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Entry version 160 (26 Feb 2020)
Sequence version 2 (19 Jul 2005)
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Protein

Probable ATP-dependent RNA helicase DDX31

Gene

DDX31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (PubMed:23019224).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi275 – 282ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • ribosome biogenesis Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX31 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 31
Helicain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16715 DDX31

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616533 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H8H2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64794

Open Targets

More...
OpenTargetsi
ENSG00000125485

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27218

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H8H2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDX31

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153334

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000550491 – 851Probable ATP-dependent RNA helicase DDX31Add BLAST851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei828Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H8H2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H8H2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H8H2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H8H2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H8H2

PeptideAtlas

More...
PeptideAtlasi
Q9H8H2

PRoteomics IDEntifications database

More...
PRIDEi
Q9H8H2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
81209 [Q9H8H2-1]
81210 [Q9H8H2-2]
81211 [Q9H8H2-3]
81212 [Q9H8H2-4]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q9H8H2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H8H2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H8H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly or undetectably expressed in normal organs. Up-regulated in renal cell carcinoma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125485 Expressed in left lobe of thyroid gland and 161 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H8H2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H8H2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020891

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NPM1; this interaction prevents interaction between NPM1 and HDM2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122302, 119 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H8H2, 103 interactors

Molecular INTeraction database

More...
MINTi
Q9H8H2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361232

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H8H2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H8H2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini262 – 443Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST182
Domaini480 – 659Helicase C-terminalPROSITE-ProRule annotationAdd BLAST180

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi230 – 259Q motifAdd BLAST30
Motifi388 – 391DEAD box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0348 Eukaryota
ENOG410XNT7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075041

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_003041_26_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H8H2

KEGG Orthology (KO)

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KOi
K14806

Identification of Orthologs from Complete Genome Data

More...
OMAi
FSRIQWL

Database of Orthologous Groups

More...
OrthoDBi
973872at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H8H2

TreeFam database of animal gene trees

More...
TreeFami
TF323273

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR025313 DUF4217
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF13959 DUF4217, 1 hit
PF00271 Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM01178 DUF4217, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H8H2-1) [UniParc]FASTAAdd to basket
Also known as: Helicain B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPDLASQRH SESFPSVNSR PNVILPGREG RREGLPPGGG TRGSLVPTRP
60 70 80 90 100
VPPSPAPLGT SPYSWSRSGP GRGGGAGSSR VPRGVPGPAV CAPGSLLHHA
110 120 130 140 150
SPTQTMAAAD GSLFDNPRTF SRRPPAQASR QAKATKRKYQ ASSEAPPAKR
160 170 180 190 200
RNETSFLPAK KTSVKETQRT FKGNAQKMFS PKKHSVSTSD RNQEERQCIK
210 220 230 240 250
TSSLFKNNPD IPELHRPVVK QVQEKVFTSA AFHELGLHPH LISTINTVLK
260 270 280 290 300
MSSMTSVQKQ SIPVLLEGRD ALVRSQTGSG KTLAYCIPVV QSLQAMESKI
310 320 330 340 350
QRSDGPYALV LVPTRELALQ SFDTVQKLLK PFTWIVPGVL MGGEKRKSEK
360 370 380 390 400
ARLRKGINIL ISTPGRLVDH IKSTKNIHFS RLRWLVFDEA DRILDLGFEK
410 420 430 440 450
DITVILNAVN AECQKRQNVL LSATLTEGVT RLADISLHDP VSISVLDKSH
460 470 480 490 500
DQLNPKDKAV QEVCPPPAGD KLDSFAIPES LKQHVTVVPS KLRLVCLAAF
510 520 530 540 550
ILQKCKFEED QKMVVFFSSC ELVEFHYSLF LQTLLSSSGA PASGQLPSAS
560 570 580 590 600
MRLKFLRLHG GMEQEERTAV FQEFSHSRRG VLLCTDVAAR GLDLPQVTWI
610 620 630 640 650
VQYNAPSSPA EYIHRIGRTA RIGCHGSSLL ILAPSEAEYV NSLASHKINV
660 670 680 690 700
SEIKMEDILC VLTRDDCFKG KRWGAQKSHA VGPQEIRERA TVLQTVFEDY
710 720 730 740 750
VHSSERRVSW AKKALQSFIQ AYATYPRELK HIFHVRSLHL GHVAKSFGLR
760 770 780 790 800
DAPRNLSALT RKKRKAHVKR PDLHKKTQSK HSLAEILRSE YSSGMEADIA
810 820 830 840 850
KVKKQNAPGE PGGRPLQHSL QPTPCFGRGK TLKWRKTQKG VQRDSKTSQK

