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UniProtKB - Q9H8W4 (PKHF2_HUMAN)

Entry version 164 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Pleckstrin homology domain-containing family F member 2

Gene

PLEKHF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H8W4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H8W4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family F member 2
Short name:
PH domain-containing family F member 2
Alternative name(s):
Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains
Short name:
EAPF
PH and FYVE domain-containing protein 2
Phafin-2
Short name:
Phafin2
Zinc finger FYVE domain-containing protein 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHF2
Synonyms:ZFYVE18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000175895.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:20757, PLEKHF2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615208, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H8W4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000175895

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394715

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H8W4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLEKHF2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762744

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002516001 – 249Pleckstrin homology domain-containing family F member 2Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei44N6-acetyllysineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H8W4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H8W4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H8W4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H8W4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H8W4

PeptideAtlas

More...PeptideAtlasi		Q9H8W4

PRoteomics IDEntifications database

More...PRIDEi		Q9H8W4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81249

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H8W4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H8W4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by TNF, bacterial lipopolysaccharides (LPS) and phorbol myristate acetate (PMA) (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175895, Expressed in secondary oocyte and 220 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H8W4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175895, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with EEA1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9H8W4
With#Exp.IntAct
ABCG4 [Q9H172]3EBI-742388,EBI-8584118
ACY3 [Q96HD9]4EBI-742388,EBI-3916242
ADAP1 [O75689]3EBI-742388,EBI-714732
AIMP2 [Q13155]3EBI-742388,EBI-745226
ANO9 [A1A5B4]3EBI-742388,EBI-3843564
ARID4B - isoform 3 [Q4LE39-3]3EBI-742388,EBI-11957452
ASPH - isoform 6 [Q12797-6]3EBI-742388,EBI-12092171
