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Protein

Putative tubulin-like protein alpha-4B

Gene

TUBA4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi81 – 87GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861 Gap junction assembly
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-389977 Post-chaperonin tubulin folding pathway
R-HSA-437239 Recycling pathway of L1
R-HSA-5617833 Cilium Assembly
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tubulin-like protein alpha-4B
Alternative name(s):
Alpha-tubulin 4B
Gene namesi
Name:TUBA4B
Synonyms:TUBA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000243910.7
HGNCiHGNC:18637 TUBA4B
neXtProtiNX_Q9H853

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000243910

Chemistry databases

DrugBankiDB05147 CYT997

Polymorphism and mutation databases

DMDMi187663995

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003315731 – 241Putative tubulin-like protein alpha-4BAdd BLAST241

Post-translational modificationi

Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.By similarity
Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.By similarity

Proteomic databases

EPDiQ9H853
MaxQBiQ9H853
PeptideAtlasiQ9H853
PRIDEiQ9H853
ProteomicsDBi81178

PTM databases

iPTMnetiQ9H853
PhosphoSitePlusiQ9H853

Expressioni

Gene expression databases

BgeeiENSG00000243910 Expressed in 183 organ(s), highest expression level in epithelium of bronchus
GenevisibleiQ9H853 HS

Interactioni

Protein-protein interaction databases

IntActiQ9H853, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9H853
SMRiQ9H853
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119060
HOVERGENiHBG000089
InParanoidiQ9H853
OMAiTTSSCWW
PhylomeDBiQ9H853

Family and domain databases

Gene3Di3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR000217 Tubulin
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H853-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHQQTERQD PSQPLSRQHG TYRQIFHPEQ LITGKEDAAN NYAWGHYTIG
60 70 80 90 100
KEFIDLLLDR IRKLADQCTG LQGFLVFHSL GRGTGSDVTS FLMEWLSVNY
110 120 130 140 150
GKKSKLGFSI YPAPQVSTAM VQPYNSILTT HTTLEHSDCA FMVDNKAIYD
160 170 180 190 200
ICHCNLDIER PTYTNLNRLI SQIVSSITAS LRFDGALNVD LTEFQTNLVS
210 220 230 240
YLTSTSPWPP MHQSSLQKRY TTSSCWWQRL PMPALSLPTR W
Length:241
Mass (Da):27,551
Last modified:April 29, 2008 - v2
Checksum:i2CC581FEF7BF53BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154C → R in BAB14767 (PubMed:14702039).Curated1
Sequence conflicti219R → K in BAB14767 (PubMed:14702039).Curated1
Sequence conflicti226W → R in BAB14767 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024002 mRNA Translation: BAB14767.1
AC068946 Genomic DNA No translation available.
CCDSiCCDS86922.1
UniGeneiHs.664469

Genome annotation databases

EnsembliENST00000490341; ENSP00000487719; ENSG00000243910

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024002 mRNA Translation: BAB14767.1
AC068946 Genomic DNA No translation available.
CCDSiCCDS86922.1
UniGeneiHs.664469

3D structure databases

ProteinModelPortaliQ9H853
SMRiQ9H853
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H853, 3 interactors

Chemistry databases

DrugBankiDB05147 CYT997

PTM databases

iPTMnetiQ9H853
PhosphoSitePlusiQ9H853

Polymorphism and mutation databases

DMDMi187663995

Proteomic databases

EPDiQ9H853
MaxQBiQ9H853
PeptideAtlasiQ9H853
PRIDEiQ9H853
ProteomicsDBi81178

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000490341; ENSP00000487719; ENSG00000243910

Organism-specific databases

EuPathDBiHostDB:ENSG00000243910.7
GeneCardsiTUBA4B
HGNCiHGNC:18637 TUBA4B
neXtProtiNX_Q9H853
OpenTargetsiENSG00000243910
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119060
HOVERGENiHBG000089
InParanoidiQ9H853
OMAiTTSSCWW
PhylomeDBiQ9H853

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861 Gap junction assembly
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-389977 Post-chaperonin tubulin folding pathway
R-HSA-437239 Recycling pathway of L1
R-HSA-5617833 Cilium Assembly
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-983189 Kinesins

Gene expression databases

BgeeiENSG00000243910 Expressed in 183 organ(s), highest expression level in epithelium of bronchus
GenevisibleiQ9H853 HS

Family and domain databases

Gene3Di3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002452 Alpha_tubulin
IPR000217 Tubulin
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PRINTSiPR01162 ALPHATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBA4B_HUMAN
AccessioniPrimary (citable) accession number: Q9H853
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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