, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256362

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vertnin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IJNH Eukaryota
ENOG4110HRD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000007874

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H8Y1

Identification of Orthologs from Complete Genome Data

More...OMAi		VLQRNIY

Database of Orthologous Groups

More...OrthoDBi		570582at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H8Y1

TreeFam database of animal gene trees

More...TreeFami		TF332015

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002514 Transposase_8
IPR010921 Trp_repressor/repl_initiator
IPR038822 Vertnin-like

The PANTHER Classification System

More...PANTHERi		PTHR16081 PTHR16081, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01527 HTH_Tnp_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48295 SSF48295, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H8Y1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSRNQLVQK VLQELQEAVE CEGLEGLIGA SLEAKQVLSS FTLPTCREGG 
        60         70         80         90        100
PGLQVLEVDS VALSLYPEDA PRNMLPLVCK GEGSLLFEAA SMLLWGDAGL 
       110        120        130        140        150
SLELRARTVV EMLLHRHYYL QGMIDSKVML QAVRYSLCSE ESPEMTSLPP 
       160        170        180        190        200
ATLEAIFDAD VKASCFPSSF SNVWHLYALA SVLQRNIYSI YPMRNLKIRP 
       210        220        230        240        250
YFNRVIRPRR CDHVPSTLHI MWAGQPLTSH FFRHQYFAPV VGLEEVEAEG 
       260        270        280        290        300
APGVAPALPA LAPLSSPAKT LELLNREPGL SYSHLCERYS VTKSTFYRWR 
       310        320        330        340        350
RQSQEHRQKV AARFSAKHFL QDSFHRGGVV PLQQFLQRFP EISRSTYYAW 
       360        370        380        390        400
KHELLGSGTC PALPPREVLG MEELEKLPEE QVAEEELECS ALAVSSPGMV 
       410        420        430        440        450
LMQRAKLYLE HCISLNTLVP YRCFKRRFPG ISRSTYYNWR RKALRRNPSF 
       460        470        480        490        500
KPAPALSAAG TPQLASVGEG AVIPWKSEAE EGAGNATGED PPAPGELLPL 
       510        520        530        540        550
RMPLSRWQRR LRRAARRQVL SGHLPFCRFR LRYPSLSPSA FWVWKSLARG 
       560        570        580        590        600
WPRGLSKLQV PVPTLGKGGQ EAEEKQEKEA GRDVTAVMAP PVGASSEDVE 
       610        620        630        640        650
GGPSREGALQ EGATAQGQPH SGPLLSQPVV AAAGGRDGRM LVMDMIATTK 
       660        670        680        690        700
FKAQAKLFLQ KRFQSKSFPS YKEFSALFPL TARSTYYMWK RALYDGLTLV 

DG
Length:702
Mass (Da):78,260
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA68C3B77387E312F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V537G3V537_HUMAN
Vertnin
VRTN
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti349A → V in BAA91826 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05087653L → F. Corresponds to variant dbSNP:rs2232032Ensembl.1
Natural variantiVAR_035677133V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773509797Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK023213 mRNA Translation: BAB14466.1
AK001673 mRNA Translation: BAA91826.1
BC053325 mRNA Translation: AAH53325.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9830.1

NCBI Reference Sequences

More...RefSeqi		NP_060698.2, NM_018228.2
XP_011535213.1, XM_011536911.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256362; ENSP00000256362; ENSG00000133980

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55237

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55237

UCSC genome browser

More...UCSCi		uc001xpw.5 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023213 mRNA Translation: BAB14466.1
AK001673 mRNA Translation: BAA91826.1
BC053325 mRNA Translation: AAH53325.1
CCDSiCCDS9830.1
RefSeqiNP_060698.2, NM_018228.2
XP_011535213.1, XM_011536911.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi120530, 8 interactors
IntActiQ9H8Y1, 8 interactors
STRINGi9606.ENSP00000256362

PTM databases

iPTMnetiQ9H8Y1
PhosphoSitePlusiQ9H8Y1

Polymorphism and mutation databases

BioMutaiVRTN
DMDMi41016925

Proteomic databases

EPDiQ9H8Y1
jPOSTiQ9H8Y1
MassIVEiQ9H8Y1
PaxDbiQ9H8Y1
PeptideAtlasiQ9H8Y1
PRIDEiQ9H8Y1
ProteomicsDBi81255

Genome annotation databases

EnsembliENST00000256362; ENSP00000256362; ENSG00000133980
GeneIDi55237
KEGGihsa:55237
UCSCiuc001xpw.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55237
DisGeNETi55237

GeneCards: human genes, protein and diseases

More...GeneCardsi		VRTN
HGNCiHGNC:20223 VRTN
HPAiHPA001460
neXtProtiNX_Q9H8Y1
OpenTargetsiENSG00000133980
PharmGKBiPA134899928

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IJNH Eukaryota
ENOG4110HRD LUCA
GeneTreeiENSGT00390000007874
InParanoidiQ9H8Y1
OMAiVLQRNIY
OrthoDBi570582at2759
PhylomeDBiQ9H8Y1
TreeFamiTF332015

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VRTN human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55237
PharosiQ9H8Y1

Protein Ontology

More...PROi		PR:Q9H8Y1

Gene expression databases

BgeeiENSG00000133980 Expressed in 101 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ9H8Y1 baseline and differential
GenevisibleiQ9H8Y1 HS

Family and domain databases

InterProiView protein in InterPro
IPR002514 Transposase_8
IPR010921 Trp_repressor/repl_initiator
IPR038822 Vertnin-like
PANTHERiPTHR16081 PTHR16081, 1 hit
PfamiView protein in Pfam
PF01527 HTH_Tnp_1, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVRTN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8Y1
Secondary accession number(s): Q9NVC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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