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UniProtKB - Q9H8S9 (MOB1A_HUMAN)

Entry version 174 (02 Jun 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

MOB kinase activator 1A

Gene

MOB1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi79Zinc1 Publication1
Metal bindingi84Zinc1 Publication1
Metal bindingi161Zinc1 Publication1
Metal bindingi166Zinc1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • hippo signaling Source: UniProtKB
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H8S9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2028269, Signaling by Hippo

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H8S9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MOB kinase activator 1A
Alternative name(s):
Mob1 alpha
Short name:
Mob1A
Mob1 homolog 1B
Mps one binder kinase activator-like 1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOB1A
Synonyms:C2orf6, MOB4B, MOBK1B, MOBKL1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16015, MOB1A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609281, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H8S9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114978.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55233

Open Targets

More...OpenTargetsi		ENSG00000114978

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25894

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H8S9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MOB1A

Domain mapping of disease mutations (DMDM)

More...DMDMi		56749356

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001935662 – 216MOB kinase activator 1AAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei12Phosphothreonine1 Publication1
Modified residuei35Phosphothreonine1 Publication1
Modified residuei74Phosphothreonine; by STK3/MST21 Publication1
Modified residuei181Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H8S9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H8S9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H8S9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H8S9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H8S9

PeptideAtlas

More...PeptideAtlasi		Q9H8S9

PRoteomics IDEntifications database

More...PRIDEi		Q9H8S9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81237 [Q9H8S9-1]
81238 [Q9H8S9-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		Q9H8S9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H8S9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H8S9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114978, Expressed in leukocyte and 258 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H8S9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114978, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds STK38 and STK38L.

Interacts with LATS1 and LATS2.

Forms a tripartite complex with STK38 and STK3/MST2.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120527, 63 interactors

Database of interacting proteins

More...DIPi		DIP-36594N

Protein interaction database and analysis system

More...IntActi		Q9H8S9, 56 interactors

Molecular INTeraction database

More...MINTi		Q9H8S9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379364

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H8S9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H8S9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9H8S9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0440, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214382

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038321_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H8S9

Identification of Orthologs from Complete Genome Data

More...OMAi		TCEVMSA

Database of Orthologous Groups

More...OrthoDBi		1127941at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H8S9

TreeFam database of animal gene trees

More...TreeFami		TF300789

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.140.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005301, MOB_kinase_act_fam
IPR036703, MOB_kinase_act_sf

The PANTHER Classification System

More...PANTHERi		PTHR22599, PTHR22599, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03637, Mob1_phocein, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01388, Mob1_phocein, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101152, SSF101152, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H8S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG 
        60         70         80         90        100
EDLNEWIAVN TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG 
       110        120        130        140        150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT 
       160        170        180        190        200
ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN TSFKHFIFFV QEFNLIDRRE 
       210 
LAPLQELIEK LGSKDR
Length:216
Mass (Da):25,080
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58043AECAD1F5987
GO
Isoform 2 (identifier: Q9H8S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-148: VPFPKNFMSVA → ELTLSKYSFFF
     149-216: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:148
Mass (Da):16,928
Checksum:i70F00C42359120F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5F → L in BAB14525 (PubMed:14702039).Curated1
Sequence conflicti176E → G in BAA91810 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012295138 – 148VPFPKNFMSVA → ELTLSKYSFFF in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_012296149 – 216Missing in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB016839 mRNA Translation: BAB19058.1
AJ577474 mRNA Translation: CAE12093.1
AK001650 mRNA Translation: BAA91810.1
AK021657 mRNA Translation: BAB13868.1
AK023321 mRNA Translation: BAB14525.1
AC073263 Genomic DNA Translation: AAX93060.1
BC003398 mRNA Translation: AAH03398.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46340.1 [Q9H8S9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001304039.1, NM_001317110.1
NP_001304040.1, NM_001317111.1
NP_001304041.1, NM_001317112.1
NP_060691.2, NM_018221.4 [Q9H8S9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396049; ENSP00000379364; ENSG00000114978 [Q9H8S9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55233

UCSC genome browser

More...UCSCi		uc002skh.5, human [Q9H8S9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016839 mRNA Translation: BAB19058.1
AJ577474 mRNA Translation: CAE12093.1
AK001650 mRNA Translation: BAA91810.1
AK021657 mRNA Translation: BAB13868.1
AK023321 mRNA Translation: BAB14525.1
AC073263 Genomic DNA Translation: AAX93060.1
BC003398 mRNA Translation: AAH03398.1
CCDSiCCDS46340.1 [Q9H8S9-1]
RefSeqiNP_001304039.1, NM_001317110.1
NP_001304040.1, NM_001317111.1
NP_001304041.1, NM_001317112.1
NP_060691.2, NM_018221.4 [Q9H8S9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PI1X-ray2.00A33-216[»]
4J1VX-ray1.95A/C33-216[»]
4JIZX-ray2.10A40-211[»]
5BRKX-ray2.30A1-216[»]
5BRMX-ray2.65A/B/C/D/E/F41-216[»]
5TWFX-ray3.14A/B1-216[»]
5TWGX-ray2.30A1-216[»]
5TWHX-ray2.50A1-216[»]
5XQZX-ray2.10A/B33-216[»]
6MCPX-ray2.50B/D33-216[»]
6MCQX-ray2.57B/D33-216[»]
SMRiQ9H8S9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120527, 63 interactors
DIPiDIP-36594N
IntActiQ9H8S9, 56 interactors
MINTiQ9H8S9
STRINGi9606.ENSP00000379364

PTM databases

iPTMnetiQ9H8S9
PhosphoSitePlusiQ9H8S9

Genetic variation databases

BioMutaiMOB1A
DMDMi56749356

2D gel databases

OGPiQ9H8S9

Proteomic databases

EPDiQ9H8S9
jPOSTiQ9H8S9
MassIVEiQ9H8S9
MaxQBiQ9H8S9
PaxDbiQ9H8S9
PeptideAtlasiQ9H8S9
PRIDEiQ9H8S9
ProteomicsDBi81237 [Q9H8S9-1]
81238 [Q9H8S9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		47474, 178 antibodies

The DNASU plasmid repository

More...DNASUi		55233

Genome annotation databases

EnsembliENST00000396049; ENSP00000379364; ENSG00000114978 [Q9H8S9-1]
GeneIDi55233
KEGGihsa:55233
UCSCiuc002skh.5, human [Q9H8S9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55233
DisGeNETi55233

GeneCards: human genes, protein and diseases

More...GeneCardsi		MOB1A
HGNCiHGNC:16015, MOB1A
HPAiENSG00000114978, Low tissue specificity
MIMi609281, gene
neXtProtiNX_Q9H8S9
OpenTargetsiENSG00000114978
PharmGKBiPA25894
VEuPathDBiHostDB:ENSG00000114978.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0440, Eukaryota
GeneTreeiENSGT01000000214382
HOGENOMiCLU_038321_3_1_1
InParanoidiQ9H8S9
OMAiTCEVMSA
OrthoDBi1127941at2759
PhylomeDBiQ9H8S9
TreeFamiTF300789

Enzyme and pathway databases

PathwayCommonsiQ9H8S9
ReactomeiR-HSA-2028269, Signaling by Hippo
SIGNORiQ9H8S9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55233, 4 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MOB1A, human
EvolutionaryTraceiQ9H8S9

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MOBKL1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55233
PharosiQ9H8S9, Tbio

Protein Ontology

More...PROi		PR:Q9H8S9
RNActiQ9H8S9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114978, Expressed in leukocyte and 258 other tissues
GenevisibleiQ9H8S9, HS

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301, MOB_kinase_act_fam
IPR036703, MOB_kinase_act_sf
PANTHERiPTHR22599, PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637, Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388, Mob1_phocein, 1 hit
SUPFAMiSSF101152, SSF101152, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOB1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8S9
Secondary accession number(s): Q53S34
, Q9H3T5, Q9HAI0, Q9NVE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 174 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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