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Protein

Zinc finger matrin-type protein 4

Gene

ZMAT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 44Matrin-type 1Add BLAST31
Zinc fingeri72 – 106Matrin-type 2Add BLAST35
Zinc fingeri145 – 175Matrin-type 3Add BLAST31
Zinc fingeri198 – 228Matrin-type 4Add BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 4
Gene namesi
Name:ZMAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000165061.14
HGNCiHGNC:25844 ZMAT4
neXtProtiNX_Q9H898

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79698
OpenTargetsiENSG00000165061
PharmGKBiPA142670525

Polymorphism and mutation databases

BioMutaiZMAT4
DMDMi74733790

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989161 – 229Zinc finger matrin-type protein 4Add BLAST229

Proteomic databases

PaxDbiQ9H898
PeptideAtlasiQ9H898
PRIDEiQ9H898
ProteomicsDBi81200
81201 [Q9H898-2]

PTM databases

iPTMnetiQ9H898
PhosphoSitePlusiQ9H898

Expressioni

Gene expression databases

BgeeiENSG00000165061
CleanExiHS_ZMAT4
ExpressionAtlasiQ9H898 baseline and differential
GenevisibleiQ9H898 HS

Organism-specific databases

HPAiHPA056671
HPA069813

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122819, 16 interactors
IntActiQ9H898, 14 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9H898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 44Matrin-type 1Add BLAST31
Zinc fingeri72 – 106Matrin-type 2Add BLAST35
Zinc fingeri145 – 175Matrin-type 3Add BLAST31
Zinc fingeri198 – 228Matrin-type 4Add BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IE5B Eukaryota
ENOG410YKRB LUCA
GeneTreeiENSGT00510000046606
HOGENOMiHOG000008682
HOVERGENiHBG061007
InParanoidiQ9H898
OMAiMLHPIDG
OrthoDBiEOG091G0GWT
PhylomeDBiQ9H898
TreeFamiTF350019

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 4 hits
SUPFAMiSSF57667 SSF57667, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H898-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP
60 70 80 90 100
RDGGCPAKRL RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA
110 120 130 140 150
KRLKLLLGEK TPLKTTATPL SPLKPPRMDT APVVASPYQR RDSDRYCGLC
160 170 180 190 200
AAWFNNPLMA QQHYDGKKHK KNAARVALLE QLGTTLDMGE LRGLRRNYRC
210 220
TICSVSLNSI EQYHAHLKGS KHQTNLKNK
Length:229
Mass (Da):25,833
Last modified:March 1, 2001 - v1
Checksum:iDB60004B797EEEFB
GO
Isoform 2 (identifier: Q9H898-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-192: Missing.

Show »
Length:153
Mass (Da):17,340
Checksum:i77BB52CB63E67E92
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034736201T → A1 PublicationCorresponds to variant dbSNP:rs17851751Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027476117 – 192Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023904 mRNA Translation: BAB14719.1
BC019598 mRNA Translation: AAH19598.1
CCDSiCCDS34885.1 [Q9H898-1]
CCDS47848.1 [Q9H898-2]
RefSeqiNP_001129203.1, NM_001135731.1 [Q9H898-2]
NP_078921.1, NM_024645.2 [Q9H898-1]
UniGeneiHs.591850

Genome annotation databases

EnsembliENST00000297737; ENSP00000297737; ENSG00000165061 [Q9H898-1]
ENST00000315769; ENSP00000319785; ENSG00000165061 [Q9H898-2]
GeneIDi79698
KEGGihsa:79698
UCSCiuc003xnr.5 human [Q9H898-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZMAT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H898
Secondary accession number(s): Q8WUT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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