V
Length:851
Mass (Da):94,087
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3C73701FF2F37E7
GO
Isoform 2 (identifier: Q9H8H2-2) [UniParc]FASTAAdd to basket
Also known as: Helicain C

The sequence of this isoform differs from the canonical sequence as follows:
     603-714: YNAPSSPAEY...ERRVSWAKKA → NTSTGLEEPP...STRWLLTKST

Show »
Length:778
Mass (Da):85,816
Checksum:i0951A29BEA4E08AF
GO
Isoform 3 (identifier: Q9H8H2-3) [UniParc]FASTAAdd to basket
Also known as: Helicain A

The sequence of this isoform differs from the canonical sequence as follows:
     302-319: RSDGPYALVLVPTRELAL → VLLLSTFYEEEQRLRKVK
     320-851: Missing.

Show »
Length:319
Mass (Da):34,611
Checksum:iC8A423CE304152C6
GO
Isoform 4 (identifier: Q9H8H2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     586-851: Missing.

Show »
Length:585
Mass (Da):64,137
Checksum:i2353C61B5C2E5AE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WAJ0F8WAJ0_HUMAN
RNA helicase
DDX31
746Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ14889 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ14890 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14644 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15620 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti206K → L in BAB15620 (PubMed:14702039).Curated1
Sequence conflicti406L → P in BAB15620 (PubMed:14702039).Curated1
Sequence conflicti527Y → C in BAB15620 (PubMed:14702039).Curated1
Sequence conflicti562M → K in BAB55146 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052164153E → K. Corresponds to variant dbSNP:rs17402080Ensembl.1
Natural variantiVAR_052165687R → Q. Corresponds to variant dbSNP:rs34246652Ensembl.1
Natural variantiVAR_023065799I → V3 PublicationsCorresponds to variant dbSNP:rs306547Ensembl.1
Natural variantiVAR_023066843R → Q. Corresponds to variant dbSNP:rs306548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014787302 – 319RSDGP…RELAL → VLLLSTFYEEEQRLRKVK in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_014788320 – 851Missing in isoform 3. 1 PublicationAdd BLAST532
Alternative sequenceiVSP_014789586 – 851Missing in isoform 4. 1 PublicationAdd BLAST266
Alternative sequenceiVSP_014790603 – 714YNAPS…WAKKA → NTSTGLEEPPGLAAMGAACS FWLLRRQNMSTRWLLTKST in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF427339 mRNA Translation: AAL26549.1
AF335567 mRNA Translation: AAQ14888.1
AF335568 mRNA Translation: AAQ14889.1 Frameshift.
AF335569 mRNA Translation: AAQ14890.1 Frameshift.
AK023695 mRNA Translation: BAB14644.1 Different initiation.
AK027002 mRNA Translation: BAB15620.1 Frameshift.
AK027484 mRNA Translation: BAB55146.1
AL160165 Genomic DNA No translation available.
AL354735 Genomic DNA No translation available.
BC012726 mRNA Translation: AAH12726.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6951.1 [Q9H8H2-1]
CCDS6952.1 [Q9H8H2-4]
CCDS83433.1 [Q9H8H2-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001309269.1, NM_001322340.1 [Q9H8H2-2]
NP_001309273.1, NM_001322344.1 [Q9H8H2-3]
NP_073616.6, NM_022779.8 [Q9H8H2-1]
NP_619526.1, NM_138620.1 [Q9H8H2-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000310532; ENSP00000310539; ENSG00000125485 [Q9H8H2-4]
ENST00000372159; ENSP00000361232; ENSG00000125485 [Q9H8H2-1]
ENST00000372153; ENSP00000361226; ENSG00000125485 [Q9H8H2-1]
ENST00000480876; ENSP00000479697; ENSG00000125485 [Q9H8H2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64794

