Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polyprenol reductase

Gene

SRD5A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • androgen biosynthetic process Source: Reactome
  • dolichol biosynthetic process Source: GO_Central
  • dolichol-linked oligosaccharide biosynthetic process Source: UniProtKB
  • dolichol metabolic process Source: UniProtKB
  • dolichyl diphosphate biosynthetic process Source: Reactome
  • polyprenol catabolic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS13249-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.3.1.22 2681
1.3.1.94 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193048 Androgen biosynthesis
R-HSA-446199 Synthesis of Dolichyl-phosphate
R-HSA-4755579 Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001637

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyprenol reductase (EC:1.3.1.94)
Alternative name(s):
3-oxo-5-alpha-steroid 4-dehydrogenase 3 (EC:1.3.1.22)
Steroid 5-alpha-reductase 2-like
Steroid 5-alpha-reductase 3
Short name:
S5AR 3
Short name:
SR type 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRD5A3
Synonyms:SRD5A2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128039.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25812 SRD5A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611715 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H8P0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Topological domaini35 – 80LumenalSequence analysisAdd BLAST46
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 117CytoplasmicSequence analysisAdd BLAST16
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 157LumenalSequence analysisAdd BLAST19
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 194CytoplasmicSequence analysisAdd BLAST16
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 260LumenalSequence analysisAdd BLAST45
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 318CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 1Q (CDG1Q)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:612379
Kahrizi syndrome (KHRZ)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by mental retardation, cataracts, coloboma, kyphosis, and coarse facial features.
See also OMIM:612713

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi296H → A: Loss of function. 2 Publications1

Keywords - Diseasei

Cataract, Congenital disorder of glycosylation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
79644

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SRD5A3

MalaCards human disease database

More...
MalaCardsi
SRD5A3
MIMi612379 phenotype
612713 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000128039

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
324737 SRD5A3-CDG

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162404779

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2363075

Drug and drug target database

More...
DrugBanki
DB00421 Spironolactone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRD5A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733864

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003177031 – 318Polyprenol reductaseAdd BLAST318

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H8P0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H8P0

PeptideAtlas

More...
PeptideAtlasi
Q9H8P0

PRoteomics IDEntifications database

More...
PRIDEi
Q9H8P0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81231

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H8P0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H8P0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128039 Expressed in 185 organ(s), highest expression level in palpebral conjunctiva

CleanEx database of gene expression profiles

More...
CleanExi
HS_SRD5A3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H8P0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H8P0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027006

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122772, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H8P0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H8P0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1640 Eukaryota
ENOG4111JQM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044920

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057797

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H8P0

KEGG Orthology (KO)

More...
KOi
K12345

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRFYETN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0F09

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H8P0

TreeFam database of animal gene trees

More...
TreeFami
TF315011

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039698 Dfg10/SRD5A3

The PANTHER Classification System

More...
PANTHERi
PTHR14624 PTHR14624, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02544 Steroid_dh, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9H8P0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPWAEAEHS ALNPLRAVWL TLTAAFLLTL LLQLLPPGLL PGCAIFQDLI
60 70 80 90 100
RYGKTKCGEP SRPAACRAFD VPKRYFSHFY IISVLWNGFL LWCLTQSLFL
110 120 130 140 150
GAPFPSWLHG LLRILGAAQF QGGELALSAF LVLVFLWLHS LRRLFECLYV
160 170 180 190 200
SVFSNVMIHV VQYCFGLVYY VLVGLTVLSQ VPMDGRNAYI TGKNLLMQAR
210 220 230 240 250
WFHILGMMMF IWSSAHQYKC HVILGNLRKN KAGVVIHCNH RIPFGDWFEY
260 270 280 290 300
VSSPNYLAEL MIYVSMAVTF GFHNLTWWLV VTNVFFNQAL SAFLSHQFYK
310
SKFVSYPKHR KAFLPFLF
Length:318
Mass (Da):36,521
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i404C7ECBB4A29E6B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9P9H0Y9P9_HUMAN
Polyprenol reductase
SRD5A3
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023414 mRNA Translation: BAB14568.1
CR457312 mRNA Translation: CAG33593.1
AC064824 Genomic DNA Translation: AAY40904.1
CH471057 Genomic DNA Translation: EAX05465.1
BC002480 mRNA Translation: AAH02480.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3498.1

NCBI Reference Sequences

More...
RefSeqi
NP_078868.1, NM_024592.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.39311

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264228; ENSP00000264228; ENSG00000128039

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79644

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79644

UCSC genome browser

More...
UCSCi
uc003hau.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023414 mRNA Translation: BAB14568.1
CR457312 mRNA Translation: CAG33593.1
AC064824 Genomic DNA Translation: AAY40904.1
CH471057 Genomic DNA Translation: EAX05465.1
BC002480 mRNA Translation: AAH02480.1
CCDSiCCDS3498.1
RefSeqiNP_078868.1, NM_024592.4
UniGeneiHs.39311

3D structure databases

ProteinModelPortaliQ9H8P0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122772, 4 interactors
IntActiQ9H8P0, 2 interactors
STRINGi9606.ENSP00000264228

Chemistry databases

ChEMBLiCHEMBL2363075
DrugBankiDB00421 Spironolactone
SwissLipidsiSLP:000001637

PTM databases

iPTMnetiQ9H8P0
PhosphoSitePlusiQ9H8P0

Polymorphism and mutation databases

BioMutaiSRD5A3
DMDMi74733864

Proteomic databases

MaxQBiQ9H8P0
PaxDbiQ9H8P0
PeptideAtlasiQ9H8P0
PRIDEiQ9H8P0
ProteomicsDBi81231

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79644
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264228; ENSP00000264228; ENSG00000128039
GeneIDi79644
KEGGihsa:79644
UCSCiuc003hau.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79644
DisGeNETi79644
EuPathDBiHostDB:ENSG00000128039.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SRD5A3
GeneReviewsiSRD5A3
HGNCiHGNC:25812 SRD5A3
HPAiHPA027006
MalaCardsiSRD5A3
MIMi611715 gene
612379 phenotype
612713 phenotype
neXtProtiNX_Q9H8P0
OpenTargetsiENSG00000128039
Orphaneti324737 SRD5A3-CDG
PharmGKBiPA162404779

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1640 Eukaryota
ENOG4111JQM LUCA
GeneTreeiENSGT00500000044920
HOVERGENiHBG057797
InParanoidiQ9H8P0
KOiK12345
OMAiRRFYETN
OrthoDBiEOG091G0F09
PhylomeDBiQ9H8P0
TreeFamiTF315011

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS13249-MONOMER
BRENDAi1.3.1.22 2681
1.3.1.94 2681
ReactomeiR-HSA-193048 Androgen biosynthesis
R-HSA-446199 Synthesis of Dolichyl-phosphate
R-HSA-4755579 Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SRD5A3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SRD5A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
79644

Protein Ontology

More...
PROi
PR:Q9H8P0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128039 Expressed in 185 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_SRD5A3
ExpressionAtlasiQ9H8P0 baseline and differential
GenevisibleiQ9H8P0 HS

Family and domain databases

InterProiView protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR039698 Dfg10/SRD5A3
PANTHERiPTHR14624 PTHR14624, 1 hit
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPORED_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8P0
Secondary accession number(s): Q4W5Q6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again