EVA1A

Functionⁱ

Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.2 Publications

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
autophagy Source: UniProtKB-KW
cellular protein metabolic process Source: Reactome
post-translational protein modification Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Autophagy

Biological process

Apoptosis, Autophagy

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Protein family/group databases

TCDBⁱ	9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

TCDBⁱ

9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein eva-1 homolog A Alternative name(s): Protein FAM176A Transmembrane protein 166
Gene namesⁱ	Name:EVA1A Synonyms:FAM176A, TMEM166 ORF Names:SP24
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115363.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25816 EVA1A
neXtProtⁱ	NX_Q9H8M9

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	35 – 55	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Lysosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84141
Open Targets More...OpenTargetsⁱ	ENSG00000115363
PharmGKBⁱ	PA162387354

Polymorphism and mutation databases

BioMutaⁱ	EVA1A
DMDMⁱ	74733858

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000278671	1 – 152	Protein eva-1 homolog AAdd BLAST		152

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	106	PhosphothreonineBy similarity		1
Modified residueⁱ	114	Phosphoserine; by FAM20C1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9H8M9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H8M9
PaxDbⁱ	Q9H8M9
PeptideAtlas More...PeptideAtlasⁱ	Q9H8M9
PRIDEⁱ	Q9H8M9
ProteomicsDBⁱ	81229

PTM databases

iPTMnetⁱ	Q9H8M9
PhosphoSitePlusⁱ	Q9H8M9

Expressionⁱ

Tissue specificityⁱ

Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000115363 Expressed in 100 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_FAM176A
ExpressionAtlasⁱ	Q9H8M9 baseline and differential
Genevisibleⁱ	Q9H8M9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008055

HPAⁱ

HPA008055

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	123910, 3 interactors
IntActⁱ	Q9H8M9, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9H8M9
STRINGⁱ	9606.ENSP00000233712

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H8M9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 60	Necessary for the localization and biological activityAdd BLAST		60

Sequence similaritiesⁱ

Belongs to the EVA1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IZJN Eukaryota ENOG410YJR4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140931
HOGENOMⁱ	HOG000294093
HOVERGENⁱ	HBG061487
InParanoidⁱ	Q9H8M9
OMAⁱ	CHTDCRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11DT
PhylomeDBⁱ	Q9H8M9
TreeFamⁱ	TF352986

Family and domain databases

InterProⁱ	View protein in InterPro IPR039500 EVA1_dom IPR039501 EVA1A
PANTHERⁱ	PTHR45242 PTHR45242, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14851 FAM176, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9H8M9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLPLSHSPE HVEMALLSNI LAAYSFVSEN PERAALYFVS GVCIGLVLTL 
        60         70         80         90        100
AALVIRISCH TDCRRRPGKK FLQDRESSSD SSDSEDGSED TVSDLSVRRH 
       110        120        130        140        150
RRFERTLNKN VFTSAEELER AQRLEERERI IREIWMNGQP EVPGTRSLNR 

YY

Length:152

Mass (Da):17,470

Last modified:March 1, 2001 - v1

Checksum:ⁱ5ED1FD97D73E801A

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B8ZZF5	B8ZZF5_HUMAN	Protein eva-1 homolog A Protein eva-1 homolog A	EVA1A	140	Annotation score:
C9J5M4	C9J5M4_HUMAN	Protein eva-1 homolog A Protein eva-1 homolog A	EVA1A	142	Annotation score:
C9JX09	C9JX09_HUMAN	Protein eva-1 homolog A Protein eva-1 homolog A	EVA1A	101	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	37	Y → C in AAG17981 (PubMed:15498874).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_054077	150	R → H. Corresponds to variant dbSNP:rs11126472Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023453 mRNA Translation: BAB14580.1 AF177337 mRNA Translation: AAG17981.1 CR457314 mRNA Translation: CAG33595.1 AC007099 Genomic DNA Translation: AAY14774.1 CH471053 Genomic DNA Translation: EAW99591.1 CH471053 Genomic DNA Translation: EAW99592.1 CH471053 Genomic DNA Translation: EAW99593.1 CH471053 Genomic DNA Translation: EAW99594.1 BC016157 mRNA Translation: AAH16157.1 BC063016 mRNA Translation: AAH63016.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1959.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001128504.1, NM_001135032.1 NP_115557.1, NM_032181.2
UniGeneⁱ	Hs.302346

