UniProtKB - Q9H8H3 (MET7A_HUMAN)
Putative methyltransferase-like protein 7A
METTL7A
Functioni
Putative methyltransferase.
Curated(Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.
1 PublicationGO - Molecular functioni
- methyltransferase activity Source: GO_Central
GO - Biological processi
- methylation Source: UniProtKB-KW
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q9H8H3 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9H8H3 |
Names & Taxonomyi
Protein namesi | Recommended name: Putative methyltransferase-like protein 7ACurated (EC:2.1.1.-Curated)Alternative name(s): Protein AAM-B1 Publication |
Gene namesi | Name:METTL7A ORF Names:PRO0066, UNQ1902/PRO4348 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24550, METTL7A |
MIMi | 618338, gene |
neXtProti | NX_Q9H8H3 |
VEuPathDBi | HostDB:ENSG00000185432 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Other locations
- Lipid droplet 3 Publications
- Membrane 1 Publication
Note: Inserted in the ER membrane and migrates from the inserted site to lipid droplet.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: Reactome
Other locations
- lipid droplet Source: UniProtKB
- membrane Source: UniProtKB-SubCell
- tertiary granule lumen Source: Reactome
Keywords - Cellular componenti
Endoplasmic reticulum, Lipid droplet, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 25840 |
OpenTargetsi | ENSG00000185432 |
PharmGKBi | PA128394635 |
Miscellaneous databases
Pharosi | Q9H8H3, Tbio |
Genetic variation databases
BioMutai | METTL7A |
DMDMi | 74761529 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000251921 | 30 – 244 | Putative methyltransferase-like protein 7AAdd BLAST | 215 |
Proteomic databases
CPTACi | CPTAC-238 CPTAC-239 |
EPDi | Q9H8H3 |
jPOSTi | Q9H8H3 |
MassIVEi | Q9H8H3 |
MaxQBi | Q9H8H3 |
PaxDbi | Q9H8H3 |
PeptideAtlasi | Q9H8H3 |
PRIDEi | Q9H8H3 |
ProteomicsDBi | 81213 |
PTM databases
iPTMneti | Q9H8H3 |
PhosphoSitePlusi | Q9H8H3 |
SwissPalmi | Q9H8H3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185432, Expressed in substantia nigra and 250 other tissues |
ExpressionAtlasi | Q9H8H3, baseline and differential |
Genevisiblei | Q9H8H3, HS |
Organism-specific databases
HPAi | ENSG00000185432, Tissue enhanced (liver) |
Interactioni
Subunit structurei
(Microbial infection) Interacts with HCV non-structural protein 4B/NS4B (via C-terminal region); this interaction may promote the recruitment of NS4B in the proximity of lipid droplet.
1 PublicationSelf-associates.
1 PublicationBinary interactionsi
Q9H8H3
Protein-protein interaction databases
BioGRIDi | 117366, 357 interactors |
IntActi | Q9H8H3, 19 interactors |
MINTi | Q9H8H3 |
STRINGi | 9606.ENSP00000448785 |
Miscellaneous databases
RNActi | Q9H8H3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | Targeting to lipid droplets1 PublicationAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG4300, Eukaryota |
GeneTreei | ENSGT00940000154786 |
InParanoidi | Q9H8H3 |
OMAi | ETWKYVE |
OrthoDBi | 1178802at2759 |
PhylomeDBi | Q9H8H3 |
TreeFami | TF331790 |
Family and domain databases
InterProi | View protein in InterPro IPR013216, Methyltransf_11 IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF08241, Methyltransf_11, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MELTIFILRL AIYILTFPLY LLNFLGLWSW ICKKWFPYFL VRFTVIYNEQ
60 70 80 90 100
MASKKRELFS NLQEFAGPSG KLSLLEVGCG TGANFKFYPP GCRVTCIDPN
110 120 130 140 150
PNFEKFLIKS IAENRHLQFE RFVVAAGENM HQVADGSVDV VVCTLVLCSV
160 170 180 190 200
KNQERILREV CRVLRPGGAF YFMEHVAAEC STWNYFWQQV LDPAWHLLFD
210 220 230 240
GCNLTRESWK ALERASFSKL KLQHIQAPLS WELVRPHIYG YAVK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VQX6 | F8VQX6_HUMAN | Methyltransferase-like protein 7A | METTL7A | 180 | Annotation score: | ||
