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UniProtKB - Q9H867 (MT21D_HUMAN)

Entry version 149 (25 May 2022)
Sequence version 2 (10 Jul 2007)
Previous versions | rss
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Protein

Protein N-lysine methyltransferase METTL21D

Gene

VCPKMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei96S-adenosyl-L-methionine1 Publication1
Binding sitei126S-adenosyl-L-methionine; via amide nitrogen1 Publication1
Binding sitei143S-adenosyl-L-methionine; via carbonyl oxygen1 Publication1
Binding sitei148S-adenosyl-L-methionine1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H867

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8876725, Protein methylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H867

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H867

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein N-lysine methyltransferase METTL21D (EC:2.1.1.-2 Publications)
Alternative name(s):
Methyltransferase-like protein 21D
VCP lysine methyltransferase
Short name:
VCP-KMT
Valosin-containing protein lysine methyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCPKMT
Synonyms:C14orf138, METTL21D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20352, VCPKMT

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615260, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H867

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100483

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi73E → Q: Loss of methyltransferase activity. 1 Publication1
Mutagenesisi96D → A or V: Loss of methyltransferase activity. 1 Publication1
Mutagenesisi144D → V: Loss of methyltransferase activity. 1 Publication1

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000100483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134866014

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H867, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3588742

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VCPKMT

Domain mapping of disease mutations (DMDM)

More...DMDMi		152031572

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899372 – 229Protein N-lysine methyltransferase METTL21DAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H867

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H867

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H867

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H867

PeptideAtlas

More...PeptideAtlasi		Q9H867

PRoteomics IDEntifications database

More...PRIDEi		Q9H867

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81183 [Q9H867-4]
81184 [Q9H867-1]
81185 [Q9H867-2]
81186 [Q9H867-3]
81187 [Q9H867-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H867

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H867

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100483, Expressed in endothelial cell and 229 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H867, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100483, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ALKBH6.

Interacts with ASPSCR1 and UBXN6; interaction with ASPSCR1, but not with UBXN6, enhances VCP methylation.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122744, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q9H867, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379201

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H867, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1229
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9H867

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H867

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 77S-adenosyl-L-methionine binding1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily. METTL21 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2793, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157135

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1890393_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H867

Identification of Orthologs from Complete Genome Data

More...OMAi		RFMKMAK

Database of Orthologous Groups

More...OrthoDBi		1494909at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H867

TreeFam database of animal gene trees

More...TreeFami		TF352990

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019410, Methyltransf_16
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...PANTHERi		PTHR14614, PTHR14614, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10294, Methyltransf_16, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 4 (identifier: Q9H867-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTLESSLE DPLRSFVRVL EKRDGTVLRL QQYSSGGVGC VVWDAAIVLS 
        60         70         80         90        100
KYLETPEFSG DGAHALSRRS VLELGSGTGA VGLMAATLGA DVVVTDLEEL 
       110        120        130        140        150
QDLLKMNINM NKHLVTGSVQ AKVLKWGEEI EGFPSPPDFI LMADCIYYEE 
       160        170        180        190        200
SLEPLLKTLK DISGFETCII CCYEQRTMGK NPEIEKKYFE LLQLDFDFEK 
       210        220 
IPLEKHDEEY RSEDIHIIYI RKKKSKFPS
Length:229
Mass (Da):25,807
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73B22FC1D14F12C7
GO
Isoform 1 (identifier: Q9H867-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-144: VLKWGEEIEGFPSPPDFILMAD → GGRNRRLSFSTRLHTDGRLHIL
     145-229: Missing.

Show »
Length:144
Mass (Da):15,565
Checksum:iA9570313CE131B75
GO
Isoform 2 (identifier: Q9H867-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MADTLESSLE...AVGLMAATLG → MWGRLLQAFPPVPTPQSTLFYR
     191-229: Missing.

Show »
Length:123
Mass (Da):14,211
Checksum:i879E819E309F8610
GO
Isoform 3 (identifier: Q9H867-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-229: Missing.

Show »
Length:89
Mass (Da):9,371
Checksum:i1E7A543768BB6488
GO
Isoform 5 (identifier: Q9H867-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     191-225: Missing.

