PLEKHF2

Functionⁱ

May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	152 – 212	FYVE-typePROSITE-ProRule annotationAdd BLAST		61

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
phosphatidylinositol binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pleckstrin homology domain-containing family F member 2 Short name: PH domain-containing family F member 2 Alternative name(s): Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains Short name: EAPF PH and FYVE domain-containing protein 2 Phafin-2 Short name: Phafin2 Zinc finger FYVE domain-containing protein 18
Gene namesⁱ	Name:PLEKHF2 Synonyms:ZFYVE18
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175895.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20757 PLEKHF2
MIMⁱ	615208 gene
neXtProtⁱ	NX_Q9H8W4

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000175895
PharmGKBⁱ	PA128394715

Polymorphism and mutation databases

BioMutaⁱ	PLEKHF2
DMDMⁱ	74762744

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000251600	1 – 249	Pleckstrin homology domain-containing family F member 2Add BLAST		249

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	44	N6-acetyllysineCombined sources	1
Modified residueⁱ	239	PhosphoserineCombined sources	1
Modified residueⁱ	248	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H8W4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H8W4
PaxDbⁱ	Q9H8W4
PeptideAtlas More...PeptideAtlasⁱ	Q9H8W4
PRIDEⁱ	Q9H8W4
ProteomicsDBⁱ	81249

PTM databases

iPTMnetⁱ	Q9H8W4
PhosphoSitePlusⁱ	Q9H8W4

Expressionⁱ

Tissue specificityⁱ

Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.1 Publication

Inductionⁱ

Up-regulated by TNF, bacterial lipopolysaccharides (LPS) and phorbol myristate acetate (PMA) (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000175895 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_PLEKHF2
Genevisibleⁱ	Q9H8W4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024829

HPAⁱ

HPA024829

Interactionⁱ

Subunit structureⁱ

May interact with EEA1.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACY3	Q96HD9	3	EBI-742388,EBI-3916242
AIMP2	Q13155	3	EBI-742388,EBI-745226
BSCL2	Q96G97-4	3	EBI-742388,EBI-10178113
CEP44	Q9C0F1	3	EBI-742388,EBI-744115
CHIC2	Q9UKJ5	3	EBI-742388,EBI-741528
DTX2	Q86UW9	3	EBI-742388,EBI-740376
FBXO28	Q9NVF7	5	EBI-742388,EBI-740282
FHL3	Q96C98	3	EBI-742388,EBI-10229248
FRMD8	Q9BZ67	5	EBI-742388,EBI-5773072
GFER	P55789	3	EBI-742388,EBI-718281
GPBP1	Q86WP2	3	EBI-742388,EBI-2349758
HSPB7	Q9UBY9	3	EBI-742388,EBI-739361
L3MBTL3	Q96JM7	3	EBI-742388,EBI-2686809
LDOC1	O95751	4	EBI-742388,EBI-740738
MAX	P61244	3	EBI-742388,EBI-751711
MBIP	Q9NS73	3	EBI-742388,EBI-741953
MBIP	Q9NS73-5	3	EBI-742388,EBI-10182361
MEAF6	Q9HAF1	5	EBI-742388,EBI-399266
NPM2	Q86SE8	3	EBI-742388,EBI-6658150
PRKAR1A	P10644	3	EBI-742388,EBI-476431
RABAC1	Q9UI14	3	EBI-742388,EBI-712367
RSPO2	Q6UXX9	3	EBI-742388,EBI-8481036
S100A1	P23297	3	EBI-742388,EBI-743686
S100A13	Q99584	3	EBI-742388,EBI-721909
SEPT2	Q15019	3	EBI-742388,EBI-741220
SEPT6	Q14141	3	EBI-742388,EBI-745901
SETBP1	Q9Y6X0	3	EBI-742388,EBI-2548259
SETBP1	Q9Y6X0-2	4	EBI-742388,EBI-12235818
TNFAIP8	O95379	4	EBI-742388,EBI-1049336
TRAF6	Q9Y4K3	3	EBI-742388,EBI-359276
TRAPPC3	O43617	3	EBI-742388,EBI-743566
TXNL4B	Q9NX01	3	EBI-742388,EBI-10309345
UBE2Z	Q9H832	5	EBI-742388,EBI-720977
ZBTB6	Q15916	4	EBI-742388,EBI-7227791
ZNF250	P15622-3	3	EBI-742388,EBI-10177272
ZNF398	Q8TD17	3	EBI-742388,EBI-8643207