BARHL2 [Q9NY43]3EBI-742388,EBI-10316571
BCAS2 [O75934]3EBI-742388,EBI-1050106
BCAS3 [Q9H6U6]3EBI-742388,EBI-6083685
BLOC1S6 [Q9UL45]4EBI-742388,EBI-465781
BOD1 - isoform 2 [Q96IK1-2]3EBI-742388,EBI-18924329
BRD7 [Q9NPI1]3EBI-742388,EBI-711221
BSCL2 - isoform 3 [Q96G97-4]3EBI-742388,EBI-10178113
C11orf45 [Q8TAV5]3EBI-742388,EBI-12810853
C3 [P01024]3EBI-742388,EBI-905851
CBX8 [Q9HC52]3EBI-742388,EBI-712912
CCDC146 [Q8IYE0]3EBI-742388,EBI-10749669
CCDC25 [Q86WR0]3EBI-742388,EBI-2690264
CDC20B - isoform 5 [Q86Y33-5]3EBI-742388,EBI-11983537
CEP44 [Q9C0F1]3EBI-742388,EBI-744115
CERK [Q8TCT0]3EBI-742388,EBI-10274247
CHCHD2 [Q9Y6H1]3EBI-742388,EBI-2321769
CHIC2 [Q9UKJ5]3EBI-742388,EBI-741528
COX5B [P10606]3EBI-742388,EBI-1053725
CRYBA1 [P05813]3EBI-742388,EBI-7043337
DAZAP2 [Q15038]3EBI-742388,EBI-724310
DMRT3 [Q9NQL9]3EBI-742388,EBI-9679045
DOCK2 [Q92608]3EBI-742388,EBI-448771
DOCK3 [Q8IZD9]3EBI-742388,EBI-1752361
DTX2 [Q86UW9]3EBI-742388,EBI-740376
DUSP4 [Q13115]3EBI-742388,EBI-6591081
EIF3C [Q99613]3EBI-742388,EBI-353741
EML2 [A0A0C4DGQ7]3EBI-742388,EBI-12112376
EXOC7 - isoform 1 [Q9UPT5-1]3EBI-742388,EBI-6251402
FAH [P16930]3EBI-742388,EBI-4397076
FBXO28 [Q9NVF7]6EBI-742388,EBI-740282
FBXW5 [Q969U6]3EBI-742388,EBI-741068
FGF13 [Q92913]3EBI-742388,EBI-1054883
FHL3 [Q96C98]3EBI-742388,EBI-10229248
FLNA - isoform 2 [P21333-2]5EBI-742388,EBI-9641086
FRMD8 [Q9BZ67]8EBI-742388,EBI-5773072
GEM [P55040]3EBI-742388,EBI-744104
GFER [P55789]3EBI-742388,EBI-718281
GPBP1 [Q86WP2]3EBI-742388,EBI-2349758
GRAMD4 [Q6IC98]3EBI-742388,EBI-10962409
GTPBP2 [Q9BX10]3EBI-742388,EBI-6115579
HEBP2 [Q9Y5Z4]3EBI-742388,EBI-741593
HSPB7 [Q9UBY9]6EBI-742388,EBI-739361
INO80 [Q9ULG1]3EBI-742388,EBI-769345
KCNAB3 [O43448]3EBI-742388,EBI-12050557
KHDC3L [Q587J8]3EBI-742388,EBI-22731520
KRTAP10-10 [P60014]3EBI-742388,EBI-11955579
KRTAP5-4 [Q6L8H1]3EBI-742388,EBI-11963072
L3MBTL3 [Q96JM7]3EBI-742388,EBI-2686809
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-742388,EBI-11985629
LDOC1 [O95751]5EBI-742388,EBI-740738
LRRC6 [Q86X45]3EBI-742388,EBI-9379658
MAGI2 - isoform 2 [Q86UL8-2]3EBI-742388,EBI-12081182
MAP2K1 [Q02750]3EBI-742388,EBI-492564
MAX [P61244]4EBI-742388,EBI-751711
MBIP [Q9NS73]3EBI-742388,EBI-741953
MBIP - isoform 4 [Q9NS73-5]3EBI-742388,EBI-10182361
MBP - isoform 2 [P02686-2]3EBI-742388,EBI-12159027
MEAF6 [Q9HAF1]5EBI-742388,EBI-399266
MFAP1 [P55081]3EBI-742388,EBI-1048159
MIDN [Q504T8]3EBI-742388,EBI-7153979
MMTAG2 [Q9BU76]3EBI-742388,EBI-742459
MPP4 [A2RU80]3EBI-742388,EBI-18924629
MRI1 [Q9BV20]3EBI-742388,EBI-747381
NDUFA5 [Q16718]3EBI-742388,EBI-746417
NFIA - isoform 2 [Q12857-2]3EBI-742388,EBI-12119652
NPM2 [Q86SE8]3EBI-742388,EBI-6658150
NPM2 - isoform 2 [Q86SE8-2]3EBI-742388,EBI-12193061
NSD2 [O96028]3EBI-742388,EBI-2693298
NUDT2 [P50583]3EBI-742388,EBI-10096247
P2RX7 [Q99572]3EBI-742388,EBI-1753251
PACSIN1 [Q9BY11]3EBI-742388,EBI-721769
PAK1IP1 [Q9NWT1]3EBI-742388,EBI-7641942
PDK4 [Q16654]3EBI-742388,EBI-2861674
PIK3R3 [Q92569]3EBI-742388,EBI-79893
PPCDC [Q96CD2]3EBI-742388,EBI-724333
PPP1R18 [Q6NYC8]3EBI-742388,EBI-2557469
PRKAG1 [P54619]3EBI-742388,EBI-1181439
PRKAR1A [P10644]3EBI-742388,EBI-476431
PTPN3 [P26045]3EBI-742388,EBI-1047946
PWWP2A - isoform 2 [Q96N64-2]3EBI-742388,EBI-18924849
RAB28 [P51157]3EBI-742388,EBI-11898753
RAB41 - isoform 2 [Q5JT25-2]3EBI-742388,EBI-12315199
RABAC1 [Q9UI14]3EBI-742388,EBI-712367
RARA [P10276]3EBI-742388,EBI-413374
RASGEF1B - isoform 3 [Q0VAM2-3]3EBI-742388,EBI-12013954
RGS10 [O43665]3EBI-742388,EBI-1057034
RGS8 - isoform 2 [P57771-2]3EBI-742388,EBI-12058229
RPAP2 [Q8IXW5]3EBI-742388,EBI-395878
RPE [Q96AT9]3EBI-742388,EBI-372480
RPRM [Q9NS64]3EBI-742388,EBI-1052363
RPS21 [P63220]6EBI-742388,EBI-714051
RSPO2 [Q6UXX9]3EBI-742388,EBI-8481036
S100A1 [P23297]3EBI-742388,EBI-743686
S100A13 [Q99584]3EBI-742388,EBI-721909
SAMD11 [Q96NU1]3EBI-742388,EBI-14067109
SCYL1 - isoform 4 [Q96KG9-4]3EBI-742388,EBI-12023020
SEC14L4 [Q9UDX3]3EBI-742388,EBI-10320311
SEPTIN2 [Q15019]3EBI-742388,EBI-741220
SEPTIN6 [Q14141]3EBI-742388,EBI-745901
SETBP1 [Q9Y6X0]3EBI-742388,EBI-2548259
SETBP1 - isoform 2 [Q9Y6X0-2]6EBI-742388,EBI-12235818
SNRNP35 - isoform 2 [Q16560-2]3EBI-742388,EBI-12938570
SOST [Q9BQB4]3EBI-742388,EBI-5746563
SPATA24 - isoform 2 [Q86W54-2]3EBI-742388,EBI-12041693
SPEF1 - isoform 2 [Q9Y4P9-2]3EBI-742388,EBI-12303571
SPON2 [Q9BUD6]3EBI-742388,EBI-10298801
STAMBPL1 [Q96FJ0]3EBI-742388,EBI-745021
STK3 [Q13188]3EBI-742388,EBI-992580
SYT16 [Q17RD7]3EBI-742388,EBI-10238936
TBCEL [Q5QJ74]3EBI-742388,EBI-10244795
TCAP [O15273]3EBI-742388,EBI-954089
TCEANC - isoform 2 [Q8N8B7-2]3EBI-742388,EBI-11955057
THAP10 [Q9P2Z0]3EBI-742388,EBI-745404
THG1L [Q9NWX6]3EBI-742388,EBI-746510
TNFAIP8 [O95379]4EBI-742388,EBI-1049336
TNFAIP8L1 [Q8WVP5]3EBI-742388,EBI-752102
TP53BP2 [Q05BL1]3EBI-742388,EBI-11952721
TRAF6 [Q9Y4K3]3EBI-742388,EBI-359276
TRAM1L1 [Q8N609]3EBI-742388,EBI-11996766
TRAPPC3 [O43617]3EBI-742388,EBI-743566
TRIAP1 [O43715]3EBI-742388,EBI-2820212
TRIM22 [Q8IYM9]3EBI-742388,EBI-954123
TTC9C [Q8N5M4]3EBI-742388,EBI-2851213
TXNL4B [Q9NX01]3EBI-742388,EBI-10309345
UBE2Z [Q9H832]9EBI-742388,EBI-720977
UGP2 [Q16851]3EBI-742388,EBI-743729
XCR1 [P46094]3EBI-742388,EBI-12960721
XRN2 [Q9H0D6]3EBI-742388,EBI-372110
YIF1A [O95070]3EBI-742388,EBI-2799703
YY1 [P25490]3EBI-742388,EBI-765538
ZBTB6 [Q15916]6EBI-742388,EBI-7227791
ZDHHC24 [Q6UX98]3EBI-742388,EBI-10254561
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-742388,EBI-8656416
ZNF165 [P49910]3EBI-742388,EBI-741694
ZNF250 - isoform 3 [P15622-3]3EBI-742388,EBI-10177272
ZNF398 [Q8TD17]3EBI-742388,EBI-8643207
ZNF439 [Q8NDP4]3EBI-742388,EBI-747580
ZNF581 [Q9P0T4]3EBI-742388,EBI-745520