Show »
Length:194
Mass (Da):21,435
Checksum:i34E94BD4A4DB2EE7
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD62329 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05962163A → D. Corresponds to variant dbSNP:rs11157729Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0088141 – 89MADTL…AATLG → MWGRLLQAFPPVPTPQSTLF YR in isoform 2. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_00881590 – 229Missing in isoform 3. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_026586123 – 144VLKWG…ILMAD → GGRNRRLSFSTRLHTDGRLH IL in isoform 1. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_026587145 – 229Missing in isoform 1. 2 PublicationsAdd BLAST85
Alternative sequenceiVSP_008816191 – 229Missing in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_043258191 – 225Missing in isoform 5. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK023982 mRNA Translation: BAB14752.1
AK129564 mRNA Translation: BAC85183.1
BX247997 mRNA Translation: CAD62329.1 Different initiation.
AL109758 Genomic DNA No translation available.
BC027585 mRNA No translation available.
BC105118 mRNA Translation: AAI05119.1
BC143673 mRNA Translation: AAI43674.1
BC143674 mRNA Translation: AAI43675.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41951.1 [Q9H867-5]
CCDS9696.2 [Q9H867-4]

NCBI Reference Sequences

More...RefSeqi		NP_001035752.1, NM_001040662.1 [Q9H867-5]
NP_078834.2, NM_024558.2 [Q9H867-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000395859.2; ENSP00000379200.2; ENSG00000100483.14 [Q9H867-5]
ENST00000395860.7; ENSP00000379201.2; ENSG00000100483.14
ENST00000491402.5; ENSP00000437113.1; ENSG00000100483.14 [Q9H867-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79609

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79609

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000395860.7; ENSP00000379201.2; NM_024558.3; NP_078834.2

UCSC genome browser

More...UCSCi		uc001wxo.2, human [Q9H867-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023982 mRNA Translation: BAB14752.1
AK129564 mRNA Translation: BAC85183.1
BX247997 mRNA Translation: CAD62329.1 Different initiation.
AL109758 Genomic DNA No translation available.
BC027585 mRNA No translation available.
BC105118 mRNA Translation: AAI05119.1
BC143673 mRNA Translation: AAI43674.1
BC143674 mRNA Translation: AAI43675.1
CCDSiCCDS41951.1 [Q9H867-5]
CCDS9696.2 [Q9H867-4]
RefSeqiNP_001035752.1, NM_001040662.1 [Q9H867-5]
NP_078834.2, NM_024558.2 [Q9H867-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LG1X-ray1.80A/B/C7-229[»]
AlphaFoldDBiQ9H867
SMRiQ9H867
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi122744, 16 interactors
IntActiQ9H867, 3 interactors
STRINGi9606.ENSP00000379201

Chemistry databases

ChEMBLiCHEMBL3588742

PTM databases

iPTMnetiQ9H867
PhosphoSitePlusiQ9H867

Genetic variation databases

BioMutaiVCPKMT
DMDMi152031572

Proteomic databases

EPDiQ9H867
MassIVEiQ9H867
MaxQBiQ9H867
PaxDbiQ9H867
PeptideAtlasiQ9H867
PRIDEiQ9H867
ProteomicsDBi81183 [Q9H867-4]
81184 [Q9H867-1]
81185 [Q9H867-2]
81186 [Q9H867-3]
81187 [Q9H867-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10369, 22 antibodies from 12 providers

The DNASU plasmid repository

More...DNASUi		79609

Genome annotation databases

EnsembliENST00000395859.2; ENSP00000379200.2; ENSG00000100483.14 [Q9H867-5]
ENST00000395860.7; ENSP00000379201.2; ENSG00000100483.14
ENST00000491402.5; ENSP00000437113.1; ENSG00000100483.14 [Q9H867-1]
GeneIDi79609
KEGGihsa:79609
MANE-SelectiENST00000395860.7; ENSP00000379201.2; NM_024558.3; NP_078834.2
UCSCiuc001wxo.2, human [Q9H867-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79609

GeneCards: human genes, protein and diseases

More...GeneCardsi		VCPKMT
HGNCiHGNC:20352, VCPKMT
HPAiENSG00000100483, Low tissue specificity
MIMi615260, gene
neXtProtiNX_Q9H867
OpenTargetsiENSG00000100483
PharmGKBiPA134866014
VEuPathDBiHostDB:ENSG00000100483

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2793, Eukaryota
GeneTreeiENSGT00940000157135
HOGENOMiCLU_1890393_0_0_1
InParanoidiQ9H867
OMAiRFMKMAK
OrthoDBi1494909at2759
PhylomeDBiQ9H867
TreeFamiTF352990

Enzyme and pathway databases

PathwayCommonsiQ9H867
ReactomeiR-HSA-8876725, Protein methylation
SignaLinkiQ9H867
SIGNORiQ9H867

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79609, 19 hits in 1055 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VCPKMT, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79609
PharosiQ9H867, Tbio

Protein Ontology

More...PROi		PR:Q9H867
RNActiQ9H867, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100483, Expressed in endothelial cell and 229 other tissues
GenevisibleiQ9H867, HS

Family and domain databases

Gene3Di3.40.50.150, 1 hit
InterProiView protein in InterPro
IPR019410, Methyltransf_16
IPR029063, SAM-dependent_MTases
PANTHERiPTHR14614, PTHR14614, 1 hit
PfamiView protein in Pfam
PF10294, Methyltransf_16, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMT21D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H867
Secondary accession number(s): B7ZLA3
, B7ZLA4, Q2M2X3, Q86T12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: July 10, 2007
Last modified: May 25, 2022
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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