Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein eva-1 homolog A

Gene

EVA1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.2 Publications

GO - Biological processi

Keywordsi

Biological processApoptosis, Autophagy

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

TCDBi9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein eva-1 homolog A
Alternative name(s):
Protein FAM176A
Transmembrane protein 166
Gene namesi
Name:EVA1A
Synonyms:FAM176A, TMEM166
ORF Names:SP24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115363.13
HGNCiHGNC:25816 EVA1A
neXtProtiNX_Q9H8M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84141
OpenTargetsiENSG00000115363
PharmGKBiPA162387354

Polymorphism and mutation databases

BioMutaiEVA1A
DMDMi74733858

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786711 – 152Protein eva-1 homolog AAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphothreonineBy similarity1
Modified residuei114Phosphoserine; by FAM20C1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H8M9
MaxQBiQ9H8M9
PaxDbiQ9H8M9
PeptideAtlasiQ9H8M9
PRIDEiQ9H8M9
ProteomicsDBi81229

PTM databases

iPTMnetiQ9H8M9
PhosphoSitePlusiQ9H8M9

Expressioni

Tissue specificityi

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000115363 Expressed in 100 organ(s), highest expression level in right lobe of liver
CleanExiHS_FAM176A
ExpressionAtlasiQ9H8M9 baseline and differential
GenevisibleiQ9H8M9 HS

Organism-specific databases

HPAiHPA008055

Interactioni

Protein-protein interaction databases

BioGridi123910, 3 interactors
IntActiQ9H8M9, 9 interactors
MINTiQ9H8M9
STRINGi9606.ENSP00000233712

Structurei

3D structure databases

ProteinModelPortaliQ9H8M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60Necessary for the localization and biological activityAdd BLAST60

Sequence similaritiesi

Belongs to the EVA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZJN Eukaryota
ENOG410YJR4 LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000294093
HOVERGENiHBG061487
InParanoidiQ9H8M9
OMAiCHTDCRQ
OrthoDBiEOG091G11DT
PhylomeDBiQ9H8M9
TreeFamiTF352986

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR039501 EVA1A
PANTHERiPTHR45242 PTHR45242, 1 hit
PfamiView protein in Pfam
PF14851 FAM176, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H8M9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPLSHSPE HVEMALLSNI LAAYSFVSEN PERAALYFVS GVCIGLVLTL
60 70 80 90 100
AALVIRISCH TDCRRRPGKK FLQDRESSSD SSDSEDGSED TVSDLSVRRH
110 120 130 140 150
RRFERTLNKN VFTSAEELER AQRLEERERI IREIWMNGQP EVPGTRSLNR

YY
Length:152
Mass (Da):17,470
Last modified:March 1, 2001 - v1
Checksum:i5ED1FD97D73E801A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZF5B8ZZF5_HUMAN
Protein eva-1 homolog A
EVA1A
140Annotation score:
C9J5M4C9J5M4_HUMAN
Protein eva-1 homolog A
EVA1A
142Annotation score:
C9JX09C9JX09_HUMAN
Protein eva-1 homolog A
EVA1A
101Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37Y → C in AAG17981 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054077150R → H. Corresponds to variant dbSNP:rs11126472Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023453 mRNA Translation: BAB14580.1
AF177337 mRNA Translation: AAG17981.1
CR457314 mRNA Translation: CAG33595.1
AC007099 Genomic DNA Translation: AAY14774.1
CH471053 Genomic DNA Translation: EAW99591.1
CH471053 Genomic DNA Translation: EAW99592.1
CH471053 Genomic DNA Translation: EAW99593.1
CH471053 Genomic DNA Translation: EAW99594.1
BC016157 mRNA Translation: AAH16157.1
BC063016 mRNA Translation: AAH63016.1
CCDSiCCDS1959.1
RefSeqiNP_001128504.1, NM_001135032.1
NP_115557.1, NM_032181.2
UniGeneiHs.302346

Genome annotation databases

EnsembliENST00000233712; ENSP00000233712; ENSG00000115363
ENST00000393913; ENSP00000377490; ENSG00000115363
ENST00000410071; ENSP00000386930; ENSG00000115363
ENST00000410113; ENSP00000386435; ENSG00000115363
GeneIDi84141
KEGGihsa:84141
UCSCiuc002sni.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023453 mRNA Translation: BAB14580.1
AF177337 mRNA Translation: AAG17981.1
CR457314 mRNA Translation: CAG33595.1
AC007099 Genomic DNA Translation: AAY14774.1
CH471053 Genomic DNA Translation: EAW99591.1
CH471053 Genomic DNA Translation: EAW99592.1
CH471053 Genomic DNA Translation: EAW99593.1
CH471053 Genomic DNA Translation: EAW99594.1
BC016157 mRNA Translation: AAH16157.1
BC063016 mRNA Translation: AAH63016.1
CCDSiCCDS1959.1
RefSeqiNP_001128504.1, NM_001135032.1
NP_115557.1, NM_032181.2
UniGeneiHs.302346

3D structure databases

ProteinModelPortaliQ9H8M9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123910, 3 interactors
IntActiQ9H8M9, 9 interactors
MINTiQ9H8M9
STRINGi9606.ENSP00000233712

Protein family/group databases

TCDBi9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiQ9H8M9
PhosphoSitePlusiQ9H8M9

Polymorphism and mutation databases

BioMutaiEVA1A
DMDMi74733858

Proteomic databases

EPDiQ9H8M9
MaxQBiQ9H8M9
PaxDbiQ9H8M9
PeptideAtlasiQ9H8M9
PRIDEiQ9H8M9
ProteomicsDBi81229

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233712; ENSP00000233712; ENSG00000115363
ENST00000393913; ENSP00000377490; ENSG00000115363
ENST00000410071; ENSP00000386930; ENSG00000115363
ENST00000410113; ENSP00000386435; ENSG00000115363
GeneIDi84141
KEGGihsa:84141
UCSCiuc002sni.3 human

Organism-specific databases

CTDi84141
DisGeNETi84141
EuPathDBiHostDB:ENSG00000115363.13
GeneCardsiEVA1A
HGNCiHGNC:25816 EVA1A
HPAiHPA008055
neXtProtiNX_Q9H8M9
OpenTargetsiENSG00000115363
PharmGKBiPA162387354
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZJN Eukaryota
ENOG410YJR4 LUCA
GeneTreeiENSGT00900000140931
HOGENOMiHOG000294093
HOVERGENiHBG061487
InParanoidiQ9H8M9
OMAiCHTDCRQ
OrthoDBiEOG091G11DT
PhylomeDBiQ9H8M9
TreeFamiTF352986

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiEVA1A human
GenomeRNAii84141
PROiPR:Q9H8M9

Gene expression databases

BgeeiENSG00000115363 Expressed in 100 organ(s), highest expression level in right lobe of liver
CleanExiHS_FAM176A
ExpressionAtlasiQ9H8M9 baseline and differential
GenevisibleiQ9H8M9 HS

Family and domain databases

InterProiView protein in InterPro
IPR039500 EVA1_dom
IPR039501 EVA1A
PANTHERiPTHR45242 PTHR45242, 1 hit
PfamiView protein in Pfam
PF14851 FAM176, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEVA1A_HUMAN
AccessioniPrimary (citable) accession number: Q9H8M9
Secondary accession number(s): D6W5J3, Q9HC41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again