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Protein

Bromodomain-containing protein 9

Gene

BRD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei169Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu1 Publication1
Binding sitei222Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lysine-acetylated histone binding Source: UniProtKB
  • nucleic acid binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain-containing protein 9
Alternative name(s):
Rhabdomyosarcoma antigen MU-RMS-40.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRD9
ORF Names:UNQ3040/PRO9856
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000028310.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25818 BRD9

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H8M2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
65980

Open Targets

More...
OpenTargetsi
ENSG00000028310

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134866578

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3108640

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2728

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRD9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
239938605

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002392191 – 597Bromodomain-containing protein 9Add BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei56PhosphoserineBy similarity1
Modified residuei373N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki373Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei566PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H8M2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H8M2

PeptideAtlas

More...
PeptideAtlasi
Q9H8M2

PRoteomics IDEntifications database

More...
PRIDEi
Q9H8M2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81218
81219 [Q9H8M2-1]
81220 [Q9H8M2-2]
81221 [Q9H8M2-3]
81222 [Q9H8M2-4]
81223 [Q9H8M2-6]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9H8M2-1 [Q9H8M2-1]
Q9H8M2-4 [Q9H8M2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H8M2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H8M2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000028310 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_BRD9

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H8M2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H8M2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021465
HPA023197

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds acetylated histones H3 and H4 (PubMed:22464331, PubMed:26365797). Binds butyrylated histone H4 (PubMed:26365797). Component of the multiprotein chromatin-remodeling subcomplex SWI/SNF called GBAF, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CATIPQ7Z7H33EBI-10258305,EBI-10258233

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122430, 13 interactors

Protein interaction database and analysis system

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IntActi
Q9H8M2, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000419765

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9H8M2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1597
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H8M2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H8M2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H8M2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini153 – 223BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni214 – 216Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu1 Publication3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 95Lys-richAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Bromo domain mediates interaction with histones that have acetylated lysine residues at specific positions (PubMed:22464331). Also recognizes and binds histones that are butyrylated (PubMed:26365797).2 Publications

Keywords - Domaini

Bromodomain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1828 Eukaryota
ENOG410XRRI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153864

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000070022

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107536

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H8M2

KEGG Orthology (KO)

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KOi
K22184

Identification of Orthologs from Complete Genome Data

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OMAi
QCDTEGE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06S4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H8M2

TreeFam database of animal gene trees

More...
TreeFami
TF106439

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR021900 DUF3512

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF12024 DUF3512, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47370 SSF47370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H8M2-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKKHKKHKA EWRSSYEDYA DKPLEKPLKL VLKVGGSEVT ELSGSGHDSS
60 70 80 90 100
YYDDRSDHER ERHKEKKKKK KKKSEKEKHL DDEERRKRKE EKKRKREREH
110 120 130 140 150
CDTEGEADDF DPGKKVEVEP PPDRPVRACR TQPAENESTP IQQLLEHFLR
160 170 180 190 200
QLQRKDPHGF FAFPVTDAIA PGYSMIIKHP MDFGTMKDKI VANEYKSVTE
210 220 230 240 250
FKADFKLMCD NAMTYNRPDT VYYKLAKKIL HAGFKMMSKQ AALLGNEDTA
260 270 280 290 300
VEEPVPEVVP VQVETAKKSK KPSREVISCM FEPEGNACSL TDSTAEEHVL
310 320 330 340 350
ALVEHAADEA RDRINRFLPG GKMGYLKRNG DGSLLYSVVN TAEPDADEEE
360 370 380 390 400
THPVDLSSLS SKLLPGFTTL GFKDERRNKV TFLSSATTAL SMQNNSVFGD
410 420 430 440 450
LKSDEMELLY SAYGDETGVQ CALSLQEFVK DAGSYSKKVV DDLLDQITGG
460 470 480 490 500
DHSRTLFQLK QRRNVPMKPP DEAKVGDTLG DSSSSVLEFM SMKSYPDVSV
510 520 530 540 550
DISMLSSLGK VKKELDPDDS HLNLDETTKL LQDLHEAQAE RGGSRPSSNL
560 570 580 590
SSLSNASERD QHHLGSPSRL SVGEQPDVTH DPYEFLQSPE PAASAKT
Length:597
Mass (Da):67,000
Last modified:June 16, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B248FA97948266E
GO
Isoform 2 (identifier: Q9H8M2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-391: Missing.