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64794

UCSC genome browser

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UCSCi
uc004cbq.1 human [Q9H8H2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF427339 mRNA Translation: AAL26549.1
AF335567 mRNA Translation: AAQ14888.1
AF335568 mRNA Translation: AAQ14889.1 Frameshift.
AF335569 mRNA Translation: AAQ14890.1 Frameshift.
AK023695 mRNA Translation: BAB14644.1 Different initiation.
AK027002 mRNA Translation: BAB15620.1 Frameshift.
AK027484 mRNA Translation: BAB55146.1
AL160165 Genomic DNA No translation available.
AL354735 Genomic DNA No translation available.
BC012726 mRNA Translation: AAH12726.2
CCDSiCCDS6951.1 [Q9H8H2-1]
CCDS6952.1 [Q9H8H2-4]
CCDS83433.1 [Q9H8H2-3]
RefSeqiNP_001309269.1, NM_001322340.1 [Q9H8H2-2]
NP_001309273.1, NM_001322344.1 [Q9H8H2-3]
NP_073616.6, NM_022779.8 [Q9H8H2-1]
NP_619526.1, NM_138620.1 [Q9H8H2-4]

3D structure databases

SMRiQ9H8H2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122302, 119 interactors
IntActiQ9H8H2, 103 interactors
MINTiQ9H8H2
STRINGi9606.ENSP00000361232

PTM databases

iPTMnetiQ9H8H2
PhosphoSitePlusiQ9H8H2

Polymorphism and mutation databases

BioMutaiDDX31
DMDMi71153334

2D gel databases

SWISS-2DPAGEiQ9H8H2

Proteomic databases

EPDiQ9H8H2
jPOSTiQ9H8H2
MassIVEiQ9H8H2
MaxQBiQ9H8H2
PaxDbiQ9H8H2
PeptideAtlasiQ9H8H2
PRIDEiQ9H8H2
ProteomicsDBi81209 [Q9H8H2-1]
81210 [Q9H8H2-2]
81211 [Q9H8H2-3]
81212 [Q9H8H2-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
64794

Genome annotation databases

EnsembliENST00000310532; ENSP00000310539; ENSG00000125485 [Q9H8H2-4]
ENST00000372159; ENSP00000361232; ENSG00000125485 [Q9H8H2-1]
ENST00000372153; ENSP00000361226; ENSG00000125485 [Q9H8H2-1]
ENST00000480876; ENSP00000479697; ENSG00000125485 [Q9H8H2-3]
GeneIDi64794
KEGGihsa:64794
UCSCiuc004cbq.1 human [Q9H8H2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64794
DisGeNETi64794

GeneCards: human genes, protein and diseases

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GeneCardsi
DDX31
HGNCiHGNC:16715 DDX31
HPAiHPA020891
MIMi616533 gene
neXtProtiNX_Q9H8H2
OpenTargetsiENSG00000125485
PharmGKBiPA27218

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0348 Eukaryota
ENOG410XNT7 LUCA
GeneTreeiENSGT00550000075041
HOGENOMiCLU_003041_26_2_1
InParanoidiQ9H8H2
KOiK14806
OMAiFSRIQWL
OrthoDBi973872at2759
PhylomeDBiQ9H8H2
TreeFamiTF323273

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DDX31 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DDX31

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64794
PharosiQ9H8H2 Tbio

Protein Ontology

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PROi
PR:Q9H8H2
RNActiQ9H8H2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125485 Expressed in left lobe of thyroid gland and 161 other tissues
ExpressionAtlasiQ9H8H2 baseline and differential
GenevisibleiQ9H8H2 HS

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR025313 DUF4217
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF13959 DUF4217, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM01178 DUF4217, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX31_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H8H2
Secondary accession number(s): Q5K6N2
, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: February 26, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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