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Protein

MOB kinase activator 1A

Gene

MOB1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Zinc1 Publication1
Metal bindingi84Zinc1 Publication1
Metal bindingi161Zinc1 Publication1
Metal bindingi166Zinc1 Publication1

GO - Molecular functioni

GO - Biological processi

  • cellular response to calcium ion Source: ARUK-UCL
  • hippo signaling Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2028269 Signaling by Hippo
SIGNORiQ9H8S9

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 1A
Alternative name(s):
Mob1 alpha
Short name:
Mob1A
Mob1 homolog 1B
Mps one binder kinase activator-like 1B
Gene namesi
Name:MOB1A
Synonyms:C2orf6, MOB4B, MOBK1B, MOBKL1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000114978.17
HGNCiHGNC:16015 MOB1A
MIMi609281 gene
neXtProtiNX_Q9H8S9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55233
OpenTargetsiENSG00000114978
PharmGKBiPA25894

Polymorphism and mutation databases

BioMutaiMOB1A
DMDMi56749356

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001935662 – 216MOB kinase activator 1AAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei12Phosphothreonine1 Publication1
Modified residuei35Phosphothreonine1 Publication1
Modified residuei74Phosphothreonine; by STK3/MST21 Publication1
Modified residuei181Phosphothreonine1 Publication1

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H8S9
MaxQBiQ9H8S9
PaxDbiQ9H8S9
PeptideAtlasiQ9H8S9
PRIDEiQ9H8S9
ProteomicsDBi81237
81238 [Q9H8S9-2]

2D gel databases

OGPiQ9H8S9

PTM databases

iPTMnetiQ9H8S9
PhosphoSitePlusiQ9H8S9

Expressioni

Tissue specificityi

Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000114978
CleanExiHS_MOBKL1B
GenevisibleiQ9H8S9 HS

Organism-specific databases

HPAiHPA047088
HPA071690

Interactioni

Subunit structurei

Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120527, 55 interactors
DIPiDIP-36594N
IntActiQ9H8S9, 62 interactors
MINTiQ9H8S9
STRINGi9606.ENSP00000379364

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 15Combined sources4
Helixi24 – 35Combined sources12
Helixi36 – 38Combined sources3
Turni42 – 45Combined sources4
Helixi53 – 75Combined sources23
Helixi76 – 78Combined sources3
Turni81 – 83Combined sources3
Beta strandi88 – 90Combined sources3
Beta strandi93 – 95Combined sources3
Beta strandi100 – 102Combined sources3
Helixi111 – 126Combined sources16
Turni129 – 131Combined sources3
Beta strandi135 – 137Combined sources3
Helixi144 – 165Combined sources22
Helixi167 – 172Combined sources6
Turni173 – 175Combined sources3
Helixi176 – 193Combined sources18
Helixi198 – 201Combined sources4
Helixi202 – 204Combined sources3
Helixi205 – 211Combined sources7

3D structure databases

ProteinModelPortaliQ9H8S9
SMRiQ9H8S9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H8S9

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG0440 Eukaryota
ENOG410XSUJ LUCA
GeneTreeiENSGT00550000074456
HOGENOMiHOG000164685
HOVERGENiHBG052489
InParanoidiQ9H8S9
KOiK06685
OMAiEFCTETS
OrthoDBiEOG091G0LDA
PhylomeDBiQ9H8S9
TreeFamiTF300789

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H8S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG
60 70 80 90 100
EDLNEWIAVN TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG
110 120 130 140 150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT
160 170 180 190 200
ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN TSFKHFIFFV QEFNLIDRRE
210
LAPLQELIEK LGSKDR
Length:216
Mass (Da):25,080
Last modified:January 23, 2007 - v4
Checksum:i58043AECAD1F5987
GO
Isoform 2 (identifier: Q9H8S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-148: VPFPKNFMSVA → ELTLSKYSFFF
     149-216: Missing.

Note: May be due to an intron retention.
Show »
Length:148
Mass (Da):16,928
Checksum:i70F00C42359120F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5F → L in BAB14525 (PubMed:14702039).Curated1
Sequence conflicti176E → G in BAA91810 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012295138 – 148VPFPKNFMSVA → ELTLSKYSFFF in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_012296149 – 216Missing in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016839 mRNA Translation: BAB19058.1
AJ577474 mRNA Translation: CAE12093.1
AK001650 mRNA Translation: BAA91810.1
AK021657 mRNA Translation: BAB13868.1
AK023321 mRNA Translation: BAB14525.1
AC073263 Genomic DNA Translation: AAX93060.1
BC003398 mRNA Translation: AAH03398.1
CCDSiCCDS46340.1 [Q9H8S9-1]
RefSeqiNP_001304039.1, NM_001317110.1
NP_001304040.1, NM_001317111.1
NP_001304041.1, NM_001317112.1
NP_060691.2, NM_018221.4 [Q9H8S9-1]
UniGeneiHs.602092

Genome annotation databases

EnsembliENST00000396049; ENSP00000379364; ENSG00000114978 [Q9H8S9-1]
GeneIDi55233
KEGGihsa:55233
UCSCiuc002skh.5 human [Q9H8S9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMOB1A_HUMAN
AccessioniPrimary (citable) accession number: Q9H8S9
Secondary accession number(s): Q53S34
, Q9H3T5, Q9HAI0, Q9NVE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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