UniProtKB - Q9H8G1 (ZN430_HUMAN)
Protein
Zinc finger protein 430
Gene
ZNF430
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 205 – 227 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 233 – 255 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 261 – 283 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 289 – 311 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 339 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 429 – 451 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 457 – 479 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 513 – 535 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
- substantia nigra development Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H8G1 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 430 |
Gene namesi | Name:ZNF430 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000118620.12 |
HGNCi | HGNC:20808, ZNF430 |
neXtProti | NX_Q9H8G1 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 80264 |
OpenTargetsi | ENSG00000118620 |
PharmGKBi | PA134987901 |
Miscellaneous databases
Pharosi | Q9H8G1, Tbio |
Polymorphism and mutation databases
BioMutai | ZNF430 |
DMDMi | 296453068 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047578 | 1 – 570 | Zinc finger protein 430Add BLAST | 570 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9H8G1 |
jPOSTi | Q9H8G1 |
MassIVEi | Q9H8G1 |
MaxQBi | Q9H8G1 |
PaxDbi | Q9H8G1 |
PeptideAtlasi | Q9H8G1 |
PRIDEi | Q9H8G1 |
ProteomicsDBi | 81205 |
PTM databases
iPTMneti | Q9H8G1 |
PhosphoSitePlusi | Q9H8G1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000118620, Expressed in female gonad and 233 other tissues |
ExpressionAtlasi | Q9H8G1, baseline and differential |
Genevisiblei | Q9H8G1, HS |
Organism-specific databases
HPAi | ENSG00000118620, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123206, 13 interactors |
IntActi | Q9H8G1, 7 interactors |
STRINGi | 9606.ENSP00000261560 |
Miscellaneous databases
RNActi | Q9H8G1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 107 | KRABPROSITE-ProRule annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 205 – 227 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 233 – 255 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 261 – 283 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 289 – 311 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 317 – 339 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 345 – 367 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 373 – 395 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 401 – 423 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 429 – 451 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 457 – 479 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 513 – 535 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT01010000222367 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9H8G1 |
OMAi | HKECYDE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9H8G1 |
TreeFami | TF342117 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q9H8G1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ
60 70 80 90 100
CLDTAQQDLY RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH
110 120 130 140 150
AMVDQPPVTY SHFAQDLWPE QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK
160 170 180 190 200
SVDECNLHKE CYDELNQCLT TTQSEIFQYD KYVNVFYKFS NPNIQKIRHT
210 220 230 240 250
GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK VFNWFSTLTR
260 270 280 290 300
HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR
310 320 330 340 350
SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC
360 370 380 390 400
GKAFNQSSTL TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF
410 420 430 440 450
YKCEECGKGF NWSSTLTKHK RIHTGEKPYK CEQCGKAFNE SSNLTAHKII
460 470 480 490 500
HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS GEKPYKCEEC GKAFNQFSNL
510 520 530 540 550
TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP YNCEEYGKAF
560 570
NQSSNLIEQS NSYWRETLQM
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QXG3 | M0QXG3_HUMAN | Zinc finger protein 430 | ZNF430 | 108 | Annotation score: | ||
M0R392 | M0R392_HUMAN | Zinc finger protein 430 | ZNF430 | 128 | Annotation score: | ||
M0R0L5 | M0R0L5_HUMAN | Zinc finger protein 430 | ZNF430 | 113 | Annotation score: | ||
A0A0G2JRS6 | A0A0G2JRS6_HUMAN | Zinc finger protein 430 | ZNF430 | 107 | Annotation score: | ||
A0A0G2JNR8 | A0A0G2JNR8_HUMAN | Zinc finger protein 430 | ZNF430 | 107 | Annotation score: | ||
M0QYF1 | M0QYF1_HUMAN | Zinc finger protein 430 | ZNF430 | 73 | Annotation score: |
Sequence cautioni
The sequence BAB14656 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | K → R in AAP30885 (Ref. 1) Curated | 1 | |
Sequence conflicti | 150 | K → R in BAB14656 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY269787 mRNA Translation: AAP30885.1 AC012627 Genomic DNA No translation available. AK023721 mRNA Translation: BAB14656.1 Frameshift. |
CCDSi | CCDS32978.1 |
RefSeqi | NP_079465.3, NM_025189.3 |
Genome annotation databases
Ensembli | ENST00000261560; ENSP00000261560; ENSG00000118620 |
GeneIDi | 80264 |
KEGGi | hsa:80264 |
UCSCi | uc002npj.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY269787 mRNA Translation: AAP30885.1 AC012627 Genomic DNA No translation available. AK023721 mRNA Translation: BAB14656.1 Frameshift. |
CCDSi | CCDS32978.1 |
RefSeqi | NP_079465.3, NM_025189.3 |
3D structure databases
SMRi | Q9H8G1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123206, 13 interactors |
IntActi | Q9H8G1, 7 interactors |
STRINGi | 9606.ENSP00000261560 |
PTM databases
iPTMneti | Q9H8G1 |
PhosphoSitePlusi | Q9H8G1 |
Polymorphism and mutation databases
BioMutai | ZNF430 |
DMDMi | 296453068 |
Proteomic databases
EPDi | Q9H8G1 |
jPOSTi | Q9H8G1 |
MassIVEi | Q9H8G1 |
MaxQBi | Q9H8G1 |
PaxDbi | Q9H8G1 |
PeptideAtlasi | Q9H8G1 |
PRIDEi | Q9H8G1 |
ProteomicsDBi | 81205 |
Protocols and materials databases
Antibodypediai | 67977, 7 antibodies |
Genome annotation databases
Ensembli | ENST00000261560; ENSP00000261560; ENSG00000118620 |
GeneIDi | 80264 |
KEGGi | hsa:80264 |
UCSCi | uc002npj.4, human |
Organism-specific databases
CTDi | 80264 |
DisGeNETi | 80264 |
EuPathDBi | HostDB:ENSG00000118620.12 |
GeneCardsi | ZNF430 |
HGNCi | HGNC:20808, ZNF430 |
HPAi | ENSG00000118620, Low tissue specificity |
neXtProti | NX_Q9H8G1 |
OpenTargetsi | ENSG00000118620 |
PharmGKBi | PA134987901 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT01010000222367 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9H8G1 |
OMAi | HKECYDE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9H8G1 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | Q9H8G1 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 80264, 5 hits in 846 CRISPR screens |
ChiTaRSi | ZNF430, human |
GenomeRNAii | 80264 |
Pharosi | Q9H8G1, Tbio |
PROi | PR:Q9H8G1 |
RNActi | Q9H8G1, protein |
Gene expression databases
Bgeei | ENSG00000118620, Expressed in female gonad and 233 other tissues |
ExpressionAtlasi | Q9H8G1, baseline and differential |
Genevisiblei | Q9H8G1, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 10 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 11 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN430_HUMAN | |
Accessioni | Q9H8G1Primary (citable) accession number: Q9H8G1 Secondary accession number(s): Q86V70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 23, 2003 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM