UniProtKB - Q9H8G2 (CAAP1_HUMAN)
Protein
Caspase activity and apoptosis inhibitor 1
Gene
CAAP1
Organism
Homo sapiens (Human)
Status
Functioni
Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.1 Publication
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q9H8G2 |
Names & Taxonomyi
Protein namesi | Recommended name: Caspase activity and apoptosis inhibitor 1Alternative name(s): Conserved anti-apoptotic protein Short name: CAAP |
Gene namesi | Name:CAAP1 Synonyms:C9orf82, CAAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25834, CAAP1 |
neXtProti | NX_Q9H8G2 |
VEuPathDBi | HostDB:ENSG00000120159.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79886 |
OpenTargetsi | ENSG00000120159 |
PharmGKBi | PA134943744 |
Miscellaneous databases
Pharosi | Q9H8G2, Tdark |
Genetic variation databases
BioMutai | CAAP1 |
DMDMi | 68565300 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089717 | 1 – 361 | Caspase activity and apoptosis inhibitor 1Add BLAST | 361 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 89 | PhosphoserineCombined sources | 1 | |
Modified residuei | 90 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 104 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 120 | PhosphoserineCombined sources | 1 | |
Modified residuei | 203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 312 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9H8G2 |
jPOSTi | Q9H8G2 |
MassIVEi | Q9H8G2 |
MaxQBi | Q9H8G2 |
PaxDbi | Q9H8G2 |
PeptideAtlasi | Q9H8G2 |
PRIDEi | Q9H8G2 |
ProteomicsDBi | 5380 81206 [Q9H8G2-1] |
PTM databases
iPTMneti | Q9H8G2 |
PhosphoSitePlusi | Q9H8G2 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000120159, Expressed in colonic mucosa and 234 other tissues |
ExpressionAtlasi | Q9H8G2, baseline and differential |
Genevisiblei | Q9H8G2, HS |
Organism-specific databases
HPAi | ENSG00000120159, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122971, 20 interactors |
IntActi | Q9H8G2, 10 interactors |
STRINGi | 9606.ENSP00000369431 |
Miscellaneous databases
RNActi | Q9H8G2, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 281 – 311 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 19 – 25 | Poly-Ala | 7 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RN9N, Eukaryota |
GeneTreei | ENSGT00390000017010 |
HOGENOMi | CLU_078683_0_0_1 |
InParanoidi | Q9H8G2 |
OMAi | LQQEAKY |
OrthoDBi | 1443498at2759 |
PhylomeDBi | Q9H8G2 |
TreeFami | TF332850 |
Family and domain databases
InterProi | View protein in InterPro IPR038991, CAAP1 |
PANTHERi | PTHR14740, PTHR14740, 1 hit |
Pfami | View protein in Pfam PF15335, CAAP1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H8G2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTGKKSSREK RRKRSSQEAA AALAAPDIVP ALASGSSGST SGCGSAGGCG
60 70 80 90 100
SVSCCGNANF SGSVTGGGSG GSCWGGSSVE RSERRKRRST DSSSVSGSLQ
110 120 130 140 150
QETKYILPTL EKELFLAEHS DLEEGGLDLT VSLKPVSFYI SDKKEMLQQC
160 170 180 190 200
FCIIGEKKLQ KMLPDVLKNC SIEEIKKLCQ EQLELLSEKK ILKILEGDNG
210 220 230 240 250
MDSDMEEEAD DGSKMGSDLV SQQDICIDSA SSVRENKQPE GLELKQGKGE
260 270 280 290 300
DSDVLSINAD AYDSDIEGPC NEEAAAPEAP ENTVQSEAGQ IDDLEKDIEK
310 320 330 340 350
SVNEILGLAE SSPNEPKAAT LAVPPPEDVQ PSAQQLELLE LEMRARAIKA
360
LMKAGDIKKP A
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFV1 | E5RFV1_HUMAN | Caspase activity and apoptosis inhi... | CAAP1 | 111 | Annotation score: | ||
E5RFW3 | E5RFW3_HUMAN | Caspase activity and apoptosis inhi... | CAAP1 | 133 | Annotation score: | ||
