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Entry version 126 (08 May 2019)
Sequence version 2 (15 May 2007)
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Protein

YY1-associated protein 1

Gene

YY1AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
YY1-associated protein 11 Publication
Alternative name(s):
Hepatocellular carcinoma susceptibility protein1 Publication
Hepatocellular carcinoma-associated protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YY1AP1Imported
Synonyms:HCCA21 Publication, YY1AP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30935 YY1AP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607860 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H869

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Grange syndrome (GRNG)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome of stenosis or occlusion of multiple arteries, including renal, abdominal, cerebral and probably coronary arteries, congenital heart defects, brachydactyly, syndactyly, bone fragility, and learning disabilities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078760150 – 796Missing in GRNG. 1 PublicationAdd BLAST647
Natural variantiVAR_078761170 – 796Missing in GRNG. 1 PublicationAdd BLAST627
Natural variantiVAR_078762705 – 796Missing in GRNG. 1 PublicationAdd BLAST92
Natural variantiVAR_078763709 – 796Missing in GRNG. 1 PublicationAdd BLAST88

Organism-specific databases

DisGeNET

More...
DisGeNETi
55249

MalaCards human disease database

More...
MalaCardsi
YY1AP1
MIMi602531 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163374

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79094 Grange syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670546

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
YY1AP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147744601

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763691 – 796YY1-associated protein 1Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei724PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H869

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H869

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H869

PeptideAtlas

More...
PeptideAtlasi
Q9H869

PRoteomics IDEntifications database

More...
PRIDEi
Q9H869

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81188
81189 [Q9H869-2]
81190 [Q9H869-3]
81191 [Q9H869-4]
81192 [Q9H869-5]
81193 [Q9H869-6]
81194 [Q9H869-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H869

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H869

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163374 Expressed in 230 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H869 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H869 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006986
HPA064249

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YY1. Interacts with MAD2L2. Interacts with INO80.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120540, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H869, 18 interactors

Molecular INTeraction database

More...
MINTi
Q9H869

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357323

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JQ2S Eukaryota
ENOG410XS4M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016256

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038018

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H869

Identification of Orthologs from Complete Genome Data

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OMAi
TSFICPL

Database of Orthologous Groups

More...
OrthoDBi
49443at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H869

TreeFam database of animal gene trees

More...
TreeFami
TF343327

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR033274 YY1AP1

The PANTHER Classification System

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PANTHERi
PTHR16088:SF9 PTHR16088:SF9, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEEASRSAA ATNPGSRLTR WPPPDKREGS AVDPGKRRSL AATPSSSLPC
60 70 80 90 100
TLIALGLRHE KEANELMEDL FETFQDEMGF SNMEDDGPEE EERVAEPQAN
110 120 130 140 150
FNTPQALRFE ELLANLLNEQ HQIAKELFEQ LKMKKPSAKQ QKEVEKVKPQ
160 170 180 190 200
CKEVHQTLIL DPAQRKRLQQ QMQQHVQLLT QIHLLATCNP NLNPEASSTR
210 220 230 240 250
ICLKELGTFA QSSIALHHQY NPKFQTLFQP CNLMGAMQLI EDFSTHVSID
260 270 280 290 300
CSPHKTVKKT ANEFPCLPKQ VAWILATSKV FMYPELLPVC SLKAKNPQDK
310 320 330 340 350
ILFTKAEDNK YLLTCKTARQ LTVRIKNLNM NRAPDNIIKF YKKTKQLPVL
360 370 380 390 400
GKCCEEIQPH QWKPPIEREE HRLPFWLKAS LPSIQEELRH MADGAREVGN
410 420 430 440 450
MTGTTEINSD QGLEKDNSEL GSETRYPLLL PKGVVLKLKP VADRFPKKAW
460 470 480 490 500
RQKRSSVLKP LLIQPSPSLQ PSFNPGKTPA QSTHSEAPPS KMVLRIPHPI
510 520 530 540 550
QPATVLQTVP GVPPLGVSGG ESFESPAALP AMPPEARTSF PLSESQTLLS
560 570 580 590 600
SAPVPKVMMP SPASSMFRKP YVRRRPSKRR GARAFRCIKP APVIHPASVI
610 620 630 640 650
FTVPATTVKI VSLGGGCNMI QPVNAAVAQS PQTIPIATLL VNPTSFPCPL
660 670 680 690 700
NQPLVASSVS PLIVSGNSVN LPIPSTPEDK AHMNVDIACA VADGENAFQG
710 720 730 740 750
LEPKLEPQEL SPLSATVFPK VEHSPGPPPV DKQCQEGLSE NSAYRWTVVK
760 770 780 790
TEEGRQALEP LPQGIQESLN NSSPGDLEEV VKMEPEDATE EISGFL
Length:796
Mass (Da):87,944
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2FC8B4DBA8DFDA7
GO
Isoform 2 (identifier: Q9H869-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Show »
Length:750
Mass (Da):83,088
Checksum:i35A05C3146FC95D7
GO
Isoform 3 (identifier: Q9H869-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Show »
Length:739
Mass (Da):81,702
Checksum:iAEE39032FCC83A53
GO
Isoform 4 (identifier: Q9H869-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Show »
Length:730
Mass (Da):80,893
Checksum:i3A7B22D694AE7E0B
GO
Isoform 5 (identifier: Q9H869-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Show »
Length:684
Mass (Da):75,330
Checksum:iE2F9E4BEAB76E3D5
GO
Isoform 6 (identifier: Q9H869-6) [UniParc]FASTAAdd to basket
Also known as: HCCA1

