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Protein

Cysteine-rich protein 2-binding protein

Gene

KAT14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.1 Publication

GO - Molecular functioni

  • histone acetyltransferase activity Source: MGI
  • LIM domain binding Source: UniProtKB

GO - Biological processi

  • G2/M transition of mitotic cell cycle Source: Ensembl
  • histone acetylation Source: GO_Central
  • histone H3 acetylation Source: BHF-UCL

Enzyme and pathway databases

BRENDAi2.3.1.48 2681
ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 2-binding protein
Short name:
CSRP2-binding protein
Alternative name(s):
ADA2A-containing complex subunit 2
Short name:
ATAC2
CRP2-binding partner
Short name:
CRP2BP
Lysine acetyltransferase 14Imported
Gene namesi
Name:KAT14Imported
Synonyms:CSRP2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000149474.13
HGNCiHGNC:15904 KAT14
MIMi617501 gene
neXtProtiNX_Q9H8E8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57325
OpenTargetsiENSG00000149474
PharmGKBiPA26969

Polymorphism and mutation databases

BioMutaiCSRP2BP
DMDMi308153608

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000746031 – 782Cysteine-rich protein 2-binding proteinAdd BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1
Modified residuei231N6-acetyllysineBy similarity1
Modified residuei285PhosphoserineCombined sources1
Modified residuei292N6-acetyllysineCombined sources1
Modified residuei416PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H8E8
MaxQBiQ9H8E8
PaxDbiQ9H8E8
PeptideAtlasiQ9H8E8
PRIDEiQ9H8E8
ProteomicsDBi81203
81204 [Q9H8E8-2]

PTM databases

iPTMnetiQ9H8E8
PhosphoSitePlusiQ9H8E8

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart, lung, placenta, brain, liver, pancreas and kidney. High expression in skeletal muscle and heart. Lower expression in lung.

Gene expression databases

BgeeiENSG00000149474 Expressed in 192 organ(s), highest expression level in frontal cortex
CleanExiHS_CSRP2BP
ExpressionAtlasiQ9H8E8 baseline and differential
GenevisibleiQ9H8E8 HS

Organism-specific databases

HPAiCAB034224
HPA068443

Interactioni

Subunit structurei

Interacts with the LIM 1 domain of CSRP2. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and WDR5.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121485, 36 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ9H8E8
IntActiQ9H8E8, 13 interactors
MINTiQ9H8E8
STRINGi9606.ENSP00000278816

Structurei

3D structure databases

ProteinModelPortaliQ9H8E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini638 – 782N-acetyltransferasePROSITE-ProRule annotationAdd BLAST145

Phylogenomic databases

eggNOGiENOG410IQJZ Eukaryota
ENOG410Y6C7 LUCA
GeneTreeiENSGT00390000001146
HOGENOMiHOG000230880
HOVERGENiHBG051142
InParanoidiQ9H8E8
OMAiDCSEDGK
OrthoDBiEOG091G0CJX
PhylomeDBiQ9H8E8
TreeFamiTF324809

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR037829 KAT14
PANTHERiPTHR20916:SF0 PTHR20916:SF0, 1 hit
PfamiView protein in Pfam
PF13673 Acetyltransf_10, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H8E8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSSIHLSSL ISRHDDEATR TSTSEGLEEG EVEGETLLIV ESEDQASVDL
60 70 80 90 100
SHDQSGDSLN SDEGDVSWME EQLSYFCDKC QKWIPASQLR EQLSYLKGDN
110 120 130 140 150
FFRFTCSDCS ADGKEQYERL KLTWQQVVML AMYNLSLEGS GRQGYFRWKE
160 170 180 190 200
DICAFIEKHW TFLLGNRKKT STWWSTVAGC LSVGSPMYFR SGAQEFGEPG
210 220 230 240 250
WWKLVHNKPP TMKPEGEKLS ASTLKIKAAS KPTLDPIITV EGLRKRASRN
260 270 280 290 300
PVESAMELKE KRSRTQEAKD IRRAQKEAAG FLDRSTSSTP VKFISRGRRP
310 320 330 340 350
DVILEKGEVI DFSSLSSSDR TPLTSPSPSP SLDFSAPGTP ASHSATPSLL
360 370 380 390 400
SEADLIPDVM PPQALFHDDD EMEGDGVIDP GMEYVPPPAG SVASGPVVGV
410 420 430 440 450
RKKVRGPEQI KQEVESEEEK PDRMDIDSED TDSNTSLQTR AREKRKPQLE
460 470 480 490 500
KDTKPKEPRY TPVSIYEEKL LLKRLEACPG AVAMTPEARR LKRKLIVRQA
510 520 530 540 550
KRDRGLPLFD LDQVVNAALL LVDGIYGAKE GGISRLPAGQ ATYRTTCQDF
560 570 580 590 600
RILDRYQTSL PSRKGFRHQT TKFLYRLVGS EDMAVDQSIV SPYTSRILKP
610 620 630 640 650
YIRRDYETKP PKLQLLSQIR SHLHRSDPHW TPEPDAPLDY CYVRPNHIPT
660 670 680 690 700
INSMCQEFFW PGIDLSECLQ YPDFSVVVLY KKVIIAFGFM VPDVKYNEAY
710 720 730 740 750
ISFLFVHPEW RRAGIATFMI YHLIQTCMGK DVTLHVSASN PAMLLYQKFG
760 770 780
FKTEEYVLDF YDKYYPLEST ECKHAFFLRL RR
Length:782
Mass (Da):88,844
Last modified:October 5, 2010 - v3
Checksum:iE84FAEF06412EA77
GO
Isoform 2 (identifier: Q9H8E8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: May be due to an intron retention.
Show »
Length:654
Mass (Da):74,324
Checksum:i2EA7F2981E7D4195
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B6H4A0A075B6H4_HUMAN
Cysteine-rich protein 2-binding pro...
KAT14
781Annotation score:
D6RAU4D6RAU4_HUMAN
Cysteine-rich protein 2-binding pro...
KAT14
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti535R → G in BAB14669 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028034214P → L. Corresponds to variant dbSNP:rs6081011Ensembl.1
Natural variantiVAR_028035400V → G2 PublicationsCorresponds to variant dbSNP:rs1205193Ensembl.1
Natural variantiVAR_020466442R → T. Corresponds to variant dbSNP:rs2295182Ensembl.1
Natural variantiVAR_033839600P → R. Corresponds to variant dbSNP:rs11557577Ensembl.1
Natural variantiVAR_048166738A → S. Corresponds to variant dbSNP:rs6081027Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0000701 – 128Missing in isoform 2. 2 PublicationsAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023759 mRNA Translation: BAB14669.1
AL050321 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10255.1
BC007537 mRNA Translation: AAH07537.1
BC009174 mRNA No translation available.
AF252257 mRNA Translation: AAG10249.1
CCDSiCCDS13133.1 [Q9H8E8-1]
RefSeqiNP_065397.3, NM_020536.4
UniGeneiHs.488051
Hs.728790

