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Entry version 109 (13 Feb 2019)
Sequence version 2 (28 Nov 2006)
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Protein

Uncharacterized protein C10orf88

Gene

C10orf88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C10orf88
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119965.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25822 C10orf88

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H8K7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80007

Open Targets

More...
OpenTargetsi
ENSG00000119965

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134993933

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C10orf88

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572224

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002600851 – 445Uncharacterized protein C10orf88Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei177PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei302PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H8K7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H8K7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H8K7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H8K7

PeptideAtlas

More...
PeptideAtlasi
Q9H8K7

PRoteomics IDEntifications database

More...
PRIDEi
Q9H8K7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81215

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H8K7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H8K7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119965 Expressed in 193 organ(s), highest expression level in forebrain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H8K7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039681
HPA040991

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123064, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H8K7, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419126

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H8K7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFFY Eukaryota
ENOG4111YRF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111695

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081190

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H8K7

Identification of Orthologs from Complete Genome Data

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OMAi
ECQENIT

Database of Orthologous Groups

More...
OrthoDBi
1345490at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H8K7

TreeFam database of animal gene trees

More...
TreeFami
TF333208

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028043 DUF4506

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14958 DUF4506, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9H8K7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METRTEDGGL TRRPTLASSW DVAGGALTHS LLLTRAGLGP GDFDWEELLA
60 70 80 90 100
PPAPGQDLVI LKRNHNNKDE NPCFLYLRCG PDGGEEIASI GILSSARNME
110 120 130 140 150
VYLGEEYCGT SRGKNVCTVL DDSEHEKIIL YKKNLKLESS THACKIKLLS
160 170 180 190 200
FGERQCVFIS KVVVHMRSVF ANSSTSSPAL GSRIDLDKVQ TIMESMGSKL
210 220 230 240 250
SPGAQQLMDM VRCQQRNCIP IGEQLQSVLG NSGYKHMIGL QSSSTLGTLN
260 270 280 290 300
KSSSTPFPFR TGLTSGNVTE NLQTYIDKST QLPGGENSTK LDECKVMPQN
310 320 330 340 350
HSFLENDLKN AMASFLPKKV SDNSNIPNSE LLPFLQNLCS QVNHLHVGNK
360 370 380 390 400
TECQENITKH GERILGVGME EQSICSYLEK ILSKNMELME KKLMDYIDQR
410 420 430 440
IHELQEHIDD KIALLLDLLQ NPNSPPTGIP LRHYDSGERL SNGER
Length:445
Mass (Da):49,249
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD541EA1E400E532B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67N → D in BAB14609 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK023552 mRNA Translation: BAB14609.1
BC032645 mRNA Translation: AAH32645.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7632.1

NCBI Reference Sequences

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RefSeqi
NP_079218.2, NM_024942.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.501286

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000481909; ENSP00000419126; ENSG00000119965

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80007

UCSC genome browser

More...
UCSCi
uc001lgw.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023552 mRNA Translation: BAB14609.1
BC032645 mRNA Translation: AAH32645.1
CCDSiCCDS7632.1
RefSeqiNP_079218.2, NM_024942.3
UniGeneiHs.501286

3D structure databases

ProteinModelPortaliQ9H8K7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123064, 26 interactors
IntActiQ9H8K7, 11 interactors
STRINGi9606.ENSP00000419126

PTM databases

iPTMnetiQ9H8K7
PhosphoSitePlusiQ9H8K7

Polymorphism and mutation databases

BioMutaiC10orf88
DMDMi118572224

Proteomic databases

EPDiQ9H8K7
jPOSTiQ9H8K7
MaxQBiQ9H8K7
PaxDbiQ9H8K7
PeptideAtlasiQ9H8K7
PRIDEiQ9H8K7
ProteomicsDBi81215

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80007
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000481909; ENSP00000419126; ENSG00000119965
GeneIDi80007
KEGGihsa:80007
UCSCiuc001lgw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80007
DisGeNETi80007
EuPathDBiHostDB:ENSG00000119965.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C10orf88
HGNCiHGNC:25822 C10orf88
HPAiHPA039681
HPA040991
neXtProtiNX_Q9H8K7
OpenTargetsiENSG00000119965
PharmGKBiPA134993933

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFFY Eukaryota
ENOG4111YRF LUCA
GeneTreeiENSGT00390000017384
HOGENOMiHOG000111695
HOVERGENiHBG081190
InParanoidiQ9H8K7
OMAiECQENIT
OrthoDBi1345490at2759
PhylomeDBiQ9H8K7
TreeFamiTF333208

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C10orf88 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80007

Protein Ontology

More...
PROi
PR:Q9H8K7

Gene expression databases

BgeeiENSG00000119965 Expressed in 193 organ(s), highest expression level in forebrain
GenevisibleiQ9H8K7 HS

Family and domain databases

InterProiView protein in InterPro
IPR028043 DUF4506
PfamiView protein in Pfam
PF14958 DUF4506, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCJ088_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8K7
Secondary accession number(s): Q0P6C6, Q8N597
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: February 13, 2019
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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