Genome annotation databases

Ensemblⁱ	ENST00000233712; ENSP00000233712; ENSG00000115363 ENST00000393913; ENSP00000377490; ENSG00000115363 ENST00000410071; ENSP00000386930; ENSG00000115363 ENST00000410113; ENSP00000386435; ENSG00000115363
GeneIDⁱ	84141
KEGGⁱ	hsa:84141
UCSC genome browser More...UCSCⁱ	uc002sni.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H8M9	Protein eva-1 homolog A (Fragment)		HUMAN		101	UniRef100_Q9H8M9
EVA1A isoform 8 (Fragment)		PANTR		143
Uncharacterized protein		PANPA		152
EVA1A isoform 9 (Fragment)		PANTR		101
EVA1A isoform 3		PANTR		152
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9H8M9	Protein eva-1 homolog A (Fragment)		HUMAN		101	UniRef90_Q9H8M9
EVA1A isoform 8 (Fragment)		PANTR		143
Uncharacterized protein		PANPA		152
Eva-1 homolog A, regulator of programmed cell death		MACMU		152
Eva-1 homolog A, regulator of programmed cell death		MACFA		152
+13

Protein	Similar proteins		Species	Score	Length	Source
Q9H8M9	Protein eva-1 homolog A (Fragment)		HUMAN		101	UniRef50_Q9H8M9
EVA1A isoform 8 (Fragment)		PANTR		143
Uncharacterized protein		PANPA		152
Uncharacterized protein		NOMLE		152
Eva-1 homolog A, regulator of programmed cell death		MACMU		152
+49

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023453 mRNA Translation: BAB14580.1 AF177337 mRNA Translation: AAG17981.1 CR457314 mRNA Translation: CAG33595.1 AC007099 Genomic DNA Translation: AAY14774.1 CH471053 Genomic DNA Translation: EAW99591.1 CH471053 Genomic DNA Translation: EAW99592.1 CH471053 Genomic DNA Translation: EAW99593.1 CH471053 Genomic DNA Translation: EAW99594.1 BC016157 mRNA Translation: AAH16157.1 BC063016 mRNA Translation: AAH63016.1
CCDSⁱ	CCDS1959.1
RefSeqⁱ	NP_001128504.1, NM_001135032.1 NP_115557.1, NM_032181.2
UniGeneⁱ	Hs.302346

3D structure databases

ProteinModelPortalⁱ	Q9H8M9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123910, 3 interactors
IntActⁱ	Q9H8M9, 9 interactors
MINTⁱ	Q9H8M9
STRINGⁱ	9606.ENSP00000233712

Protein family/group databases

TCDBⁱ	9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

TCDBⁱ

9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetⁱ	Q9H8M9
PhosphoSitePlusⁱ	Q9H8M9

Polymorphism and mutation databases

BioMutaⁱ	EVA1A
DMDMⁱ	74733858

Proteomic databases

EPDⁱ	Q9H8M9
MaxQBⁱ	Q9H8M9
PaxDbⁱ	Q9H8M9
PeptideAtlasⁱ	Q9H8M9
PRIDEⁱ	Q9H8M9
ProteomicsDBⁱ	81229

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000233712; ENSP00000233712; ENSG00000115363 ENST00000393913; ENSP00000377490; ENSG00000115363 ENST00000410071; ENSP00000386930; ENSG00000115363 ENST00000410113; ENSP00000386435; ENSG00000115363
GeneIDⁱ	84141
KEGGⁱ	hsa:84141
UCSCⁱ	uc002sni.3 human

Organism-specific databases

CTDⁱ	84141
DisGeNETⁱ	84141
EuPathDBⁱ	HostDB:ENSG00000115363.13
GeneCardsⁱ	EVA1A
HGNCⁱ	HGNC:25816 EVA1A
HPAⁱ	HPA008055
neXtProtⁱ	NX_Q9H8M9
OpenTargetsⁱ	ENSG00000115363
PharmGKBⁱ	PA162387354
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZJN Eukaryota ENOG410YJR4 LUCA
GeneTreeⁱ	ENSGT00900000140931
HOGENOMⁱ	HOG000294093
HOVERGENⁱ	HBG061487
InParanoidⁱ	Q9H8M9
OMAⁱ	CHTDCRQ
OrthoDBⁱ	EOG091G11DT
PhylomeDBⁱ	Q9H8M9
TreeFamⁱ	TF352986

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSⁱ	EVA1A human
GenomeRNAiⁱ	84141
Protein Ontology More...PROⁱ	PR:Q9H8M9

Gene expression databases

Bgeeⁱ	ENSG00000115363 Expressed in 100 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_FAM176A
ExpressionAtlasⁱ	Q9H8M9 baseline and differential
Genevisibleⁱ	Q9H8M9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039500 EVA1_dom IPR039501 EVA1A
PANTHERⁱ	PTHR45242 PTHR45242, 1 hit
Pfamⁱ	View protein in Pfam PF14851 FAM176, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EVA1A_HUMAN
Accessionⁱ	Q9H8M9Primary (citable) accession number: Q9H8M9 Secondary accession number(s): D6W5J3, Q9HC41
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
	Last sequence update:	March 1, 2001
	Last modified:	October 10, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H8M9 (EVA1A_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein eva-1 homolog A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Endoplasmic reticulum

Endoplasmic reticulum

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