Genome annotation databases

EnsembliENST00000435364; ENSP00000392318; ENSG00000149474 [Q9H8E8-1]
ENST00000489634; ENSP00000425909; ENSG00000149474 [Q9H8E8-2]
GeneIDi57325
KEGGihsa:57325
UCSCiuc002wqk.3 human [Q9H8E8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023759 mRNA Translation: BAB14669.1
AL050321 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10255.1
BC007537 mRNA Translation: AAH07537.1
BC009174 mRNA No translation available.
AF252257 mRNA Translation: AAG10249.1
CCDSiCCDS13133.1 [Q9H8E8-1]
RefSeqiNP_065397.3, NM_020536.4
UniGeneiHs.488051
Hs.728790

3D structure databases

ProteinModelPortaliQ9H8E8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121485, 36 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ9H8E8
IntActiQ9H8E8, 13 interactors
MINTiQ9H8E8
STRINGi9606.ENSP00000278816

PTM databases

iPTMnetiQ9H8E8
PhosphoSitePlusiQ9H8E8

Polymorphism and mutation databases

BioMutaiCSRP2BP
DMDMi308153608

Proteomic databases

EPDiQ9H8E8
MaxQBiQ9H8E8
PaxDbiQ9H8E8
PeptideAtlasiQ9H8E8
PRIDEiQ9H8E8
ProteomicsDBi81203
81204 [Q9H8E8-2]

Protocols and materials databases

DNASUi57325
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435364; ENSP00000392318; ENSG00000149474 [Q9H8E8-1]
ENST00000489634; ENSP00000425909; ENSG00000149474 [Q9H8E8-2]
GeneIDi57325
KEGGihsa:57325
UCSCiuc002wqk.3 human [Q9H8E8-1]

Organism-specific databases

CTDi57325
DisGeNETi57325
EuPathDBiHostDB:ENSG00000149474.13
GeneCardsiKAT14
HGNCiHGNC:15904 KAT14
HPAiCAB034224
HPA068443
MIMi617501 gene
neXtProtiNX_Q9H8E8
OpenTargetsiENSG00000149474
PharmGKBiPA26969
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJZ Eukaryota
ENOG410Y6C7 LUCA
GeneTreeiENSGT00390000001146
HOGENOMiHOG000230880
HOVERGENiHBG051142
InParanoidiQ9H8E8
OMAiDCSEDGK
OrthoDBiEOG091G0CJX
PhylomeDBiQ9H8E8
TreeFamiTF324809

Enzyme and pathway databases

BRENDAi2.3.1.48 2681
ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

GeneWikiiCSRP2BP
GenomeRNAii57325
PROiPR:Q9H8E8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149474 Expressed in 192 organ(s), highest expression level in frontal cortex
CleanExiHS_CSRP2BP
ExpressionAtlasiQ9H8E8 baseline and differential
GenevisibleiQ9H8E8 HS

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR037829 KAT14
PANTHERiPTHR20916:SF0 PTHR20916:SF0, 1 hit
PfamiView protein in Pfam
PF13673 Acetyltransf_10, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSR2B_HUMAN
AccessioniPrimary (citable) accession number: Q9H8E8
Secondary accession number(s): A2A2I5
, Q96GW6, Q96IH3, Q9HBF0, Q9UIY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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