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:719
Mass (Da):79,508
Checksum:i3C3288D1B4E1CEF2
GO
Isoform 7 (identifier: Q9H869-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Show »
Length:467
Mass (Da):50,634
Checksum:i8A0B641CD01FAEC3
GO
Isoform 8 (identifier: Q9H869-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEEEASRSAAATNPG → MAGVGRSGGP...LSLLLSRISA

Note: No experimental confirmation available.
Show »
Length:868
Mass (Da):95,521
Checksum:i07F36903760F9C75
GO
Isoform 9 (identifier: Q9H869-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEEEASRSAAATNPG → MAGVGRSGGP...LSLLLSRISA
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Note: No experimental confirmation available.
Show »
Length:888
Mass (Da):97,716
Checksum:i237B12A7917D6593
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QZ55B0QZ55_HUMAN
YY1-associated protein 1
YY1AP1
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q68CT8Q68CT8_HUMAN
YY1-associated protein 1
YY1AP1 DKFZp686J14104
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KFK1A3KFK1_HUMAN
YY1-associated protein 1
YY1AP1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A3KFK2A3KFK2_HUMAN
YY1-associated protein 1
YY1AP1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DZQ4B4DZQ4_HUMAN
YY1-associated protein 1
YY1AP1
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD62F8WD62_HUMAN
YY1-associated protein 1
YY1AP1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91871 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti27R → Q in BAB14748 (PubMed:14702039).Curated1
Sequence conflicti498H → R in BAG59954 (PubMed:14702039).Curated1
Sequence conflicti541P → L (PubMed:11710830).Curated1
Sequence conflicti553P → L in AAH01655 (PubMed:15489334).Curated1
Sequence conflicti553P → L in AAH01843 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078760150 – 796Missing in GRNG. 1 PublicationAdd BLAST647
Natural variantiVAR_078761170 – 796Missing in GRNG. 1 PublicationAdd BLAST627
Natural variantiVAR_051497412G → S. Corresponds to variant dbSNP:rs35098429Ensembl.1
Natural variantiVAR_078762705 – 796Missing in GRNG. 1 PublicationAdd BLAST92
Natural variantiVAR_078763709 – 796Missing in GRNG. 1 PublicationAdd BLAST88
Natural variantiVAR_051498786E → Q. Corresponds to variant dbSNP:rs7539Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0165851 – 329Missing in isoform 7. 1 PublicationAdd BLAST329
Alternative sequenceiVSP_0165861 – 132Missing in isoform 5. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_0165871 – 77Missing in isoform 3 and isoform 6. 3 PublicationsAdd BLAST77
Alternative sequenceiVSP_0165881 – 66Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST66