A0A3B3ISJ3 | A0A3B3ISJ3_HUMAN | Caspase activity and apoptosis inhi... | CAAP1 | 237 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | S → G in BAB14655 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 188 | E → K in AAH14658 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 292 | D → N in AAH71953 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056818 | 233 | V → M. Corresponds to variant dbSNP:rs12342214Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044253 | 1 – 145 | Missing in isoform 2. 1 PublicationAdd BLAST | 145 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023719 mRNA Translation: BAB14655.1 AK301673 mRNA Translation: BAG63146.1 AL356133 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58576.1 CH471071 Genomic DNA Translation: EAW58577.1 BC014658 mRNA Translation: AAH14658.1 BC071953 mRNA Translation: AAH71953.1 |
CCDSi | CCDS55299.1 [Q9H8G2-2] CCDS6516.1 [Q9H8G2-1] |
RefSeqi | NP_001161047.1, NM_001167575.1 [Q9H8G2-2] NP_079104.3, NM_024828.3 [Q9H8G2-1] |
Genome annotation databases
Ensembli | ENST00000333916; ENSP00000369431; ENSG00000120159 [Q9H8G2-1] ENST00000625311; ENSP00000487373; ENSG00000120159 [Q9H8G2-2] |
GeneIDi | 79886 |
KEGGi | hsa:79886 |
UCSCi | uc003zqc.4, human [Q9H8G2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023719 mRNA Translation: BAB14655.1 AK301673 mRNA Translation: BAG63146.1 AL356133 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58576.1 CH471071 Genomic DNA Translation: EAW58577.1 BC014658 mRNA Translation: AAH14658.1 BC071953 mRNA Translation: AAH71953.1 |
CCDSi | CCDS55299.1 [Q9H8G2-2] CCDS6516.1 [Q9H8G2-1] |
RefSeqi | NP_001161047.1, NM_001167575.1 [Q9H8G2-2] NP_079104.3, NM_024828.3 [Q9H8G2-1] |
3D structure databases
SMRi | Q9H8G2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122971, 20 interactors |
IntActi | Q9H8G2, 10 interactors |
STRINGi | 9606.ENSP00000369431 |
PTM databases
iPTMneti | Q9H8G2 |
PhosphoSitePlusi | Q9H8G2 |
Genetic variation databases
BioMutai | CAAP1 |
DMDMi | 68565300 |
Proteomic databases
EPDi | Q9H8G2 |
jPOSTi | Q9H8G2 |
MassIVEi | Q9H8G2 |
MaxQBi | Q9H8G2 |
PaxDbi | Q9H8G2 |
PeptideAtlasi | Q9H8G2 |
PRIDEi | Q9H8G2 |
ProteomicsDBi | 5380 81206 [Q9H8G2-1] |
Protocols and materials databases
Antibodypediai | 10518, 28 antibodies |
DNASUi | 79886 |
Genome annotation databases
Ensembli | ENST00000333916; ENSP00000369431; ENSG00000120159 [Q9H8G2-1] ENST00000625311; ENSP00000487373; ENSG00000120159 [Q9H8G2-2] |
GeneIDi | 79886 |
KEGGi | hsa:79886 |
UCSCi | uc003zqc.4, human [Q9H8G2-1] |
Organism-specific databases
CTDi | 79886 |
DisGeNETi | 79886 |
GeneCardsi | CAAP1 |
HGNCi | HGNC:25834, CAAP1 |
HPAi | ENSG00000120159, Low tissue specificity |
neXtProti | NX_Q9H8G2 |
OpenTargetsi | ENSG00000120159 |
PharmGKBi | PA134943744 |
VEuPathDBi | HostDB:ENSG00000120159.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RN9N, Eukaryota |
GeneTreei | ENSGT00390000017010 |
HOGENOMi | CLU_078683_0_0_1 |
InParanoidi | Q9H8G2 |
OMAi | LQQEAKY |
OrthoDBi | 1443498at2759 |
PhylomeDBi | Q9H8G2 |
TreeFami | TF332850 |
Enzyme and pathway databases
PathwayCommonsi | Q9H8G2 |
Miscellaneous databases
BioGRID-ORCSi | 79886, 15 hits in 874 CRISPR screens |
ChiTaRSi | CAAP1, human |
GeneWikii | C9orf82 |
GenomeRNAii | 79886 |
Pharosi | Q9H8G2, Tdark |
PROi | PR:Q9H8G2 |
RNActi | Q9H8G2, protein |
Gene expression databases
Bgeei | ENSG00000120159, Expressed in colonic mucosa and 234 other tissues |
ExpressionAtlasi | Q9H8G2, baseline and differential |
Genevisiblei | Q9H8G2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR038991, CAAP1 |
PANTHERi | PTHR14740, PTHR14740, 1 hit |
Pfami | View protein in Pfam PF15335, CAAP1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAAP1_HUMAN | |
Accessioni | Q9H8G2Primary (citable) accession number: Q9H8G2 Secondary accession number(s): B4DWT4 Q96C59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM