VCPKMT

Functionⁱ

Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	43	S-adenosyl-L-methionine; via amide nitrogen1 Publication	1
Binding siteⁱ	96	S-adenosyl-L-methionine1 Publication	1
Binding siteⁱ	126	S-adenosyl-L-methionine; via amide nitrogen1 Publication	1
Binding siteⁱ	143	S-adenosyl-L-methionine; via carbonyl oxygen1 Publication	1
Binding siteⁱ	148	S-adenosyl-L-methionine1 Publication	1

GO - Molecular functionⁱ

ATPase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23349634
protein-lysine N-methyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22948820
- 23349634

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of ATPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23349634
peptidyl-lysine methylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23349634
peptidyl-lysine trimethylation
Source: UniProtKB
Inferred from direct assayⁱ
- 22948820
protein methylation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, Transferase
Ligand	S-adenosyl-L-methionine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8876725 Protein methylation
SIGNORⁱ	Q9H867

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein-lysine methyltransferase METTL21D (EC:2.1.1.-) Alternative name(s): Methyltransferase-like protein 21D VCP lysine methyltransferase Short name: VCP-KMT Valosin-containing protein lysine methyltransferase
Gene namesⁱ	Name:VCPKMT Synonyms:C14orf138, METTL21D
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100483.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20352 VCPKMT
MIMⁱ	615260 gene
neXtProtⁱ	NX_Q9H867

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	73	E → Q: Loss of methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	96	D → A or V: Loss of methyltransferase activity. 1 Publication	1
Mutagenesisⁱ	144	D → V: Loss of methyltransferase activity. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000100483
PharmGKBⁱ	PA134866014

Chemistry databases

ChEMBLⁱ	CHEMBL3588742

ChEMBLⁱ

CHEMBL3588742

Polymorphism and mutation databases

BioMutaⁱ	METTL21D
DMDMⁱ	152031572

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000089937	2 – 229	Protein-lysine methyltransferase METTL21DAdd BLAST		228

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1
Modified residueⁱ	8	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H867
PaxDbⁱ	Q9H867
PeptideAtlas More...PeptideAtlasⁱ	Q9H867
PRIDEⁱ	Q9H867
ProteomicsDBⁱ	81183 81184 [Q9H867-1] 81185 [Q9H867-2] 81186 [Q9H867-3] 81187 [Q9H867-5]

PTM databases

iPTMnetⁱ	Q9H867
PhosphoSitePlusⁱ	Q9H867

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100483 Expressed in 216 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_C14orf138
Genevisibleⁱ	Q9H867 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001146 HPA076561

HPAⁱ

HPA001146
HPA076561

Interactionⁱ

Subunit structureⁱ

Interacts with ALKBH6. Interacts with ASPSCR1 and UBXN6; interaction with ASPSCR1, but not with UBXN6, enhances VCP methylation.2 Publications

GO - Molecular functionⁱ

ATPase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23349634

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	122744, 15 interactors
IntActⁱ	Q9H867, 1 interactor
STRINGⁱ	9606.ENSP00000379201

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	8 – 10	Combined sources	3
Helixⁱ	12 – 16	Combined sources	5
Beta strandⁱ	17 – 21	Combined sources	5
Beta strandⁱ	27 – 33	Combined sources	7
Helixⁱ	44 – 53	Combined sources	10
Helixⁱ	56 – 59	Combined sources	4
Beta strandⁱ	61 – 63	Combined sources	3
Turnⁱ	65 – 68	Combined sources	4
Beta strandⁱ	70 – 75	Combined sources	6
Helixⁱ	80 – 86	Combined sources	7
Turnⁱ	87 – 89	Combined sources	3
Beta strandⁱ	91 – 96	Combined sources	6
Helixⁱ	98 – 100	Combined sources	3
Helixⁱ	101 – 110	Combined sources	10
Helixⁱ	112 – 114	Combined sources	3
Beta strandⁱ	116 – 123	Combined sources	8
Beta strandⁱ	138 – 144	Combined sources	7
Helixⁱ	149 – 151	Combined sources	3
Helixⁱ	153 – 162	Combined sources	10
Beta strandⁱ	168 – 174	Combined sources	7
Helixⁱ	181 – 192	Combined sources	12
Turnⁱ	193 – 195	Combined sources	3
Beta strandⁱ	196 – 200	Combined sources	5
Helixⁱ	203 – 205	Combined sources	3
Beta strandⁱ	208 – 210	Combined sources	3
Beta strandⁱ	215 – 222	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H867
SMRⁱ	Q9H867
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	75 – 77	S-adenosyl-L-methionine binding1 Publication		3

Sequence similaritiesⁱ

Belongs to the methyltransferase superfamily. METTL21 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410ISZE Eukaryota ENOG4111MAT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074572
HOGENOMⁱ	HOG000007089
HOVERGENⁱ	HBG054931
InParanoidⁱ	Q9H867
KEGG Orthology (KO) More...KOⁱ	K21806
OMAⁱ	EDIHILY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NXA
PhylomeDBⁱ	Q9H867
TreeFamⁱ	TF352990

Family and domain databases

InterProⁱ	View protein in InterPro IPR019410 Methyltransf_16 IPR029063 SAM-dependent_MTases
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10294 Methyltransf_16, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 4 (identifier: Q9H867-4) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTLESSLE DPLRSFVRVL EKRDGTVLRL QQYSSGGVGC VVWDAAIVLS 
        60         70         80         90        100
KYLETPEFSG DGAHALSRRS VLELGSGTGA VGLMAATLGA DVVVTDLEEL 
       110        120        130        140        150
QDLLKMNINM NKHLVTGSVQ AKVLKWGEEI EGFPSPPDFI LMADCIYYEE 
       160        170        180        190        200
SLEPLLKTLK DISGFETCII CCYEQRTMGK NPEIEKKYFE LLQLDFDFEK 
       210        220 
IPLEKHDEEY RSEDIHIIYI RKKKSKFPS

Length:229

Mass (Da):25,807

Last modified:July 10, 2007 - v2

Checksum:ⁱ73B22FC1D14F12C7

GO

Isoform 1 (identifier: Q9H867-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
123-144: VLKWGEEIEGFPSPPDFILMAD → GGRNRRLSFSTRLHTDGRLHIL
145-229: Missing.

« Hide

        10         20         30         40         50
MADTLESSLE DPLRSFVRVL EKRDGTVLRL QQYSSGGVGC VVWDAAIVLS 
        60         70         80         90        100
KYLETPEFSG DGAHALSRRS VLELGSGTGA VGLMAATLGA DVVVTDLEEL 
       110        120        130        140 
QDLLKMNINM NKHLVTGSVQ AKGGRNRRLS FSTRLHTDGR LHIL

Show »

Length:144

Mass (Da):15,565

Checksum:ⁱA9570313CE131B75

GO

Isoform 2 (identifier: Q9H867-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-89: MADTLESSLE...AVGLMAATLG → MWGRLLQAFPPVPTPQSTLFYR
191-229: Missing.

« Hide

        10         20         30         40         50
MWGRLLQAFP PVPTPQSTLF YRADVVVTDL EELQDLLKMN INMNKHLVTG 
        60         70         80         90        100
SVQAKVLKWG EEIEGFPSPP DFILMADCIY YEESLEPLLK TLKDISGFET 
       110        120 
CIICCYEQRT MGKNPEIEKK YFE

Note: No experimental confirmation available.

Show »

Length:123

Mass (Da):14,211

Checksum:ⁱ879E819E309F8610

GO

Isoform 3 (identifier: Q9H867-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
90-229: Missing.

« Hide

        10         20         30         40         50
MADTLESSLE DPLRSFVRVL EKRDGTVLRL QQYSSGGVGC VVWDAAIVLS 
        60         70         80 
KYLETPEFSG DGAHALSRRS VLELGSGTGA VGLMAATLG

Note: No experimental confirmation available.

Show »

Length:89

Mass (Da):9,371

Checksum:ⁱ1E7A543768BB6488

GO

Isoform 5 (identifier: Q9H867-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
191-225: Missing.

« Hide

        10         20         30         40         50
MADTLESSLE DPLRSFVRVL EKRDGTVLRL QQYSSGGVGC VVWDAAIVLS 
        60         70         80         90        100
KYLETPEFSG DGAHALSRRS VLELGSGTGA VGLMAATLGA DVVVTDLEEL 
       110        120        130        140        150
QDLLKMNINM NKHLVTGSVQ AKVLKWGEEI EGFPSPPDFI LMADCIYYEE 
       160        170        180        190 
SLEPLLKTLK DISGFETCII CCYEQRTMGK NPEIEKKYFE KFPS

Note: No experimental confirmation available.

