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Protein

Pleckstrin homology domain-containing family F member 2

Gene

PLEKHF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family F member 2
Short name:
PH domain-containing family F member 2
Alternative name(s):
Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains
Short name:
EAPF
PH and FYVE domain-containing protein 2
Phafin-2
Short name:
Phafin2
Zinc finger FYVE domain-containing protein 18
Gene namesi
Name:PLEKHF2
Synonyms:ZFYVE18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000175895.3
HGNCiHGNC:20757 PLEKHF2
MIMi615208 gene
neXtProtiNX_Q9H8W4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175895
PharmGKBiPA128394715

Polymorphism and mutation databases

BioMutaiPLEKHF2
DMDMi74762744

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002516001 – 249Pleckstrin homology domain-containing family F member 2Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei44N6-acetyllysineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H8W4
MaxQBiQ9H8W4
PaxDbiQ9H8W4
PeptideAtlasiQ9H8W4
PRIDEiQ9H8W4
ProteomicsDBi81249

PTM databases

iPTMnetiQ9H8W4
PhosphoSitePlusiQ9H8W4

Expressioni

Tissue specificityi

Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.1 Publication

Inductioni

Up-regulated by TNF, bacterial lipopolysaccharides (LPS) and phorbol myristate acetate (PMA) (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000175895 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExiHS_PLEKHF2
GenevisibleiQ9H8W4 HS

Organism-specific databases

HPAiHPA024829

Interactioni

Subunit structurei

May interact with EEA1.

Binary interactionsi

Protein-protein interaction databases

BioGridi122791, 67 interactors
IntActiQ9H8W4, 157 interactors
MINTiQ9H8W4
STRINGi9606.ENSP00000322373

Structurei

3D structure databases

ProteinModelPortaliQ9H8W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 131PHPROSITE-ProRule annotationAdd BLAST97

Domaini

The PH and FYVE domains may be important for TNF-induced localization to the endoplasmic reticulum and for enhanced cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). The FYVE domain is important for binding to the endosomal membrane.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
ENOG410XPJK LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000231519
HOVERGENiHBG059973
InParanoidiQ9H8W4
OMAiGEHAAVW
OrthoDBiEOG091G0OVV
PhylomeDBiQ9H8W4
TreeFamiTF315235

Family and domain databases

CDDicd01218 PH_Phafin2-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037871 PH_Phafin
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H8W4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDRLANSEA NTRRISIVEN CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP
60 70 80 90 100
KARQFFLFND ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGDLRNGW
110 120 130 140 150
LIKTPTKSFA VYAATATEKS EWMNHINKCV TDLLSKSGKT PSNEHAAVWV
160 170 180 190 200
PDSEATVCMR CQKAKFTPVN RRHHCRKCGF VVCGPCSEKR FLLPSQSSKP
210 220 230 240
VRICDFCYDL LSAGDMATCQ PARSDSYSQS LKSPLNDMSD DDDDDDSSD
Length:249
Mass (Da):27,798
Last modified:March 1, 2001 - v1
Checksum:iF5E3F84595A98886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434819 mRNA Translation: AAL30774.1
AK023249 mRNA Translation: BAB14486.1
AL834473 mRNA Translation: CAD39132.1
BC011806 mRNA Translation: AAH11806.1
CCDSiCCDS6267.1
RefSeqiNP_078889.1, NM_024613.3
UniGeneiHs.29724

Genome annotation databases

EnsembliENST00000315367; ENSP00000322373; ENSG00000175895
ENST00000519516; ENSP00000427792; ENSG00000175895
GeneIDi79666
KEGGihsa:79666
UCSCiuc003yhn.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434819 mRNA Translation: AAL30774.1
AK023249 mRNA Translation: BAB14486.1
AL834473 mRNA Translation: CAD39132.1
BC011806 mRNA Translation: AAH11806.1
CCDSiCCDS6267.1
RefSeqiNP_078889.1, NM_024613.3
UniGeneiHs.29724

3D structure databases

ProteinModelPortaliQ9H8W4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122791, 67 interactors
IntActiQ9H8W4, 157 interactors
MINTiQ9H8W4
STRINGi9606.ENSP00000322373

PTM databases

iPTMnetiQ9H8W4
PhosphoSitePlusiQ9H8W4

Polymorphism and mutation databases

BioMutaiPLEKHF2
DMDMi74762744

Proteomic databases

EPDiQ9H8W4
MaxQBiQ9H8W4
PaxDbiQ9H8W4
PeptideAtlasiQ9H8W4
PRIDEiQ9H8W4
ProteomicsDBi81249

Protocols and materials databases

DNASUi79666
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315367; ENSP00000322373; ENSG00000175895
ENST00000519516; ENSP00000427792; ENSG00000175895
GeneIDi79666
KEGGihsa:79666
UCSCiuc003yhn.3 human

Organism-specific databases

CTDi79666
EuPathDBiHostDB:ENSG00000175895.3
GeneCardsiPLEKHF2
HGNCiHGNC:20757 PLEKHF2
HPAiHPA024829
MIMi615208 gene
neXtProtiNX_Q9H8W4
OpenTargetsiENSG00000175895
PharmGKBiPA128394715
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1729 Eukaryota
ENOG410XPJK LUCA
GeneTreeiENSGT00920000148981
HOGENOMiHOG000231519
HOVERGENiHBG059973
InParanoidiQ9H8W4
OMAiGEHAAVW
OrthoDBiEOG091G0OVV
PhylomeDBiQ9H8W4
TreeFamiTF315235

Miscellaneous databases

GeneWikiiPLEKHF2
GenomeRNAii79666
PROiPR:Q9H8W4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175895 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExiHS_PLEKHF2
GenevisibleiQ9H8W4 HS

Family and domain databases

CDDicd01218 PH_Phafin2-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037871 PH_Phafin
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363 FYVE, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00064 FYVE, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKHF2_HUMAN
AccessioniPrimary (citable) accession number: Q9H8W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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