Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inositol-pentakisphosphate 2-kinase

Gene

IPPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.2 Publications

Catalytic activityi

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.1 Publication

Kineticsi

  1. KM=0.43 µM for Ins(1,3,4,5,6)P51 Publication
  2. KM=21 µM for ATP1 Publication
  1. Vmax=31 nmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • inositol pentakisphosphate 2-kinase activity Source: HGNC
  • protein-containing complex scaffold activity Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS05071-MONOMER
ReactomeiR-HSA-1855167 Synthesis of pyrophosphates in the cytosol
R-HSA-1855191 Synthesis of IPs in the nucleus

Protein family/group databases

MoonProtiQ9H8X2

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-pentakisphosphate 2-kinase (EC:2.7.1.158)
Alternative name(s):
IPK1 homolog
Inositol-1,3,4,5,6-pentakisphosphate 2-kinase
Ins(1,3,4,5,6)P5 2-kinase
Short name:
InsP5 2-kinase
Gene namesi
Name:IPPK
Synonyms:C9orf12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000127080.9
HGNCiHGNC:14645 IPPK
neXtProtiNX_Q9H8X2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127080
PharmGKBiPA25970

Polymorphism and mutation databases

BioMutaiIPPK
DMDMi74752731

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105291 – 491Inositol-pentakisphosphate 2-kinaseAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8X2
MaxQBiQ9H8X2
PaxDbiQ9H8X2
PeptideAtlasiQ9H8X2
PRIDEiQ9H8X2
ProteomicsDBi81252

PTM databases

iPTMnetiQ9H8X2
PhosphoSitePlusiQ9H8X2

Expressioni

Tissue specificityi

Ubiquitously expressed, with high expression in heart, brain, testis and placenta.1 Publication

Gene expression databases

BgeeiENSG00000127080 Expressed in 209 organ(s), highest expression level in esophagus mucosa
CleanExiHS_IPPK
ExpressionAtlasiQ9H8X2 baseline and differential
GenevisibleiQ9H8X2 HS

Organism-specific databases

HPAiHPA020603

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122279, 109 interactors
IntActiQ9H8X2, 1 interactor
STRINGi9606.ENSP00000287996

Structurei

3D structure databases

ProteinModelPortaliQ9H8X2
SMRiQ9H8X2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 140EXKPK motif5

Domaini

The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

Sequence similaritiesi

Belongs to the IPK1 type 2 family.Curated

Phylogenomic databases

eggNOGiKOG4749 Eukaryota
ENOG410XSF2 LUCA
GeneTreeiENSGT00390000010053
HOGENOMiHOG000113092
HOVERGENiHBG079461
InParanoidiQ9H8X2
KOiK10572
OMAiENEWKYH
OrthoDBiEOG091G05DL
PhylomeDBiQ9H8X2
TreeFamiTF106142

Family and domain databases

InterProiView protein in InterPro
IPR009286 Ins_P5_2-kin
PANTHERiPTHR14456 PTHR14456, 1 hit
PfamiView protein in Pfam
PF06090 Ins_P5_2-kin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H8X2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGKMDENE WGYHGEGNKS LVVAHAQRCV VLRFLKFPPN RKKTSEEIFQ
60 70 80 90 100
HLQNIVDFGK NVMKEFLGEN YVHYGEVVQL PLEFVKQLCL KIQSERPESR
110 120 130 140 150
CDKDLDTLSG YAMCLPNLTR LQTYRFAEHR PILCVEIKPK CGFIPFSSDV
160 170 180 190 200
THEMKHKVCR YCMHQHLKVA TGKWKQISKY CPLDLYSGNK QRMHFALKSL
210 220 230 240 250
LQEAQNNLKI FKNGELIYGC KDARSPVADW SELAHHLKPF FFPSNGLASG
260 270 280 290 300
PHCTRAVIRE LVHVITRVLL SGSDKGRAGT LSPGLGPQGP RVCEASPFSR
310 320 330 340 350
SLRCQGKNTP ERSGLPKGCL LYKTLQVQML DLLDIEGLYP LYNRVERYLE
360 370 380 390 400
EFPEERKTLQ IDGPYDEAFY QKLLDLSTED DGTVAFALTK VQQYRVAMTA
410 420 430 440 450
KDCSIMIALS PCLQDASSDQ RPVVPSSRSR FAFSVSVLDL DLKPYESIPH
460 470 480 490
QYKLDGKIVN YYSKTVRAKD NAVMSTRFKE SEDCTLVLHK V
Length:491
Mass (Da):56,017
Last modified:March 1, 2001 - v1
Checksum:iAE7A125F3BD709C0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R9A6X6R9A6_HUMAN
Inositol-pentakisphosphate 2-kinase
IPPK
163Annotation score:

Sequence cautioni

The sequence BAB14866 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti264V → A in BAB14866 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049641277R → W. Corresponds to variant dbSNP:rs2277168Ensembl.1
Natural variantiVAR_049642376L → F. Corresponds to variant dbSNP:rs2277170Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520811 mRNA Translation: AAM75353.1
AF351202 mRNA Translation: AAK69692.1
AK023225 mRNA Translation: BAB14476.1
AK024267 mRNA Translation: BAB14866.1 Different initiation.
AL137074 Genomic DNA No translation available.
AL157827 Genomic DNA No translation available.
BC026154 mRNA Translation: AAH26154.1
CCDSiCCDS6699.1
RefSeqiNP_073592.1, NM_022755.5
UniGeneiHs.459896
Hs.713775

Genome annotation databases

EnsembliENST00000287996; ENSP00000287996; ENSG00000127080
GeneIDi64768
KEGGihsa:64768
UCSCiuc004asl.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520811 mRNA Translation: AAM75353.1
AF351202 mRNA Translation: AAK69692.1
AK023225 mRNA Translation: BAB14476.1
AK024267 mRNA Translation: BAB14866.1 Different initiation.
AL137074 Genomic DNA No translation available.
AL157827 Genomic DNA No translation available.
BC026154 mRNA Translation: AAH26154.1
CCDSiCCDS6699.1
RefSeqiNP_073592.1, NM_022755.5
UniGeneiHs.459896
Hs.713775

3D structure databases

ProteinModelPortaliQ9H8X2
SMRiQ9H8X2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122279, 109 interactors
IntActiQ9H8X2, 1 interactor
STRINGi9606.ENSP00000287996

Protein family/group databases

MoonProtiQ9H8X2

PTM databases

iPTMnetiQ9H8X2
PhosphoSitePlusiQ9H8X2

Polymorphism and mutation databases

BioMutaiIPPK
DMDMi74752731

Proteomic databases

EPDiQ9H8X2
MaxQBiQ9H8X2
PaxDbiQ9H8X2
PeptideAtlasiQ9H8X2
PRIDEiQ9H8X2
ProteomicsDBi81252

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287996; ENSP00000287996; ENSG00000127080
GeneIDi64768
KEGGihsa:64768
UCSCiuc004asl.1 human

Organism-specific databases

CTDi64768
EuPathDBiHostDB:ENSG00000127080.9
GeneCardsiIPPK
HGNCiHGNC:14645 IPPK
HPAiHPA020603
neXtProtiNX_Q9H8X2
OpenTargetsiENSG00000127080
PharmGKBiPA25970
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4749 Eukaryota
ENOG410XSF2 LUCA
GeneTreeiENSGT00390000010053
HOGENOMiHOG000113092
HOVERGENiHBG079461
InParanoidiQ9H8X2
KOiK10572
OMAiENEWKYH
OrthoDBiEOG091G05DL
PhylomeDBiQ9H8X2
TreeFamiTF106142

Enzyme and pathway databases

BioCyciMetaCyc:HS05071-MONOMER
ReactomeiR-HSA-1855167 Synthesis of pyrophosphates in the cytosol
R-HSA-1855191 Synthesis of IPs in the nucleus

Miscellaneous databases

ChiTaRSiIPPK human
GenomeRNAii64768
PROiPR:Q9H8X2

Gene expression databases

BgeeiENSG00000127080 Expressed in 209 organ(s), highest expression level in esophagus mucosa
CleanExiHS_IPPK
ExpressionAtlasiQ9H8X2 baseline and differential
GenevisibleiQ9H8X2 HS

Family and domain databases

InterProiView protein in InterPro
IPR009286 Ins_P5_2-kin
PANTHERiPTHR14456 PTHR14456, 1 hit
PfamiView protein in Pfam
PF06090 Ins_P5_2-kin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPPK_HUMAN
AccessioniPrimary (citable) accession number: Q9H8X2
Secondary accession number(s): Q5T9F7, Q9H7V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again