Alternative sequenceiVSP_0468581 – 15MEEEA…ATNPG → MAGVGRSGGPWGRTRGGRSG RLGVSLGALSSLPLEELPRP LCCRRCRRHFGFALRGETIP VSVAGSASSQFAPLALHLSL LLSRISA in isoform 8 and isoform 9. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_016589309N → NLLALGLKHFEGTEFLNPLI S in isoform 2, isoform 3, isoform 5 and isoform 9. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF206328 mRNA Translation: AAL74055.1
AF466401 mRNA Translation: AAL75971.1
AF203474 mRNA Translation: AAO13249.1
AY604179 mRNA Translation: AAT34990.1
AK001737 mRNA Translation: BAA91871.1 Different initiation.
AK023976 mRNA Translation: BAB14748.1
AK297562 mRNA Translation: BAG59954.1
AK303386 mRNA Translation: BAG64442.1
AL162734 Genomic DNA No translation available.
BX088689 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53052.1
CH471121 Genomic DNA Translation: EAW53055.1
CH471121 Genomic DNA Translation: EAW53056.1
CH471121 Genomic DNA Translation: EAW53057.1
CH471121 Genomic DNA Translation: EAW53060.1
BC001655 mRNA Translation: AAH01655.2
BC001843 mRNA Translation: AAH01843.2
BC003500 mRNA No translation available.
BC008766 mRNA Translation: AAH08766.2
BC009358 mRNA Translation: AAH09358.2
BC014906 mRNA Translation: AAH14906.1
BC025272 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1115.1 [Q9H869-1]
CCDS1116.1 [Q9H869-2]
CCDS55643.1 [Q9H869-4]
CCDS55644.1 [Q9H869-8]
CCDS55645.1 [Q9H869-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001185828.1, NM_001198899.1 [Q9H869-3]
NP_001185829.1, NM_001198900.1 [Q9H869-3]
NP_001185830.1, NM_001198901.1 [Q9H869-2]
NP_001185831.1, NM_001198902.1 [Q9H869-2]
NP_001185832.1, NM_001198903.1 [Q9H869-9]
NP_001185833.1, NM_001198904.1 [Q9H869-8]
NP_001185834.1, NM_001198905.1 [Q9H869-4]
NP_001185835.1, NM_001198906.1
NP_060723.2, NM_018253.3 [Q9H869-3]
NP_620829.1, NM_139118.2 [Q9H869-1]
NP_620830.1, NM_139119.2 [Q9H869-2]
NP_620832.1, NM_139121.2 [Q9H869-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295566; ENSP00000295566; ENSG00000163374 [Q9H869-1]
ENST00000311573; ENSP00000311138; ENSG00000163374 [Q9H869-6]
ENST00000347088; ENSP00000316079; ENSG00000163374 [Q9H869-2]
ENST00000355499; ENSP00000347686; ENSG00000163374 [Q9H869-2]
ENST00000359205; ENSP00000352134; ENSG00000163374 [Q9H869-3]
ENST00000361831; ENSP00000355298; ENSG00000163374 [Q9H869-3]
ENST00000368330; ENSP00000357314; ENSG00000163374 [Q9H869-2]
ENST00000368339; ENSP00000357323; ENSG00000163374 [Q9H869-9]
ENST00000368340; ENSP00000357324; ENSG00000163374 [Q9H869-8]
ENST00000404643; ENSP00000385390; ENSG00000163374 [Q9H869-4]
ENST00000407221; ENSP00000385791; ENSG00000163374 [Q9H869-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55249