H0YI09 | H0YI09_HUMAN | Methyltransferase-like protein 7A | METTL7A | 244 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | F → L in BAB14913 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050296 | 134 | A → T. Corresponds to variant dbSNP:rs28372674Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ536233 mRNA Translation: CAD60207.1 AY358797 mRNA Translation: AAQ89157.1 AK023693 mRNA Translation: BAB14643.1 AK024409 mRNA Translation: BAB14913.1 BC004492 mRNA Translation: AAH04492.1 BC008180 mRNA Translation: AAH08180.1 AL050159 mRNA Translation: CAB43300.1 AF113007 mRNA Translation: AAF20268.1 Different initiation. |
CCDSi | CCDS8804.1 |
PIRi | T08785 |
RefSeqi | NP_054752.3, NM_014033.3 XP_006719395.1, XM_006719332.1 |
Genome annotation databases
Ensembli | ENST00000332160; ENSP00000331787; ENSG00000185432 ENST00000547104; ENSP00000447542; ENSG00000185432 ENST00000548553; ENSP00000448785; ENSG00000185432 |
GeneIDi | 25840 |
KEGGi | hsa:25840 |
MANE-Selecti | ENST00000332160.5; ENSP00000331787.4; NM_014033.4; NP_054752.3 |
UCSCi | uc001rxb.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ536233 mRNA Translation: CAD60207.1 AY358797 mRNA Translation: AAQ89157.1 AK023693 mRNA Translation: BAB14643.1 AK024409 mRNA Translation: BAB14913.1 BC004492 mRNA Translation: AAH04492.1 BC008180 mRNA Translation: AAH08180.1 AL050159 mRNA Translation: CAB43300.1 AF113007 mRNA Translation: AAF20268.1 Different initiation. |
CCDSi | CCDS8804.1 |
PIRi | T08785 |
RefSeqi | NP_054752.3, NM_014033.3 XP_006719395.1, XM_006719332.1 |
3D structure databases
SMRi | Q9H8H3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117366, 357 interactors |
IntActi | Q9H8H3, 19 interactors |
MINTi | Q9H8H3 |
STRINGi | 9606.ENSP00000448785 |
PTM databases
iPTMneti | Q9H8H3 |
PhosphoSitePlusi | Q9H8H3 |
SwissPalmi | Q9H8H3 |
Genetic variation databases
BioMutai | METTL7A |
DMDMi | 74761529 |
Proteomic databases
CPTACi | CPTAC-238 CPTAC-239 |
EPDi | Q9H8H3 |
jPOSTi | Q9H8H3 |
MassIVEi | Q9H8H3 |
MaxQBi | Q9H8H3 |
PaxDbi | Q9H8H3 |
PeptideAtlasi | Q9H8H3 |
PRIDEi | Q9H8H3 |
ProteomicsDBi | 81213 |
Protocols and materials databases
Antibodypediai | 2699, 235 antibodies from 26 providers |
DNASUi | 25840 |
Genome annotation databases
Ensembli | ENST00000332160; ENSP00000331787; ENSG00000185432 ENST00000547104; ENSP00000447542; ENSG00000185432 ENST00000548553; ENSP00000448785; ENSG00000185432 |
GeneIDi | 25840 |
KEGGi | hsa:25840 |
MANE-Selecti | ENST00000332160.5; ENSP00000331787.4; NM_014033.4; NP_054752.3 |
UCSCi | uc001rxb.3, human |
Organism-specific databases
CTDi | 25840 |
DisGeNETi | 25840 |
GeneCardsi | METTL7A |
HGNCi | HGNC:24550, METTL7A |
HPAi | ENSG00000185432, Tissue enhanced (liver) |
MIMi | 618338, gene |
neXtProti | NX_Q9H8H3 |
OpenTargetsi | ENSG00000185432 |
PharmGKBi | PA128394635 |
VEuPathDBi | HostDB:ENSG00000185432 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4300, Eukaryota |
GeneTreei | ENSGT00940000154786 |
InParanoidi | Q9H8H3 |
OMAi | ETWKYVE |
OrthoDBi | 1178802at2759 |
PhylomeDBi | Q9H8H3 |
TreeFami | TF331790 |
Enzyme and pathway databases
PathwayCommonsi | Q9H8H3 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9H8H3 |
Miscellaneous databases
BioGRID-ORCSi | 25840, 47 hits in 1041 CRISPR screens |
ChiTaRSi | METTL7A, human |
GenomeRNAii | 25840 |
Pharosi | Q9H8H3, Tbio |
PROi | PR:Q9H8H3 |
RNActi | Q9H8H3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185432, Expressed in substantia nigra and 250 other tissues |
ExpressionAtlasi | Q9H8H3, baseline and differential |
Genevisiblei | Q9H8H3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013216, Methyltransf_11 IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF08241, Methyltransf_11, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MET7A_HUMAN | |
Accessioni | Q9H8H3Primary (citable) accession number: Q9H8H3 Secondary accession number(s): Q9H7R3, Q9UHZ7, Q9Y422 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families