Note: No experimental confirmation available.
Show »
Length:206
Mass (Da):22,534
Checksum:i05D72FAD8109A693
GO
Isoform 3 (identifier: Q9H8M2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-133: EVEPPPDRPVRACRTQP → MKGYQSLVFNFFFLKLS

Note: No experimental confirmation available.
Show »
Length:481
Mass (Da):53,249
Checksum:i4961C172226405D2
GO
Isoform 4 (identifier: Q9H8M2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-133: EVEPPPDRPVRACRTQP → MKGYQSLVFNFFFLKLS
     323-349: MGYLKRNGDGSLLYSVVNTAEPDADEE → VVLCGHRERVPRGPRLSVCLSFWVGAV
     350-597: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,247
Checksum:i7043139E52BD6B40
GO
Isoform 5 (identifier: Q9H8M2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-133: EVEPPPDRPVRACRTQP → MKGYQSLVFNFFFLKLS
     239-239: K → KERLLALKRSMSFMQDMDFSQ

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:501
Mass (Da):55,665
Checksum:i5C68F53097BA073C
GO
Isoform 6 (identifier: Q9H8M2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-155: EVEPPPDRPV...EHFLRQLQRK → MMTGQTMSER...SWNTSSASFR

Note: No experimental confirmation available.
Show »
Length:544
Mass (Da):60,763
Checksum:i00E885F57A1EC36B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBY0C9JBY0_HUMAN
Bromodomain-containing protein 9
BRD9
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAW8H0YAW8_HUMAN
Bromodomain-containing protein 9
BRD9
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBR9H0YBR9_HUMAN
Bromodomain-containing protein 9
BRD9
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBF1H0YBF1_HUMAN
Bromodomain-containing protein 9
BRD9
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBX9H0YBX9_HUMAN
Bromodomain-containing protein 9
BRD9
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2E8F2Z2E8_HUMAN
Bromodomain-containing protein 9
BRD9
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15565 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti146E → D in BAB14907 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059143170A → T. Corresponds to variant dbSNP:rs34292369Ensembl.1
Natural variantiVAR_033635266A → T. Corresponds to variant dbSNP:rs34292369Ensembl.1
Natural variantiVAR_033636389A → T. Corresponds to variant dbSNP:rs414349Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0191121 – 391Missing in isoform 2. 1 PublicationAdd BLAST391
Alternative sequenceiVSP_0374931 – 116Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsAdd BLAST116
Alternative sequenceiVSP_043234117 – 155EVEPP…QLQRK → MMTGQTMSERGTKKRKRRRR RSPRRRSIWTMRKEGSERKR RSGSERGSTVTRRERLTTLI LGRRWRWSRPQIGQSERAGH SQPKMRAHLFSNSWNTSSAS FR in isoform 6. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_037494117 – 133EVEPP…CRTQP → MKGYQSLVFNFFFLKLS in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST17
Alternative sequenceiVSP_019113239K → KERLLALKRSMSFMQDMDFS Q in isoform 5. 1 Publication1
Alternative sequenceiVSP_019114323 – 349MGYLK…DADEE → VVLCGHRERVPRGPRLSVCL SFWVGAV in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_019115350 – 597Missing in isoform 4. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY358630 mRNA Translation: AAQ88993.1
AK023503 mRNA Translation: BAB14591.1
AK024392 mRNA Translation: BAB14907.1
AK026830 mRNA Translation: BAB15565.1 Different initiation.
AK297573 mRNA Translation: BAG59964.1
AK299157 mRNA Translation: BAG61205.1
AC122719 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08192.1
BC041590 mRNA Translation: AAH41590.1
DQ248311 mRNA Translation: ABB55266.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34127.2 [Q9H8M2-5]
CCDS34128.2 [Q9H8M2-6]

NCBI Reference Sequences

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RefSeqi
NP_001009877.2, NM_001009877.2 [Q9H8M2-6]
NP_001304880.1, NM_001317951.1 [Q9H8M2-1]
NP_076413.3, NM_023924.4 [Q9H8M2-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.449278

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000467963; ENSP00000419765; ENSG00000028310 [Q9H8M2-5]
ENST00000483173; ENSP00000419845; ENSG00000028310 [Q9H8M2-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
65980

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:65980

UCSC genome browser

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UCSCi
uc003jbq.4 human [Q9H8M2-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358630 mRNA Translation: AAQ88993.1
AK023503 mRNA Translation: BAB14591.1
AK024392 mRNA Translation: BAB14907.1
AK026830 mRNA Translation: BAB15565.1 Different initiation.
AK297573 mRNA Translation: BAG59964.1
AK299157 mRNA Translation: BAG61205.1
AC122719 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08192.1
BC041590 mRNA Translation: AAH41590.1
DQ248311 mRNA Translation: ABB55266.1
CCDSiCCDS34127.2 [Q9H8M2-5]
CCDS34128.2 [Q9H8M2-6]
RefSeqiNP_001009877.2, NM_001009877.2 [Q9H8M2-6]
NP_001304880.1, NM_001317951.1 [Q9H8M2-1]
NP_076413.3, NM_023924.4 [Q9H8M2-5]
UniGeneiHs.449278