Protein-protein interaction databases

BioGridⁱ	122791, 67 interactors
IntActⁱ	Q9H8W4, 157 interactors
Molecular INTeraction database More...MINTⁱ	Q9H8W4
STRINGⁱ	9606.ENSP00000322373

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H8W4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 131	PHPROSITE-ProRule annotationAdd BLAST		97

Domainⁱ

The PH and FYVE domains may be important for TNF-induced localization to the endoplasmic reticulum and for enhanced cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). The FYVE domain is important for binding to the endosomal membrane.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	152 – 212	FYVE-typePROSITE-ProRule annotationAdd BLAST		61

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1729 Eukaryota ENOG410XPJK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148981
HOGENOMⁱ	HOG000231519
HOVERGENⁱ	HBG059973
InParanoidⁱ	Q9H8W4
OMAⁱ	GEHAAVW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OVV
PhylomeDBⁱ	Q9H8W4
TreeFamⁱ	TF315235

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01218 PH_Phafin2-like, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR037871 PH_Phafin IPR000306 Znf_FYVE IPR017455 Znf_FYVE-rel IPR011011 Znf_FYVE_PHD IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01363 FYVE, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00064 FYVE, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit PS50178 ZF_FYVE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9H8W4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVDRLANSEA NTRRISIVEN CFGAAGQPLT IPGRVLIGEG VLTKLCRKKP 
        60         70         80         90        100
KARQFFLFND ILVYGNIVIQ KKKYNKQHII PLENVTIDSI KDEGDLRNGW 
       110        120        130        140        150
LIKTPTKSFA VYAATATEKS EWMNHINKCV TDLLSKSGKT PSNEHAAVWV 
       160        170        180        190        200
PDSEATVCMR CQKAKFTPVN RRHHCRKCGF VVCGPCSEKR FLLPSQSSKP 
       210        220        230        240 
VRICDFCYDL LSAGDMATCQ PARSDSYSQS LKSPLNDMSD DDDDDDSSD

Length:249

Mass (Da):27,798

Last modified:March 1, 2001 - v1

Checksum:ⁱF5E3F84595A98886

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF434819 mRNA Translation: AAL30774.1 AK023249 mRNA Translation: BAB14486.1 AL834473 mRNA Translation: CAD39132.1 BC011806 mRNA Translation: AAH11806.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6267.1
NCBI Reference Sequences More...RefSeqⁱ	NP_078889.1, NM_024613.3
UniGeneⁱ	Hs.29724

Genome annotation databases

Ensemblⁱ	ENST00000315367; ENSP00000322373; ENSG00000175895 ENST00000519516; ENSP00000427792; ENSG00000175895
GeneIDⁱ	79666
KEGGⁱ	hsa:79666
UCSC genome browser More...UCSCⁱ	uc003yhn.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H8W4	PLEKHF2 isoform 1		PANTR		249	UniRef100_Q9H8W4
Uncharacterized protein		PANPA		249
Pleckstrin homology and FYVE domain containing 2		GORGO		249

Protein	Similar proteins		Species	Score	Length	Source
Q9H8W4	Pleckstrin homology domain-containing family F member 2		MOUSE		249	UniRef90_Q9H8W4
Pleckstrin homology domain-containing family F member 2		CHICK		249
PLEKHF2 isoform 1		PANTR		249
Uncharacterized protein		PANPA		249
Pleckstrin homology and FYVE domain containing 2		GORGO		249
+163

Protein	Similar proteins		Species	Score	Length	Source
Q9H8W4	Pleckstrin homology domain-containing family F member 2		CHICK		249	UniRef50_Q9H8W4
Pleckstrin homology domain-containing family F member 2		MOUSE		249
PLEKHF2 isoform 1		PANTR		249
Uncharacterized protein		PANPA		249
Pleckstrin homology and FYVE domain containing 2		GORGO		249
+264

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF434819 mRNA Translation: AAL30774.1 AK023249 mRNA Translation: BAB14486.1 AL834473 mRNA Translation: CAD39132.1 BC011806 mRNA Translation: AAH11806.1
CCDSⁱ	CCDS6267.1
RefSeqⁱ	NP_078889.1, NM_024613.3
UniGeneⁱ	Hs.29724

3D structure databases

ProteinModelPortalⁱ	Q9H8W4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122791, 67 interactors
IntActⁱ	Q9H8W4, 157 interactors
MINTⁱ	Q9H8W4
STRINGⁱ	9606.ENSP00000322373

PTM databases

iPTMnetⁱ	Q9H8W4
PhosphoSitePlusⁱ	Q9H8W4

Polymorphism and mutation databases

BioMutaⁱ	PLEKHF2
DMDMⁱ	74762744

Proteomic databases

EPDⁱ	Q9H8W4
MaxQBⁱ	Q9H8W4
PaxDbⁱ	Q9H8W4
PeptideAtlasⁱ	Q9H8W4
PRIDEⁱ	Q9H8W4
ProteomicsDBⁱ	81249

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79666
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000315367; ENSP00000322373; ENSG00000175895 ENST00000519516; ENSP00000427792; ENSG00000175895
GeneIDⁱ	79666
KEGGⁱ	hsa:79666
UCSCⁱ	uc003yhn.3 human

Organism-specific databases

CTDⁱ	79666
EuPathDBⁱ	HostDB:ENSG00000175895.3
GeneCardsⁱ	PLEKHF2
HGNCⁱ	HGNC:20757 PLEKHF2
HPAⁱ	HPA024829
MIMⁱ	615208 gene
neXtProtⁱ	NX_Q9H8W4
OpenTargetsⁱ	ENSG00000175895
PharmGKBⁱ	PA128394715
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1729 Eukaryota ENOG410XPJK LUCA
GeneTreeⁱ	ENSGT00920000148981
HOGENOMⁱ	HOG000231519
HOVERGENⁱ	HBG059973
InParanoidⁱ	Q9H8W4
OMAⁱ	GEHAAVW
OrthoDBⁱ	EOG091G0OVV
PhylomeDBⁱ	Q9H8W4
TreeFamⁱ	TF315235

Miscellaneous databases

GeneWikiⁱ	PLEKHF2
GenomeRNAiⁱ	79666
Protein Ontology More...PROⁱ	PR:Q9H8W4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175895 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_PLEKHF2
Genevisibleⁱ	Q9H8W4 HS

Family and domain databases

CDDⁱ	cd01218 PH_Phafin2-like, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR037871 PH_Phafin IPR000306 Znf_FYVE IPR017455 Znf_FYVE-rel IPR011011 Znf_FYVE_PHD IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF01363 FYVE, 1 hit PF00169 PH, 1 hit
SMARTⁱ	View protein in SMART SM00064 FYVE, 1 hit SM00233 PH, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit PS50178 ZF_FYVE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PKHF2_HUMAN
Accessionⁱ	Q9H8W4Primary (citable) accession number: Q9H8W4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9H8W4 (PKHF2_HUMAN)

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Pleckstrin homology domain-containing family F member 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Endoplasmic reticulum

Endoplasmic reticulum

Endosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