UCSC genome browser

More...
UCSCi
uc001flh.4 human [Q9H869-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206328 mRNA Translation: AAL74055.1
AF466401 mRNA Translation: AAL75971.1
AF203474 mRNA Translation: AAO13249.1
AY604179 mRNA Translation: AAT34990.1
AK001737 mRNA Translation: BAA91871.1 Different initiation.
AK023976 mRNA Translation: BAB14748.1
AK297562 mRNA Translation: BAG59954.1
AK303386 mRNA Translation: BAG64442.1
AL162734 Genomic DNA No translation available.
BX088689 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53052.1
CH471121 Genomic DNA Translation: EAW53055.1
CH471121 Genomic DNA Translation: EAW53056.1
CH471121 Genomic DNA Translation: EAW53057.1
CH471121 Genomic DNA Translation: EAW53060.1
BC001655 mRNA Translation: AAH01655.2
BC001843 mRNA Translation: AAH01843.2
BC003500 mRNA No translation available.
BC008766 mRNA Translation: AAH08766.2
BC009358 mRNA Translation: AAH09358.2
BC014906 mRNA Translation: AAH14906.1
BC025272 mRNA No translation available.
CCDSiCCDS1115.1 [Q9H869-1]
CCDS1116.1 [Q9H869-2]
CCDS55643.1 [Q9H869-4]
CCDS55644.1 [Q9H869-8]
CCDS55645.1 [Q9H869-9]
RefSeqiNP_001185828.1, NM_001198899.1 [Q9H869-3]
NP_001185829.1, NM_001198900.1 [Q9H869-3]
NP_001185830.1, NM_001198901.1 [Q9H869-2]
NP_001185831.1, NM_001198902.1 [Q9H869-2]
NP_001185832.1, NM_001198903.1 [Q9H869-9]
NP_001185833.1, NM_001198904.1 [Q9H869-8]
NP_001185834.1, NM_001198905.1 [Q9H869-4]
NP_001185835.1, NM_001198906.1
NP_060723.2, NM_018253.3 [Q9H869-3]
NP_620829.1, NM_139118.2 [Q9H869-1]
NP_620830.1, NM_139119.2 [Q9H869-2]
NP_620832.1, NM_139121.2 [Q9H869-5]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120540, 33 interactors
IntActiQ9H869, 18 interactors
MINTiQ9H869
STRINGi9606.ENSP00000357323

PTM databases

iPTMnetiQ9H869
PhosphoSitePlusiQ9H869

Polymorphism and mutation databases

BioMutaiYY1AP1
DMDMi147744601

Proteomic databases

jPOSTiQ9H869
MaxQBiQ9H869
PaxDbiQ9H869
PeptideAtlasiQ9H869
PRIDEiQ9H869
ProteomicsDBi81188
81189 [Q9H869-2]
81190 [Q9H869-3]
81191 [Q9H869-4]
81192 [Q9H869-5]
81193 [Q9H869-6]
81194 [Q9H869-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55249
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295566; ENSP00000295566; ENSG00000163374 [Q9H869-1]
ENST00000311573; ENSP00000311138; ENSG00000163374 [Q9H869-6]
ENST00000347088; ENSP00000316079; ENSG00000163374 [Q9H869-2]
ENST00000355499; ENSP00000347686; ENSG00000163374 [Q9H869-2]
ENST00000359205; ENSP00000352134; ENSG00000163374 [Q9H869-3]
ENST00000361831; ENSP00000355298; ENSG00000163374 [Q9H869-3]
ENST00000368330; ENSP00000357314; ENSG00000163374 [Q9H869-2]
ENST00000368339; ENSP00000357323; ENSG00000163374 [Q9H869-9]
ENST00000368340; ENSP00000357324; ENSG00000163374 [Q9H869-8]
ENST00000404643; ENSP00000385390; ENSG00000163374 [Q9H869-4]
ENST00000407221; ENSP00000385791; ENSG00000163374 [Q9H869-6]
GeneIDi55249
KEGGihsa:55249
UCSCiuc001flh.4 human [Q9H869-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55249
DisGeNETi55249

GeneCards: human genes, protein and diseases

More...
GeneCardsi
YY1AP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0028706
HGNCiHGNC:30935 YY1AP1
HPAiHPA006986
HPA064249
MalaCardsiYY1AP1
MIMi602531 phenotype
607860 gene
neXtProtiNX_Q9H869
OpenTargetsiENSG00000163374
Orphaneti79094 Grange syndrome
PharmGKBiPA142670546

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JQ2S Eukaryota
ENOG410XS4M LUCA
GeneTreeiENSGT00390000016256
HOGENOMiHOG000038018
InParanoidiQ9H869
OMAiTSFICPL
OrthoDBi49443at2759
PhylomeDBiQ9H869
TreeFamiTF343327

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
YY1AP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
YY1AP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55249

Protein Ontology

More...
PROi
PR:Q9H869

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163374 Expressed in 230 organ(s), highest expression level in testis
ExpressionAtlasiQ9H869 baseline and differential
GenevisibleiQ9H869 HS

Family and domain databases

InterProiView protein in InterPro
IPR033274 YY1AP1
PANTHERiPTHR16088:SF9 PTHR16088:SF9, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYYAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H869
Secondary accession number(s): B0QZ54
, B4DMP2, B4E0I0, D3DV96, D3DV98, H7BY62, Q5VYZ1, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9NV84
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 15, 2007
Last modified: May 8, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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