Show »

Length:194

Mass (Da):21,435

Checksum:ⁱ34E94BD4A4DB2EE7

GO

Sequence cautionⁱ

The sequence CAD62329 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059621	63	A → D. Corresponds to variant dbSNP:rs11157729Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_008814	1 – 89	MADTL…AATLG → MWGRLLQAFPPVPTPQSTLF YR in isoform 2. 1 PublicationAdd BLAST	89
Alternative sequenceⁱVSP_008815	90 – 229	Missing in isoform 3. 1 PublicationAdd BLAST	140
Alternative sequenceⁱVSP_026586	123 – 144	VLKWG…ILMAD → GGRNRRLSFSTRLHTDGRLH IL in isoform 1. 2 PublicationsAdd BLAST	22
Alternative sequenceⁱVSP_026587	145 – 229	Missing in isoform 1. 2 PublicationsAdd BLAST	85
Alternative sequenceⁱVSP_008816	191 – 229	Missing in isoform 2. 1 PublicationAdd BLAST	39
Alternative sequenceⁱVSP_043258	191 – 225	Missing in isoform 5. 1 PublicationAdd BLAST	35

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023982 mRNA Translation: BAB14752.1 AK129564 mRNA Translation: BAC85183.1 BX247997 mRNA Translation: CAD62329.1 Different initiation. AL109758 Genomic DNA No translation available. BC027585 mRNA No translation available. BC105118 mRNA Translation: AAI05119.1 BC143673 mRNA Translation: AAI43674.1 BC143674 mRNA Translation: AAI43675.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41951.1 [Q9H867-5] CCDS9696.2 [Q9H867-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035752.1, NM_001040662.1 [Q9H867-5] NP_078834.2, NM_024558.2 [Q9H867-4]
UniGeneⁱ	Hs.558541

Genome annotation databases

Ensemblⁱ	ENST00000395859; ENSP00000379200; ENSG00000100483 [Q9H867-5] ENST00000395860; ENSP00000379201; ENSG00000100483 [Q9H867-4] ENST00000491402; ENSP00000437113; ENSG00000100483 [Q9H867-1]
GeneIDⁱ	79609
KEGGⁱ	hsa:79609
UCSC genome browser More...UCSCⁱ	uc001wxo.2 human [Q9H867-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9H867	Protein-lysine methyltransferase METTL21D		MOUSE		228	UniRef90_Q9H867
Valosin containing protein lysine methyltransferase		MACFA		235
Valosin containing protein lysine methyltransferase		CERAT		235
Valosin containing protein lysine methyltransferase		MACNE		235
Valosin containing protein lysine methyltransferase		PAPAN		235
+84
Q9H867-1	MGC159550 protein		BOVIN		139	UniRef90_A8WFM0
VCPKMT isoform 2		PONAB		144
VCPKMT isoform 2		PANTR		144
Q9H867-5	Uncharacterized protein (Fragment)		NEOLE		238	UniRef90_Q9H867-5
Valosin containing protein lysine methyltransferase		CANLF		197
Valosin containing protein lysine methyltransferase		MACFA		194
Valosin containing protein lysine methyltransferase		CERAT		194
Valosin containing protein lysine methyltransferase		PAPAN		194
+32

Protein	Similar proteins		Species	Score	Length	Source
Q9H867	Protein-lysine methyltransferase METTL21D		MOUSE		228	UniRef50_Q9H867
Valosin containing protein lysine methyltransferase		PAPAN		235
Valosin containing protein lysine methyltransferase		MANLE		235
Valosin containing protein lysine methyltransferase		MACFA		235
Valosin containing protein lysine methyltransferase		MACNE		235
+101
Q9H867-1	MGC159550 protein		BOVIN		139	UniRef50_A8WFM0
VCPKMT isoform 2		PANTR		144
VCPKMT isoform 2		PONAB		144
Protein-lysine methyltransferase METTL21D (Fragment)		ESCRO		154
VCPKMT isoform 6		PANTR		154
Q9H867-5	Uncharacterized protein (Fragment)		NEOLE		238	UniRef50_Q9H867-5
Valosin containing protein lysine methyltransferase		CANLF		197
Valosin containing protein lysine methyltransferase		RHIRO		194
Valosin containing protein lysine methyltransferase		RHIBE		194
Valosin containing protein lysine methyltransferase		CERAT		194
+155

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023982 mRNA Translation: BAB14752.1 AK129564 mRNA Translation: BAC85183.1 BX247997 mRNA Translation: CAD62329.1 Different initiation. AL109758 Genomic DNA No translation available. BC027585 mRNA No translation available. BC105118 mRNA Translation: AAI05119.1 BC143673 mRNA Translation: AAI43674.1 BC143674 mRNA Translation: AAI43675.1
CCDSⁱ	CCDS41951.1 [Q9H867-5] CCDS9696.2 [Q9H867-4]
RefSeqⁱ	NP_001035752.1, NM_001040662.1 [Q9H867-5] NP_078834.2, NM_024558.2 [Q9H867-4]
UniGeneⁱ	Hs.558541

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4LG1	X-ray	1.80	A/B/C	7-229	[»]
ProteinModelPortalⁱ	Q9H867
SMRⁱ	Q9H867
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122744, 15 interactors
IntActⁱ	Q9H867, 1 interactor
STRINGⁱ	9606.ENSP00000379201

Chemistry databases

ChEMBLⁱ	CHEMBL3588742

ChEMBLⁱ

CHEMBL3588742

PTM databases

iPTMnetⁱ	Q9H867
PhosphoSitePlusⁱ	Q9H867

Polymorphism and mutation databases

BioMutaⁱ	METTL21D
DMDMⁱ	152031572

Proteomic databases

EPDⁱ	Q9H867
PaxDbⁱ	Q9H867
PeptideAtlasⁱ	Q9H867
PRIDEⁱ	Q9H867
ProteomicsDBⁱ	81183 81184 [Q9H867-1] 81185 [Q9H867-2] 81186 [Q9H867-3] 81187 [Q9H867-5]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000395859; ENSP00000379200; ENSG00000100483 [Q9H867-5] ENST00000395860; ENSP00000379201; ENSG00000100483 [Q9H867-4] ENST00000491402; ENSP00000437113; ENSG00000100483 [Q9H867-1]
GeneIDⁱ	79609
KEGGⁱ	hsa:79609
UCSCⁱ	uc001wxo.2 human [Q9H867-4]

Organism-specific databases

CTDⁱ	79609
EuPathDBⁱ	HostDB:ENSG00000100483.13
GeneCardsⁱ	VCPKMT
HGNCⁱ	HGNC:20352 VCPKMT
HPAⁱ	HPA001146 HPA076561
MIMⁱ	615260 gene
neXtProtⁱ	NX_Q9H867
OpenTargetsⁱ	ENSG00000100483
PharmGKBⁱ	PA134866014
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ISZE Eukaryota ENOG4111MAT LUCA
GeneTreeⁱ	ENSGT00550000074572
HOGENOMⁱ	HOG000007089
HOVERGENⁱ	HBG054931
InParanoidⁱ	Q9H867
KOⁱ	K21806
OMAⁱ	EDIHILY
OrthoDBⁱ	EOG091G0NXA
PhylomeDBⁱ	Q9H867
TreeFamⁱ	TF352990

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8876725 Protein methylation
SIGNORⁱ	Q9H867

Miscellaneous databases

ChiTaRSⁱ	VCPKMT human
GenomeRNAiⁱ	79609
Protein Ontology More...PROⁱ	PR:Q9H867
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100483 Expressed in 216 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_C14orf138
Genevisibleⁱ	Q9H867 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019410 Methyltransf_16 IPR029063 SAM-dependent_MTases
Pfamⁱ	View protein in Pfam PF10294 Methyltransf_16, 1 hit
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MT21D_HUMAN
Accessionⁱ	Q9H867Primary (citable) accession number: Q9H867 Secondary accession number(s): B7ZLA3 , B7ZLA4, Q2M2X3, Q86T12
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
	Last sequence update:	July 10, 2007
	Last modified:	September 12, 2018
	This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - Q9H867 (MT21D_HUMAN)

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Protein-lysine methyltransferase METTL21D

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