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HMEX-ray2.23A/B134-239[»]
4NQNX-ray1.73A134-239[»]
4UITX-ray1.30A134-238[»]
4UIUX-ray1.64A134-238[»]
4UIVX-ray1.72A134-238[»]
4UIWX-ray1.73A134-238[»]
4XY8X-ray1.70A134-239[»]
4YY4X-ray1.47A134-239[»]
4YY6X-ray1.45A134-239[»]
4YYDX-ray1.52A134-239[»]
4YYGX-ray2.10A134-239[»]
4YYHX-ray1.74A/B134-239[»]
4YYIX-ray1.50A/B/D/E134-239[»]
4YYJX-ray1.85A/B/D/E134-239[»]
4YYKX-ray1.79A/B/D/E134-239[»]
4Z6HX-ray1.80A/B134-239[»]
4Z6IX-ray1.95A/B134-239[»]
5E9VX-ray1.80A/B134-239[»]
5EU1X-ray1.60A/B134-239[»]
5F1HX-ray1.82A/B134-239[»]
5F1LX-ray2.30A/B134-239[»]
5F25X-ray1.68A/B134-239[»]
5F2PX-ray1.80A/B134-239[»]
5I40X-ray1.04A138-239[»]
5I7XX-ray1.18A138-238[»]
5I7YX-ray1.45A138-238[»]
5IGMX-ray1.60A/B134-239[»]
5IGNX-ray1.70A/B134-239[»]
5JI8X-ray1.42A137-239[»]
5MKYX-ray1.67A134-238[»]
5TWXX-ray2.55A/B/C/D134-250[»]
ProteinModelPortaliQ9H8M2
SMRiQ9H8M2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122430, 13 interactors
IntActiQ9H8M2, 3 interactors
STRINGi9606.ENSP00000419765

Chemistry databases

BindingDBiQ9H8M2
ChEMBLiCHEMBL3108640
GuidetoPHARMACOLOGYi2728

PTM databases

iPTMnetiQ9H8M2
PhosphoSitePlusiQ9H8M2

Polymorphism and mutation databases

BioMutaiBRD9
DMDMi239938605

Proteomic databases

EPDiQ9H8M2
PaxDbiQ9H8M2
PeptideAtlasiQ9H8M2
PRIDEiQ9H8M2
ProteomicsDBi81218
81219 [Q9H8M2-1]
81220 [Q9H8M2-2]
81221 [Q9H8M2-3]
81222 [Q9H8M2-4]
81223 [Q9H8M2-6]
TopDownProteomicsiQ9H8M2-1 [Q9H8M2-1]
Q9H8M2-4 [Q9H8M2-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
65980
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000467963; ENSP00000419765; ENSG00000028310 [Q9H8M2-5]
ENST00000483173; ENSP00000419845; ENSG00000028310 [Q9H8M2-6]
GeneIDi65980
KEGGihsa:65980
UCSCiuc003jbq.4 human [Q9H8M2-5]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
65980
DisGeNETi65980
EuPathDBiHostDB:ENSG00000028310.17

GeneCards: human genes, protein and diseases

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GeneCardsi
BRD9
HGNCiHGNC:25818 BRD9
HPAiHPA021465
HPA023197
neXtProtiNX_Q9H8M2
OpenTargetsiENSG00000028310
PharmGKBiPA134866578

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1828 Eukaryota
ENOG410XRRI LUCA
GeneTreeiENSGT00940000153864
HOGENOMiHOG000070022
HOVERGENiHBG107536
InParanoidiQ9H8M2
KOiK22184
OMAiQCDTEGE
OrthoDBiEOG091G06S4
PhylomeDBiQ9H8M2
TreeFamiTF106439

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BRD9 human
EvolutionaryTraceiQ9H8M2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
65980

Protein Ontology

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PROi
PR:Q9H8M2

Gene expression databases

BgeeiENSG00000028310 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_BRD9
ExpressionAtlasiQ9H8M2 baseline and differential
GenevisibleiQ9H8M2 HS

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR021900 DUF3512
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF12024 DUF3512, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRD9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8M2
Secondary accession number(s): A6NFY8
, B4DMQ2, B4DR93, Q2XUS1, Q6UWU9, Q8IUS4, Q9H5Q5, Q9H7R9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 16, 2009
Last modified: December 5, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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