UniProtKB - Q9H8M9 (EVA1A_HUMAN)
Protein
Protein eva-1 homolog A
Gene
EVA1A
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.2 Publications
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- autophagy Source: UniProtKB-KW
- cellular protein metabolic process Source: Reactome
- post-translational protein modification Source: Reactome
Keywordsi
Biological process | Apoptosis, Autophagy |
Enzyme and pathway databases
PathwayCommonsi | Q9H8M9 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Protein family/group databases
TCDBi | 9.A.15.2.1, the autophagy-related phagophore-formation transporter (apt) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein eva-1 homolog AAlternative name(s): Protein FAM176A Transmembrane protein 166 |
Gene namesi | Name:EVA1A Synonyms:FAM176A, TMEM166 ORF Names:SP24 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25816, EVA1A |
MIMi | 618990, gene |
neXtProti | NX_Q9H8M9 |
VEuPathDBi | HostDB:ENSG00000115363.13 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication
Lysosome
- Lysosome membrane 1 Publication; Single-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84141 |
OpenTargetsi | ENSG00000115363 |
PharmGKBi | PA162387354 |
Miscellaneous databases
Pharosi | Q9H8M9, Tbio |
Genetic variation databases
BioMutai | EVA1A |
DMDMi | 74733858 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278671 | 1 – 152 | Protein eva-1 homolog AAdd BLAST | 152 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 106 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 114 | Phosphoserine; by FAM20C1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H8M9 |
jPOSTi | Q9H8M9 |
MassIVEi | Q9H8M9 |
MaxQBi | Q9H8M9 |
PaxDbi | Q9H8M9 |
PeptideAtlasi | Q9H8M9 |
PRIDEi | Q9H8M9 |
ProteomicsDBi | 81229 |
PTM databases
iPTMneti | Q9H8M9 |
PhosphoSitePlusi | Q9H8M9 |
Expressioni
Tissue specificityi
Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000115363, Expressed in liver and 127 other tissues |
ExpressionAtlasi | Q9H8M9, baseline and differential |
Genevisiblei | Q9H8M9, HS |
Organism-specific databases
HPAi | ENSG00000115363, Tissue enhanced (liver, pancreas) |
Interactioni
Binary interactionsi
Hide detailsQ9H8M9
With | #Exp. | IntAct |
---|---|---|
GYPA [P02724] | 3 | EBI-715362,EBI-702665 |
MS4A13 [Q5J8X5] | 3 | EBI-715362,EBI-12070086 |
SGTB [Q96EQ0] | 3 | EBI-715362,EBI-744081 |
TSPAN4 [O14817] | 3 | EBI-715362,EBI-8652667 |
Protein-protein interaction databases
BioGRIDi | 123910, 11 interactors |
IntActi | Q9H8M9, 9 interactors |
MINTi | Q9H8M9 |
STRINGi | 9606.ENSP00000233712 |
Miscellaneous databases
RNActi | Q9H8M9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | Necessary for the localization and biological activityAdd BLAST | 60 |
Sequence similaritiesi
Belongs to the EVA1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S091, Eukaryota |
GeneTreei | ENSGT00940000154096 |
InParanoidi | Q9H8M9 |
OMAi | CHTDCRQ |
OrthoDBi | 1277536at2759 |
PhylomeDBi | Q9H8M9 |
TreeFami | TF352986 |
Family and domain databases
InterProi | View protein in InterPro IPR039500, EVA1_dom IPR039501, EVA1A |
PANTHERi | PTHR46780:SF14, PTHR46780:SF14, 1 hit |
Pfami | View protein in Pfam PF14851, FAM176, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9H8M9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLPLSHSPE HVEMALLSNI LAAYSFVSEN PERAALYFVS GVCIGLVLTL
60 70 80 90 100
AALVIRISCH TDCRRRPGKK FLQDRESSSD SSDSEDGSED TVSDLSVRRH
110 120 130 140 150
RRFERTLNKN VFTSAEELER AQRLEERERI IREIWMNGQP EVPGTRSLNR
YY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB8ZZF5 | B8ZZF5_HUMAN | Protein eva-1 homolog A | EVA1A | 140 | Annotation score: | ||
C9J5M4 | C9J5M4_HUMAN | Protein eva-1 homolog A | EVA1A | 142 | Annotation score: | ||