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122791, 174 interactors

Protein interaction database and analysis system

More...IntActi		Q9H8W4, 168 interactors

Molecular INTeraction database

More...MINTi		Q9H8W4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000322373

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H8W4, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 131PHPROSITE-ProRule annotationAdd BLAST97

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH and FYVE domains may be important for TNF-induced localization to the endoplasmic reticulum and for enhanced cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). The FYVE domain is important for binding to the endosomal membrane.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 212FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1729, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156408

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_064864_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H8W4

Identification of Orthologs from Complete Genome Data

More...OMAi		GEHAAVW

Database of Orthologous Groups

More...OrthoDBi		1237900at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H8W4

TreeFam database of animal gene trees

More...TreeFami		TF315235

Family and domain databases

Conserved Domains Database

More...CDDi		cd01218, PH_Phafin2-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037871, PH_Phafin
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01363, FYVE, 1 hit
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00064, FYVE, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50178, ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H8W4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDRLANSEA NTRRISIVEN CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP 
        60         70         80         90        100
KARQFFLFND ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGDLRNGW 
       110        120        130        140        150
LIKTPTKSFA VYAATATEKS EWMNHINKCV TDLLSKSGKT PSNEHAAVWV 
       160        170        180        190        200
PDSEATVCMR CQKAKFTPVN RRHHCRKCGF VVCGPCSEKR FLLPSQSSKP 
       210        220        230        240 
VRICDFCYDL LSAGDMATCQ PARSDSYSQS LKSPLNDMSD DDDDDDSSD
Length:249
Mass (Da):27,798
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5E3F84595A98886
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF434819 mRNA Translation: AAL30774.1
AK023249 mRNA Translation: BAB14486.1
AL834473 mRNA Translation: CAD39132.1
BC011806 mRNA Translation: AAH11806.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6267.1

NCBI Reference Sequences

More...RefSeqi		NP_078889.1, NM_024613.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000315367; ENSP00000322373; ENSG00000175895
ENST00000519516; ENSP00000427792; ENSG00000175895

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79666

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79666

UCSC genome browser

More...UCSCi		uc003yhn.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434819 mRNA Translation: AAL30774.1
AK023249 mRNA Translation: BAB14486.1
AL834473 mRNA Translation: CAD39132.1
BC011806 mRNA Translation: AAH11806.1
CCDSiCCDS6267.1
RefSeqiNP_078889.1, NM_024613.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122791, 174 interactors
IntActiQ9H8W4, 168 interactors
MINTiQ9H8W4
STRINGi9606.ENSP00000322373

PTM databases

iPTMnetiQ9H8W4
PhosphoSitePlusiQ9H8W4

Polymorphism and mutation databases

BioMutaiPLEKHF2
DMDMi74762744

Proteomic databases

EPDiQ9H8W4
jPOSTiQ9H8W4
MassIVEiQ9H8W4
MaxQBiQ9H8W4
PaxDbiQ9H8W4
PeptideAtlasiQ9H8W4
PRIDEiQ9H8W4
ProteomicsDBi81249

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25937, 115 antibodies

The DNASU plasmid repository

More...DNASUi		79666

Genome annotation databases

EnsembliENST00000315367; ENSP00000322373; ENSG00000175895
ENST00000519516; ENSP00000427792; ENSG00000175895
GeneIDi79666
KEGGihsa:79666
UCSCiuc003yhn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79666
EuPathDBiHostDB:ENSG00000175895.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLEKHF2
HGNCiHGNC:20757, PLEKHF2
HPAiENSG00000175895, Low tissue specificity
MIMi615208, gene
neXtProtiNX_Q9H8W4
OpenTargetsiENSG00000175895
PharmGKBiPA128394715

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1729, Eukaryota
GeneTreeiENSGT00940000156408
HOGENOMiCLU_064864_1_0_1
InParanoidiQ9H8W4
OMAiGEHAAVW
OrthoDBi1237900at2759
PhylomeDBiQ9H8W4
TreeFamiTF315235

Enzyme and pathway databases

PathwayCommonsiQ9H8W4
SIGNORiQ9H8W4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79666, 10 hits in 840 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLEKHF2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PLEKHF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79666
PharosiQ9H8W4, Tbio

Protein Ontology

More...PROi		PR:Q9H8W4
RNActiQ9H8W4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175895, Expressed in secondary oocyte and 220 other tissues
GenevisibleiQ9H8W4, HS

Family and domain databases

CDDicd01218, PH_Phafin2-like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR037871, PH_Phafin
IPR000306, Znf_FYVE
IPR017455, Znf_FYVE-rel
IPR011011, Znf_FYVE_PHD
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF01363, FYVE, 1 hit
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00064, FYVE, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50178, ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8W4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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