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Protein

Zinc finger protein 430

Gene

ZNF430

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 430
Gene namesi
Name:ZNF430
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000118620.12
HGNCiHGNC:20808 ZNF430
neXtProtiNX_Q9H8G1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80264
OpenTargetsiENSG00000118620
PharmGKBiPA134987901

Polymorphism and mutation databases

BioMutaiZNF430
DMDMi296453068

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475781 – 570Zinc finger protein 430Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H8G1
MaxQBiQ9H8G1
PaxDbiQ9H8G1
PeptideAtlasiQ9H8G1
PRIDEiQ9H8G1
ProteomicsDBi81205

PTM databases

iPTMnetiQ9H8G1
PhosphoSitePlusiQ9H8G1

Expressioni

Gene expression databases

BgeeiENSG00000118620 Expressed in 220 organ(s), highest expression level in female gonad
CleanExiHS_ZNF430
ExpressionAtlasiQ9H8G1 baseline and differential
GenevisibleiQ9H8G1 HS

Organism-specific databases

HPAiHPA059135

Interactioni

Protein-protein interaction databases

BioGridi123206, 9 interactors
STRINGi9606.ENSP00000261560

Structurei

3D structure databases

ProteinModelPortaliQ9H8G1
SMRiQ9H8G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 107KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri205 – 227C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri429 – 451C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri457 – 479C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri485 – 507C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri513 – 535C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9H8G1
KOiK09228
OMAiSNSYWRE
OrthoDBiEOG091G02KC
PhylomeDBiQ9H8G1
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9H8G1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ
60 70 80 90 100
CLDTAQQDLY RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH
110 120 130 140 150
AMVDQPPVTY SHFAQDLWPE QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK
160 170 180 190 200
SVDECNLHKE CYDELNQCLT TTQSEIFQYD KYVNVFYKFS NPNIQKIRHT
210 220 230 240 250
GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK VFNWFSTLTR
260 270 280 290 300
HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR
310 320 330 340 350
SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC
360 370 380 390 400
GKAFNQSSTL TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF
410 420 430 440 450
YKCEECGKGF NWSSTLTKHK RIHTGEKPYK CEQCGKAFNE SSNLTAHKII
460 470 480 490 500
HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS GEKPYKCEEC GKAFNQFSNL
510 520 530 540 550
TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP YNCEEYGKAF
560 570
NQSSNLIEQS NSYWRETLQM
Length:570
Mass (Da):66,319
Last modified:May 18, 2010 - v3
Checksum:iF6A22E01714AB99E
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R392M0R392_HUMAN
Zinc finger protein 430
ZNF430
128Annotation score:
M0R0L5M0R0L5_HUMAN
Zinc finger protein 430
ZNF430
113Annotation score:
M0QXG3M0QXG3_HUMAN
Zinc finger protein 430
ZNF430
108Annotation score:
A0A0G2JRS6A0A0G2JRS6_HUMAN
Zinc finger protein 430
ZNF430
107Annotation score:
A0A0G2JNR8A0A0G2JNR8_HUMAN
Zinc finger protein 430
ZNF430
107Annotation score:
M0QYF1M0QYF1_HUMAN
Zinc finger protein 430
ZNF430
73Annotation score:

Sequence cautioni

The sequence BAB14656 differs from that shown. Reason: Frameshift at position 293.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150K → R in AAP30885 (Ref. 1) Curated1
Sequence conflicti150K → R in BAB14656 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY269787 mRNA Translation: AAP30885.1
AC012627 Genomic DNA No translation available.
AK023721 mRNA Translation: BAB14656.1 Frameshift.
CCDSiCCDS32978.1
RefSeqiNP_079465.3, NM_025189.3
UniGeneiHs.729202

Genome annotation databases

EnsembliENST00000261560; ENSP00000261560; ENSG00000118620
GeneIDi80264
KEGGihsa:80264
UCSCiuc002npj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY269787 mRNA Translation: AAP30885.1
AC012627 Genomic DNA No translation available.
AK023721 mRNA Translation: BAB14656.1 Frameshift.
CCDSiCCDS32978.1
RefSeqiNP_079465.3, NM_025189.3
UniGeneiHs.729202

3D structure databases

ProteinModelPortaliQ9H8G1
SMRiQ9H8G1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123206, 9 interactors
STRINGi9606.ENSP00000261560

PTM databases

iPTMnetiQ9H8G1
PhosphoSitePlusiQ9H8G1

Polymorphism and mutation databases

BioMutaiZNF430
DMDMi296453068

Proteomic databases

EPDiQ9H8G1
MaxQBiQ9H8G1
PaxDbiQ9H8G1
PeptideAtlasiQ9H8G1
PRIDEiQ9H8G1
ProteomicsDBi81205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261560; ENSP00000261560; ENSG00000118620
GeneIDi80264
KEGGihsa:80264
UCSCiuc002npj.4 human

Organism-specific databases

CTDi80264
DisGeNETi80264
EuPathDBiHostDB:ENSG00000118620.12
GeneCardsiZNF430
HGNCiHGNC:20808 ZNF430
HPAiHPA059135
neXtProtiNX_Q9H8G1
OpenTargetsiENSG00000118620
PharmGKBiPA134987901
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9H8G1
KOiK09228
OMAiSNSYWRE
OrthoDBiEOG091G02KC
PhylomeDBiQ9H8G1
TreeFamiTF342117

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii80264
PROiPR:Q9H8G1

Gene expression databases

BgeeiENSG00000118620 Expressed in 220 organ(s), highest expression level in female gonad
CleanExiHS_ZNF430
ExpressionAtlasiQ9H8G1 baseline and differential
GenevisibleiQ9H8G1 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 10 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 11 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN430_HUMAN
AccessioniPrimary (citable) accession number: Q9H8G1
Secondary accession number(s): Q86V70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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