C9JX09 | C9JX09_HUMAN | Protein eva-1 homolog A | EVA1A | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | Y → C in AAG17981 (PubMed:15498874).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054077 | 150 | R → H. Corresponds to variant dbSNP:rs11126472Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023453 mRNA Translation: BAB14580.1 AF177337 mRNA Translation: AAG17981.1 CR457314 mRNA Translation: CAG33595.1 AC007099 Genomic DNA Translation: AAY14774.1 CH471053 Genomic DNA Translation: EAW99591.1 CH471053 Genomic DNA Translation: EAW99592.1 CH471053 Genomic DNA Translation: EAW99593.1 CH471053 Genomic DNA Translation: EAW99594.1 BC016157 mRNA Translation: AAH16157.1 BC063016 mRNA Translation: AAH63016.1 |
CCDSi | CCDS1959.1 |
RefSeqi | NP_001128504.1, NM_001135032.1 NP_115557.1, NM_032181.2 |
Genome annotation databases
Ensembli | ENST00000233712; ENSP00000233712; ENSG00000115363 ENST00000393913; ENSP00000377490; ENSG00000115363 ENST00000410071; ENSP00000386930; ENSG00000115363 ENST00000410113; ENSP00000386435; ENSG00000115363 |
GeneIDi | 84141 |
KEGGi | hsa:84141 |
UCSCi | uc002sni.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023453 mRNA Translation: BAB14580.1 AF177337 mRNA Translation: AAG17981.1 CR457314 mRNA Translation: CAG33595.1 AC007099 Genomic DNA Translation: AAY14774.1 CH471053 Genomic DNA Translation: EAW99591.1 CH471053 Genomic DNA Translation: EAW99592.1 CH471053 Genomic DNA Translation: EAW99593.1 CH471053 Genomic DNA Translation: EAW99594.1 BC016157 mRNA Translation: AAH16157.1 BC063016 mRNA Translation: AAH63016.1 |
CCDSi | CCDS1959.1 |
RefSeqi | NP_001128504.1, NM_001135032.1 NP_115557.1, NM_032181.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123910, 11 interactors |
IntActi | Q9H8M9, 9 interactors |
MINTi | Q9H8M9 |
STRINGi | 9606.ENSP00000233712 |
Protein family/group databases
TCDBi | 9.A.15.2.1, the autophagy-related phagophore-formation transporter (apt) family |
PTM databases
iPTMneti | Q9H8M9 |
PhosphoSitePlusi | Q9H8M9 |
Genetic variation databases
BioMutai | EVA1A |
DMDMi | 74733858 |
Proteomic databases
EPDi | Q9H8M9 |
jPOSTi | Q9H8M9 |
MassIVEi | Q9H8M9 |
MaxQBi | Q9H8M9 |
PaxDbi | Q9H8M9 |
PeptideAtlasi | Q9H8M9 |
PRIDEi | Q9H8M9 |
ProteomicsDBi | 81229 |
Protocols and materials databases
Antibodypediai | 2359, 130 antibodies |
Genome annotation databases
Ensembli | ENST00000233712; ENSP00000233712; ENSG00000115363 ENST00000393913; ENSP00000377490; ENSG00000115363 ENST00000410071; ENSP00000386930; ENSG00000115363 ENST00000410113; ENSP00000386435; ENSG00000115363 |
GeneIDi | 84141 |
KEGGi | hsa:84141 |
UCSCi | uc002sni.3, human |
Organism-specific databases
CTDi | 84141 |
DisGeNETi | 84141 |
GeneCardsi | EVA1A |
HGNCi | HGNC:25816, EVA1A |
HPAi | ENSG00000115363, Tissue enhanced (liver, pancreas) |
MIMi | 618990, gene |
neXtProti | NX_Q9H8M9 |
OpenTargetsi | ENSG00000115363 |
PharmGKBi | PA162387354 |
VEuPathDBi | HostDB:ENSG00000115363.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S091, Eukaryota |
GeneTreei | ENSGT00940000154096 |
InParanoidi | Q9H8M9 |
OMAi | CHTDCRQ |
OrthoDBi | 1277536at2759 |
PhylomeDBi | Q9H8M9 |
TreeFami | TF352986 |
Enzyme and pathway databases
PathwayCommonsi | Q9H8M9 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 84141, 6 hits in 872 CRISPR screens |
ChiTaRSi | EVA1A, human |
GenomeRNAii | 84141 |
Pharosi | Q9H8M9, Tbio |
PROi | PR:Q9H8M9 |
RNActi | Q9H8M9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115363, Expressed in liver and 127 other tissues |
ExpressionAtlasi | Q9H8M9, baseline and differential |
Genevisiblei | Q9H8M9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039500, EVA1_dom IPR039501, EVA1A |
PANTHERi | PTHR46780:SF14, PTHR46780:SF14, 1 hit |
Pfami | View protein in Pfam PF14851, FAM176, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EVA1A_HUMAN | |
Accessioni | Q9H8M9Primary (citable) accession number: Q9H8M9 Secondary accession number(s): D6W5J3, Q9HC41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants